Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0045 | 0.0331 | 0.0331 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0345 | 0.2718 | 0.2718 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0225 | 0.1765 | 0.1746 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0999 | 0.7937 | 0.7932 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1765 | 0.1735 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0331 | 0.0295 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1258 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0999 | 0.7937 | 0.7937 |
Onchocerca volvulus | 0.0345 | 0.2718 | 0.2578 | |
Plasmodium falciparum | transporter, putative | 0.0345 | 0.2718 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0999 | 0.7937 | 0.7929 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.0381 | 0.0359 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0045 | 0.0331 | 0.0295 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0223 | 0.1746 | 0.1715 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0345 | 0.2718 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0345 | 0.2718 | 0.2701 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1258 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0345 | 0.2718 | 0.2692 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0999 | 0.7937 | 0.7932 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 0.2692 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0037 | 0.0013 |
Onchocerca volvulus | 0.1258 | 1 | 1 | |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0345 | 0.2718 | 0.2701 |
Toxoplasma gondii | hypothetical protein | 0.0345 | 0.2718 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0223 | 0.1746 | 0.1716 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0225 | 0.1765 | 0.1746 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.0381 | 0.0359 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0201 | 0.0201 |
Plasmodium falciparum | amino acid transporter, putative | 0.0345 | 0.2718 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.0381 | 0.0381 |
Schistosoma mansoni | survival motor neuron protein | 0.0046 | 0.0335 | 0.0335 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0345 | 0.2718 | 0.2701 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.2718 | 0.2691 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0045 | 0.0331 | 0.0331 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1258 | 1 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0045 | 0.0331 | 0.0308 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0189 | 0.0153 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0201 | 0.0179 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0345 | 0.2718 | 0.2701 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0999 | 0.7937 | 0.7932 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0045 | 0.0331 | 0.0331 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.0381 | 0.0359 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 0.2691 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0179 | 0.1396 | 0.1377 |
Onchocerca volvulus | 0.0345 | 0.2718 | 0.2578 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0999 | 0.7937 | 0.7937 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0999 | 0.7937 | 0.7929 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1258 | 1 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0189 | 0.0189 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.0381 | 0.0346 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1258 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.1258 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 0.2692 |
Loa Loa (eye worm) | hypothetical protein | 0.1258 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0023 | 0.0023 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.0381 | 0.0346 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0045 | 0.0331 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.2718 | 0.2691 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0345 | 0.2718 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.1258 | 1 | 1 |
Brugia malayi | mbt repeat family protein | 0.0045 | 0.0331 | 0.0296 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2701 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0179 | 0.1396 | 0.1377 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0345 | 0.2718 | 0.2718 |
Brugia malayi | hypothetical protein | 0.0225 | 0.1765 | 0.1735 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.2718 | 0.2691 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0189 | 0.0154 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0045 | 0.0331 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.2718 | 0.2691 |
Brugia malayi | hypothetical protein | 0.0345 | 0.2718 | 0.2692 |
Loa Loa (eye worm) | serotonin transporter b | 0.1258 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0.0331 | 0.0145 | |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0045 | 0.0331 | 0.0145 |
Onchocerca volvulus | 0.0046 | 0.0335 | 0.0149 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0037 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0999 | 0.7937 | 0.7929 |
Echinococcus granulosus | serotonin transporter | 0.1258 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2718 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0345 | 0.2718 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.0381 | 0.0359 |
Onchocerca volvulus | 0.0345 | 0.2718 | 0.2578 | |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0999 | 0.7937 | 0.7932 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0045 | 0.0331 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0381 | 0.0346 |
Toxoplasma gondii | hypothetical protein | 0.0345 | 0.2718 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.0436 | 0.0436 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0345 | 0.2718 | 0.2718 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0046 | 0.0335 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.2718 | 0.2691 |
Plasmodium vivax | amine transporter, putative | 0.0345 | 0.2718 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0045 | 0.0331 | 0.0296 |
Echinococcus multilocularis | serotonin transporter | 0.1258 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0201 | 0.0201 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0345 | 0.2718 | 0.2701 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0201 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0999 | 0.7937 | 0.7929 |
Plasmodium vivax | hypothetical protein, conserved | 0.0345 | 0.2718 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inactivation (binding) | = 5 % | Ability to inactivate E. coli adenylate kinase after exposing enzyme to 0 mM levels of MgATP at concentration of 13.5mM, pH 7.6 | ChEMBL. | 6279845 |
Inhibition (binding) | = -11 % | Compound was tested for the initial inhibition of thymidine kinase by 1.4 mM compound in the presence of 5.7 mM ATP in Escherichia coli | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Compound was tested for the lose of thymidine kinase activity after 6 h , at 0 degrees celsius , with 10 mM ATP derivative . values were expressed in percent | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of hexokinase activity after 6 h , at 0 degrees celsius, with 10 mM ATP derivative in yeast. | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of Hexokinase type I activity after 6 h, at 0 degrees celsius, at 10 mM compound | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of hexokinase 2 activity after 6 h, at 10 mM compound | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of Hexokinase type III activity after 6 h, at 0 degrees celsius, at 10 mM | ChEMBL. | 7040662 |
T1/2 (ADMET) | = 8.4 hr | Ability of the 1.76 mM compound to inactivate rat muscle adenylate kinase was determined, after exposing enzyme to 0 mM levels of MgATPHalf-time for enzyme inactivation was determined | ChEMBL. | 6279845 |
Velocity (binding) | = 71 % | Tested for the velocity of 2.8 mM compound relative to that of 2.8 mM MgATP in the assay | ChEMBL. | 7040662 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.