Detailed information for compound 221916

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.11 | Formula: C28H32ClN6O3S-
  • H donors: 4 H acceptors: 3 LogP: 3.98 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H](NS(=O)(=O)c1ccc2c(c1)cccc2)Cc1c[nH]c2c1cccc2)NC[C@@H]1CCCN(C1)C(=N)N.[Cl-]
  • InChi: 1S/C28H32N6O3S.ClH/c29-28(30)34-13-5-6-19(18-34)16-32-27(35)26(15-22-17-31-25-10-4-3-9-24(22)25)33-38(36,37)23-12-11-20-7-1-2-8-21(20)14-23;/h1-4,7-12,14,17,19,26,31,33H,5-6,13,15-16,18H2,(H3,29,30)(H,32,35);1H/p-1/t19-,26+;/m0./s1
  • InChiKey: HVLSJACRSUDQQE-ZSLVVFSXSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi neuropeptide F receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0399 0.1006
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0061 0.0288 0.1745
Echinococcus granulosus 7tm_1 domain containing protein 0.0061 0.0288 0.1745
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0061 0.0288 0.0726
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0399 0.1006
Brugia malayi Animal haem peroxidase family protein 0.0034 0.006 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0399 0.1006
Onchocerca volvulus 0.0031 0.0039 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0347 0.2661 0.6711
Schistosoma mansoni lamin 0.0032 0.0044 0.0112
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0098 0.0485
Echinococcus granulosus glycoprotein Antigen 5 0.0054 0.0228 0.1386
Onchocerca volvulus 0.0031 0.0039 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0224 0.1355
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0146 0.0996 0.5942
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0098 0.0059
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0037 0.0088 0.0425
Loa Loa (eye worm) polyprenyl synthetase 0.0146 0.0996 0.2511
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0054 0.0228 0.0576
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0044 0.0112
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Onchocerca volvulus Chorion peroxidase homolog 0.0034 0.006 0.0152
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0039 0.0123
Brugia malayi Polyprenyl synthetase family protein 0.0037 0.0088 0.0222
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0037 0.0088 0.0222
Brugia malayi Polyprenyl synthetase family protein 0.0146 0.0996 0.2511
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0098 0.0592
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0029 0.0019 0.0113
Echinococcus granulosus transmembrane protease serine 3 0.0054 0.0228 0.1386
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0225 0.1649 1
Schistosoma mansoni peroxidasin 0.0034 0.006 0.0152
Schistosoma mansoni neuropeptide receptor 0.0061 0.0288 0.0726
Schistosoma mansoni multidrug resistance protein 0.0029 0.0019 0.0047
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0098 0.0592
Echinococcus multilocularis allatostatin A receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0098 0.0981
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Leishmania major polyprenyl synthase, putative 0.0037 0.0088 0.0425
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Plasmodium falciparum thioredoxin reductase 0.0053 0.0224 0.1257
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0031 0.0039 0.0097
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0065 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0288 0.0726
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0098 0.0485
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Schistosoma mansoni neuropeptide f receptor 76f 0.0061 0.0288 0.0726
Echinococcus multilocularis neuropeptide FF receptor 2 0.0061 0.0288 0.1745
Echinococcus multilocularis lamin dm0 0.0032 0.0044 0.027
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0194 0.1392 0.8442
Schistosoma mansoni opsin-like receptor 0.0061 0.0288 0.0726
Brugia malayi Protein kinase domain containing protein 0.0126 0.0829 0.2091
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0054 0.0228 0.0576
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0224 0.0205
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0037 0.0088 0.0425
Onchocerca volvulus 0.0504 0.3966 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0126 0.0829 0.4971
Schistosoma mansoni inositol monophosphatase 0.0038 0.0098 0.0246
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0225 0.1649 0.4159
Schistosoma mansoni hypothetical protein 0.0054 0.0228 0.0576
Brugia malayi follicle stimulating hormone receptor 0.0061 0.0288 0.0726
Echinococcus granulosus tar DNA binding protein 0.0074 0.0399 0.2419
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0288 0.1745
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0061 0.0288 0.0726
Brugia malayi hypothetical protein 0.0054 0.0228 0.0576
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.0576
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0504 0.3966 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0029 0.0019 0.0113
Schistosoma mansoni hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi Trypsin family protein 0.0504 0.3966 1
Brugia malayi Animal haem peroxidase family protein 0.0034 0.006 0.0152
Schistosoma mansoni opsin-like receptor 0.0061 0.0288 0.0726
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0224 0.0564
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) glutathione reductase 0.0053 0.0224 0.0564
Loa Loa (eye worm) hypothetical protein 0.0179 0.1265 0.319
Echinococcus multilocularis glycoprotein Antigen 5 0.0054 0.0228 0.1386
