TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 767.805 | Formula: C38H50N5O10P
H donors: 7 H acceptors: 8 LogP: 1.53 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: COc1cc2cccc(c2cc1OC)CCCNC(=O)[C@@H](NC(=O)C1(CCCCC1)NC(=O)[C@H](Cc1ccc(cc1)CP(=O)(O)O)NC(=O)C)CC(=O)N
InChi: 1S/C38H50N5O10P/c1-24(44)41-30(19-25-12-14-26(15-13-25)23-54(49,50)51)36(47)43-38(16-5-4-6-17-38)37(48)42-31(22-34(39)45)35(46)40-18-8-11-27-9-7-10-28-20-32(52-2)33(53-3)21-29(27)28/h7,9-10,12-15,20-21,30-31H,4-6,8,11,16-19,22-23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,44)(H,42,48)(H,43,47)(H2,49,50,51)/t30-,31-/m0/s1
InChiKey: SLXHIXKJEPUSKD-CONSDPRKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	growth factor receptor-bound protein 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	sex muscle abnormal protein 5	Get druggable targets OG5_131257	All targets in OG5_131257
Schistosoma mansoni	growth factor receptor-bound protein	Get druggable targets OG5_131257	All targets in OG5_131257
Schistosoma japonicum	Growth factor receptor-bound protein 2, putative	Get druggable targets OG5_131257	All targets in OG5_131257
Schistosoma japonicum	ko:K04364 growth factor receptor-binding protein 2, putative	Get druggable targets OG5_131257	All targets in OG5_131257
Echinococcus granulosus	growth factor receptor bound protein 2	Get druggable targets OG5_131257	All targets in OG5_131257
Schistosoma mansoni	growth factor receptor-bound protein	Get druggable targets OG5_131257	All targets in OG5_131257
Echinococcus multilocularis	growth factor receptor bound protein 2	Get druggable targets OG5_131257	All targets in OG5_131257
Brugia malayi	Sex muscle abnormal protein 5	Get druggable targets OG5_131257	All targets in OG5_131257

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	hypothetical protein, conserved	growth factor receptor-bound protein 2	217 aa	200 aa	23.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0132	0.0449	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0369
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0143	0.0496	0.1808
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0045	0.0081	0.0061
Echinococcus granulosus	expressed protein	0.0361	0.1427	0.5062
Brugia malayi	Glutamate receptor 2 precursor	0.0043	0.0072	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0174	0.0616
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0048	0.0094	0.032
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0049	0.0095	0.9227
Loa Loa (eye worm)	lethal(1)discs large-1 tumor suppressor	0.0045	0.0079	0.0264
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0055	0.0121	0.043
Trypanosoma brucei	ubiquitin-conjugating enzyme E2, putative	0.005	0.0102	0.0351
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0047	0.0089	0.0317
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0043	0.0072	0.0257
Schistosoma mansoni	diflavin oxidoreductase	0.0036	0.0043	0.0023
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0043	0.0072	0.0257
Echinococcus multilocularis	disks large 3	0.0049	0.0095	0.0339
Echinococcus multilocularis	GPCR, family 2	0.0031	0.002	0.007
Echinococcus multilocularis	kelch ECH associated protein 1	0.0095	0.0292	0.1036
Trypanosoma brucei	CHAP domain containing protein, putative	0.0067	0.0175	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0123	0.041	0.149
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain)	0.0143	0.0496	0.1667
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0687	0.2819	1
Schistosoma mansoni	glutamate receptor AMPA	0.0043	0.0072	0.0053
Trypanosoma cruzi	glutathionylspermidine synthase, putative	0.1095	0.4566	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0047	0.0089	0.0317
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0662	0.2713	1
Schistosoma mansoni	glutamate receptor AMPA	0.0043	0.0072	0.0053
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.005	0.0102	0.0209
Echinococcus multilocularis	glutamate receptor 2	0.0047	0.0089	0.0317
Plasmodium vivax	aspartyl protease, putative	0.0132	0.0449	0.1633
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0662	0.2713	0.5937
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0047	0.0089	0.0317
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0073	0.0201	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0031	0.002	0.0047
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0662	0.2713	1
Leishmania major	trypanothione synthetase-like protein	0.0067	0.0175	0.0621
Onchocerca volvulus		0.0132	0.0449	1
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0662	0.2713	1
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0239	0.0906	0.0888
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0254	0.0973	0.3568
Schistosoma mansoni	cell polarity protein	0.0049	0.0095	0.0076
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0254	0.0973	0.345
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0369
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0254	0.0973	0.345
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0254	0.0973	0.0955
Schistosoma mansoni	cathepsin D (A01 family)	0.0567	0.2309	0.2294
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0687	0.2819	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0049	0.0095	0.0336
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0333	0.1309	0.4644
Leishmania major	cytochrome P450 reductase, putative	0.0065	0.0165	0.0584
Loa Loa (eye worm)	apoptosis regulator protein	0.0055	0.0121	0.0422
