Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0841 | 0.106 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0022 | 0.0319 | 0.8264 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | G-protein coupled receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Mycobacterium ulcerans | transmembrane transport protein | 0.0022 | 0.0319 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0164 | 0.7209 | 0.7934 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0164 | 0.7209 | 0.7935 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0019 | 0.0213 | 0.0234 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0841 | 0.106 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0841 | 0.106 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0022 | 0.0319 | 0.0319 |
Brugia malayi | Protein kinase c protein 2 | 0.0048 | 0.1581 | 0.1581 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.014 | 0.6062 | 0.7637 |
Mycobacterium tuberculosis | Probable conserved transmembrane transport protein | 0.0022 | 0.0319 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0022 | 0.0319 | 0.0477 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.014 | 0.6062 | 0.6672 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein Cmr | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | larval opioid receptor | 0.014 | 0.6062 | 0.6062 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0153 | 0.6686 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0841 | 0.106 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | sex peptide receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0346 | 0.0436 |
Brugia malayi | Dopamine receptor protein 2 | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0186 | 0.0234 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | Dopamine receptor protein 1 | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | neuropeptide receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | neuropeptide Y receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0022 | 0.0319 | 0.0351 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0022 | 0.0319 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.014 | 0.6062 | 0.6672 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0213 | 1 |
Loa Loa (eye worm) | TYRA-2 protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog | 0.0022 | 0.0319 | 0.0319 |
Echinococcus multilocularis | orexin receptor type 2 | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0022 | 0.0346 | 0.0379 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0016 | 0.0063 | 0.0068 |
Schistosoma mansoni | amine GPCR | 0.014 | 0.6062 | 0.7637 |
Leishmania major | protein kinase, putative | 0.0022 | 0.0346 | 0.4408 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0022 | 0.0346 | 0.0381 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0022 | 0.0346 | 0.0381 |
Schistosoma mansoni | similar to Protein C20orf152 homolog | 0.0022 | 0.0319 | 0.0402 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0164 | 0.7209 | 0.7191 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0032 | 0.0841 | 0.0926 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | ORL1-like opioid receptor | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.616 | 0.6136 |
Echinococcus multilocularis | g-protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | allatostatin A receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.004 | 0.1197 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0346 | 0.0436 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0022 | 0.0346 | 0.0379 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | neuropeptide Y receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | G-protein coupled receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0032 | 0.0841 | 0.0926 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0048 | 0.1571 | 0.1729 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | serotonin receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0022 | 0.0319 | 0.0351 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0213 | 0.0318 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0841 | 0.0783 |
Trichomonas vaginalis | cAMP-dependent protein kinase type I-beta regulatory subunit, putative | 0.0022 | 0.0319 | 0.0477 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Schistosoma mansoni | amine GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.004 | 0.1197 | 0.1318 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0319 | 0.0477 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Echinococcus granulosus | neuropeptide receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | opsin-like receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.004 | 0.1197 | 0.1316 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0019 | 0.0186 | 0.0204 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1989 | 0.2506 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0213 | 0.0318 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0164 | 0.7209 | 0.7209 |
Echinococcus multilocularis | fmrfamide receptor | 0.014 | 0.6062 | 0.6672 |
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | neuropeptide receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | neuropeptide s receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0213 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | somatostatin receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | neuropeptide receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0019 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0222 | 1 | 1 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | Serotonin receptor | 0.014 | 0.6062 | 0.6062 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.0319 | 0.0402 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0203 | 0.9085 | 1 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0032 | 0.0841 | 0.0924 |
Echinococcus multilocularis | expressed conserved protein | 0.0022 | 0.0346 | 0.0379 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1571 | 0.1979 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0213 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0186 | 0.0123 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1571 | 0.1979 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0213 | 0.0268 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0019 | 0.0186 | 0.0203 |
Echinococcus granulosus | orexin receptor type 2 | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | allatostatin A receptor | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | Dopamine receptor | 0.014 | 0.6062 | 0.6062 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0032 | 0.0841 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0022 | 0.0319 | 0.0349 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | neuropeptide receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0841 | 0.106 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1571 | 0.1517 |
Loa Loa (eye worm) | cAMP-dependent protein kinase regulatory subunit | 0.0022 | 0.0319 | 0.0258 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | AKH receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0032 | 0.0841 | 0.0924 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0022 | 0.0346 | 1 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0022 | 0.0319 | 0.0402 |