Echinococcus granulosus serotonin receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0807 0.2035
Leishmania major farnesyl pyrophosphate synthase 0.0146 0.0996 0.5992
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0098 0.0367
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.123 1 1
Onchocerca volvulus Peroxidasin homolog 0.0034 0.006 0.0152
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0288 0.1745
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0031 0.0039 0.0097
Brugia malayi Animal haem peroxidase family protein 0.0034 0.006 0.0152
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0029 0.0019 0.0113
Schistosoma mansoni growth hormone secretagogue receptor 0.0061 0.0288 0.0726
Brugia malayi AKH receptor 0.0061 0.0288 0.0726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Schistosoma mansoni glutathione synthetase 0.0037 0.0088 0.0222
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Echinococcus granulosus neuropeptide s receptor 0.0061 0.0288 0.1745
Trypanosoma brucei trypanothione reductase 0.0053 0.0224 0.1148
Onchocerca volvulus 0.0054 0.0228 0.0576
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0288 0.0726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.062 0.3758
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Brugia malayi ORL1-like opioid receptor 0.0061 0.0288 0.0726
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0347 0.2661 0.6711
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.062 0.3758
Schistosoma mansoni lamin 0.0032 0.0044 0.0112
Brugia malayi Trypsin family protein 0.0054 0.0228 0.0576
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Schistosoma mansoni immunophilin 0.0225 0.1649 0.4159
Loa Loa (eye worm) trypsin family protein 0.0054 0.0228 0.0576
Brugia malayi Trypsin family protein 0.0054 0.0228 0.0576
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.062 0.1563
Onchocerca volvulus 0.045 0.3519 0.8873
Onchocerca volvulus 0.0034 0.006 0.0152
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0225 0.1649 1
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0019 0.0113
Brugia malayi larval opioid receptor 0.0061 0.0288 0.0726
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0097
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0288 0.1745
Echinococcus granulosus FK506 binding protein 2 0.0031 0.0039 0.0234
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0194 0.1392 0.8442
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi ABC transporter family protein 0.0029 0.0019 0.0047
Treponema pallidum octaprenyl-diphosphate synthase 0.0037 0.0088 0.0306
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0054 0.0228 0.1386
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0054 0.0228 0.0576
Schistosoma mansoni amine GPCR 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0225 0.1649 0.1617
Echinococcus multilocularis musashi 0.0032 0.0044 0.027
Echinococcus multilocularis multidrug resistance protein 1 0.0029 0.0019 0.0113
Leishmania major trypanothione reductase 0.0053 0.0224 0.1257
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0146 0.0996 0.5942
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0288 0.1745
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.079 0.0772
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0037 0.0088 0.0069
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) TYRA-2 protein 0.0061 0.0288 0.0726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.062 0.1563
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0288 0.0726
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0029 0.0019 0.0113
Onchocerca volvulus 0.0029 0.0019 0.0047
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0037 0.0088 0.0425
Brugia malayi G-protein coupled receptor 0.0061 0.0288 0.0726
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0288 0.0726
Echinococcus granulosus peptide allatostatin:somatostatin 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0054 0.0228 0.0576
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0146 0.0996 0.6037
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Schistosoma mansoni immunophilin 0.0194 0.1392 0.3511
Echinococcus granulosus neuropeptide receptor 0.0061 0.0288 0.1745
Schistosoma mansoni fk506 binding protein 0.0031 0.0039 0.0097
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi neuropeptide F receptor 0.0061 0.0288 0.0726
Leishmania major fk506-binding protein 1-like protein 0.0225 0.1649 1
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0288 0.0726
Echinococcus multilocularis serotonin receptor 0.0179 0.1265 0.7671
Onchocerca volvulus Peroxidase homolog 0.0034 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0288 0.1745
Echinococcus granulosus tachykinin peptides receptor 99D 0.0061 0.0288 0.1745
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.079 0.0772
Schistosoma mansoni biogenic amine receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) multidrug resistance protein 3 0.0029 0.0019 0.0047
Echinococcus granulosus allatostatin A receptor 0.0061 0.0288 0.1745
Echinococcus granulosus enteropeptidase 0.0054 0.0228 0.1386
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0347 0.2661 0.6711
Brugia malayi GnHR receptor homolog 0.0061 0.0288 0.0726
Echinococcus granulosus 7TM GPCR rhodopsin 0.0061 0.0288 0.1745
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0225 0.1649 0.4159
Loa Loa (eye worm) hypothetical protein 0.0126 0.0829 0.2091
Brugia malayi Serotonin receptor 0.0061 0.0288 0.0726
Trypanosoma cruzi hypothetical protein, conserved 0.0126 0.0829 0.4908
