Detailed information for compound 2203642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 570.363 | Formula: C35H47BN2O4
  • H donors: 2 H acceptors: 2 LogP: 7.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](B1OC2[C@](O1)(C)[C@H]1C[C@@H](C2)C1(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2c1cccc2)C
  • InChi: InChI=1S/C35H47BN2O4/c1-22(2)18-31(36-41-30-21-25-20-29(34(25,3)4)35(30,5)42-36)38-33(40)28(19-23-12-7-6-8-13-23)37-32(39)27-17-11-15-24-14-9-10-16-26(24)27/h6-10,12-14,16,22,25,27-31H,11,15,17-21H2,1-5H3,(H,37,39)(H,38,40)/t25-,27-,28-,29-,30?,31-,35-/m0/s1
  • InChiKey: VOTDVUBZDFZSLV-XWRXRWDISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 5 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania infantum proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium falciparum proteasome subunit beta type-5 Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium ulcerans proteasome PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Babesia bovis proteasome epsilon subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Neospora caninum Family T1, proteasome beta subunit, threonine peptidase, related Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium vivax proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02737 20S proteasome subunit beta 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania donovani proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127100 All targets in OG5_127100
Toxoplasma gondii proteasome subunit beta type, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania mexicana proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei gambiense proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium leprae proteasome (beta subunit) PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania braziliensis proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) Get druggable targets OG5_127100 All targets in OG5_127100
Theileria parva proteasome subunit beta type 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus granulosus proteasome prosome macropain Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium berghei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium yoelii proteosome PSMB5/8 protein Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium knowlesi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Giardia lamblia Proteasome subunit beta type 5 precursor Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium parvum Pre2p/proteasome subunit beta type 5; NTN hydrolase fold Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi Proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania major proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum proteasome subunit alpha type-5, putative proteasome (prosome, macropain) subunit, beta type, 5 160 aa 148 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0288 0.0288
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.221 0.5842
Schistosoma mansoni ap endonuclease 0.002 0.0144 0.0214
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2822 0.298
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Echinococcus multilocularis geminin 0.0535 0.6755 0.6755
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.221 0.221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0346 0.0512
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0906 0.8943
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0405 0.3206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0349 0.065
Mycobacterium tuberculosis Conserved protein 0.0036 0.0349 0.0228
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 0.4191 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0086 0.0996 0.0948
Schistosoma mansoni hypothetical protein 0.0031 0.0288 0.0426
Schistosoma mansoni cpg binding protein 0.0028 0.0248 0.0367
Entamoeba histolytica fatty acid elongase, putative 0.0093 0.109 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0346 0.0346
Onchocerca volvulus 0.0036 0.0349 0.1822
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0144 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0627 0.1327
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0719 0.9127 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0906 0.2006
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0405 0.0873
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0512 0.1353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0512 0.0512
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0349 0.0922
Mycobacterium tuberculosis Conserved protein 0.0036 0.0349 0.0228
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0349 0.065
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0349 0.0228
Brugia malayi hypothetical protein 0.0036 0.0348 0.0921
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.1926 0.4487
Schistosoma mansoni hypothetical protein 0.0031 0.0288 0.0426
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0144 0.0169
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0405 0.0873
Brugia malayi MH2 domain containing protein 0.0126 0.1505 0.3978
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0349 0.0722
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0288 0.076
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0379 0.0722
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1926 0.4487
Echinococcus granulosus geminin 0.0535 0.6755 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0719 0.9127 1
Loa Loa (eye worm) glutaminase 2 0.0303 0.3783 1
Brugia malayi hypothetical protein 0.0129 0.1547 0.409
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0248 0.0656
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0906 0.2006
Loa Loa (eye worm) hypothetical protein 0.0067 0.0749 0.198
Brugia malayi hypothetical protein 0.0079 0.0906 0.2395
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0086 0.0996 0.1474
Toxoplasma gondii proteasome subunit beta type, putative 0.0086 0.0996 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0379 0.0379
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0379 0.0261
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0349 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0405 0.0786
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0379 0.0722
Mycobacterium ulcerans hypothetical protein 0.0176 0.2156 0.2239
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1505 0.3978
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.2647
Brugia malayi beta-lactamase family protein 0.0036 0.0349 0.0922
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0349 0.0228
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 0.4191 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0349 0.0722
Mycobacterium ulcerans proteasome PrcB 0.0086 0.0996 0.0948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0512 0.0758
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0405 0.0873
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0379 0.0722
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0719 0.9127 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0348 0.0516
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0086 0.0996 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0349 0.2401
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0996 0.2225
Onchocerca volvulus 0.0036 0.0349 0.1822
Leishmania major hypothetical protein, conserved 0.0036 0.0349 0.065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0568 0.4978
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0144 0.0382
Leishmania major proteasome beta 5 subunit, putative 0.0086 0.0996 0.2225
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.221 0.3272
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.2647
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0349 0.0722
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0495 0.1005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0405 0.0873
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0349 0.0516
Schistosoma mansoni alpha-glucosidase 0.0156 0.1887 0.2794
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0405 0.0873
Mycobacterium tuberculosis Conserved protein 0.0036 0.0349 0.0228
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0405 0.3059
Schistosoma mansoni hypothetical protein 0.0036 0.0348 0.0516
Schistosoma mansoni hypothetical protein 0.0031 0.0288 0.0426
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0379 0.275
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0379 0.1001
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0379 0.056
Leishmania major hypothetical protein, conserved 0.0079 0.0906 0.2006
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0086 0.0996 0.9071
