Detailed information for compound 221694

Basic information

Technical information
  • TDR Targets ID: 221694
  • Name: 4-(4-chlorophenyl)-1-[(4S)-4-(4-fluorophenyl) -4-hydroxybutyl]piperidin-4-ol
  • MW: 377.88 | Formula: C21H25ClFNO2
  • H donors: 2 H acceptors: 2 LogP: 3.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)[C@H](CCCN1CCC(CC1)(O)c1ccc(cc1)Cl)O
  • InChi: 1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2/t20-/m0/s1
  • InChiKey: WNZBBTJFOIOEMP-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-chlorophenyl)-1-[(4S)-4-(4-fluorophenyl)-4-hydroxy-butyl]piperidin-4-ol
  • 4-(4-chlorophenyl)-1-[(4S)-4-(4-fluorophenyl)-4-hydroxybutyl]-4-piperidinol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D3 receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D3 receptor   446 aa 478 aa 22.8 %
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D3 receptor   446 aa 501 aa 28.5 %
Onchocerca volvulus Dopamine D3 receptor   446 aa 462 aa 26.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D3 receptor   446 aa 455 aa 28.6 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Dopamine D3 receptor   446 aa 463 aa 25.5 %
Loa Loa (eye worm) TYRA-2 protein Dopamine D3 receptor   446 aa 494 aa 24.3 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D3 receptor   446 aa 489 aa 22.9 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D3 receptor   446 aa 426 aa 28.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 440 aa 30.0 %
Schistosoma mansoni amine GPCR Dopamine D3 receptor   446 aa 420 aa 31.4 %
Echinococcus multilocularis biogenic amine (5HT) receptor Dopamine D3 receptor   446 aa 499 aa 30.9 %
Onchocerca volvulus Dopamine D3 receptor   446 aa 434 aa 19.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D3 receptor   446 aa 463 aa 29.8 %
Echinococcus multilocularis alpha 1A adrenergic receptor Dopamine D3 receptor   446 aa 473 aa 21.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Dopamine D3 receptor   446 aa 460 aa 21.1 %
Loa Loa (eye worm) hypothetical protein Dopamine D3 receptor   446 aa 425 aa 21.4 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neurotransmitter gated ion channel 0.017 0.0182 0.0761
Echinococcus granulosus tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0158 0.0486
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0012 0.0323
Schistosoma mansoni histone deacetylase 0.0745 0.0955 0.3995
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0137 0.0421
Toxoplasma gondii hypothetical protein 0.0181 0.0197 0.0774
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0035 0.0145
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0182 0.0198 0.0828
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Giardia lamblia Tenascin-X 0.0082 0.0064 0.0611
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0007 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0035 0.0107
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0012 0.0122
Loa Loa (eye worm) AUR protein kinase 0.0055 0.0027 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Loa Loa (eye worm) LGC-31 protein 0.0306 0.0365 0.1125
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0007 0.0021
Echinococcus granulosus transmembrane protease serine 3 0.0182 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.006 0.0035 0.0107
Echinococcus multilocularis glycine receptor subunit beta 0.0306 0.0365 0.0365
Echinococcus multilocularis tyrosine kinase 0.0043 0.0012 0.0012
Echinococcus granulosus allatostatin A receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Giardia lamblia hypothetical protein 0.0082 0.0064 0.0611
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0012 0.007
Brugia malayi Protein kinase domain containing protein 0.0043 0.0012 0.0036
Loa Loa (eye worm) PAN domain-containing protein 0.0181 0.0197 0.0606
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0136 0.0137 0.0421
Schistosoma mansoni nck2/grb4 0.006 0.0035 0.0145
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Onchocerca volvulus Histone deacetylase 10 homolog 0.0255 0.0296 0.186
Brugia malayi Serotonin receptor 0.0299 0.0356 0.1094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.0365 0.0365
Onchocerca volvulus 0.0043 0.0012 0.0044
Onchocerca volvulus 0.0043 0.0012 0.0045
Echinococcus multilocularis neuropeptide s receptor 0.0299 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0182 0.0198 0.0827
Schistosoma mansoni glutamate receptor NMDA 0.0038 0.0005 0.002
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0007 0.0021
Brugia malayi steroid hormone receptor 0.004 0.0007 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0012 0.0101
Entamoeba histolytica hypothetical protein 0.017 0.0182 0.1899
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0007 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0004 0.004
Schistosoma mansoni hypothetical protein 0.0182 0.0198 0.0827
Echinococcus multilocularis glycine receptor subunit beta 0.0306 0.0365 0.0365
Toxoplasma gondii PAN domain-containing protein 0.0181 0.0197 0.0774
Schistosoma mansoni adenoreceptor 0.0299 0.0356 0.1486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Loa Loa (eye worm) PAN domain-containing protein 0.0181 0.0197 0.0606
Loa Loa (eye worm) TK/ROR protein kinase 0.028 0.033 0.1014
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0097 0.0084 0.0084
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis tyrosine protein kinase Src42A 0.031 0.0371 0.0371
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis integrin beta 2 0.1886 0.249 0.249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0076
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0299 0.0356 0.1094
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0181 0.0197 0.0774
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0299 0.0356 0.0356
Mycobacterium ulcerans beta-lactamase 0.0043 0.0012 0.0323
Loa Loa (eye worm) sex muscle abnormal protein 5 0.006 0.0035 0.0107
Brugia malayi Protein kinase domain containing protein 0.0043 0.0012 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Onchocerca volvulus 0.0181 0.0197 0.1227
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0006 0.0024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0365 0.1528
Toxoplasma gondii hypothetical protein 0.0181 0.0197 0.0774
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase Srms 0.028 0.0331 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0082 0.0064 0.0196
Echinococcus multilocularis transmembrane protease serine 3 0.0182 0.0198 0.0198
Toxoplasma gondii microneme protein, putative 0.0181 0.0197 0.0774
Loa Loa (eye worm) TK protein kinase 0.028 0.0331 0.1017
Toxoplasma gondii PAN domain-containing protein 0.0181 0.0197 0.0774
Entamoeba histolytica protein kinase, putative 0.0055 0.0027 0.0278
Brugia malayi beta-lactamase family protein 0.0043 0.0012 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis orexin receptor type 2 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0097 0.0084 0.0084
Brugia malayi histone deacetylase 3 (HD3) 0.0745 0.0955 0.294
Echinococcus multilocularis histone deacetylase 7 0.0393 0.0482 0.0482
Onchocerca volvulus 0.0182 0.0198 0.1234
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0482 0.417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0007 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.086 0.086
Onchocerca volvulus 0.0043 0.0012 0.0044
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Onchocerca volvulus 0.0082 0.0064 0.0376
Brugia malayi Receptor family ligand binding region containing protein 0.0131 0.013 0.04
Schistosoma mansoni histamine h1 receptor 0.0299 0.0356 0.1486
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Echinococcus multilocularis nAChR subunit 0.017 0.0182 0.0182
Echinococcus multilocularis voltage dependent calcium channel 0.0097 0.0084 0.0084
Echinococcus granulosus dna polymerase eta 0.0039 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0007 0.0021
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0299 0.0356 0.1094
Echinococcus granulosus voltage dependent calcium channel 0.0097 0.0084 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0017 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0027 0.0284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0018 0.0018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0306 0.0365 0.1125