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0049	0.0095	0.2016
Echinococcus granulosus	glutamate receptor 2	0.0047	0.0089	0.0317
Echinococcus granulosus	nmda type glutamate receptor	0.0041	0.0061	0.0216
Plasmodium vivax	plasmepsin V, putative	0.0132	0.0449	0.1633
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0045	0.0081	0.0272
Toxoplasma gondii	aspartyl protease ASP1	0.0254	0.0973	0.3482
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0662	0.2713	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0095	0.0351
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.002	0.0053
Leishmania major	p450 reductase, putative	0.0073	0.0201	0.0715
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0047	0.0089	0.0317
Schistosoma mansoni	hypothetical protein	0.0095	0.0293	0.0274
Schistosoma mansoni	growth factor receptor-bound protein	0.0157	0.0557	0.0538
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1808
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0157	0.0557	0.1975
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.0143	0.0496	0.1761
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0613	0.2504	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0201	0.0715
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0095	0.0075
Trypanosoma cruzi	trypanothione synthetase, putative	0.0067	0.0175	0.0369
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0043	0.0072	0.0053
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.022	0.0828	0.3043
Echinococcus granulosus	growth factor receptor bound protein 2	0.0157	0.0557	0.1975
Schistosoma mansoni	glutamate receptor kainate	0.0043	0.0072	0.0053
Plasmodium falciparum	plasmepsin VI	0.0254	0.0973	0.3568
Plasmodium falciparum	nitric oxide synthase, putative	0.0073	0.0201	0.0715
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0613	0.2504	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0049	0.0095	0.0324
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.0143	0.0496	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0973	0.3568
Plasmodium falciparum	plasmepsin II	0.0254	0.0973	0.3568
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0043	0.0072	0.0257
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.002	0.0047
Brugia malayi	FAD binding domain containing protein	0.0073	0.0201	0.0721
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Plasmodium vivax	aspartyl protease, putative	0.0132	0.0449	0.1633
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1074
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0662	0.2713	1
Plasmodium falciparum	SUMO-conjugating enzyme UBC9	0.005	0.0102	0.0351
Trichomonas vaginalis	ubiquitin-conjugating enzyme rad6, putative	0.005	0.0102	0.0381
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0662	0.2713	0.9624
Plasmodium vivax	RNA helicase-1, putative	0.0049	0.0095	0.0324
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0188	0.069	0.1498
Brugia malayi	Guanylate kinase family protein	0.006	0.0141	0.0502
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0095	0.0324
Plasmodium falciparum	plasmepsin III	0.0132	0.0449	0.1633
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0073	0.0201	0.0712
Echinococcus multilocularis	glutamate receptor 2	0.0043	0.0072	0.0257
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0254	0.0973	0.3867
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0048	0.0094	0.032
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0095	0.0075
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)	0.0143	0.0496	0.1667
Toxoplasma gondii	subtilisin SUB1	0.0176	0.064	0.2238
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0073	0.0201	0.0715
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0662	0.2713	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0073	0.0201	0.0425
Brugia malayi	Glutamate receptor 1 precursor	0.0043	0.0072	0.0248
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0055	0.0121	0.0428
Toxoplasma gondii	aspartyl protease ASP3	0.0132	0.0449	0.1521
Plasmodium vivax	aspartyl proteinase, putative	0.0254	0.0973	0.3568
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0086	0.0254	0.0235
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1808
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0073	0.0201	0.0715
Schistosoma mansoni	apoptosis regulator bax	0.0055	0.0121	0.0102
Schistosoma mansoni	glutamate receptor NMDA	0.0047	0.0089	0.007
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.005	0.0102	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0073	0.0201	0.0715
Brugia malayi	hypothetical protein	0.0057	0.0129	0.0458
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0095	0.0351
Echinococcus multilocularis	methionine synthase reductase	0.0045	0.0081	0.0286
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0143	0.0496	0.1808
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0073	0.0201	0.0444
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.005	0.0102	0.0223
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0095	0.0292	0.1036
Plasmodium falciparum	plasmepsin X	0.0132	0.0449	0.1633
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0047	0.0089	0.0317
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit beta	0.0143	0.0496	0.1579
Toxoplasma gondii	aspartyl protease	0.0132	0.0449	0.1521
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0095	0.0193
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Loa Loa (eye worm)	ube2i2 protein	0.005	0.0102	0.0351