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0225 0.1649 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0037 0.0088 0.0533
Schistosoma mansoni inositol monophosphatase 0.0038 0.0098 0.0246
Onchocerca volvulus 0.0061 0.0288 0.0726
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0037 0.0088 0.005
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0037 0.0088 0.0069
Loa Loa (eye worm) hypothetical protein 0.0504 0.3966 1
Brugia malayi putative neuropeptide receptor 0.0061 0.0288 0.0726
Toxoplasma gondii thioredoxin reductase 0.0053 0.0224 0.2245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0224 0.1355
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0029 0.0019 0.0113
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0902 0.0885
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0288 0.1745
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.006 0.0152
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.0576
Echinococcus multilocularis peroxidasin 0.0034 0.006 0.0365
Brugia malayi RE15519p 0.0061 0.0288 0.0726
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0037 0.0088 0.0883
Brugia malayi TAR-binding protein 0.0074 0.0399 0.1006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0061 0.0288 0.1745
Brugia malayi Tachykinin-like peptides receptor 99D 0.0061 0.0288 0.0726
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0039 0.0123
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0029 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0054 0.0228 0.0576
Echinococcus multilocularis ATP binding cassette sub family B 0.0028 0.0016 0.0097
Onchocerca volvulus Dual oxidase homolog 0.0034 0.006 0.0152
Brugia malayi multidrug resistance protein 3 0.0029 0.0019 0.0047
Echinococcus granulosus intermediate filament protein 0.0032 0.0044 0.027
Echinococcus multilocularis sex peptide receptor 0.0061 0.0288 0.1745
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0054 0.0228 0.0576
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus granulosus neuropeptide receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Leishmania major hypothetical protein, conserved 0.0126 0.0829 0.4971
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0194 0.1392 0.3511
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.079 0.0754
Brugia malayi RNA binding protein 0.0074 0.0399 0.1006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.0576
Schistosoma mansoni adenoreceptor 0.0061 0.0288 0.0726
Echinococcus granulosus Mastin 0.0054 0.0228 0.1386
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Echinococcus granulosus g protein coupled receptor 0.0061 0.0288 0.1745
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0031 0.0039 0.0234
Schistosoma mansoni intermediate filament proteins 0.0032 0.0044 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0399 0.1006
Brugia malayi Melatonin receptor type 1A 0.0061 0.0288 0.0726
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0019 0.0113
Echinococcus granulosus neuropeptide receptor A26 0.0061 0.0288 0.1745
Brugia malayi glutathione reductase 0.0053 0.0224 0.0564
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0146 0.0996 0.5992
Brugia malayi Thioredoxin reductase 0.0053 0.0224 0.0564
Schistosoma mansoni neuropeptide receptor 0.0061 0.0288 0.0726
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0146 0.0996 0.5992
Echinococcus multilocularis somatostatin receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0037 0.0088 0.0533
Onchocerca volvulus Peroxidasin homolog 0.0034 0.006 0.0152
Echinococcus granulosus hypothetical protein 0.0061 0.0288 0.1745
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0902 0.0885
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0032 0.0044 0.0112
Loa Loa (eye worm) TK/ROR protein kinase 0.0126 0.0829 0.2091
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Onchocerca volvulus Neuropeptide F receptor homolog 0.0061 0.0288 0.0726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0039 0.0388
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Echinococcus multilocularis neuropeptide receptor A26 0.0061 0.0288 0.1745
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0225 0.1649 0.4159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.062 0.3758
Brugia malayi Kringle domain containing protein 0.0126 0.0829 0.2091
Leishmania major solanesyl-diphosphate synthase, putative 0.0037 0.0088 0.0425
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Schistosoma mansoni peroxidasin 0.0034 0.006 0.0152
Schistosoma mansoni myosin xvIII 0.0061 0.0288 0.0726
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0065 0.0026
Plasmodium falciparum glutathione reductase 0.0053 0.0224 0.1257
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0902 0.0867
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0807 0.2035
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0146 0.0996 0.5992
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0037 0.0088 0.0425
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0288 0.1745
Echinococcus granulosus lamin 0.0032 0.0044 0.027
Leishmania major peptidylprolyl isomerase-like protein 0.0225 0.1649 1
Brugia malayi Dopamine receptor protein 1 0.0061 0.0288 0.0726
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0031 0.0039 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0399 0.1006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0031 0.0039 0.002
Onchocerca volvulus 0.0054 0.0228 0.0576
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0037 0.0088 0.0069