Toxoplasma gondii aurora kinase 0.0055 0.0027 0.0106
Onchocerca volvulus 0.0299 0.0356 0.2239
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0267 0.0312 0.3268
Schistosoma mansoni histone deacetylase 4 5 0.0393 0.0482 0.2014
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Schistosoma mansoni alpha-glucosidase 0.0145 0.0149 0.0623
Brugia malayi Importin beta-1 subunit 0.0035 0 0.0001
Echinococcus multilocularis geminin 0.0205 0.0229 0.0229
Schistosoma mansoni metabotropic glutamate receptor 0.0038 0.0005 0.002
Brugia malayi Histone deacetylase 1 0.0745 0.0955 0.294
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0299 0.0356 0.0356
Brugia malayi Trypsin family protein 0.0182 0.0198 0.0609
Brugia malayi hypothetical protein 0.0387 0.0474 0.1458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0453 0.1395
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Brugia malayi sulfakinin receptor protein 0.0299 0.0356 0.1094
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0136 0.0137 0.0421
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1264 0.1654 0.6916
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi G protein-coupled receptor 0.0299 0.0356 0.1094
Echinococcus granulosus tyrosine kinase 0.028 0.0331 0.0331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0012 0.005
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0019 0.0135
Trypanosoma brucei aurora B kinase 0.0055 0.0027 0.0234
Loa Loa (eye worm) hypothetical protein 0.0528 0.0664 0.2044
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Plasmodium falciparum cysteine repeat modular protein 1 0.0267 0.0312 0.3268
Brugia malayi RE15519p 0.0299 0.0356 0.1094
Giardia lamblia Tenascin-like 0.0082 0.0064 0.0611
Brugia malayi beta-lactamase 0.0043 0.0012 0.0037
Onchocerca volvulus 0.0043 0.0012 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Echinococcus granulosus aurora kinase A 0.0055 0.0027 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.0356 0.1486
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0027 0.0114
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni tyrosine kinase 0.0073 0.0052 0.0217
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0299 0.0356 0.2239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Echinococcus granulosus tyrosine kinase 0.0051 0.0022 0.0022
Schistosoma mansoni alpha glucosidase 0.0037 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Schistosoma mansoni hypothetical protein 0.005 0.0021 0.0088
Brugia malayi larval opioid receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.1202 0.1571 0.4834
Echinococcus multilocularis tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0182 0.0198 0.0198
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0038 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0082 0.0064 0.0196
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0299 0.0356 0.1094
Echinococcus granulosus histone deacetylase 1 0.0745 0.0955 0.0955
Echinococcus granulosus histone deacetylase 7 0.0393 0.0482 0.0482
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0327 1
Loa Loa (eye worm) neuropeptide F receptor 0.0299 0.0356 0.1094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.1021 0.1327 0.8439
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0306 0.0365 0.1125
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0043 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase HCK 0.025 0.0289 0.0289
Brugia malayi EGF-like domain containing protein 0.0082 0.0064 0.0196
Echinococcus multilocularis snurportin 1 0.0372 0.0453 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0158 0.0486
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0455 0.0565 0.1738
Giardia lamblia Histone deacetylase 0.0745 0.0955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Schistosoma mansoni tyrosine kinase 0.0051 0.0022 0.0092
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0889 0.115 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0306 0.0365 0.0365
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0073 0.0052 0.0052
Schistosoma mansoni DNA polymerase eta 0.0039 0.0006 0.0024
Onchocerca volvulus 0.0299 0.0356 0.2239
Schistosoma mansoni biogenic amine receptor 0.0299 0.0356 0.1486
Schistosoma mansoni histone deacetylase hda2 0.0255 0.0296 0.1238
Onchocerca volvulus 0.0528 0.0664 0.4211
Echinococcus multilocularis histone deacetylase 6 0.0393 0.0482 0.0482
Toxoplasma gondii PAN domain-containing protein 0.0181 0.0197 0.0774
Schistosoma mansoni tyrosine kinase 0.031 0.0371 0.155
Schistosoma mansoni neuropeptide receptor 0.0299 0.0356 0.1486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0007 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Brugia malayi hypothetical protein 0.0136 0.0137 0.0421
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0018 0.0018
Loa Loa (eye worm) AUR protein kinase 0.0055 0.0027 0.0084
Brugia malayi follicle stimulating hormone receptor 0.0538 0.0677 0.2082
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.0356 0.0356
Leishmania major hypothetical protein, conserved 0.0267 0.0312 0.2693
Echinococcus multilocularis fmrfamide receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0082 0.0064 0.0196
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0007 0.0007
Onchocerca volvulus 0.0306 0.0365 0.2303
Echinococcus granulosus tachykinin peptides receptor 99D 0.0299 0.0356 0.0356
Onchocerca volvulus 0.0181 0.0197 0.1227
Toxoplasma gondii kringle domain-containing protein 0.0267 0.0312 0.1229
Giardia lamblia High cysteine protein 0.0082 0.0064 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0012 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0299 0.0356 0.0356
Echinococcus granulosus neuropeptides capa receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) G-protein coupled receptor 0.0299 0.0356 0.1094
Onchocerca volvulus 0.0299 0.0356 0.2239
Schistosoma mansoni importin beta-1 0.0035 0 0.0001
Echinococcus granulosus glycine receptor subunit beta 0.0306 0.0365 0.0365
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0182 0.0198 0.0827
Echinococcus multilocularis dna polymerase eta 0.0039 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Onchocerca volvulus 0.0306 0.0365 0.2303
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0038 0.0005 0.0005
Echinococcus granulosus receptor type guanylyl cyclase 0.0131 0.013 0.013
Echinococcus granulosus 7tm_1 domain containing protein 0.0299 0.0356 0.0356
Entamoeba histolytica protein kinase, putative 0.025 0.0289 0.3025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0012 0.0193
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni amine GPCR 0.0299 0.0356 0.1486
Onchocerca volvulus 0.0299 0.0356 0.2239
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0073 0.0052 0.0217
Leishmania major protein kinase, putative 0.0055 0.0027 0.0203
Toxoplasma gondii histone deacetylase HDAC5 0.0255 0.0296 0.1165
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1202 0.1571 0.6569
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0012 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0017 0.0053
Onchocerca volvulus 0.0181 0.0197 0.1227
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0136 0.0137 0.0137
Loa Loa (eye worm) trypsin family protein 0.0182 0.0198 0.0609
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0012 0.0124
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Echinococcus granulosus peptide allatostatin:somatostatin 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Echinococcus granulosus NCK adaptor protein 0.006 0.0035 0.0035
Leishmania major DNA polymerase eta, putative 0.0039 0.0006 0.0016
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0745 0.0955 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0136 0.0137 0.0137
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Brugia malayi excitatory GABA receptor EXP-1A 0.0306 0.0365 0.1125
Plasmodium falciparum histone deacetylase, putative 0.0393 0.0482 0.504
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0299 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0205 0.0229 0.0956
Onchocerca volvulus 0.0181 0.0197 0.1227
