TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.067 | Formula: C21H13ClN2O2
H donors: 1 H acceptors: 4 LogP: 4.69 Rotable bonds: 3
Rule of 5 violations (Lipinski): 0
SMILES: Clc1ccc(cc1)c1nc2cc(ccc2nc1c1ccccc1)C(=O)O
InChi: InChI=1S/C21H13ClN2O2/c22-16-9-6-14(7-10-16)20-19(13-4-2-1-3-5-13)23-17-11-8-15(21(25)26)12-18(17)24-20/h1-12H,(H,25,26)
InChiKey: NUTMAJXOCBTZGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	PAS domain containing serine/threonine kinase		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	Get druggable targets OG5_131169	All targets in OG5_131169
Candida albicans	similar to S. cerevisiae PAS domain-containing Serine/threonine Kinase	Get druggable targets OG5_131169	All targets in OG5_131169
Onchocerca volvulus		Get druggable targets OG5_131169	All targets in OG5_131169

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0067	0.0344
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0284	0.1553
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0079	0.0074
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0323	0.7531
Leishmania major	cathepsin L-like protease	0.0017	0.0079	0.0347
Schistosoma mansoni	tar DNA-binding protein	0.0141	0.0984	0.098
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0218	0.4927
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0031	0.0149
Onchocerca volvulus		0.0017	0.0079	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0197	0.1103
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0218	0.4244
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0031	0.0026
Loa Loa (eye worm)	fibroinase	0.0017	0.0079	0.0428
Echinococcus granulosus	cathepsin l1	0.0017	0.0079	0.0074
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0079	0.0273
Onchocerca volvulus		0.0011	0.0039	0.0045
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.008	0.0544	0.3109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0197	0.0191
Echinococcus multilocularis	microtubule associated protein 2	0.1378	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Entamoeba histolytica	cysteine proteinase 2	0.0009	0.002	0.0037
Echinococcus multilocularis	cysteine protease	0.0017	0.0079	0.0074
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0271	0.1481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0716
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0217	0.1181
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0031	0.0149
Schistosoma mansoni	gabp alpha	0.008	0.0544	0.0539
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.002	0.0024
Onchocerca volvulus		0.0017	0.0079	0.0273
Loa Loa (eye worm)	fli-1 protein	0.0244	0.1738	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.0713	0.4083
Onchocerca volvulus		0.0017	0.0079	0.0273
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Trichomonas vaginalis	ferritin, putative	0.0054	0.0351	0.1923
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0079	0.2627
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0015	0.0067	0.1591
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0012	0.0043	0.0037
Schistosoma mansoni	tar DNA-binding protein	0.0141	0.0984	0.098
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0218	0.516
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0039	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0237	0.1287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0031	0.0026
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0067	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0079	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0039	0.0195
Onchocerca volvulus		0.0017	0.0079	0.0273
Schistosoma mansoni	elf1	0.0012	0.0043	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0284	0.1553
Leishmania major	cathepsin L-like protease	0.0064	0.0422	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0197	0.0191
Onchocerca volvulus	Cirhin homolog	0.0115	0.0794	0.4306
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0031	0.0026
Plasmodium vivax	vivapain-2	0.0017	0.0079	0.2353
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0043	0.0037
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0054	0.0351	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0197	0.0191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0031	0.0026
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.019	0.6769
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0141	0.0984	0.565
Echinococcus multilocularis	serine protein kinase ATM	0.0008	0.0019	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0716
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Onchocerca volvulus		0.0032	0.019	0.0897
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Brugia malayi	nuclear hormone receptor	0.001	0.0031	0.0149
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.017	0.0915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0284	0.1553
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0153	0.0821
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0715
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0271	0.1481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0045	0.0222
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus multilocularis	beta catenin	0.0116	0.0799	0.0795
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0715
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0039	0.0188
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0284	0.6738
Schistosoma mansoni	tar DNA-binding protein	0.0141	0.0984	0.098
Loa Loa (eye worm)	HMP-2 protein	0.0116	0.0799	0.4584
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0217	0.1181
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0031	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0031	0.0149
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0031	0.0149
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0079	0.0074
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0019	0.0081
Mycobacterium ulcerans	bacterioferritin BfrA	0.0054	0.0351	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0151	0.081
Schistosoma mansoni	apoferritin-2	0.0054	0.0351	0.0346
Brugia malayi	RNA recognition motif domain containing protein	0.0141	0.0984	0.565
Brugia malayi	Fli-1 protein	0.0244	0.1738	1
Treponema pallidum	bacterioferrin (TpF1)	0.0054	0.0351	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0422	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0031	0.0149
