Detailed information for compound 2075495

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.417 | Formula: C20H22F6N6O4
  • H donors: 2 H acceptors: 8 LogP: 3.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: c1cnc(nc1)N1CCC2(C1)CCCN(C2)c1ncccn1.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F
  • InChi: 1S/C16H20N6.2C2HF3O2/c1-4-16(12-21(10-1)14-17-6-2-7-18-14)5-11-22(13-16)15-19-8-3-9-20-15;2*3-2(4,5)1(6)7/h2-3,6-9H,1,4-5,10-13H2;2*(H,6,7)
  • InChiKey: DIIYWPBQOJLDBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0123 0.1463 0.3804
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1246 0.3381
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0035 0.0094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0011 0.0035 0.002
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0011 0.0035 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.2526
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0339 0.092
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0011 0.0035 0.0009
Brugia malayi Protein cec-1. 0.0011 0.0033 0.0088
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.0298 0.3684 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0011 0.0035 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0053 0.0142
Plasmodium vivax gamma-glutamylcysteine synthetase, putative 0.0298 0.3684 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0035 0.002
Echinococcus multilocularis glutamate cysteine ligase, catalytic subunit 0.0298 0.3684 0.3684
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0138
Echinococcus granulosus lamin dm0 0.0026 0.0227 0.0615
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0035 0.0094
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0033 0.0032
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0035 0.0009
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0011 0.0035 0.002
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0033 0.0088
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1246 0.324
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Giardia lamblia Glutamate synthase 0.0011 0.0035 0.0094
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0033 0.0088
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0035 0.0094
Trichomonas vaginalis apoptosis inducing factor, putative 0.0011 0.0035 0.0009
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1246 0.3322
Brugia malayi Pre-SET motif family protein 0.0204 0.2485 0.6746
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0035 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.0435 0.1103
Schistosoma mansoni chromobox protein 0.0068 0.0759 0.206
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.007 0.0188
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0035 0.0035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.0435 0.1181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.1463 0.3916
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.0184
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0123 0.1463 1
Echinococcus multilocularis lamin 0.0026 0.0227 0.0226
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0257 0.0696
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0759 0.2584
Plasmodium falciparum glutathione reductase 0.0123 0.1463 0.3969
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0035 0.0094
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0011 0.0035 0.0007
Echinococcus multilocularis Chromo domain 0.0011 0.0033 0.0032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0123 0.1463 0.1462
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0033 0.0032
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0759 0.1975
Loa Loa (eye worm) hypothetical protein 0.003 0.0272 0.0708
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0263 0.0712
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.0435 0.1432
Brugia malayi Uncoordinated protein 44 0.0014 0.007 0.0188
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0033 0.0088
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2844 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0035 0.0094
Echinococcus granulosus chromobox protein 1 0.0068 0.0759 0.206
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0011 0.0035 0.0007
Schistosoma mansoni netrin receptor unc5 0.0014 0.007 0.0188
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0101 0.0272
Onchocerca volvulus 0.0011 0.0035 0.0007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0044 0.0072
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0011 0.0035 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0712
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0435 0.1103
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0684
Brugia malayi Death domain containing protein 0.0014 0.007 0.0188
Echinococcus granulosus Chromo domain 0.0011 0.0033 0.0088
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0035 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1246 0.4315
Brugia malayi Thioredoxin reductase 0.0123 0.1463 0.3969
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0257 0.183
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1246 1
Onchocerca volvulus 0.0011 0.0033 0.000000071155
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1246 0.3381
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0405 0.1098
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0033 0.0088
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0124 0.0336
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.0435 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1246 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0035 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.0435 0.1103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0122
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0033 0.0086
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0088
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0257 0.0696
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.0435 0.1181
Brugia malayi glutamate synthase 0.0011 0.0035 0.0094
Echinococcus multilocularis musashi 0.0026 0.0227 0.0226
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0033 0.0088
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0035 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0415 0.1358
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1246 1
Entamoeba histolytica thioredoxin reductase, putative 0.0011 0.0035 0.002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.0435 0.1181
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0033 0.00000000012401
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.0435 0.1181
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0033 0.0032
Brugia malayi chromobox protein homolog 3 0.0038 0.0378 0.1024
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0033 0.0088
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1246 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Trypanosoma brucei trypanothione reductase 0.0123 0.1463 0.3916
Plasmodium falciparum gamma-glutamylcysteine synthetase 0.0298 0.3684 1
Plasmodium vivax glutathione reductase, putative 0.0123 0.1463 0.3916
Brugia malayi hypothetical protein 0.0035 0.0339 0.092
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.0435 0.1103
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.0435 0.1181
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.0435 0.1103
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1246 0.4315
