Detailed information for compound 2074525

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 222.714 | Formula: C12H15ClN2
  • H donors: 1 H acceptors: 0 LogP: 2.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC/C(=N\c2cc(C)ccc2Cl)/N1
  • InChi: 1S/C12H15ClN2/c1-8-3-5-10(13)11(7-8)15-12-6-4-9(2)14-12/h3,5,7,9H,4,6H2,1-2H3,(H,14,15)
  • InChiKey: QQARYPWIHQZGRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aspartyl protease 0.0411 0.0873 0.2402
Mycobacterium ulcerans 6-phosphofructokinase 0.0093 0.0169 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0093 0.0169 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Plasmodium vivax aspartyl proteinase, putative 0.1078 0.2349 0.6481
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.002 0.002
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0107 0.0201 0.0857
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0018 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.1078 0.2349 1
Loa Loa (eye worm) fibroinase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Schistosoma mansoni intermediate filament proteins 0.0023 0.0015 0.0015
Plasmodium vivax vivapain-1 0.0031 0.0031 0.0077
Echinococcus granulosus cathepsin b 0.0371 0.0785 0.3341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0093 0.0169 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0004 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0018 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0015
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0036 0.0044 0.0188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0371 0.0785 0.0785
Echinococcus granulosus cysteine protease 0.0031 0.0031 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Echinococcus granulosus 6 phosphofructokinase 0.0093 0.0169 0.0719
Brugia malayi Cathepsin L-like precursor 0.0036 0.0044 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0083 0.0083
Plasmodium vivax plasmepsin IV, putative 0.1078 0.2349 0.6481
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0031 0.0077
Brugia malayi cathepsin Z-like cysteine proteinase 0.0018 0.0004 0.0034
Loa Loa (eye worm) RNA binding protein 0.0054 0.0083 0.0355
Loa Loa (eye worm) 6-phosphofructokinase 0.0093 0.0169 0.0719
Plasmodium vivax aspartyl protease, putative 0.0411 0.0873 0.2402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0072 0.079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.002 0.002
Echinococcus granulosus cathepsin L 0.0018 0.0004 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0031 0.1858
Onchocerca volvulus 0.0023 0.0015 0.0129
Schistosoma mansoni 6-phosphofructokinase 0.0093 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0015
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.1078 0.2349 1
Echinococcus multilocularis tar DNA binding protein 0.0054 0.0083 0.0355
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0025 0.0019 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0072 0.0308
Brugia malayi Pepsin A precursor 0.0411 0.0873 0.8283
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0004 0.0015
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0049 0.0072 0.019
Echinococcus granulosus lamin dm0 0.0023 0.0015 0.0063
Echinococcus multilocularis 6 phosphofructokinase 0.0093 0.0169 0.0719
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Leishmania major ATP-dependent phosphofructokinase 0.0093 0.0169 0.5592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0044 0.0189
Brugia malayi intermediate filament protein 0.0023 0.0015 0.014
Onchocerca volvulus 0.0049 0.0072 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0072 0.0686
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Giardia lamblia Cathepsin B precursor 0.0127 0.0245 1
Loa Loa (eye worm) cysteine protease 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Onchocerca volvulus 0.0411 0.0873 1
Echinococcus granulosus geminin 0.0145 0.0284 0.1207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0018 0.0004 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Entamoeba histolytica cysteine protease, putative 0.0049 0.0072 0.4276
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0018 0.0004 0.0209
Schistosoma mansoni lamin 0.0023 0.0015 0.0015
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0015 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Onchocerca volvulus 0.0049 0.0072 0.079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0031 0.0031
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.005 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0145 0.0284 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0018 0.0004 0.0015
Giardia lamblia Histone acetyltransferase GCN5 0.0033 0.0038 0.1408
Loa Loa (eye worm) phosphofructokinase 0.0093 0.0169 0.0719
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0072 0.0879
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0371 0.0785 0.0785
Trypanosoma brucei RNA helicase, putative 0.0177 0.0355 1
Echinococcus granulosus intermediate filament protein 0.0023 0.0015 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Entamoeba histolytica acetyltransferase, GNAT family 0.0033 0.0038 0.2223
Plasmodium falciparum plasmepsin V 0.0411 0.0873 0.2402
Entamoeba histolytica phosphofructokinase, putative 0.0093 0.0169 1
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Brugia malayi aspartic protease BmAsp-2, identical 0.0411 0.0873 0.8283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0093 0.0169 0.4257
