Detailed information for compound 216209

Basic information

Technical information
  • TDR Targets ID: 216209
  • Name: 2-aminobenzohydrazide
  • MW: 151.166 | Formula: C7H9N3O
  • H donors: 3 H acceptors: 1 LogP: 0.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1ccccc1N
  • InChi: 1S/C7H9N3O/c8-6-4-2-1-3-5(6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
  • InChiKey: GRWMSCBKWMQPON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-azanylbenzohydrazide
  • 46004-62-0
  • 1904-58-1
  • AC-907/25014182
  • 2-Aminobenzoic acid, hydrazide
  • 2NPhCON2
  • AIDS-009034
  • AIDS009034
  • EINECS 217-604-7
  • NSC 642
  • ZINC00155740
  • ARONIS014347
  • Anthranilohydrazide
  • 565490_ALDRICH
  • 2-Aminobenzhydrazide
  • 2-Aminobenzoic acid hydrazide
  • 2-Aminobenzoylhydrazine
  • Anthranilic acid hydrazide
  • Anthranilic acid, hydrazide
  • Anthranilic hydrazide
  • Anthraniloyl hydrazide
  • Benzoic acid, 2-amino-, hydrazide
  • NSC642
  • o-Aminobenzhydrazide
  • o-Aminobenzoic acid hydrazide
  • o-Aminobenzoic hydrazide
  • ST5409685
  • 2-Aminobenzoyl hydrazide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Plasmodium falciparum geranylgeranyltransferase, putative 0.0035 0.0223 0.0415
Loa Loa (eye worm) hypothetical protein 0.0092 0.0848 0.1579
Toxoplasma gondii DNA polymerase 0.0504 0.5375 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0131 0.03
Toxoplasma gondii DNA polymerase family B protein 0.0074 0.0647 0.1204
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.0529
Mycobacterium tuberculosis Conserved protein 0.0064 0.0541 0.1243
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0074 0.0647 0.1204
Brugia malayi DNA polymerase family B containing protein 0.0166 0.1662 0.3092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0923 0.1717
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0131 0.0243
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.2293 1
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0166 0.1662 0.3092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0178 0.0331
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0166 0.1662 0.3092
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.013 0.1269 0.2362
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.1597 0.2972
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.007 0.0605 0.1127
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0056 0.0103
Brugia malayi Pre-SET motif family protein 0.0034 0.0208 0.0386
Plasmodium vivax geranylgeranyltransferase, putative 0.0035 0.0223 0.0415
Echinococcus multilocularis sodium channel protein 0.0026 0.0124 0.0124
Trichomonas vaginalis hypothetical protein 0.0223 0.2293 0.4017
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0166 0.1662 0.3092
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0187 0.1892 0.324
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0243
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0363 0.0676
Giardia lamblia Rab geranylgeranyltransferase 0.0048 0.0367 0.028
Brugia malayi Pre-SET motif family protein 0.0237 0.2443 0.4545
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0074 0.0647 0.1204
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0035 0.0223 0.0415
Trypanosoma brucei protein farnesyltransferase beta subunit 0.013 0.1269 0.2362
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Mycobacterium tuberculosis Probable lipase LipE 0.0064 0.0541 0.1243
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0187 0.1892 0.352
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0363 0.0676
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0411 0.4353 1
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0541 0.1006
Echinococcus multilocularis protein dispatched 1 0.0055 0.0438 0.0438
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0504 0.5375 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0103
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1393 0.6077
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0166 0.1662 0.1662
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0056 0.0103
Giardia lamblia Rab geranylgeranyltransferase 0.0187 0.1892 0.324
Loa Loa (eye worm) hypothetical protein 0.0048 0.0363 0.0676
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0166 0.1662 0.3092
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0166 0.1662 0.3092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3026 0.5631
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.007 0.0605 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0647 0.0823
Echinococcus multilocularis GPCR, family 2 0.0031 0.0178 0.0178
Plasmodium falciparum protein farnesyltransferase subunit beta 0.013 0.1269 0.2362
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0056 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.1068 0.1987
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0043 0.01
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Giardia lamblia DNA polymerase alpha subunit A 0.0074 0.0647 0.0823
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0166 0.1662 0.3092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0178 0.0331
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0035 0.0223 0.0223
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0064 0.0541 0.1243
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0131 0.0243
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0074 0.0647 0.1204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0064 0.0541 0.1006
Mycobacterium ulcerans hypothetical protein 0.0027 0.0131 0.057
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0331
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0166 0.1662 0.3092
Loa Loa (eye worm) hypothetical protein 0.0166 0.1662 0.3092
Schistosoma mansoni hypothetical protein 0.0046 0.0344 0.064
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.1597 0.1597
Echinococcus multilocularis expressed conserved protein 0.0105 0.0993 0.0993
Echinococcus granulosus sodium channel protein 0.0026 0.0124 0.0231
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0541 0.2359