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0306	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0449	0.1633
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0073	0.0201	0.0715
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0073	0.0201	0.0712
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0143	0.0496	0.1808
Echinococcus multilocularis	expressed protein	0.0361	0.1427	0.5062
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0049	0.0097	0.0008
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0132	0.0449	0.1521
Plasmodium falciparum	subtilisin-like protease 1	0.0176	0.064	0.234
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0613	0.2504	1
Schistosoma mansoni	glutamate receptor kainate	0.0043	0.0072	0.0053
Schistosoma mansoni	cytochrome P450 reductase	0.0073	0.0201	0.0181
Trypanosoma brucei	trypanothione synthetase	0.0211	0.0786	0.2879
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0662	0.2713	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0095	0.0351
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.005	0.0102	0.0351
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0073	0.0201	0.0425
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0613	0.2504	1
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0055	0.0121	0.043
Loa Loa (eye worm)	hypothetical protein	0.04	0.1596	0.5871
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0621
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0369
Leishmania major	trypanothione synthetase, putative	0.0211	0.0786	0.2879
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0049	0.0095	0.0336
Loa Loa (eye worm)	reprolysin	0.0043	0.0072	0.0241
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Giardia lamblia	UBC3	0.005	0.0102	0.1047
Chlamydia trachomatis	transcriptional repressor NrdR	0.0049	0.0097	0.0061
Echinococcus granulosus	adam	0.0057	0.0129	0.0459
Leishmania major	hypothetical protein, conserved	0.0067	0.0175	0.0621
Brugia malayi	ube2i2 protein	0.005	0.0102	0.0357
Echinococcus granulosus	GPCR family 2	0.0031	0.002	0.007
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0131	0.0448	0.1588
Schistosoma mansoni	hypothetical protein	0.0067	0.0174	0.0154
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0306	0.1106
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.002	0.007
Schistosoma mansoni	ATP-binding cassette transporter	0.0043	0.0072	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0095	0.0324
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0043	0.0072	0.0053
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1808
Loa Loa (eye worm)	aspartyl protease 6	0.0132	0.0449	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0121	0.0422
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0132	0.0449	0.1633
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0621
Brugia malayi	Sex muscle abnormal protein 5	0.0157	0.0557	0.2037
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0047	0.0089	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0449	0.1633
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0095	0.0193
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0132	0.0449	0.1638
Plasmodium vivax	aspartyl proteinase, putative	0.0132	0.0449	0.1633
Brugia malayi	Pepsin A precursor	0.0132	0.0449	0.1638
Plasmodium falciparum	plasmepsin I	0.0254	0.0973	0.3568
Brugia malayi	flavodoxin family protein	0.0028	0.0007	0.0006
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0055	0.0121	0.0102
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1074
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0175	0.0369
Echinococcus granulosus	kelch ECH associated protein 1	0.0095	0.0292	0.1036
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.0097	0.0013
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.0143	0.0496	0.1808
Brugia malayi	eukaryotic initiation factor 4A	0.0049	0.0095	0.033
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1808
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0073	0.0201	0.0715
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.005	0.0102	0.0209
Treponema pallidum	ATP-dependent RNA helicase	0.0049	0.0095	0.0324
Echinococcus multilocularis	kelch ECH associated protein 1	0.0095	0.0292	0.1036
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0041	0.0061	0.0216
Echinococcus multilocularis	Kelch repeat type 1	0.0095	0.0293	0.104
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0073	0.0201	0.0712
Plasmodium vivax	flavodoxin domain containing protein	0.0065	0.0165	0.0584
Echinococcus multilocularis	nmda type glutamate receptor	0.0041	0.0061	0.0216
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0037	0.0045	0.0025
Leishmania major	trypanothione synthetase, putative	0.0067	0.0175	0.0621
Brugia malayi	ribonucleotide reductase 2	0.0143	0.0496	0.1813
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0095	0.0324
Schistosoma mansoni	glutamate receptor kainate	0.0043	0.0072	0.0053
Echinococcus granulosus	disks large 3	0.0049	0.0095	0.0339
Schistosoma mansoni	cathepsin D (A01 family)	0.0567	0.2309	0.2294
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.0143	0.0496	0.1699
Trypanosoma cruzi	trypanothione synthetase	0.0211	0.0786	0.1709
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1312	0.5491	0.5482
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0369
Echinococcus granulosus	methionine synthase reductase	0.0045	0.0081	0.0286