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0225 0.1649 1
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0061 0.0288 0.1745
Schistosoma mansoni hypothetical protein 0.0054 0.0228 0.0576
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi Animal haem peroxidase family protein 0.0034 0.006 0.0152
Echinococcus granulosus g-protein coupled receptor 0.0061 0.0288 0.1745
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0146 0.0996 0.0961
Onchocerca volvulus 0.0034 0.006 0.0152
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0037 0.0088 0.0306
Echinococcus multilocularis enteropeptidase 0.0054 0.0228 0.1386
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi intermediate filament protein 0.0032 0.0044 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0288 0.1745
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0097
Mycobacterium tuberculosis Probable reductase 0.0121 0.079 0.0772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0047
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0028 0.0016 0.0097
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0037 0.0088 0.0306
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0061 0.0288 0.0726
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0902 0.0885
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0098 0.0485
Mycobacterium ulcerans hypothetical protein 0.0054 0.0228 0.0191
Brugia malayi G-protein coupled receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis transmembrane protease serine 3 0.0054 0.0228 0.1386
Schistosoma mansoni trans-prenyltransferase 0.0037 0.0088 0.0222
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0037 0.0088 0.8351
Echinococcus multilocularis g-protein coupled receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0054 0.0228 0.0576
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0399 0.1006
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0225 0.1649 1
Echinococcus granulosus orexin receptor type 2 0.0061 0.0288 0.1745
Echinococcus multilocularis G protein coupled receptor 139 0.0061 0.0288 0.1745
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0098 0.0485
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0029 0.0019 0.0047
Loa Loa (eye worm) melatonin receptor type 1A 0.0061 0.0288 0.0726
Echinococcus multilocularis lamin 0.0032 0.0044 0.027
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0037 0.0088 0.0222
Echinococcus granulosus tissue type plasminogen activator 0.0126 0.0829 0.5027
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0061 0.0288 0.0726
Loa Loa (eye worm) polyprenyl synthetase 0.0037 0.0088 0.0222
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi Animal haem peroxidase family protein 0.0034 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0224 0.1148
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0288 0.1745
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0504 0.3966 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0034 0.006 0.0152
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0037 0.0088 0.0533
Onchocerca volvulus 0.0061 0.0288 0.0726
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.006 0.0152
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0146 0.0996 0.5992
Echinococcus multilocularis neuropeptide s receptor 0.0061 0.0288 0.1745
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0146 0.0996 0.5942
Schistosoma mansoni amine GPCR 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0061 0.0288 0.1745
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0225 0.1649 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0225 0.1649 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0225 0.1649 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0146 0.0996 0.2511
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0146 0.0996 0.0979
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0225 0.1649 1
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0037 0.0088 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Schistosoma mansoni amine GPCR 0.0061 0.0288 0.0726
Schistosoma mansoni histamine h1 receptor 0.0061 0.0288 0.0726
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.1386
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0039 0.0123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0504 0.3966 1
Schistosoma mansoni hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0288 0.0726
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0061 0.0288 0.0726
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0061 0.0288 0.0726
Echinococcus granulosus sex peptide receptor 0.0061 0.0288 0.1745
Brugia malayi Blistered cuticle protein 3 0.0034 0.006 0.0152
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0031 0.0039 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0029 0.0019 0.0113
Echinococcus granulosus neuropeptide FF receptor 2 0.0061 0.0288 0.1745
Schistosoma mansoni hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.0576
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis 0.0031 0.0039 0.0234
Giardia lamblia Farnesyl diphosphate synthase 0.0146 0.0996 0.5942
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0037 0.0088 0.0306
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0288 0.1745
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis tissue type plasminogen activator 0.0126 0.0829 0.5027
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0288 0.1745
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0061 0.0288 0.0726
Loa Loa (eye worm) inositol-1 0.0038 0.0098 0.0246