Trichomonas vaginalis D-aminoacylase, putative 0.0064 0.0541 0.0617
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0411 0.436 0.8111
Onchocerca volvulus 0.0034 0.0208 0.0386
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0178 0.0331
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0092 0.0848 0.1579
Schistosoma mansoni hypothetical protein 0.0046 0.0344 0.064
Schistosoma mansoni hypothetical protein 0.0046 0.0344 0.064
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.013 0.1269 0.2031
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0103
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0504 0.5375 1
Toxoplasma gondii ABC1 family protein 0.0064 0.0541 0.1006
Onchocerca volvulus 0.0027 0.0131 0.0243
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0035 0.0223 0.0415
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0504 0.5375 1
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.0529
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0504 0.5375 0.5375
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0035 0.0223 0.0415
Brugia malayi DNA polymerase alpha catalytic subunit 0.0166 0.1662 0.3092
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0504 0.5375 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0504 0.5375 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.2293 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0187 0.1892 0.352
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0131 0.057
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0578 0.1076
Onchocerca volvulus 0.027 0.2803 0.5216
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0048 0.0367 0.0683
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0056 0.0128
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0187 0.1892 0.352
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.2293 0.4266
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0504 0.5375 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0166 0.1662 0.3092
Onchocerca volvulus 0.0064 0.0541 0.1006
Brugia malayi CHE-14 protein 0.0048 0.0363 0.0676
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0131 0.0243
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0223 0.0415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Trypanosoma cruzi lanosterol synthase, putative 0.0035 0.0223 0.0415
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0166 0.1662 0.3092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.007 0.0605 0.1127
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0166 0.1662 0.1662
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.013 0.1269 0.2031
Brugia malayi beta-lactamase 0.0064 0.0541 0.1006
Echinococcus granulosus expressed conserved protein 0.0105 0.0993 0.1848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0208 0.0386
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0048 0.0367 0.0367
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0131 0.0243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0178 0.0178
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0035 0.0223 0.0415
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0208 0.0208
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0223 0.0415
Schistosoma mansoni hypothetical protein 0.0046 0.0344 0.064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Loa Loa (eye worm) beta-lactamase 0.0064 0.0541 0.1006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0285 0.0529
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0043 0.01
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0243
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0166 0.1662 0.3092
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0166 0.1662 0.2793
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0182 0.1832 0.3408
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.1068 0.1987
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0363 0.0272
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0074 0.0647 0.1204
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0131 0.057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0208 0.0208
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0504 0.5375 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.2293 0.5266
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0166 0.1662 0.3092
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0178 0.0331
Loa Loa (eye worm) hypothetical protein 0.0074 0.0647 0.1204
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3026 0.5631
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.2293 0.4266
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0048 0.0367 0.0683
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0166 0.1662 0.2793
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0035 0.0223 0.0512
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0223 0.0415
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0187 0.1892 0.352
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0541 0.1006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.007 0.0605 0.1127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0048 0.0367 0.0367
Plasmodium vivax DNA polymerase alpha, putative 0.0166 0.1662 0.3092
Toxoplasma gondii hypothetical protein 0.0139 0.1358 0.2527
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0131 0.0243
Onchocerca volvulus 0.0064 0.0541 0.1006
Mycobacterium ulcerans beta-lactamase 0.0064 0.0541 0.2359
Trichomonas vaginalis set domain proteins, putative 0.027 0.2803 0.5009
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0131 0.0243
Schistosoma mansoni patched 1 0.0048 0.0363 0.0676
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.2293 0.4266
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0223 0.0415
Leishmania major farnesyltransferase beta subunit 0.013 0.1269 0.2362
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0035 0.0223 0.0415
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0285 0.0285
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0048 0.0367 0.0683
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.013 0.1269 0.2031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0178 0.0331