Brugia malayi SET domain containing protein 0.0012 0.0047 0.0125
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0415 0.1045
Schistosoma mansoni hypothetical protein 0.0011 0.0035 0.0094
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0035 0.0094
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0435 1
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0035 0.0007
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0033 0.0088
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.2526
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.007 0.0069
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0263 0.0262
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0035 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Schistosoma mansoni lamin 0.0026 0.0227 0.0615
Plasmodium falciparum glutathione reductase 0.0043 0.0435 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0721
Brugia malayi CHD4 protein 0.0011 0.0033 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0257 0.5536
Brugia malayi intermediate filament protein 0.0026 0.0227 0.0615
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0227 0.059
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0011 0.0035 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0044 0.0115
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0002
Entamoeba histolytica disulphide oxidoreductase, putative 0.0011 0.0035 0.002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0033 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.007 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0035 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0712
Echinococcus granulosus glutamate cysteine ligase catalytic subunit 0.0298 0.3684 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0033 0.0088
Plasmodium vivax thioredoxin reductase, putative 0.0123 0.1463 0.3916
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0044 0.0031
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0257 0.0797
Plasmodium vivax SET domain protein, putative 0.0029 0.0263 0.063
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0157 0.0441
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.0298 0.3684 1
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0035 0.0009
Plasmodium falciparum thioredoxin reductase 0.0043 0.0435 0.1181
Echinococcus granulosus lamin 0.0026 0.0227 0.0615
Loa Loa (eye worm) helicase 0.0011 0.0033 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0415 0.1358
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0033 0.0088
Trypanosoma brucei NADH dehydrogenase 0.0011 0.0035 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0268
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0035 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0378 0.1227
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0033 0.0088
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0257 0.0696
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0257 0.0613
Brugia malayi Pre-SET motif family protein 0.0029 0.0263 0.0712
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0035 0.0007
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0011 0.0035 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.0123 0.1463 0.3804
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0257 0.0696
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0035 0.0094
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0035 0.0094
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1246 0.3322
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0257 0.1847
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.0435 0.1103
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0809 0.2194
Brugia malayi hypothetical protein 0.0011 0.0034 0.0092
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0435 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0043 0.0435 0.2803
Leishmania major trypanothione reductase 0.0123 0.1463 0.3916
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0035 0.0007
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.2526
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0263 0.0712
Plasmodium falciparum ferrodoxin reductase-like protein 0.0011 0.0035 0.0094
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0044 0.0031
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0035 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0291 0.0788
Schistosoma mansoni glutamate synthase 0.0011 0.0035 0.0094
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.007 0.0188
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1246 0.3322
Loa Loa (eye worm) hypothetical protein 0.0311 0.3846 1
Echinococcus granulosus Ankyrin 0.0014 0.0072 0.0193
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0257 0.5536
Treponema pallidum NADH oxidase 0.0043 0.0435 0.3306
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0339 0.0339
Schistosoma mansoni lamin 0.0026 0.0227 0.0615
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0157 0.0441
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0378 0.0944
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0035 0.0009
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1246 0.324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0186
Leishmania major gamma-glutamylcysteine synthetase, putative 0.0298 0.3684 1
Brugia malayi phosphofructokinase 0.0106 0.1246 0.3381
Giardia lamblia NADH oxidase lateral transfer candidate 0.0043 0.0435 0.1181
Echinococcus multilocularis Ankyrin 0.0014 0.0072 0.0071
Echinococcus granulosus glutamate synthase 0.0011 0.0035 0.0094
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0011 0.0035 0.0094
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0035 0.0094
Schistosoma mansoni chromobox protein 0.0011 0.0033 0.0088
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0291 0.0788
Plasmodium falciparum thioredoxin reductase 0.0123 0.1463 0.3969
Echinococcus granulosus chromobox protein 2 0.0011 0.0033 0.0088
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.2526
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0072 0.0193
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0033 0.0088
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0035 0.0035
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0035 0.0094
Loa Loa (eye worm) RecQ helicase 0.0021 0.0157 0.0408
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0035 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0035 0.0035
Echinococcus granulosus bloom syndrome protein 0.0021 0.0157 0.0424
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1246 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0759 0.0759
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0257 0.0696
Echinococcus multilocularis chromobox protein 1 0.0068 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Onchocerca volvulus Netrin receptor homolog 0.0014 0.007 0.0102
Brugia malayi Cytochrome P450 family protein 0.0012 0.0044 0.0118
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0033 0.0088
Toxoplasma gondii selenide, water dikinase 0.0011 0.0035 0.0094
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0257 0.0696
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0011 0.0035 0.0094
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0043 0.0435 0.2803
Echinococcus granulosus chromobox protein 1 0.0068 0.0759 0.206
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0035 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0721