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0083 0.0083
Onchocerca volvulus 0.0049 0.0072 0.079
Echinococcus granulosus histone acetyltransferase KAT2B 0.0036 0.0044 0.0188
Trichomonas vaginalis set domain proteins, putative 0.0202 0.0411 0.1749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0189
Echinococcus multilocularis cysteine protease 0.0049 0.0072 0.0308
Loa Loa (eye worm) hypothetical protein 0.0038 0.0048 0.0203
Brugia malayi TAR-binding protein 0.0054 0.0083 0.0791
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0093 0.0169 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0038 0.0048 0.0048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0004 0.0004
Entamoeba histolytica phosphofructokinase, putative 0.0093 0.0169 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0127 0.0245 0.6616
Trichomonas vaginalis phosphofructokinase, putative 0.0093 0.0169 0.0719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.002 0.002
Plasmodium falciparum plasmepsin III 0.0411 0.0873 0.2402
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0019 0.0043
Echinococcus multilocularis geminin 0.0145 0.0284 0.1207
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0018 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0044 0.0421
Onchocerca volvulus 0.0202 0.0411 0.4685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0004 0.0004
Onchocerca volvulus 0.0411 0.0873 1
Brugia malayi small heat shock protein 0.0493 0.1054 1
Onchocerca volvulus 0.0049 0.0072 0.079
Schistosoma mansoni cathepsin D (A01 family) 0.4222 0.9302 0.9302
Plasmodium vivax unspecified product 0.0031 0.0031 0.0077
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0889 0.1931 0.1931
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0019 0.0082
Plasmodium vivax vivapain-2 0.0049 0.0072 0.019
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0031 0.1858
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0018 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0054 0.0083 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0083 0.0083
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0031 0.0134
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0031 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Echinococcus multilocularis expressed protein 0.0319 0.0668 0.2845
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0025 0.0019 0.0082
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Echinococcus multilocularis lamin 0.0023 0.0015 0.0063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0072 0.0308
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.0411 0.0873 0.3716
Echinococcus granulosus cathepsin l1 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0018 0.0004 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0072 0.4276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0072 0.0308
Echinococcus granulosus lamin 0.0023 0.0015 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0116 0.022 0.022
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0031 0.1858
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0072 0.0308
Toxoplasma gondii cathepsin CPL 0.0049 0.0072 0.019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0072 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0063
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Loa Loa (eye worm) aspartic protease BmAsp-2 0.1078 0.2349 1
Plasmodium vivax plasmepsin V, putative 0.0411 0.0873 0.2402
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0004 0.0015
Toxoplasma gondii 6-phosphofructokinase 0.0025 0.0019 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0083 0.0083
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.1078 0.2349 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0036 0.0044 0.0188
Echinococcus granulosus adam 0.005 0.0073 0.0313
Echinococcus multilocularis cysteine protease 0.0049 0.0072 0.0308
Plasmodium falciparum plasmepsin I 0.1078 0.2349 0.6481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Schistosoma mansoni cathepsin S (C01 family) 0.0018 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0093 0.0169 0.5
Brugia malayi cathepsin B-like cysteine proteinase 0.0371 0.0785 0.7447
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Giardia lamblia Cathepsin B precursor 0.0127 0.0245 1
Echinococcus granulosus cathepsin b 0.0371 0.0785 0.3341
Brugia malayi Reprolysin 0.0022 0.0013 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0031 0.1858
Loa Loa (eye worm) acetyltransferase 0.0124 0.0237 0.101
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0031 0.0357
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0072 0.079
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0019 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0093 0.0169 0.0719
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0093 0.0169 0.2117
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0031 0.0357
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0072 0.0072
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Entamoeba histolytica hypothetical protein 0.0018 0.0004 0.0209
Plasmodium vivax vivapain-2 0.0049 0.0072 0.019
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0004 0.0034
Brugia malayi ADAM-TS Spacer 1 family protein 0.0022 0.0013 0.0122
Echinococcus granulosus tar DNA binding protein 0.0054 0.0083 0.0355