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0613	0.2504	1
Loa Loa (eye worm)	glutamate receptor 1	0.0043	0.0072	0.0242
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0049	0.0095	0.0336
Schistosoma mansoni	hypothetical protein	0.0055	0.0121	0.0102
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0143	0.0496	0.1808
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0073	0.0201	0.0715
Trypanosoma brucei	glutathionylspermidine synthetase, putative	0.0067	0.0175	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0241
Plasmodium vivax	aspartyl protease, putative	0.0132	0.0449	0.1633
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0049	0.0095	0.0336
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Trypanosoma cruzi	p450 reductase, putative	0.0073	0.0201	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0461	0.1679
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0049	0.0095	0.0195
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0049	0.0095	0.0324
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0073	0.0201	0.0712
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.005	0.0102	1
Plasmodium vivax	SUMO-conjugating enzyme UBC9, putative	0.005	0.0102	0.0351
Trypanosoma cruzi	trypanothione synthetase	0.0211	0.0786	0.1709
Plasmodium vivax	subtilisin-like protease 1	0.0176	0.064	0.234
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.0143	0.0496	0.0478
Trypanosoma cruzi	trypanothione synthetase-like protein, putative	0.0067	0.0175	0.0369
Loa Loa (eye worm)	guanylate kinase	0.0047	0.0086	0.0292
Brugia malayi	hypothetical protein	0.0132	0.0449	0.1638
Trypanosoma brucei	trypanothione synthetase, putative	0.0211	0.0786	0.2879
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0333	0.1309	0.4644
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0621
Echinococcus multilocularis	ubiquitin conjugating enzyme e2 i	0.005	0.0102	0.0362
Plasmodium falciparum	plasmepsin IX	0.0132	0.0449	0.1633
Schistosoma mansoni	glutamate receptor NMDA	0.0043	0.0072	0.0053
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0621
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0067	0.0175	0.0369
Trichomonas vaginalis	sulfite reductase, putative	0.0073	0.0201	0.0775
Plasmodium falciparum	plasmepsin VIII, putative	0.0132	0.0449	0.1633
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0047	0.0089	0.0317
Treponema pallidum	ribonucleotide-diphosphate reductase subunit beta	0.0143	0.0496	0.1808
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0049	0.0097	0.0013
Schistosoma mansoni	hypothetical protein	0.0055	0.0121	0.0102
Brugia malayi	aspartic protease BmAsp-1, identical	0.0132	0.0449	0.1638
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0047	0.0089	0.0317
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.002	0.007
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0157	0.0557	0.2032
Echinococcus granulosus	ubiquitin conjugating enzyme e2 i	0.005	0.0102	0.0362
Giardia lamblia	Nitric oxide synthase, inducible	0.0065	0.0165	1
Echinococcus multilocularis	adam	0.0057	0.0129	0.0459
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0254	0.0973	0.3482
Brugia malayi	aspartic protease BmAsp-2, identical	0.0132	0.0449	0.1638
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.04	0.1596	0.5873
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0662	0.2713	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0132	0.0449	0.043
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0662	0.2713	1
Schistosoma mansoni	ubiquitin-conjugating enzyme E2 I	0.005	0.0102	0.0083
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0065	0.0165	0.0633
Brugia malayi	FAD binding domain containing protein	0.0045	0.0081	0.0278
Schistosoma mansoni	growth factor receptor-bound protein	0.0157	0.0557	0.0538
Loa Loa (eye worm)	glutamate receptor 2	0.0043	0.0072	0.0242
Plasmodium falciparum	plasmepsin V	0.0132	0.0449	0.1633
Giardia lamblia	Hypothetical protein	0.0065	0.0165	1
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0662	0.2713	0.2699
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0268	0.0965
Schistosoma mansoni	hypothetical protein	0.0055	0.0121	0.0102
Plasmodium falciparum	plasmepsin IV	0.0254	0.0973	0.3568
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0174	0.0621
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0057	0.0129	0.011
Plasmodium falciparum	plasmepsin VII	0.0132	0.0449	0.1633
Trypanosoma cruzi	trypanothione synthetase, putative	0.0067	0.0175	0.0369
Plasmodium vivax	ribonucleotide reductase small subunit, putative	0.0048	0.0094	0.032
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0043	0.0072	0.0257
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0662	0.2713	0.9624
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0073	0.0201	0.0715
Brugia malayi	hypothetical protein	0.0132	0.0449	0.1638
Plasmodium vivax	plasmepsin IV, putative	0.0254	0.0973	0.3568
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0095	0.0292	0.1036
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.002	0.0053
Trypanosoma brucei	amidase, putative	0.0067	0.0175	0.0621
Brugia malayi	flavodoxin family protein	0.0073	0.0201	0.0721

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 84.4 nM	Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay	ChEMBL.	11354377
IC50 (binding)	= 84.4 nM	Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay	ChEMBL.	11354377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 21635