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0996 0.2225
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0288 0.0426
Onchocerca volvulus Huntingtin homolog 0.0129 0.1547 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0349 0.0722
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0349 0.0228
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0379 0.275
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1926 0.4487
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0405 0.0873
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0405 0.0873
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0144 0.0152
Schistosoma mansoni hypothetical protein 0.0035 0.0346 0.0512
Mycobacterium ulcerans glutaminase 0.0303 0.3783 0.4051
Brugia malayi CXXC zinc finger family protein 0.0028 0.0248 0.0656
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0405 0.0786
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0379 0.0261
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.2647
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0144 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1147 0.3031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0405 0.0873
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0405 0.0873
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0349 0.0349
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0405 0.0405
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0288 0.0288
Schistosoma mansoni alpha glucosidase 0.004 0.0405 0.0599
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0719 0.9127 1
Onchocerca volvulus Huntingtin homolog 0.0129 0.1547 1
Loa Loa (eye worm) glutaminase 0.0303 0.3783 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0144 0.0382
Echinococcus granulosus proteasome prosome macropain 0.0086 0.0996 0.1474
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0719 0.9127 1
Brugia malayi glutaminase DH11.1 0.0303 0.3783 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0288 0.076
Schistosoma mansoni ap endonuclease 0.002 0.0144 0.0214
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0719 0.9127 0.5
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0086 0.0996 1
Brugia malayi beta-lactamase 0.0036 0.0349 0.0922
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0512 0.0758
Entamoeba histolytica fatty acid elongase, putative 0.0093 0.109 1
Schistosoma mansoni hypothetical protein 0.0031 0.0288 0.0426
Trichomonas vaginalis esterase, putative 0.0036 0.0349 0.0722
Echinococcus granulosus GPCR family 2 0.0031 0.0288 0.0426
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.2647
Onchocerca volvulus 0.0036 0.0349 0.1822
Echinococcus multilocularis proteasome (prosome, macropain) 0.0086 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.0098 0.1147 0.3031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0495 0.1005
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0349 0.0722
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0335 0.4191 1
Trichomonas vaginalis glutaminase, putative 0.0303 0.3783 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0348 0.0516
Echinococcus granulosus cpg binding protein 0.0029 0.0268 0.0397
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0906 0.0848
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0512 0.1353
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0349 0.0516
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.221 0.5842
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0082 0.0216
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.221 0.221
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0144 0.0152
Entamoeba histolytica fatty acid elongase, putative 0.0093 0.109 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0144 0.0144
Mycobacterium ulcerans hypothetical protein 0.0036 0.0349 0.0228
Echinococcus multilocularis GPCR, family 2 0.0031 0.0288 0.0288
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0405 0.107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1147 0.3031
Echinococcus multilocularis cpg binding protein 0.0029 0.0268 0.0268
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0405 0.3206
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0749 0.198
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0405 0.0786
Schistosoma mansoni glutaminase 0.0303 0.3783 0.56
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.0922
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0379 0.0722
Leishmania major mitochondrial DNA polymerase beta 0.0335 0.4191 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0288 0.0426
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0397
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0086 0.0996 0.247
Plasmodium vivax proteasome subunit beta type-5, putative 0.0086 0.0996 0.0948
Loa Loa (eye worm) hypothetical protein 0.0129 0.1547 0.409
Schistosoma mansoni hypothetical protein 0.0535 0.6755 1
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0906 0.0848
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0349 0.0228
Onchocerca volvulus 0.0105 0.1232 0.7849
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0144 0.0152
Brugia malayi Proteasome A-type and B-type family protein 0.0086 0.0996 0.2633
Schistosoma mansoni hypothetical protein 0.0067 0.0749 0.1109
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0906 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0512 0.0758
Plasmodium falciparum proteasome subunit beta type-5 0.0086 0.0996 0.0948
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0144 0.0152
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1505 0.3978
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0512 0.0512
Brugia malayi hypothetical protein 0.0051 0.0546 0.1443
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1147 0.3031
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0719 0.9127 1
Schistosoma mansoni hypothetical protein 0.0535 0.6755 1
Onchocerca volvulus 0.0028 0.0248 0.1135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.2156 0.2239
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0349 0.0228
Loa Loa (eye worm) beta-lactamase 0.0036 0.0349 0.0922
Brugia malayi Augmenter of liver regeneration 0.0038 0.0379 0.1001
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0719 0.9127 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0512 0.0758
Entamoeba histolytica fatty acid elongase, putative 0.0093 0.109 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0288 0.076
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0349 0.0228
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0349 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0348 0.0348
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0405 0.0599
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0397
Trypanosoma brucei glucosidase, putative 0.004 0.0405 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0349 0.065
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0144 0.0169
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0495 0.1005
Loa Loa (eye worm) hypothetical protein 0.0079 0.0906 0.2395
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0349 0.0922
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0349 0.0228
Brugia malayi beta-lactamase family protein 0.0036 0.0349 0.0922
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0405 0.107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0349 0.0516
Toxoplasma gondii hypothetical protein 0.0054 0.0584 0.5159
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0086 0.0996 0.2633
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0906 0.2006
Loa Loa (eye worm) hypothetical protein 0.0129 0.1547 0.409
Mycobacterium ulcerans lipase LipD 0.0036 0.0349 0.0228
Leishmania major hypothetical protein, conserved 0.0038 0.0379 0.0722
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0144 0.0622
Schistosoma mansoni alpha-glucosidase 0.0156 0.1887 0.2794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0512 0.0758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0649 0.0961
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0495 0.1005
Mycobacterium ulcerans beta-lactamase 0.0036 0.0349 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0349 0.0228
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0086 0.0996 0.2225
Entamoeba histolytica fatty acid elongase, putative 0.0093 0.109 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0288 0.076

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.049 Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis ChEMBL. 27117691
IC50 (binding) = 1.12 nM Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis ChEMBL. 27117691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.