Toxoplasma gondii thioredoxin reductase 0.0123 0.1463 0.3969
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0071 0.0103
Schistosoma mansoni intermediate filament proteins 0.0026 0.0227 0.0615
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0092
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0257 0.0613
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Onchocerca volvulus 0.0026 0.0227 0.0531
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0435 0.1103
Onchocerca volvulus 0.0026 0.0227 0.0531
Leishmania major cytochrome p450-like protein 0.0012 0.0044 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0378 0.0982
Echinococcus multilocularis lamin dm0 0.0026 0.0227 0.0226
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0227 0.0615
Brugia malayi Cytochrome P450 family protein 0.0012 0.0044 0.0118
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0071 0.0184
Brugia malayi 6-phosphofructokinase 0.0106 0.1246 0.3381
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0035 0.0094
Schistosoma mansoni glutamate synthase 0.0011 0.0035 0.0094
Echinococcus granulosus intermediate filament protein 0.0026 0.0227 0.0615
Echinococcus multilocularis chromobox protein 2 0.0011 0.0033 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1246 0.4315
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.0435 0.0435
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2485 0.6463
Schistosoma mansoni hypothetical protein 0.0035 0.0339 0.092
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0011 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0574
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.007 0.0182
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0435 0.1103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Giardia lamblia Glutamate-cysteine ligase 0.0298 0.3684 1
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2808 0.7621
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.0435 0.1432
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0249 0.0675
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0044 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0043 0.0435 0.2803
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0033 0.0088
Toxoplasma gondii glutamate-cysteine ligase, catalytic subunit domain-containing protein 0.0298 0.3684 1
Echinococcus granulosus Chromobox protein 3 0.0011 0.0033 0.0088
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Schistosoma mansoni hypothetical protein 0.0014 0.007 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0227 0.059
Leishmania major hypothetical protein, conserved 0.0011 0.0035 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0227 0.059
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0044 0.0115
Loa Loa (eye worm) glutamate-cysteine ligase 0.0298 0.3684 0.958
Schistosoma mansoni glutamate synthase 0.0011 0.0035 0.0094
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0035 0.0007
Brugia malayi Heterochromatin protein 1 0.0068 0.0759 0.206
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0035 0.0007
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0035 0.0035
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1246 0.8481
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi glutamate--cysteine ligase 0.0298 0.3684 1
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.0435 0.1181
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0157 0.0156
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.007 0.0069
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0043 0.0435 0.3306
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0339 0.092
Onchocerca volvulus 0.004 0.0405 0.1019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0086
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Echinococcus multilocularis glutamate synthase 0.0011 0.0035 0.0035
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0035 0.0094
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0257 0.0797
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0809 0.0808
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000013577
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0035 0.0007
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1246 0.3381
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1246 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0157 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0435 0.1103
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2808 0.7301
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0435 0.1103
Brugia malayi 6-phosphofructokinase 0.0106 0.1246 0.3381
Leishmania major NADH dehydrogenase, putative 0.0011 0.0035 0.0007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.0435 0.1103
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0035 0.0007
Onchocerca volvulus 0.0232 0.2845 0.7703
Onchocerca volvulus 0.003 0.0272 0.0656
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0044 0.0031
Giardia lamblia Thioredoxin reductase 0.0011 0.0035 0.0094
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0033 0.0088
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0035 0.0007
Brugia malayi hypothetical protein 0.0119 0.1408 0.3822
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1246 0.4315
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1246 0.1245
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0035 0.0007
Leishmania major hypothetical protein, conserved 0.0011 0.0035 0.0007
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0035 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Trypanosoma brucei gamma-glutamylcysteine synthetase 0.0298 0.3684 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.007 0.0188
Echinococcus granulosus thioredoxin glutathione reductase 0.0123 0.1463 0.3969
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0035 0.0092
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0435 0.2803
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0053 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.0435 0.3306
Leishmania major hypothetical protein, conserved 0.0011 0.0035 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.007 0.0188
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0033 0.0088
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0035 0.0094
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0071 0.0191
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.0435 0.1181
Echinococcus granulosus netrin receptor unc 5 0.0014 0.007 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0759 0.2584
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0035 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0378 0.1227
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0263 0.0262
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.0435 0.3306
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.0435 0.3306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0435 0.1103
Schistosoma mansoni glutamate-cysteine ligase 0.0298 0.3684 1
Brugia malayi glutathione reductase 0.0123 0.1463 0.3969
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1246 0.324
Plasmodium vivax ferrodoxin reductase, putative 0.0011 0.0035 0.0007
Schistosoma mansoni chromobox protein 0.0011 0.0033 0.0088
Schistosoma mansoni chromobox protein 0.0068 0.0759 0.206
Echinococcus granulosus death domain containing protein 0.0014 0.007 0.0188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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