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0054 0.0228 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0039 0.0123
Echinococcus granulosus somatostatin receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis fk506 binding protein 0.0225 0.1649 1
Brugia malayi hypothetical protein 0.0034 0.006 0.0152
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0031 0.0039 0.289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.062 0.1563
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0037 0.0088 0.8351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni biogenic amine receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Echinococcus multilocularis dro:myosuppressin receptor 0.0061 0.0288 0.1745
Echinococcus granulosus G protein coupled receptor 139 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0061 0.0288 0.0726
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0061 0.0288 0.0726
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0399 0.2419
Brugia malayi Serotonin receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0061 0.0288 0.0726
Trichomonas vaginalis fk506-binding protein, putative 0.0225 0.1649 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0037 0.0088 0.0306
Onchocerca volvulus Peroxidase homolog 0.0034 0.006 0.0152
Brugia malayi Dopamine receptor 0.0061 0.0288 0.0726
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0225 0.1649 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0225 0.1649 1
Schistosoma mansoni opsin-like receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0054 0.0228 0.0576
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0037 0.0088 0.005
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Echinococcus multilocularis G-protein coupled receptor, putative 0.0061 0.0288 0.1745
Onchocerca volvulus 0.0061 0.0288 0.0726
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0061 0.0288 0.0726
Schistosoma mansoni hypothetical protein 0.0126 0.0829 0.2091
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0029 0.0019 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.062 0.3758
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0225 0.1649 1
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0288 0.0726
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0098 1
Brugia malayi Peroxidasin 0.0034 0.006 0.0152
Schistosoma mansoni alpha-1 adrenergic receptor 0.0061 0.0288 0.0726
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0146 0.0996 0.0961
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0399 0.1006
Toxoplasma gondii kringle domain-containing protein 0.0126 0.0829 0.8328
Onchocerca volvulus 0.0061 0.0288 0.0726
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0225 0.1649 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0228 0.0576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.062 0.1563
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0399 0.1006
Brugia malayi putative neuropeptide receptor NPR1 0.0061 0.0288 0.0726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0288 0.1745
Echinococcus granulosus lamin dm0 0.0032 0.0044 0.027
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0288 0.0726
Schistosoma mansoni multidrug resistance protein 0.0029 0.0019 0.0047
Brugia malayi Trypsin family protein 0.0054 0.0228 0.0576
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0225 0.1649 1
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0224 0.1257
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0019 0.0187
Mycobacterium ulcerans naphthoate synthase 0.123 1 1
Onchocerca volvulus 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0112
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0098 0.0367
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0054 0.0228 0.0576
Echinococcus granulosus fmrfamide receptor 0.0061 0.0288 0.1745
Echinococcus granulosus peroxidasin 0.0034 0.006 0.0365
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0098 0.0367
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0031 0.0039 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0288 0.1745
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0044 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.062 0.1563
Brugia malayi Trypsin-like protease protein 5 0.0054 0.0228 0.0576
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Schistosoma mansoni neuropeptide receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0037 0.0088 0.0222
Schistosoma mansoni biogenic amine receptor 0.0061 0.0288 0.0726
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0039 0.0123
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0146 0.0996 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0179 0.1265 0.7671
Brugia malayi Inositol-1 0.0038 0.0098 0.0246
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0225 0.1649 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.0399 0.1006
Echinococcus multilocularis serotonin receptor 0.0179 0.1265 0.7671
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0288 0.0726
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0098 0.0485
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0288 0.1745
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.079 0.0772
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0037 0.0088 0.0533
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.079 0.0772
Echinococcus multilocularis Mastin 0.0054 0.0228 0.1386
Loa Loa (eye worm) blistered cuticle protein 3 0.0034 0.006 0.0152
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0061 0.0288 0.0726