Schistosoma mansoni | amine GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | cyclic nucleotide-gated ion channel | 0.0022 | 0.0319 | 0.0402 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0019 | 0.0213 | 0.0232 |
Echinococcus multilocularis | neuropeptide receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0319 | 0.0258 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | neuropeptide s receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | voltage gated potassium channel | 0.0048 | 0.1571 | 0.1729 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | myosin xvIII | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0056 | 0.1989 | 0.219 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0022 | 0.0319 | 0.0402 |
Echinococcus multilocularis | serotonin receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | cAMP dependent protein kinase regulatory | 0.0022 | 0.0319 | 0.0349 |
Echinococcus multilocularis | sex peptide receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | protein kinase C II. | 0.0016 | 0.0063 | 0.0063 |
Echinococcus multilocularis | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | fmrfamide receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Trichomonas vaginalis | cAMP-dependent protein kinase regulatory subunit, putative | 0.0022 | 0.0319 | 0.0477 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | camp-dependent protein kinase type II regulatory subunit | 0.0022 | 0.0319 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1197 | 0.1141 |
Brugia malayi | Melatonin receptor type 1A | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | WH1 domain containing protein | 0.0019 | 0.0186 | 0.0186 |
Brugia malayi | cAMP-dependent protein kinase regulatory chain, putative | 0.0022 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0063 | 0.0079 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.014 | 0.6062 | 0.7637 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Chlamydia trachomatis | cAMP-dependent protein kinase regulatory subunit | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0179 | 0.7938 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Treponema pallidum | catabolite gene activator (Crp) | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0186 | 0.0234 |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0022 | 0.0319 | 0.8264 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0213 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0213 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Trypanosoma brucei | protein kinase A regulatory subunit | 0.0022 | 0.0319 | 0.8264 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0032 | 0.0841 | 0.0926 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0319 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.014 | 0.6062 | 0.6672 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Brugia malayi | Protein kinase domain | 0.0019 | 0.0213 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0186 | 0.0234 |
Brugia malayi | follicle stimulating hormone receptor | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0022 | 0.0319 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0048 | 0.1571 | 0.1571 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0032 | 0.0841 | 0.0926 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.0841 | 0.1258 |
Schistosoma mansoni | tyrosine kinase | 0.0019 | 0.0186 | 0.0234 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0048 | 0.1571 | 0.1727 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.014 | 0.6062 | 0.6062 |
Brugia malayi | putative neuropeptide receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0924 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0213 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0022 | 0.0346 | 0.0381 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0022 | 0.0319 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1492 | 0.1438 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | fmrfamide receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.014 | 0.6062 | 0.6672 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0319 | 0.0258 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0186 | 0.0234 |
Schistosoma mansoni | biogenic amine receptor | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | RE15519p | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0019 | 0.0186 | 0.0186 |
Echinococcus multilocularis | cAMP dependent protein kinase type II regulatory | 0.0022 | 0.0319 | 0.0349 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0213 | 0.0232 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0019 | 0.0186 | 0.0203 |
Trypanosoma cruzi | cAMP binding protein, putative | 0.0023 | 0.038 | 1 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0346 | 0.0436 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.6062 | 0.7637 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.014 | 0.6062 | 0.6672 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Echinococcus granulosus | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | opsin-like receptor | 0.014 | 0.6062 | 0.7637 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1989 | 0.2506 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0213 | 0.0268 |
Echinococcus granulosus | protein kinase c iota type | 0.0015 | 0.0002 | 0.0002 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0022 | 0.0319 | 0.0477 |
Echinococcus granulosus | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0153 | 0.6686 | 1 |
Echinococcus granulosus | serotonin receptor | 0.014 | 0.6062 | 0.6672 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0213 | 0.0234 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0926 |
Schistosoma mansoni | camp-dependent protein kinase type II-alpha regulatory subunit | 0.0022 | 0.0319 | 0.0402 |
Treponema pallidum | catabolite gene activator | 0.0022 | 0.0319 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0022 | 0.0319 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.014 | 0.6062 | 0.6037 |
Trypanosoma brucei | Flagellar Member 6 | 0.0022 | 0.0319 | 0.8264 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0016 | 0.0063 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0022 | 0.0319 | 0.0402 |
Echinococcus granulosus | g-protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0022 | 0.0346 | 1 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0022 | 0.0346 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.014 | 0.6062 | 0.6037 |
Mycobacterium ulcerans | regulatory protein | 0.0022 | 0.0319 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0022 | 0.0319 | 0.0319 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0213 | 0.0268 |
Echinococcus granulosus | neuropeptide receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | cAMP dependent protein kinase type II regulatory | 0.0022 | 0.0319 | 0.0351 |
Entamoeba histolytica | p21-activated kinase | 0.0019 | 0.0213 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | G protein-coupled receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.014 | 0.6062 | 0.6672 |
Giardia lamblia | CAMP-dependent protein kinase regulatory chain | 0.0022 | 0.0319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0048 | 0.1571 | 0.1727 |
Brugia malayi | hypothetical protein | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | amine GPCR | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | neuropeptide F receptor | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0186 | 0.0234 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0203 | 0.9085 | 1 |