Brugia malayi acetyltransferase, GNAT family protein 0.0124 0.0237 0.2252
Onchocerca volvulus 0.0036 0.0044 0.047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0116 0.022 0.0939
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0004 0.0004
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0025 0.0019 0.065
Toxoplasma gondii cathepsin B 0.0127 0.0245 0.0668
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0072 0.0879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0004 0.0034
Onchocerca volvulus 0.0025 0.002 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0189
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0031 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.002 0.0086
Schistosoma mansoni hypothetical protein 0.0145 0.0284 0.0284
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Plasmodium falciparum cysteine proteinase falcipain 3 0.0049 0.0072 0.019
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0049 0.0072 0.019
Brugia malayi fibroinase precursor 0.0018 0.0004 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0093 0.0169 0.0719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0086
Schistosoma mansoni cathepsin C 0.0018 0.0004 0.0004
Brugia malayi 6-phosphofructokinase 0.0093 0.0169 0.1603
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0127 0.0245 0.3093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0072 0.0879
Brugia malayi hypothetical protein 0.0411 0.0873 0.8283
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.0245 0.1044
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0127 0.0245 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0004 0.0015
Echinococcus granulosus cathepsin l1 0.0036 0.0044 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Schistosoma mansoni hypothetical protein 0.0107 0.0201 0.0201
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Trypanosoma cruzi cruzipain precursor, putative 0.0049 0.0072 0.0879
Toxoplasma gondii aspartyl protease ASP3 0.1654 0.3623 1
Plasmodium falciparum plasmepsin II 0.1078 0.2349 0.6481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0411 0.0873 0.3716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Loa Loa (eye worm) reprolysin 0.0038 0.0048 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0038 0.0048 0.0048
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0031 0.0031
Echinococcus multilocularis adam 0.005 0.0073 0.0313
Loa Loa (eye worm) 6-phosphofructokinase 0.0093 0.0169 0.0719
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.0044 0.0523
Schistosoma mansoni memapsin-2 (A01 family) 0.0411 0.0873 0.0873
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.002 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0189
Plasmodium vivax aspartyl proteinase, putative 0.0411 0.0873 0.2402
Brugia malayi Pre-SET motif family protein 0.0178 0.0357 0.3384
Schistosoma mansoni lamin 0.0023 0.0015 0.0015
Brugia malayi Eukaryotic aspartyl protease family protein 0.0411 0.0873 0.8283
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0018 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0031 0.0134
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0004 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0116 0.022 0.022
Brugia malayi ADAMTS-like protease 0.0022 0.0013 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Brugia malayi 6-phosphofructokinase 0.0093 0.0169 0.1603
Giardia lamblia Cathepsin B precursor 0.0127 0.0245 1
Toxoplasma gondii phosphofructokinase PFKII 0.0025 0.0019 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.012 0.023 0.0978
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Echinococcus multilocularis lamin dm0 0.0023 0.0015 0.0063
Brugia malayi RNA binding protein 0.0054 0.0083 0.0791
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0178 0.0357 0.1518
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0018 0.0004 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0072 0.1264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Brugia malayi cathepsin L precursor 0.0018 0.0004 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0031 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Onchocerca volvulus 0.0049 0.0072 0.079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.002 0.0046
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0209
Brugia malayi hypothetical protein 0.005 0.0073 0.0697
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.1078 0.2349 0.6481
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0018 0.0004 0.0209
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0038 0.0048 0.0203
Plasmodium falciparum histone acetyltransferase GCN5 0.0033 0.0038 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Brugia malayi phosphofructokinase 0.0093 0.0169 0.1603
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0015
Echinococcus multilocularis cathepsin L 0.0031 0.0031 0.0134
Echinococcus multilocularis cathepsin L 0.0018 0.0004 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0018 0.0004 0.0015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0004 0.0015
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0038 0.0048 0.0203
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.002 0.0086
Loa Loa (eye worm) ctsf protein 0.0049 0.0072 0.0308
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0015 0.0063
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0049 0.0072 0.0308