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0032	0.019	0.1066
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.002	0.0037
Echinococcus granulosus	ferritin	0.0054	0.0351	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.002	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0031	0.0149
Schistosoma mansoni	ets-related	0.0244	0.1738	0.1734
Echinococcus granulosus	cathepsin l1	0.0011	0.0039	0.0034
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.019	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0215
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0031	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0153	0.0821
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Loa Loa (eye worm)	acetyltransferase	0.0147	0.1025	0.5886
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0009	0.0026	0.028
Brugia malayi	Ets-domain containing protein	0.0012	0.0043	0.0215
Leishmania major	cathepsin L-like protease	0.0064	0.0422	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0067	0.0344
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Brugia malayi	DNA-binding protein D-ETS-3	0.0012	0.0043	0.0215
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0031	0.0026
Echinococcus multilocularis	GA binding protein alpha chain	0.008	0.0544	0.0539
Schistosoma mansoni	microtubule-associated protein tau	0.1378	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0422	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0026	0.0117
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0079	0.0428
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0093	0.221
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.002	0.0015
Schistosoma mansoni	ferritin	0.0054	0.0351	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0217	0.1181
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0284	0.6581
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0031	0.0149
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0031	0.0149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0039	0.0188
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.019	0.0185
Loa Loa (eye worm)	D-ets-2 protein	0.0012	0.0043	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0474	0.2704
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0079	0.2627
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0079	0.0428
Echinococcus granulosus	T cell transcription factor 4 long C terminal	0.0077	0.052	0.0515
Echinococcus granulosus	pangolin	0.0077	0.052	0.0515
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0284	0.161
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0284	0.0279
Schistosoma mansoni	tar DNA-binding protein	0.0141	0.0984	0.098
Schistosoma mansoni	ferritin	0.0054	0.0351	0.0346
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0079	0.2268
Brugia malayi	Ets-domain containing protein	0.008	0.0544	0.3109
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.1025	0.5886
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0012	0.0043	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0217	0.1181
Onchocerca volvulus		0.0017	0.0079	0.0273
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0031	0.0149
Echinococcus granulosus	ewsr:fli fusion protein type	0.0012	0.0043	0.0037
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0067	0.0062
Brugia malayi	Ets-domain containing protein	0.008	0.0544	0.3109
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0067	0.0357
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0031	0.0026
Brugia malayi	Armadillo/beta-catenin-like repeat family protein	0.0116	0.0799	0.4584
Echinococcus granulosus	protein C ets 2	0.0012	0.0043	0.0037
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0067	0.0357
Schistosoma mansoni	hypothetical protein	0.0071	0.0474	0.0469
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0031	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0067	0.0344
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0031	0.0026
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0031	0.0026
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.0874	0.0869
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus granulosus	hypothetical protein	0.0358	0.2565	0.2561
Schistosoma mansoni	ferritin	0.0054	0.0351	0.0346
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.002	0.0015
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.002	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0054	0.0351	0.5
Schistosoma mansoni	ets	0.0012	0.0043	0.0037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0031	0.0149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Loa Loa (eye worm)	cysteine protease	0.0017	0.0079	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0039	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Schistosoma mansoni	ferritin	0.0054	0.0351	0.0346
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0031	0.0026
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0031	0.0026
Schistosoma mansoni	coup transcription factor	0.001	0.0031	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Trypanosoma cruzi	cysteine protease, putative	0.0009	0.002	0.0024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0009	0.002	0.0024
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0271	1
Echinococcus multilocularis	expressed protein	0.0054	0.0351	0.0346
Echinococcus granulosus	GPCR family 2	0.0033	0.0197	0.0191
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0284	0.6121
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0054	0.0351	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0136	0.0948	0.0943
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.1578	0.9079
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0026	0.0122
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0031	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0109
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.0713	0.4083
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0031	0.0149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0008	0.0019	0.0014
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.0874	0.0869
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.002	0.0087
Schistosoma mansoni	pangolin	0.0077	0.052	0.0515
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0284	0.0279
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0031	0.0026
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0031	0.0149