Schistosoma mansoni nuclear hormone receptor 0.004 0.0007 0.0028
Onchocerca volvulus Neuropeptide F receptor homolog 0.0299 0.0356 0.2239
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0007 0.0028
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0007 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0299 0.0356 0.0356
Brugia malayi Protein kinase domain containing protein 0.0043 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni hypothetical protein 0.0267 0.0312 0.1306
Echinococcus granulosus tyrosine protein kinase Srms 0.0043 0.0012 0.0012
Onchocerca volvulus 0.0043 0.0012 0.0044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis somatostatin receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0007 0.0007
Brugia malayi Muscle positioning protein 4 0.0182 0.0198 0.0609
Echinococcus granulosus G protein coupled receptor 139 0.0299 0.0356 0.0356
Echinococcus multilocularis tyrosine protein kinase Fgr 0.031 0.0371 0.0371
Brugia malayi Guanylyl cyclase protein 23 0.0061 0.0035 0.0109
Schistosoma mansoni nAChR subunit 0.0136 0.0137 0.0572
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0097 0.0084 0.035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0538 0.0677 0.2082
Brugia malayi histone deacetylase 11 0.0255 0.0296 0.0911
Echinococcus multilocularis glycoprotein Antigen 5 0.0182 0.0198 0.0198
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0182 0.0198 0.0198
Brugia malayi Trypsin family protein 0.0182 0.0198 0.0609
Loa Loa (eye worm) histone deacetylase 1 0.0745 0.0955 0.294
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.031 0.0371 0.0371
Loa Loa (eye worm) PAN domain-containing protein 0.0181 0.0197 0.0606
Brugia malayi Histone deacetylase family protein 0.0393 0.0482 0.1482
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0299 0.0356 0.1486
Mycobacterium tuberculosis Conserved protein 0.0043 0.0012 0.0193
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.0137 0.0572
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0035 0.0145
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Echinococcus granulosus metabotropic glutamate receptor 5 0.0038 0.0005 0.0005
Schistosoma mansoni adapter molecule crk 0.006 0.0035 0.0145
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Onchocerca volvulus 0.0216 0.0243 0.1523
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Toxoplasma gondii microneme protein MIC4 0.0181 0.0197 0.0774
Onchocerca volvulus 0.0043 0.0012 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0007 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0011 0.0045
Schistosoma mansoni alpha-glucosidase 0.0145 0.0149 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0007 0.0021
Echinococcus multilocularis histone deacetylase 6 0.0423 0.0522 0.0522
Echinococcus granulosus neuropeptide receptor A26 0.0299 0.0356 0.0356
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0306 0.0365 0.0365
Echinococcus multilocularis tyrosine protein kinase Src64B 0.031 0.0371 0.0371
Schistosoma mansoni amine GPCR 0.0299 0.0356 0.1486
Toxoplasma gondii ABC1 family protein 0.0043 0.0012 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0007 0.0021
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0745 0.0955 1
Giardia lamblia Neurogenic locus notch-like protein 0.0082 0.0064 0.0611
Leishmania major cathepsin L-like protease 0.0062 0.0037 0.0291
Echinococcus multilocularis histone deacetylase 8 0.0255 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Echinococcus multilocularis NCK adaptor protein 0.006 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0007 0.0021
Echinococcus granulosus neuropeptide receptor 0.0609 0.0772 0.0772
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0006 0.0053
Echinococcus granulosus histone deacetylase 8 0.0255 0.0296 0.0296
Schistosoma mansoni myosin xvIII 0.0299 0.0356 0.1486
Echinococcus granulosus fibrillin 2 0.0082 0.0064 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0006 0.0016
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0181 0.0181
Brugia malayi Protein kinase domain containing protein 0.028 0.033 0.1014
Schistosoma mansoni neuropeptide f receptor 76f 0.0299 0.0356 0.1486
Onchocerca volvulus 0.0182 0.0198 0.1233
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0037 0.0291
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0097 0.0084 0.0084
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0097 0.0084 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0007 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0299 0.0356 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0299 0.0356 0.0356
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus histone deacetylase 0.0393 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni metabotropic glutamate receptor 0.0038 0.0005 0.002
Onchocerca volvulus 0.0182 0.0198 0.1234
Onchocerca volvulus 0.0181 0.0197 0.1227
Schistosoma mansoni hypothetical protein 0.0299 0.0356 0.1486
Brugia malayi putative neuropeptide receptor NPR1 0.0299 0.0356 0.1094
Onchocerca volvulus 0.0181 0.0197 0.1227
Loa Loa (eye worm) RGC/RGC protein kinase 0.0131 0.013 0.04
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0306 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.0104 0.0093 0.039
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0181 0.0181
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.028 0.0331 0.0331
Echinococcus granulosus tyrosine protein kinase Src64B 0.031 0.0371 0.0371
Echinococcus granulosus tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Brugia malayi Tachykinin-like peptides receptor 99D 0.0299 0.0356 0.1094
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Brugia malayi Histone deacetylase family protein 0.0393 0.0482 0.1482
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.017 0.0182 0.056
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0306 0.0365 0.1125
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0053 0.0222
Echinococcus granulosus neuropeptide s receptor 0.0299 0.0356 0.0356
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0268 0.0313 0.0313
Schistosoma mansoni tyrosine kinase 0.0043 0.0012 0.0049
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Brugia malayi hypothetical protein 0.0043 0.0012 0.0036
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0306 0.0365 0.1125
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0038 0.0038
Echinococcus granulosus sex peptide receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0528 0.0664 0.2044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0038 0.0038
Brugia malayi solute carrier family 40, member 1 0.0216 0.0243 0.0749
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0004 0.004
Schistosoma mansoni hypothetical protein 0.0372 0.0453 0.1896
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0528 0.0664 0.4211
Mycobacterium ulcerans lipase LipD 0.0043 0.0012 0.0323
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0104 0.0093 0.0287
Schistosoma mansoni integrin beta subunit 0.1499 0.197 0.8236
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Loa Loa (eye worm) TK/ABL protein kinase 0.0043 0.0012 0.0036
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0037 0.0112
Brugia malayi Metabotropic glutamate receptor precursor. 0.0038 0.0005 0.0015
Toxoplasma gondii histone deacetylase HDAC3 0.0745 0.0955 0.376
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0109 0.0099 0.0099
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0306 0.0365 0.1125
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0005 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Leishmania major histone deacetylase, putative 0.0745 0.0955 0.8304
Schistosoma mansoni protein kinase 0.0055 0.0027 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Echinococcus multilocularis tyrosine protein kinase Blk 0.028 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Toxoplasma gondii hypothetical protein 0.0082 0.0064 0.025
Schistosoma mansoni acetylcholine receptor subunit beta 0.0136 0.0137 0.0572
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Loa Loa (eye worm) hypothetical protein 0.0255 0.0296 0.0911
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0528 0.0664 0.2778
Echinococcus multilocularis fibrillin 2 0.0082 0.0064 0.0064