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0107 0.0201 0.0857
Echinococcus multilocularis cathepsin b 0.0371 0.0785 0.3341
Loa Loa (eye worm) aspartyl protease 6 0.0411 0.0873 0.3716
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0072 0.4276
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Plasmodium falciparum plasmepsin IV 0.1078 0.2349 0.6481
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0371 0.0785 0.0785
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0072 0.0879
Onchocerca volvulus 0.0049 0.0072 0.079
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0411 0.0873 0.2402
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.1078 0.2349 0.2349
Plasmodium falciparum plasmepsin VII 0.0411 0.0873 0.2402
Brugia malayi Pre-SET motif family protein 0.0025 0.002 0.0191
Echinococcus granulosus expressed protein 0.0319 0.0668 0.2845
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0036 0.0044 0.0113
Plasmodium vivax aspartyl protease, putative 0.1654 0.3623 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0059
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Echinococcus granulosus cathepsin l cysteine peptidase 0.0049 0.0072 0.0308
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0044 0.2628
Brugia malayi RNA recognition motif domain containing protein 0.0054 0.0083 0.0791
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0371 0.0785 0.0785
Echinococcus multilocularis cathepsin b 0.0371 0.0785 0.3341
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0371 0.0785 1
Onchocerca volvulus 0.0023 0.0015 0.0129
Schistosoma mansoni cathepsin B (C01 family) 0.0018 0.0004 0.0004
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0031 0.0357
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0072 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0044 0.0189
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0044 0.0044
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0031 0.1858
Echinococcus granulosus cathepsin L 0.0031 0.0031 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0031 0.0298
Plasmodium vivax SET domain protein, putative 0.0025 0.002 0.0046
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0025 0.0019 0.0043
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0019 0.0043
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0093 0.0169 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0072 0.0308
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0054 0.0083 0.0355
Echinococcus granulosus cathepsin L cysteine proteinase 0.0049 0.0072 0.0308
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0124 0.0237 0.0237
Loa Loa (eye worm) cathepsin B 0.0127 0.0245 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0031 0.0134
Brugia malayi hypothetical protein 0.0411 0.0873 0.8283
Plasmodium vivax vivapain-3 0.0031 0.0031 0.0077
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0004 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.002 0.002
Brugia malayi Cathepsin L-like precursor 0.0036 0.0044 0.0421
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0124 0.0237 0.101
Loa Loa (eye worm) hypothetical protein 0.0411 0.0873 0.3716
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Plasmodium falciparum plasmepsin IX 0.1654 0.3623 1
Brugia malayi angiogenesis inhibito 0.0022 0.0013 0.0122
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0018 0.0004 0.0004
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0036 0.0044 0.0113
Brugia malayi aspartic protease BmAsp-1, identical 0.0411 0.0873 0.8283
Onchocerca volvulus Cathepsin F homolog 0.0049 0.0072 0.079
Brugia malayi cathepsin Z-like cysteine proteinase 0.0018 0.0004 0.0034
Plasmodium falciparum plasmepsin VIII, putative 0.0411 0.0873 0.2402
Echinococcus multilocularis musashi 0.0023 0.0015 0.0063
Plasmodium vivax aspartyl protease, putative 0.1654 0.3623 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0493 0.1054 0.4486
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0411 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.0371 0.0785 0.3341
Plasmodium falciparum plasmepsin X 0.1654 0.3623 1
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0031 0.1858
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0031 0.0357
Plasmodium falciparum plasmepsin VI 0.1078 0.2349 0.6481
Schistosoma mansoni cathepsin D (A01 family) 0.4222 0.9302 0.9302
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0019 0.0043
Entamoeba histolytica cysteine protease, putative 0.0031 0.0031 0.1858
Brugia malayi Cathepsin L-like precursor 0.0049 0.0072 0.0686
Brugia malayi cathepsin L-like cysteine proteinase 0.0018 0.0004 0.0034
Brugia malayi cathepsin L-like precursor 0.0036 0.0044 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0015
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0036 0.0044 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0093 0.0169 0.0719
Toxoplasma gondii aspartyl protease ASP1 0.1078 0.2349 0.6481
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0025 0.0019 0.1139
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0025 0.0019 0.5
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0083 0.0083
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.1078 0.2349 1
Onchocerca volvulus 0.0049 0.0072 0.079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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