Detailed information for compound 220085

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.838 | Formula: C19H23ClO2
  • H donors: 1 H acceptors: 2 LogP: 3.87 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCc2c1ccc(c(=O)c2)Cl
  • InChi: 1S/C19H23ClO2/c1-19-9-8-13-12-4-6-16(20)17(21)10-11(12)2-3-14(13)15(19)5-7-18(19)22/h4,6,10,13-15,18,22H,2-3,5,7-9H2,1H3/t13-,14-,15+,18+,19+/m1/s1
  • InChiKey: OVRXJMGWINPBQC-GVYRHCHYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin beta chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Bile acid receptor homolog 0.0088 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.1992 0.1992
Giardia lamblia Beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin, putative 0.003 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0088 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Trypanosoma brucei beta tubulin 0.003 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.1992 0.1992
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.1992 0.1992
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.285 0.285
Leishmania major beta tubulin 0.003 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0088 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.285 0.285
Brugia malayi hypothetical protein 0.0041 0.1992 0.1992
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.1992 0.1992
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 1 1
Brugia malayi hypothetical protein 0.0041 0.1992 0.1992
Leishmania major beta tubulin 0.003 0 0.5
Toxoplasma gondii beta-tubulin, putative 0.003 0 0.5
Giardia lamblia Beta tubulin 0.003 0 0.5
Onchocerca volvulus 0.0088 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.1992 0.1992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 1 1
Brugia malayi tailless protein 0.0041 0.1992 0.1992
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 1 1
Schistosoma mansoni thyroid hormone receptor 0.0088 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0088 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.285 0.285
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Loa Loa (eye worm) steroid hormone receptor 0.0088 1 1
Brugia malayi nuclear hormone receptor 0.0041 0.1992 0.1992
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.1992 0.1992
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.285 0.285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.1992 0.1992
Schistosoma mansoni coup transcription factor 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.285 0.285
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.1992 0.1992
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.1992 0.1992
Schistosoma mansoni nuclear hormone receptor 0.0041 0.1992 0.1992
Schistosoma mansoni RAR-like nuclear receptor 0.0088 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.285 0.285
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.1992 0.1992
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 1 1
Trypanosoma brucei beta tubulin 0.003 0 0.5
Brugia malayi ecdysone receptor 0.0041 0.1992 0.1992
Brugia malayi Nuclear hormone receptor-like 1 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.285 0.285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 1 1
Brugia malayi nuclear receptor NHR-67 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Trypanosoma brucei beta tubulin 0.003 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 1 1
Brugia malayi nuclear receptor RXR 0.0046 0.285 0.285
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.1992 0.1992
Toxoplasma gondii beta-1 tubulin, putative 0.003 0 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0088 1 1
Brugia malayi Nuclear hormone receptor E75 0.0041 0.1992 0.1992
Brugia malayi conserved hypotetical protein 0.0041 0.1992 0.1992
Trichomonas vaginalis tubulin beta chain, putative 0.003 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 1 1
Giardia lamblia Beta tubulin 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Leishmania major beta tubulin 0.003 0 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.1992 0.1992
Brugia malayi nuclear receptor NHR-88 0.0088 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 1 1
Schistosoma mansoni thyroid hormone receptor 0.0088 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 1 1
Loa Loa (eye worm) DR-78 0.0041 0.1992 0.1992
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5
Trypanosoma brucei beta tubulin 0.003 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0088 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.1992 0.1992
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.285 0.285
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.1992 0.1992
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0046 0.285 0.285
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi hypothetical protein 0.0046 0.285 0.285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.1992 0.1992
Leishmania major beta tubulin 0.003 0 0.5
Schistosoma mansoni nuclear receptor 0.0041 0.1992 0.1992
Schistosoma mansoni nuclear hormone receptor 0.0041 0.1992 0.1992
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.285 0.285
Leishmania major beta tubulin 0.003 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.1992 0.1992
Entamoeba histolytica tubulin family protein 0.003 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0088 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.1992 0.1992
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0041 0.1992 0.1992
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 1 1
Entamoeba histolytica tubulin family protein 0.003 0 0.5
Brugia malayi Nuclear hormone receptor E75 0.0041 0.1992 0.1992
Brugia malayi nuclear receptor RXR 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi nuclear hormone receptor 0.0088 1 1
Plasmodium falciparum tubulin beta chain 0.003 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.1992 0.1992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Brugia malayi steroid hormone receptor 0.0088 1 1
Toxoplasma gondii beta tubulin 0.003 0 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Plasmodium vivax tubulin beta chain, putative 0.003 0 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 1 1
Leishmania major beta tubulin 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.1992 0.1992
Schistosoma mansoni nuclear receptor 0.0041 0.1992 0.1992
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 1 1
Schistosoma mansoni zinc finger protein 0.0041 0.1992 0.1992
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.1992 0.1992
Trypanosoma cruzi beta tubulin, putative 0.003 0 0.5
Brugia malayi hypothetical protein 0.0046 0.285 0.285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0046 0.285 0.285
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.285 0.285

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 4 Inhibition of tubulin polymerization by colchicine to that of compound (IC50colchicine/IC50 drug) ChEMBL. 9371249
Activity (functional) = 4 Inhibition of tubulin polymerization by colchicine to that of compound (IC50colchicine/IC50 drug) ChEMBL. 9371249
IC50 (functional) = 2.8 uM Inhibition of tubulin polymerization ChEMBL. 9371249
IC50 (functional) = 2.8 uM Inhibition of tubulin polymerization ChEMBL. 9371249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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