Onchocerca volvulus 0.0182 0.0198 0.1234
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) PAN domain-containing protein 0.0181 0.0197 0.0606
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0017 0.0017
Echinococcus multilocularis adam 0.0082 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0007 0.0021
Loa Loa (eye worm) histone deacetylase 3 0.0745 0.0955 0.294
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0006 0.0016
Loa Loa (eye worm) DOMON domain-containing protein 0.0182 0.0198 0.0609
Schistosoma mansoni lipoxygenase 0.0086 0.0068 0.0286
Trichomonas vaginalis esterase, putative 0.0043 0.0012 0.0124
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0007 0.0007
Trypanosoma cruzi histone deacetylase, putative 0.0255 0.0296 0.2551
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0306 0.0365 0.1125
Echinococcus granulosus tm gpcr rhodopsin 0.0299 0.0356 0.0356
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0136 0.0137 0.0137
Onchocerca volvulus 0.0182 0.0198 0.1233
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0007 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0004 0.0033
Brugia malayi Trypsin family protein 0.0182 0.0198 0.0609
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0027 0.0278
Onchocerca volvulus 0.0181 0.0197 0.1227
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.017 0.0182 0.056
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0387 0.0474 0.1458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Echinococcus multilocularis serotonin receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0299 0.0356 0.1094
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0038 0.1009
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0745 0.0955 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0136 0.0137 0.0137
Trypanosoma cruzi histone deacetylase 1, putative 0.0745 0.0955 0.8304
Loa Loa (eye worm) hypothetical protein 0.0216 0.0243 0.0749
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Schistosoma mansoni histone deacetylase 4 5 0.0393 0.0482 0.2014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Echinococcus granulosus fibrillin 1 0.0082 0.0064 0.0064
Onchocerca volvulus 0.017 0.0182 0.1131
Echinococcus granulosus integrin beta 2 0.1886 0.249 0.249
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0097 0.0084 0.035
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0037 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0027 0.0284
Echinococcus granulosus g-protein coupled receptor 0.0299 0.0356 0.0356
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0004 0.004
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0055 0.0027 0.0282
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Toxoplasma gondii microneme protein MIC17A 0.0181 0.0197 0.0774
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0158 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0007 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Echinococcus granulosus alpha 1A adrenergic receptor 0.0299 0.0356 0.0356
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0007 0.0021
Plasmodium vivax histone deacetylase 2, putative 0.0393 0.0482 0.504
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0528 0.0664 0.2778
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Onchocerca volvulus 0.0182 0.0198 0.1234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0035 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0038 0.1688
Onchocerca volvulus 0.0181 0.0197 0.1227
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Echinococcus multilocularis neuropeptides capa receptor 0.0299 0.0356 0.0356
Brugia malayi Variant SH3 domain containing protein 0.006 0.0035 0.0107
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0097 0.0084 0.0084
Echinococcus multilocularis g protein coupled receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.031 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Schistosoma mansoni histone deacetylase 1 2 3 0.0255 0.0296 0.1238
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0306 0.0365 0.1125
Echinococcus multilocularis enteropeptidase 0.0182 0.0198 0.0198
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0038 0.0005 0.0015
Brugia malayi Integrin beta pat-3 precursor 0.2451 0.325 1
Schistosoma mansoni opsin-like receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Brugia malayi Dopamine receptor protein 2 0.0299 0.0356 0.1094
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0004 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0012 0.0323
Schistosoma mansoni opsin-like receptor 0.0299 0.0356 0.1486
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0038 0.0159
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.0356 0.1486
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0079 0.0079
Loa Loa (eye worm) acetylcholine receptor protein 0.0136 0.0137 0.0421
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0055 0.0027 0.0278
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0365 0.1125
Loa Loa (eye worm) GABA receptor subunit 0.017 0.0182 0.056
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0059 0.0033 0.0283
Onchocerca volvulus 0.0299 0.0356 0.2239
Echinococcus granulosus tm gpcr rhodopsin 0.0299 0.0356 0.0356
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Brugia malayi nuclear receptor NHR-88 0.004 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Echinococcus multilocularis Mastin 0.0182 0.0198 0.0198
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0097 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0062 0.0037 0.0112
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase shark 0.0043 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0182 0.0198 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0005 0.0005
Trypanosoma cruzi histone deacetylase, putative 0.0255 0.0296 0.2551
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0052 0.0052
Schistosoma mansoni protein kinase 0.0131 0.013 0.0543
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0306 0.0365 0.1528
Onchocerca volvulus 0.0136 0.0137 0.0843
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.031 0.0371 0.0371
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0018 0.0056
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0076
Mycobacterium tuberculosis Conserved protein 0.0043 0.0012 0.0193
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.0056
Echinococcus granulosus adam 0.0082 0.0064 0.0064
Brugia malayi ORL1-like opioid receptor 0.0299 0.0356 0.1094
Echinococcus granulosus neuropeptide receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis neuropeptide Y receptor 0.0299 0.0356 0.0356
Trypanosoma brucei histone deacetylase 3 0.0393 0.0482 0.4188
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.0093 0.0079 0.0243
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0006 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0365 0.1125
Toxoplasma gondii histone deacetylase HDAC1 0.0393 0.0482 0.1895
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Echinococcus granulosus glutamate receptor 2 0.0038 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0043 0.0012 0.0193
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Toxoplasma gondii PAN/Apple domain-containing protein 0.0181 0.0197 0.0774
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0299 0.0356 0.1094
Trypanosoma brucei C-8 sterol isomerase, putative 0.0889 0.115 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0012 0.0193
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0079 0.0079
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0012 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0299 0.0356 0.0356
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.0137 0.0572
Brugia malayi SEA domain containing protein 0.0182 0.0198 0.0609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0306 0.0365 0.0365
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7468 1 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0179 0.0552
Echinococcus granulosus tyrosine kinase 0.0043 0.0012 0.0012
Echinococcus granulosus tissue type plasminogen activator 0.0267 0.0312 0.0312
Onchocerca volvulus 0.1202 0.1571 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0006 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0181 0.0556