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0067	0.0344
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Echinococcus multilocularis	cathepsin L	0.0009	0.002	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0019	0.0078
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0245	1
Brugia malayi	Pre-SET motif family protein	0.0222	0.1578	0.9079
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0031	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0217	0.1181
Brugia malayi	steroid hormone receptor	0.001	0.0031	0.0149
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0031	0.0149
Echinococcus multilocularis	protein C ets 2	0.0012	0.0043	0.0037
Onchocerca volvulus		0.0253	0.1802	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0031	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Schistosoma mansoni	hypothetical protein	0.0281	0.2007	0.2003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.002	0.0482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0153	0.0821
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0031	0.0026
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0079	0.1492
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0031	0.0149
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0031	0.0149
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0043	0.0037
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0031	0.0026
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0031	0.0026
Schistosoma mansoni	beta-catenin	0.0116	0.0799	0.0795
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0008	0.0019	0.0459
Echinococcus granulosus	ETS transcription factor Elf 5	0.0012	0.0043	0.0037
Brugia malayi	transcription factor E74 isoform	0.0012	0.0043	0.0215
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0031	0.0026
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0474	0.2704
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0012	0.0043	0.0037
Schistosoma mansoni	tar DNA-binding protein	0.0141	0.0984	0.098
Echinococcus granulosus	expressed protein	0.0054	0.0351	0.0346
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0284	0.6581
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0284	0.6738
Schistosoma mansoni	ets-related	0.0012	0.0043	0.0037
Echinococcus multilocularis	tar DNA binding protein	0.0141	0.0984	0.098
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0079	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0181	0.0176
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0197	0.1103
Brugia malayi	RNA binding protein	0.0141	0.0984	0.565
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0079	0.0074
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0067	0.0062
Brugia malayi	TAR-binding protein	0.0141	0.0984	0.565
Loa Loa (eye worm)	TAR-binding protein	0.0141	0.0984	0.565
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0012	0.0043	0.0215
Loa Loa (eye worm)	ets-domain-containing protein	0.0012	0.0043	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0008	0.0019	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0422	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0079	0.0074
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0197	0.0191
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.0995	0.099
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0079	0.0273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Leishmania major	cathepsin L-like protease	0.0064	0.0422	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0031	0.0149
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0031	0.0149
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0067	0.0062
Onchocerca volvulus		0.0017	0.0079	0.0273
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Leishmania major	cathepsin L-like protease	0.0017	0.0079	0.0347
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0197	0.1103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.002	0.0084
Schistosoma mansoni	ferritin light chain	0.0054	0.0351	0.0346
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0079	0.0412
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Schistosoma mansoni	hypothetical protein	0.0033	0.0197	0.0191
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0008	0.0019	0.0014
Leishmania major	cathepsin L-like protease	0.0017	0.0079	0.0347
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0039	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0713	0.4083
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0136	0.0948	0.0943
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0197	0.1103
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0197	0.0191
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0015	0.0067	0.1591
Echinococcus granulosus	GA binding protein alpha chain	0.008	0.0544	0.0539
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0031	0.0026
Echinococcus multilocularis	protein pangolin J	0.0077	0.052	0.0515
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.002	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0019	0.0078
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0284	0.6121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0031	0.0149
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0079	0.2268
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.002	0.0037
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0039	0.0034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0031	0.0149
Echinococcus multilocularis	ferritin	0.0054	0.0351	0.0346
Echinococcus granulosus	ETS transcription factor Elf 1	0.0012	0.0043	0.0037
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0055	0.0355	0.2018
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.0713	0.4083
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0012	0.0043	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0079	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0215
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0079	0.0074
Schistosoma mansoni	hypothetical protein	0.0033	0.0197	0.0191
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0054	0.0351	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0177	0.0954
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0019	0.0078
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0284	0.161
Toxoplasma gondii	cathepsin CPL	0.0017	0.0079	0.2383
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0039	0.0747
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0043	0.0037