Mycobacterium leprae Probable lipase LipE 0.0064 0.0541 0.2359
Mycobacterium tuberculosis Conserved protein 0.0064 0.0541 0.1243
Giardia lamblia Prenyltransferase 0.013 0.1269 0.2031
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0187 0.1892 0.1892
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.0529
Brugia malayi beta-lactamase family protein 0.0064 0.0541 0.1006
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0166 0.1662 0.3092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0131 0.057
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0187 0.1892 0.324
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0363 0.0676
Schistosoma mansoni hypothetical protein 0.0041 0.0285 0.0529
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0166 0.1662 0.3092
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.013 0.1269 0.2362
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0074 0.0647 0.1204
Mycobacterium ulcerans hypothetical protein 0.0064 0.0541 0.2359
Trypanosoma cruzi lanosterol synthase, putative 0.0035 0.0223 0.0415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0243
Loa Loa (eye worm) hypothetical protein 0.0068 0.0578 0.1076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0131 0.057
Trichomonas vaginalis penicillin-binding protein, putative 0.0064 0.0541 0.0617
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0103
Loa Loa (eye worm) hypothetical protein 0.0074 0.0647 0.1204
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0166 0.1662 0.3092
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0187 0.1892 0.352
Mycobacterium ulcerans esterase/lipase LipP 0.0064 0.0541 0.2359
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.007 0.0605 0.1127
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0363 0.0363
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0166 0.1662 0.3092
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0048 0.0367 0.0683
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0131 0.057
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0074 0.0647 0.1204
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0367 0.0683
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.013 0.1269 0.2031
Schistosoma mansoni protein farnesyltransferase subunit beta 0.013 0.1269 0.2362
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0131 0.057
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0035 0.0223 0.0415
Echinococcus multilocularis beta LACTamase domain containing family member 0.0064 0.0541 0.0541
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.2293 1
Mycobacterium tuberculosis Probable esterase LipL 0.0064 0.0541 0.1243
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0923 0.1717
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0504 0.5375 1
Echinococcus granulosus GPCR family 2 0.0031 0.0178 0.0331
Leishmania major hypothetical protein, conserved 0.0064 0.0541 0.1006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0056 0.0242
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.013 0.1269 0.1269
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0131 0.0243
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0035 0.0223 0.0415
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0386
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0074 0.0647 0.1204
Trichomonas vaginalis D-aminoacylase, putative 0.0064 0.0541 0.0617
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.1068 0.1987
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.2293 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.013 0.1269 0.2362
Brugia malayi DNA polymerase delta catalytic subunit 0.0504 0.5375 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0095 0.088 0.1637
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0223 0.0415
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0048 0.0367 0.0683
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.007 0.0605 0.1127
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.013 0.1269 0.2031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0064 0.0541 0.1243
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0064 0.0541 0.1243
Brugia malayi beta-lactamase family protein 0.0064 0.0541 0.1006
Mycobacterium tuberculosis Probable hydrolase 0.0064 0.0541 0.1243
Brugia malayi follicle stimulating hormone receptor 0.0182 0.1832 0.3408
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0208 0.0386
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0331
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0285 0.0529
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0208 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0043 0.01
Plasmodium vivax farnesyltransferase beta subunit, putative 0.013 0.1269 0.2362
Mycobacterium ulcerans lipase LipD 0.0064 0.0541 0.2359
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0166 0.1662 0.3092
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0131 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0223 0.0415
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0131 0.03
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0064 0.0541 0.2359
Loa Loa (eye worm) hypothetical protein 0.0064 0.0541 0.1006
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0504 0.5375 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0208 0.0386
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1393 0.32
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0504 0.5375 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0139 0.1358 0.2204
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0331
Trypanosoma cruzi protein farnesyltransferase, putative 0.013 0.1269 0.2362
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.2443 0.4545
Echinococcus multilocularis protein patched 0.0048 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0103
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0035 0.0223 0.0415
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0208 0.0386
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.1087 0.2022
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.013 0.1269 0.2362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.007 0.0605 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0208 0.0386