Giardia lamblia High cysteine protein 0.0082 0.0064 0.0611
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0012 0.0124
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0299 0.0356 0.1094
Echinococcus multilocularis fmrfamide receptor 0.0299 0.0356 0.0356
Schistosoma mansoni biogenic amine receptor 0.0299 0.0356 0.1486
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Echinococcus granulosus growth factor receptor bound protein 2 0.006 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0889 0.115 0.3538
Loa Loa (eye worm) ACC-1 protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0182 0.0198 0.1233
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Echinococcus granulosus tyrosine protein kinase Lyn 0.0311 0.0371 0.0371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0012 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0004 0.004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.006 0.0035 0.0145
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0299 0.0356 0.0356
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.003 0.0228
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.021 0.0237 0.0989
Schistosoma mansoni amine GPCR 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0051 0.0022 0.0068
Schistosoma mansoni growth hormone secretagogue receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) glutamate receptor 0.0038 0.0005 0.0015
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0268 0.0313 0.0313
Onchocerca volvulus 0.0299 0.0356 0.2239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0017 0.0072
Echinococcus multilocularis tyrosine kinase 0.0051 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0889 0.115 0.3538
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0299 0.0356 0.0356
Echinococcus granulosus tyrosine protein kinase Src42A 0.031 0.0371 0.0371
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0182 0.0198 0.0827
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0012 0.0037
Echinococcus multilocularis sodium channel protein 0.0041 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0048 0.0018 0.0018
Toxoplasma gondii PAN domain-containing protein 0.1923 0.2541 1
Schistosoma mansoni neuropeptide receptor 0.0609 0.0772 0.3228
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0012 0.0193
Schistosoma mansoni biogenic amine receptor 0.0299 0.0356 0.1486
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0006 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0365 0.1528
Brugia malayi neuropeptide F receptor 0.0299 0.0356 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0007 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0006 0.0047
Brugia malayi Serotonin receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0038 0.0005 0.0015
Echinococcus multilocularis tyrosine protein kinase Fyn 0.028 0.0331 0.0331
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0055 0.0027 0.0278
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0017 0.0017
Onchocerca volvulus 0.0061 0.0035 0.0195
Onchocerca volvulus 0.0528 0.0664 0.4211
Echinococcus multilocularis serotonin receptor 0.0299 0.0356 0.0356
Schistosoma mansoni voltage-gated cation channel 0.0097 0.0084 0.035
Leishmania major hypothetical protein, conserved 0.0043 0.0012 0.007
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0131 0.013 0.0799
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0038 0.0005 0.0005
Onchocerca volvulus 0.0043 0.0012 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0006 0.0017
Brugia malayi Dopamine receptor protein 1 0.0299 0.0356 0.1094
Schistosoma mansoni neuropeptide F-like receptor 0.0299 0.0356 0.1486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0004 0.004
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Onchocerca volvulus 0.0299 0.0356 0.2239
Brugia malayi serine/threonine protein kinase 6 0.0055 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Brugia malayi EGF-like domain containing protein 0.0082 0.0064 0.0196
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Leishmania major DNA polymerase kappa, putative 0.0039 0.0006 0.0016
Echinococcus granulosus fmrfamide receptor 0.0299 0.0356 0.0356
Onchocerca volvulus Putative nachr subunit 0.0306 0.0365 0.2303
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0012 0.0193
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0299 0.0356 0.2239
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Echinococcus granulosus nAChR subunit 0.0306 0.0365 0.0365
Schistosoma mansoni nAChR subunit 0.0136 0.0137 0.0572
Brugia malayi hypothetical protein 0.0182 0.0198 0.0609
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0038 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) G-protein coupled receptor 0.0299 0.0356 0.1094
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0059
Loa Loa (eye worm) histone deacetylase 11 0.0255 0.0296 0.0911
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0007 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Brugia malayi serine/threonine-protein kinase 6 0.0055 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0006 0.0006
Giardia lamblia Tenascin precursor 0.0082 0.0064 0.0611
Schistosoma mansoni neuropeptide receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Trypanosoma cruzi hypothetical protein, conserved 0.0267 0.0312 0.2693
Onchocerca volvulus 0.0043 0.0012 0.0045
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0182 0.0198 0.0198
Mycobacterium ulcerans hypothetical protein 0.0043 0.0012 0.0323
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0136 0.0137 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0038 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Onchocerca volvulus 0.0136 0.0137 0.0843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0017 0.0072
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Schistosoma mansoni acetylcholine receptor-related 0.0136 0.0137 0.0572
Schistosoma mansoni hypothetical protein 0.0299 0.0356 0.1486
Echinococcus granulosus tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0306 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Echinococcus granulosus geminin 0.0205 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0182 0.0198 0.0827
Echinococcus multilocularis neuropeptide receptor 0.0609 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Onchocerca volvulus 0.0182 0.0198 0.1234
Toxoplasma gondii PAN domain-containing protein 0.1923 0.2541 1
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Onchocerca volvulus 0.0182 0.0198 0.1233
Brugia malayi Kelch motif family protein 0.0415 0.0512 0.1576
Echinococcus multilocularis histone deacetylase 1 0.0745 0.0955 0.0955
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0037 0.0291
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0037 0.0291
Leishmania major histone deacetylase, putative 0.0393 0.0482 0.417
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0004 0.0033
Schistosoma mansoni tyrosine kinase 0.0043 0.0012 0.0049
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0306 0.0365 0.0365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0299 0.0356 0.0356
Brugia malayi AKH receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0482 0.417
Echinococcus multilocularis histone deacetylase 0.0393 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Echinococcus granulosus neuropeptide FF receptor 2 0.0299 0.0356 0.0356
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.0365 0.0365
Echinococcus multilocularis voltage dependent calcium channel 0.0097 0.0084 0.0084
Echinococcus granulosus tyrosine protein kinase ABL1 0.0043 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0205 0.0229 0.0956
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Entamoeba histolytica histone deacetylase, putative 0.0745 0.0955 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0306 0.0365 0.0365
Brugia malayi SRC-1 0.031 0.0371 0.1141
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0007 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0038 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0004 0.004
Echinococcus granulosus g protein coupled receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0182 0.0198 0.0609