Brugia malayi | GnHR receptor homolog | 0.014 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0213 | 0.0318 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0179 | 0.7938 | 1 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0019 | 0.0186 | 0.0123 |
Trypanosoma brucei | cAMP binding protein, putative | 0.0023 | 0.038 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0783 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.6062 | 0.7637 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | serine threonine protein kinase | 0.005 | 0.1694 | 0.1863 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.038 | 1 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | camp-dependent protein kinase regulatory chain | 0.0022 | 0.0319 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | protein kinase C gamma type | 0.005 | 0.1694 | 0.1865 |
Echinococcus multilocularis | cAMP dependent protein kinase type I beta | 0.0022 | 0.0319 | 0.0349 |
Schistosoma mansoni | biogenic amine receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.014 | 0.6062 | 0.7637 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0522 | 0.0658 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0022 | 0.0319 | 0.5 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | neuropeptides capa receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | histamine h1 receptor | 0.014 | 0.6062 | 0.7637 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.0841 | 0.1258 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0213 | 0.0318 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | g protein coupled receptor | 0.014 | 0.6062 | 0.6672 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0213 | 0.0318 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0841 | 0.106 |
Echinococcus multilocularis | somatostatin receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0056 | 0.1989 | 0.2188 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0319 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0022 | 0.0319 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.014 | 0.6062 | 0.6062 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Plasmodium vivax | rap guanine nucleotide exchange factor, putative | 0.0022 | 0.0319 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | Egg laying defective protein 4 | 0.0022 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.6062 | 0.6037 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0019 | 0.0186 | 0.0234 |
Brugia malayi | Serotonin receptor | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0022 | 0.0319 | 0.0402 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0042 | 0.1286 | 0.123 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0019 | 0.0186 | 0.0204 |
Onchocerca volvulus | 0.014 | 0.6062 | 1 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.014 | 0.6062 | 0.6062 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus granulosus | cAMP dependent protein kinase regulatory | 0.0022 | 0.0319 | 0.0351 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | atypical protein kinase C | 0.0015 | 0.0002 | 0.0002 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0032 | 0.0841 | 0.0926 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0019 | 0.0213 | 0.0232 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0022 | 0.0319 | 0.0402 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0022 | 0.0319 | 1 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.014 | 0.6062 | 0.6037 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.014 | 0.6062 | 0.6062 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.014 | 0.6062 | 0.6062 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0026 | 0.0522 | 0.0658 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.014 | 0.6062 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | adenoreceptor | 0.014 | 0.6062 | 0.7637 |
Plasmodium vivax | CAMP-dependent protein kinase regulatory subunit, putative | 0.0022 | 0.0319 | 0.5 |
Trypanosoma brucei | cAMP response protein 1, putative | 0.0022 | 0.0319 | 0.8264 |
Schistosoma mansoni | amine GPCR | 0.014 | 0.6062 | 0.7637 |
Brugia malayi | neuropeptide F receptor | 0.014 | 0.6062 | 0.6062 |
Echinococcus granulosus | cAMP dependent protein kinase type I beta | 0.0022 | 0.0319 | 0.0351 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.014 | 0.6062 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.014 | 0.6062 | 0.6672 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0186 | 0.0278 |
Leishmania major | protein kinase, putative | 0.0022 | 0.0346 | 0.4408 |
Echinococcus granulosus | hypothetical protein | 0.014 | 0.6062 | 0.6672 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.014 | 0.6062 | 0.6037 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.014 | 0.6062 | 0.6672 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0032 | 0.0841 | 0.0924 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.014 | 0.6062 | 0.6672 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.014 | 0.6062 | 0.7637 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0022 | 0.0319 | 0.0402 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0019 | 0.0186 | 0.0204 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity in Swiss albino mouse assessed as inability of animal to maintain equilibrium on rod at 300 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 26519928 | |
Activity (ADMET) | Neurotoxicity in Swiss albino mouse assessed as inability of animal to maintain equilibrium on rod at 300 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 26519928 | |
ED50 (functional) | = 11.4 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of maximal electroshock-induced seizure | ChEMBL. | 26519928 |
ED50 (functional) | = 73.2 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of subcutaneous pentylenetetrazole-induced seizure | ChEMBL. | 26519928 |
MED (functional) | = 30 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of maximal electroshock-induced seizure after 0.5 hrs | ChEMBL. | 26519928 |
MED (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of maximal electroshock-induced seizure after 4 hrs | ChEMBL. | 26519928 |
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of subcutaneous pentylenetetrazole-induced seizure after 4 hrs | ChEMBL. | 26519928 |
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as reduction of subcutaneous pentylenetetrazole-induced seizure after 0.5 hrs | ChEMBL. | 26519928 |
Ratio TD50/ED50 | = 2.6 | Protective index, ratio of TD50 for ip dosed Swiss albino mouse assessed as inability of animal to maintain equilibrium on rod after 0.5 hrs by rotarod test to ED50 for Swiss albino mouse assessed as subcutaneous pentylenetetrazole-induced seizure | ChEMBL. | 26519928 |
Ratio TD50/ED50 | = 16.7 | Protective index, ratio of TD50 for ip dosed Swiss albino mouse assessed as inability of animal to maintain equilibrium on rod after 0.5 hrs by rotarod test to ED50 for Swiss albino mouse assessed as reduction of maximal electroshock-induced seizure | ChEMBL. | 26519928 |
TD50 (ADMET) | = 190.4 mg kg-1 | Neurotoxicity in ip dosed Swiss albino mouse assessed as inability of animal to maintain equilibrium on rod after 0.5 hrs by rotarod test | ChEMBL. | 26519928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.