Loa Loa (eye worm)	HMG box family protein	0.0077	0.052	0.2972
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0031	0.0149
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0422	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0067	0.1187
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0031	0.0149
Schistosoma mansoni	hypothetical protein	0.0126	0.0874	0.0869
Echinococcus multilocularis	T cell transcription factor 4 long C terminal	0.0077	0.052	0.0515
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.1025	0.102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0067	0.0344
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0271	1
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Onchocerca volvulus		0.0055	0.0355	0.1829
Loa Loa (eye worm)	RNA binding protein	0.0141	0.0984	0.565
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0271	0.0266
Echinococcus granulosus	beta catenin	0.0116	0.0799	0.0795
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Schistosoma mansoni	ferritin light chain	0.0054	0.0351	0.0346
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0043	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0284	1
Leishmania major	cathepsin L-like protease	0.0017	0.0079	0.0347
Giardia lamblia	GTOR	0.0045	0.0284	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0039	0.0195
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0245	0.8528
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0012	0.0043	0.0037
Echinococcus granulosus	cysteine protease	0.0009	0.002	0.0015
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0284	0.0279
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0079	0.0428
Loa Loa (eye worm)	ctsf protein	0.0017	0.0079	0.0428
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.019	0.0185
Brugia malayi	ecdysteroid receptor	0.001	0.0031	0.0149
Leishmania major	cathepsin L-like protease	0.0017	0.0079	0.0347
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0112	0.2656
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0019	0.0081
Plasmodium vivax	vivapain-2	0.0017	0.0079	0.2353
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0031	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.002	0.0482
Plasmodium vivax	SET domain protein, putative	0.0032	0.019	0.6757
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0382	0.8999
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0716
Schistosoma mansoni	hypothetical protein	0.0033	0.0197	0.0191
Echinococcus multilocularis	ets variant gene 4	0.0012	0.0043	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0134	0.0716
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0031	0.0026
Onchocerca volvulus		0.0017	0.0079	0.0273
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0079	0.0074
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0012	0.0043	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.002	0.0015
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0079	0.0428
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0079	0.2268
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0197	0.0191
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0012	0.0043	0.0215
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.1025	0.102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0031	0.0149
Schistosoma mansoni	thyroid hormone receptor	0.0136	0.0948	0.0943
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.002	0.0084
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0008	0.0019	0.0014
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0079	0.0074
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.019	0.0185
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.019	0.0185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0079	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0422	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0149
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0019	0.0081
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.1802	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0284	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0079	0.2627
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0079	0.0347
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.002	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0151	0.081
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0031	0.0026
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0039	0.0195
Mycobacterium ulcerans	bacterioferritin BfrB	0.0054	0.0351	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0079	0.0273
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0271	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0009	0.002	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0031	0.0149
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0201	0.7188
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0031	0.0149
Echinococcus granulosus	serine protein kinase ATM	0.0008	0.0019	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0037
Brugia malayi	Pre-SET motif family protein	0.0032	0.019	0.1066
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.019	0.0185
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0031	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Echinococcus granulosus	tar DNA binding protein	0.0141	0.0984	0.098
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.002	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.019	0.0185
Entamoeba histolytica	cysteine protease, putative	0.0009	0.002	0.0037
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0031	0.0026
Brugia malayi	cathepsin L-like precursor	0.0011	0.0039	0.0195
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0031	0.0149
Echinococcus granulosus	cathepsin L	0.0009	0.002	0.0015
Brugia malayi	HMG box family protein	0.0077	0.052	0.2972
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.1087
Schistosoma mansoni	apoferritin-2	0.0054	0.0351	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0459	0.2618

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	<= 10 uM	Inhibition of N-terminal GST-tagged human recombinant PASK kinase domain (879 to 1323 residues) expressed in insect cells using MBP protein substrate incubated for 120 mins in presence of [33P]ATP by scintillation counting method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3716471

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2182007