Plasmodium vivax histone deacetylase, putative 0.0255 0.0296 0.3099
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0299 0.0356 0.1094
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0299 0.0356 0.1094
Onchocerca volvulus 0.0136 0.0137 0.0843
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0033 0.01
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Schistosoma mansoni thyroid hormone receptor 0.004 0.0007 0.0028
Loa Loa (eye worm) RGC/RGC protein kinase 0.0131 0.013 0.04
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Trypanosoma brucei unspecified product 0.0039 0.0006 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0018 0.0056
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0136 0.0137 0.0421
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0118 0.0118
Leishmania major histone deacetylase, putative 0.0745 0.0955 0.8304
Loa Loa (eye worm) histone deacetylase 7A 0.0393 0.0482 0.1482
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0043 0.0012 0.0116
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0052 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0006 0.0017
Brugia malayi Receptor family ligand binding region containing protein 0.0038 0.0005 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0017 0.0053
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0306 0.0365 0.1125
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi G-protein coupled receptor 0.0299 0.0356 0.1094
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0299 0.0356 0.0356
Brugia malayi hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) neuropeptide F receptor 0.0299 0.0356 0.1094
Echinococcus granulosus tyrosine protein kinase shark 0.0043 0.0012 0.0012
Schistosoma mansoni lipoxygenase 0.0122 0.0118 0.0493
Schistosoma mansoni histone deacetylase hda2 0.0423 0.0522 0.2184
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0006 0.0006
Schistosoma mansoni amine GPCR 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0043 0.0012 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0001 0.0003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.031 0.0371 0.0371
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0299 0.0356 0.0356
Echinococcus multilocularis aurora kinase A 0.0055 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Onchocerca volvulus 0.0299 0.0356 0.2239
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0082 0.0064 0.0667
Trypanosoma brucei histone deacetylase, putative 0.0393 0.0482 0.4188
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Brugia malayi Trypsin family protein 0.1202 0.1571 0.4834
Echinococcus multilocularis GPCR, family 2 0.0048 0.0018 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0365 0.1125
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Toxoplasma gondii microneme protein MIC17B 0.0181 0.0197 0.0774
Brugia malayi metabotropic glutamate receptor type 2 0.0038 0.0005 0.0015
Brugia malayi Protein kinase domain containing protein 0.0043 0.0012 0.0036
Onchocerca volvulus 0.0181 0.0197 0.1227
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0181 0.0197 0.1227
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0097 0.0084 0.0258
Echinococcus granulosus enteropeptidase 0.0182 0.0198 0.0198
Brugia malayi EGF-like domain containing protein 0.0082 0.0064 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0181 0.0181
Onchocerca volvulus 0.0098 0.0085 0.0511
Toxoplasma gondii histone deacetylase HDAC4 0.0255 0.0296 0.1165
Schistosoma mansoni serine-type protease inhibitor 0.1813 0.2392 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0038 0.0159
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus somatostatin receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) melatonin receptor type 1A 0.0299 0.0356 0.1094
Giardia lamblia Neurogenic locus Notch protein precursor 0.0082 0.0064 0.0611
Echinococcus multilocularis neuropeptide receptor 0.0299 0.0356 0.0356
Onchocerca volvulus 0.0299 0.0356 0.2239
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0299 0.0356 0.2239
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0004 0.0014
Loa Loa (eye worm) TK protein kinase 0.025 0.0289 0.0891
Onchocerca volvulus 0.017 0.0182 0.1131
Trypanosoma cruzi histone deacetylase 1, putative 0.0745 0.0955 0.8304
Echinococcus multilocularis dro:myosuppressin receptor 0.0299 0.0356 0.0356
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0027 0.0284
Echinococcus granulosus metabotropic glutamate receptor 2 0.0038 0.0005 0.0005
Schistosoma mansoni coup transcription factor 0.004 0.0007 0.0028
Loa Loa (eye worm) ACC-1 protein 0.0306 0.0365 0.1125
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0027 0.0284
Schistosoma mansoni neuropeptide F-like receptor 0.0299 0.0356 0.1486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0299 0.0356 0.1486
Brugia malayi hypothetical protein 0.0136 0.0137 0.0421
Schistosoma mansoni histone deacetylase 0.0745 0.0955 0.3995
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.008 0.0061 0.2895
Onchocerca volvulus 0.0299 0.0356 0.2239
Echinococcus granulosus histone deacetylase 6 0.0423 0.0522 0.0522
Loa Loa (eye worm) AUR protein kinase 0.0055 0.0027 0.0084
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0052 0.0217
Loa Loa (eye worm) hypothetical protein 0.0082 0.0064 0.0196
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0076
Loa Loa (eye worm) beta-lactamase 0.0043 0.0012 0.0037
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi RNA, U transporter 1 0.0099 0.0087 0.0266
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0136 0.0137 0.0421
Echinococcus multilocularis nAChR subunit 0.0306 0.0365 0.0365
Echinococcus multilocularis glutamate receptor 2 0.0038 0.0005 0.0005
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Echinococcus multilocularis histone deacetylase 3 0.0745 0.0955 0.0955
Onchocerca volvulus 0.0181 0.0197 0.1227
Echinococcus multilocularis neuropeptide receptor A26 0.0299 0.0356 0.0356
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.031 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0267 0.0312 0.0961
Trypanosoma brucei histone deacetylase 1 0.0745 0.0955 0.8309
Echinococcus granulosus nAChR subunit 0.017 0.0182 0.0182
Onchocerca volvulus 0.0043 0.0012 0.0044
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0306 0.0365 0.1125
Loa Loa (eye worm) hypothetical protein 0.0745 0.0955 0.294
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0482 0.417
Brugia malayi SH2 domain containing protein 0.0043 0.0012 0.0036
Echinococcus granulosus Mastin 0.0182 0.0198 0.0198
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0306 0.0365 0.1125
Echinococcus granulosus nmda type glutamate receptor 0.0038 0.0005 0.0005
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0306 0.0365 0.1125
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0006 0.0006
Brugia malayi G-protein coupled receptor 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Brugia malayi Cation transporter family protein 0.0306 0.0365 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0007 0.0021
Leishmania major C-8 sterol isomerase-like protein 0.0889 0.115 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0299 0.0356 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Brugia malayi GnHR receptor homolog 0.0299 0.0356 0.1094
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0007 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0007 0.0007
Trichomonas vaginalis hypothetical protein 0.0082 0.0064 0.0667
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Echinococcus granulosus glycoprotein Antigen 5 0.0182 0.0198 0.0198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0018 0.0056
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0306 0.0365 0.1125
Leishmania major histone deacetylase, putative 0.0393 0.0482 0.417
Giardia lamblia Tenascin-37 0.0082 0.0064 0.0611
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Onchocerca volvulus 0.0299 0.0356 0.2239
Plasmodium vivax histone deacetylase 1, putative 0.0745 0.0955 1
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.086 0.3596
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0004 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0007 0.0007
Brugia malayi Dopamine receptor 0.0299 0.0356 0.1094