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0061 0.0288 0.0726
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0225 0.1649 1
Echinococcus multilocularis orexin receptor type 2 0.0061 0.0288 0.1745
Schistosoma mansoni amine GPCR 0.0061 0.0288 0.0726
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0054 0.0228 0.1386
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Trichomonas vaginalis immunophilin, putative 0.0225 0.1649 1
Brugia malayi G protein-coupled receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0061 0.0288 0.0726
Plasmodium falciparum cysteine repeat modular protein 1 0.0126 0.0829 0.4971
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Trypanosoma cruzi polyprenyl synthase, putative 0.0037 0.0088 0.0306
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Trichomonas vaginalis fk506 binding protein, putative 0.0031 0.0039 0.0123
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0225 0.1649 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0031 0.0039 0.0123
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0288 0.1745
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0225 0.1649 0.4159
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0029 0.0019 0.0113
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0031 0.0039 0.0097
Onchocerca volvulus 0.0061 0.0288 0.0726
Echinococcus multilocularis multidrug resistance protein 1 0.0029 0.0019 0.0113
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0146 0.0996 0.6037
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0039 0.0123
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0039 0.0123
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0029 0.0019 0.0187
Brugia malayi MH2 domain containing protein 0.0123 0.0807 0.2035
Plasmodium vivax glutathione reductase, putative 0.0053 0.0224 0.1257
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.006 0.0152
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0031 0.0039 0.0123
Brugia malayi Dopamine receptor protein 2 0.0061 0.0288 0.0726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0044 0.0112
Schistosoma mansoni amine GPCR 0.0061 0.0288 0.0726
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0061 0.0288 0.0726
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0037 0.0088 0.0425
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0031 0.0039 0.0097
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0061 0.0288 0.1745
Echinococcus granulosus dro:myosuppressin receptor 0.0061 0.0288 0.1745
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0288 0.1745
Schistosoma mansoni neuropeptide receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0179 0.1265 0.319
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0031 0.0039 0.0097
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0037 0.0088 0.0533
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0037 0.0088 0.0533
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Schistosoma mansoni immunophilin 0.0225 0.1649 0.4159
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0126 0.0829 0.2091
Schistosoma mansoni biogenic amine (5HT) receptor 0.0179 0.1265 0.319
Brugia malayi sulfakinin receptor protein 0.0061 0.0288 0.0726
Schistosoma mansoni multidrug resistance protein 0.0029 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Loa Loa (eye worm) FKBP5 protein 0.0225 0.1649 0.4159
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0039 0.0388
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.006 0.0152
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0228 0.0576
Schistosoma mansoni smdr2 0.0029 0.0019 0.0047
Echinococcus granulosus g protein coupled receptor 0.0061 0.0288 0.1745
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0152
Brugia malayi G protein-coupled receptor F59B2.13 0.0061 0.0288 0.0726
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0037 0.0088 0.005
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0146 0.0996 0.5992
Loa Loa (eye worm) hypothetical protein 0.0347 0.2661 0.6711
Brugia malayi hypothetical protein 0.0061 0.0288 0.0726
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0061 0.0288 0.0726
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Onchocerca volvulus 0.0032 0.0044 0.0112
Trypanosoma cruzi polyprenyl synthase, putative 0.0037 0.0088 0.0306
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0228 0.0576
Echinococcus granulosus g protein coupled receptor 0.0061 0.0288 0.1745
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0288 0.0726
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0288 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0288 0.0726
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.079 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0039 0.0123
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0225 0.1649 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0039 0.0388
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0288 0.1745
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0039 0.0123

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.009 uM In vitro binding affinity by measuring the inhibition of human thrombin ChEMBL. 7966150
Ki (binding) = 17 uM In vitro binding affinity by measuring the inhibition of bovine trypsin ChEMBL. 7966150
Selectivity (binding) = 1889 Selectivity of the compound is the ratio of Ki's against inhibition of thrombin and trypsin ChEMBL. 7966150

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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