Mycobacterium tuberculosis Probable lipase LipD 0.0064 0.0541 0.1243
Loa Loa (eye worm) hypothetical protein 0.0059 0.0482 0.0897
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0178 0.0178
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0166 0.1662 0.3092
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0026 0.0124 0.0231
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.0529
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0166 0.1662 0.3092
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0541 0.1006
Trichomonas vaginalis DNA polymerase II, putative 0.0166 0.1662 0.2793
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0541 0.1006
Echinococcus granulosus protein farnesyltransferase subunit beta 0.013 0.1269 0.2362
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0166 0.1662 0.3092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0043 0.01
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.3026 0.5442
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0092 0.0848 0.1579
Echinococcus granulosus beta LACTamase domain containing family member 0.0064 0.0541 0.1006
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0504 0.5375 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0048 0.0367 0.0683
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0187 0.1892 0.352
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0131 0.057
Loa Loa (eye worm) hypothetical protein 0.0092 0.0848 0.1579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0131 0.057
Mycobacterium tuberculosis Conserved protein 0.0064 0.0541 0.1243
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0048 0.0367 0.028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0064 0.0541 0.1006
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0035 0.0223 0.0415
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1393 0.6077
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0026 0.0124 0.0231
Onchocerca volvulus 0.0048 0.0367 0.0683
Loa Loa (eye worm) hypothetical protein 0.0187 0.1892 0.352
Trichomonas vaginalis D-aminoacylase, putative 0.0064 0.0541 0.0617
Trichomonas vaginalis penicillin-binding protein, putative 0.0064 0.0541 0.0617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0064 0.0541 0.1006
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0131 0.057
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0048 0.0367 0.0683
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0331
Toxoplasma gondii DNA polymerase family B protein 0.0166 0.1662 0.3092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.007 0.0605 0.0605
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0223 0.0415
Onchocerca volvulus 0.0064 0.0541 0.1006
Leishmania major geranylgeranyltransferase, putative 0.0035 0.0223 0.0415
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0092 0.0848 0.1214
Loa Loa (eye worm) hypothetical protein 0.0099 0.0923 0.1717
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0048 0.0367 0.0683
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0035 0.0223 0.0223
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.3026 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0178 0.0331
Brugia malayi hypothetical protein 0.0041 0.0285 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.007 0.0605 0.1127
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0504 0.5375 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3026 0.5442
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0166 0.1662 0.3092
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0187 0.1892 0.324
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0103
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0048 0.0367 0.0683
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0035 0.0223 0.0415
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0166 0.1662 0.2793
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0194 0.0361
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0064 0.0541 0.1006
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0131 0.0243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0208 0.0386
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0187 0.1892 0.352
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.013 0.1269 0.2031
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0166 0.1662 0.2793
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.013 0.1269 0.2362
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0048 0.0367 0.0683
Trypanosoma brucei lanosterol synthase 0.0035 0.0223 0.0415
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.1068 0.1068
Toxoplasma gondii hypothetical protein 0.0048 0.0367 0.0683
Trichomonas vaginalis esterase, putative 0.0064 0.0541 0.0617
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0923 0.1717
Onchocerca volvulus DNA polymerase homolog 0.0166 0.1662 0.3092
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0367 0.0683
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0166 0.1662 0.1662
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0367 0.0683
Loa Loa (eye worm) hypothetical protein 0.0112 0.1068 0.1987
Schistosoma mansoni hypothetical protein 0.0068 0.0578 0.1076

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of HIV-1 integrase enzyme by 3'-processing method ChEMBL. 9083482
IC50 (binding) > 100 uM Inhibition of HIV-1 integrase enzyme ChEMBL. 9083482
IC50 (binding) > 100 uM Inhibition of HIV-1 integrase enzyme by 3'-processing method ChEMBL. 9083482
IC50 (binding) > 100 uM Inhibition of HIV-1 integrase enzyme ChEMBL. 9083482
MIC (functional) = 30 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis BCG ChEMBL. 24246731
pMIC (functional) = 1.52 Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). ChEMBL. 15239654
pMIC (functional) = 1.52 Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). ChEMBL. 15239654

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6263  
Annotator: crowther@u.washington.edu Comment: 2007-12-07 References: 15239654

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.