Mycobacterium leprae Probable lipase LipE 0.0043 0.0012 0.5
Loa Loa (eye worm) integrin beta-2 0.2451 0.325 1
Brugia malayi CUB domain containing protein 0.0062 0.0037 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0017 0.0072
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi ecdysteroid receptor 0.004 0.0007 0.0021
Schistosoma mansoni tyrosine kinase 0.031 0.0371 0.155
Entamoeba histolytica protein kinase, putative 0.0055 0.0027 0.0278
Brugia malayi Variant SH3 domain containing protein 0.006 0.0035 0.0107
Toxoplasma gondii subtilisin SUB12 0.0181 0.0197 0.0774
Echinococcus granulosus neuropeptide Y receptor 0.0299 0.0356 0.0356
Onchocerca volvulus 0.004 0.0007 0.0012
Brugia malayi PAN domain containing protein 0.0181 0.0197 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0012 0.0124
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0007 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0182 0.0198 0.0609
Echinococcus multilocularis neuropeptides capa receptor 0.0299 0.0356 0.0356
Entamoeba histolytica hypothetical protein 0.0038 0.0005 0.0044
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0415 0.0512 0.1576
Onchocerca volvulus 0.0306 0.0365 0.2303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0006 0.0047
Echinococcus granulosus neuropeptides capa receptor 0.0299 0.0356 0.0356
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0093 0.0287
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0007 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0299 0.0356 0.0356
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0097 0.0084 0.0084
Brugia malayi hypothetical protein 0.0136 0.0137 0.0421
Plasmodium falciparum histone deacetylase 1 0.0745 0.0955 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis protein jagged 2 0.0082 0.0064 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Brugia malayi Trypsin-like protease protein 5 0.0182 0.0198 0.0609
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0012 0.0012
Plasmodium vivax histone deacetylase, putative 0.0393 0.0482 0.504
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0136 0.0137 0.0421
Trypanosoma cruzi extracellular receptor, putative 0.0038 0.0005 0.0009
Onchocerca volvulus 0.0182 0.0198 0.1233
Echinococcus multilocularis neuropeptide Y receptor 0.0299 0.0356 0.0356
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.017 0.0182 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0007 0.0021
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0036
Schistosoma mansoni hypothetical protein 0.0035 0.0001 0.0003
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0055 0.0027 0.0027
Brugia malayi hypothetical protein 0.0038 0.0005 0.0015
Toxoplasma gondii histone deacetylase HDAC2 0.0745 0.0955 0.376
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0007 0.0028
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0306 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0097 0.0084 0.0258
Brugia malayi histone deacetylase 1 (HD1) 0.0745 0.0955 0.294
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0018 0.0018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0182 0.0198 0.0827
Brugia malayi Cation transporter family protein 0.0306 0.0365 0.1125
Trypanosoma brucei histone deacetylase 2 0.0255 0.0296 0.2575
Brugia malayi protein-tyrosine kinase 0.028 0.0331 0.1017
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis glutamate receptor 2 0.0038 0.0005 0.0005
Toxoplasma gondii PAN domain-containing protein 0.0181 0.0197 0.0774
Onchocerca volvulus 0.0299 0.0356 0.2239
Schistosoma mansoni nAChR subunit 0.0306 0.0365 0.1528
Schistosoma mansoni opsin-like receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Brugia malayi hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0006 0.0047
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) TYRA-2 protein 0.0299 0.0356 0.1094
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Leishmania major cathepsin L-like protease 0.0062 0.0037 0.0291
Brugia malayi putative neuropeptide receptor 0.0299 0.0356 0.1094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0007 0.0028
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0299 0.0356 0.1486
Echinococcus multilocularis fibrillin 1 0.0082 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0038 0.0005 0.0015
Brugia malayi Melatonin receptor type 1A 0.0299 0.0356 0.1094
Plasmodium falciparum histone deacetylase 2 0.0393 0.0482 0.504
Schistosoma mansoni tyrosine kinase 0.0051 0.0022 0.0092
Echinococcus granulosus tyrosine protein kinase Blk 0.028 0.0331 0.0331
Brugia malayi SH2 domain containing protein 0.0043 0.0012 0.0036
Brugia malayi G protein-coupled receptor F59B2.13 0.0299 0.0356 0.1094
Echinococcus granulosus FTZ F1 alpha 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.017 0.0182 0.056
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0052 0.016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0006 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0007 0.0021
Echinococcus multilocularis nmda type glutamate receptor 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0138 0.0139 0.0427
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0137 0.0421
Echinococcus granulosus histone deacetylase 6 0.0393 0.0482 0.0482
Leishmania major cathepsin L-like protease 0.0062 0.0037 0.0291
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0015
Brugia malayi Kringle domain containing protein 0.0267 0.0312 0.0961
Loa Loa (eye worm) hypothetical protein 0.0152 0.0158 0.0486
Echinococcus multilocularis tyrosine protein kinase Fyn 0.031 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0306 0.0365 0.1125
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0012 0.0124
Trichomonas vaginalis histone deacetylase, putative 0.0745 0.0955 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0306 0.0365 0.0365
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0055 0.0027 0.0278
Echinococcus multilocularis histone deacetylase 6 0.0393 0.0482 0.0482
Trypanosoma cruzi aurora B kinase, putative 0.0055 0.0027 0.0203
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0118 0.0118
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0012 0.0193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0181 0.0556
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0043 0.0012 0.0037
Echinococcus granulosus snurportin 1 0.0372 0.0453 0.0453
Echinococcus granulosus microtubule associated protein 2 0.0674 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.0182 0.056
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.017 0.0182 0.0761
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0037
Brugia malayi EGF-like domain containing protein 0.0082 0.0064 0.0196
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0182 0.0198 0.0827
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Loa Loa (eye worm) calcium channel 0.0097 0.0084 0.0258
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Leishmania major extracellular receptor, putative 0.0038 0.0005 0.0009
Echinococcus granulosus hypothetical protein 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Brugia malayi Protein kinase domain containing protein 0.0043 0.0012 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Echinococcus granulosus histone deacetylase 3 0.0745 0.0955 0.0955
Echinococcus multilocularis allatostatin A receptor 0.0299 0.0356 0.0356
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0043 0.0012 0.0012
Echinococcus granulosus orexin receptor type 2 0.0299 0.0356 0.0356
Echinococcus granulosus dna polymerase kappa 0.0039 0.0006 0.0006
Entamoeba histolytica protein kinase , putative 0.0055 0.0027 0.0278
Echinococcus granulosus histone deacetylase 6 0.0393 0.0482 0.0482
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0365 0.0365
Schistosoma mansoni amine GPCR 0.0299 0.0356 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0007 0.0021
Echinococcus multilocularis neuropeptide FF receptor 2 0.0299 0.0356 0.0356
Onchocerca volvulus 0.0267 0.0312 0.1964
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0038 0.1688
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0181 0.0197 0.0606
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0012 0.0193
Brugia malayi serine/threonine kinase 12 0.0055 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.004 0.0007 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Brugia malayi hypothetical protein 0.0035 0.0001 0.0002
Echinococcus multilocularis G protein coupled receptor 139 0.0609 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Trypanosoma brucei glucosidase, putative 0.0037 0.0004 0.0031
Schistosoma mansoni neuropeptide receptor 0.0299 0.0356 0.1486
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0365 0.1125
Loa Loa (eye worm) PAN domain-containing protein 0.0181 0.0197 0.0606
Schistosoma mansoni alpha-1 adrenergic receptor 0.0299 0.0356 0.1486
Echinococcus granulosus dro:myosuppressin receptor 0.0299 0.0356 0.0356
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0136 0.0137 0.0421
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0007 0.0007
Onchocerca volvulus 0.0299 0.0356 0.2239
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0007 0.0012
Echinococcus granulosus serotonin receptor 0.0299 0.0356 0.0356
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0306 0.0365 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0037 0.0322
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0038 0.0299
Brugia malayi nuclear hormone receptor 0.004 0.0007 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0007 0.0021
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0392 0.0481 0.148
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0306 0.0365 0.0365
Onchocerca volvulus 0.0299 0.0356 0.2239
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0299 0.0356 0.1486
Toxoplasma gondii microneme protein MIC17C 0.0181 0.0197 0.0774
Echinococcus multilocularis growth factor receptor bound protein 2 0.006 0.0035 0.0035
Schistosoma mansoni cercarial elastase (S01 family) 0.0182 0.0198 0.0827
Echinococcus granulosus jumonji domain containing protein 0.004 0.0007 0.0007
Brugia malayi Cation transporter family protein 0.0528 0.0664 0.2044
Echinococcus multilocularis sex peptide receptor 0.0299 0.0356 0.0356
Echinococcus granulosus atrial natriuretic peptide receptor 0.0109 0.0099 0.0099
Trypanosoma brucei histone deacetylase 4 0.0393 0.0482 0.4188
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0012 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0006 0.0047
Giardia lamblia Aurora kinase 0.0055 0.0027 0.0226
Loa Loa (eye worm) histone deacetylase 0.0393 0.0482 0.1482
Schistosoma mansoni hypothetical protein 0.0299 0.0356 0.1486
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0055 0.0027 0.0027
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0006 0.0017
Schistosoma mansoni serine-type protease inhibitor 0.1813 0.2392 1
Echinococcus granulosus g protein coupled receptor 0.0299 0.0356 0.0356
Echinococcus granulosus glycine receptor subunit beta 0.0306 0.0365 0.0365
Plasmodium falciparum serine/threonine protein kinase, putative 0.0055 0.0027 0.0282
Loa Loa (eye worm) SRC-1 0.031 0.0371 0.1141
Echinococcus granulosus neuropeptide Y receptor 0.0299 0.0356 0.0356
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0299 0.0356 0.1486
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1271 0.1271
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.0182 0.056
Brugia malayi Sex muscle abnormal protein 5 0.006 0.0035 0.0107
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0182 0.0198 0.0198
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0299 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0039 0.0006 0.0017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0365 0.1528
Echinococcus multilocularis tissue type plasminogen activator 0.0267 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0001 0.0001
Echinococcus multilocularis receptor type guanylyl cyclase 0.0131 0.013 0.013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0299 0.0356 0.0356
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0306 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.1202 0.1571 0.4834
Echinococcus multilocularis tyrosine protein kinase HCK 0.025 0.0289 0.0289
Echinococcus granulosus g protein coupled receptor 0.0299 0.0356 0.0356
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0012 0.0124
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0005 0.0005
Onchocerca volvulus 0.0299 0.0356 0.2239
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0306 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0007 0.0021
Echinococcus granulosus glutamate receptor 2 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0299 0.0356 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0012 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0299 0.0356 0.0356
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0007 0.0028
Brugia malayi hypothetical protein 0.0136 0.0137 0.0421
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0006 0.0059
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0059 0.0033 0.0252

Activities

Activity type Activity value Assay description Source Reference
Concentration (functional) = 0.523 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC/DA in rat striatum ChEMBL. 7902870
Concentration (functional) = 0.588 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC/DA in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 1.7 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC/DA in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 19 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DA in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 32 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 80 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of HVA in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 156 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HIAA in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 165 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HT in rat frontal cortex ChEMBL. 7902870
Concentration (functional) = 367 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HT in rat striatum ChEMBL. 7902870
Concentration (functional) = 437 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HIAA in rat striatum ChEMBL. 7902870
Concentration (functional) = 527 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HIAA in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 639 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of 5-HT in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 788 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of HVA in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 1313 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 1977 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of HVA in rat striatum ChEMBL. 7902870
Concentration (functional) = 2233 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DA in rat mesolimbic region ChEMBL. 7902870
Concentration (functional) = 2735 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DOPAC in rat striatum ChEMBL. 7902870
Concentration (functional) = 5233 ng (g of tissue)-1 Effect of compound (2 mg/kg ip) on the concentration of DA in rat striatum ChEMBL. 7902870
Ki (binding) = 2.2 nM Tested for [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membrane ChEMBL. 7902870
Ki (binding) = 2.2 nM Tested for [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membrane ChEMBL. 7902870
Ki (binding) = 3 nM Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting method ChEMBL. 25461306
Ki (binding) = 8.2 nM Tested for [3H]-DTG binding to sigma-2 receptor in NG108-15 membrane ChEMBL. 7902870
Ki (binding) = 71 nM Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting method ChEMBL. 25461306
Ki (binding) = 73 nM Displacement of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine receptor D2 ChEMBL. 7902870
Ki (binding) = 73 nM Displacement of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine receptor D2 ChEMBL. 7902870
Ki (binding) = 330 nM Displacemnt of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine 3 receptors ChEMBL. 7902870
Ki (binding) = 330 nM Displacemnt of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine 3 receptors ChEMBL. 7902870
Ki (binding) = 353 nM Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting method ChEMBL. 25461306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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