TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.644 | Formula: C25H46N2O4
H donors: 3 H acceptors: 4 LogP: 5.32 Rotable bonds: 16
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)[C@@H]([C@@H](NC(=O)[C@@H](NC(=O)CCC(C)C)CC(C)C)CC1CCCCC1)O
InChi: 1S/C25H46N2O4/c1-6-10-22(28)24(30)20(16-19-11-8-7-9-12-19)27-25(31)21(15-18(4)5)26-23(29)14-13-17(2)3/h17-21,24,30H,6-16H2,1-5H3,(H,26,29)(H,27,31)/t20-,21-,24+/m0/s1
InChiKey: VYOYUMHNYHPBOT-AWRGLXIESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APH1B gamma secretase subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma mansoni	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus granulosus	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma japonicum	ko:K06172 anterior pharynx defective 1, putative	Get druggable targets OG5_130831	All targets in OG5_130831
Brugia malayi	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus multilocularis	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.003	0.0073	0.0069
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0066	0.0062
Schistosoma mansoni	hypothetical protein	0.0054	0.0158	0.0154
Echinococcus granulosus	sodium and chloride dependent glycine	0.0477	0.167	0.167
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0011	0.0007	0.0007
Loa Loa (eye worm)	solute carrier family 6 member 4	0.2811	1	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0477	0.167	0.167
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0136	0.0451	0.0447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0004	0.0004
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0477	0.167	0.1667
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0028	0.0067	0.1142
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0136	0.0451	0.9203
Echinococcus multilocularis	protein C ets 2	0.0011	0.0007	0.0007
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0028	0.0067	0.0872
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0025	0.0025
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0477	0.167	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.0007
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.2811	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0188	0.2868
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0477	0.167	0.167
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0015	0.0015
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Brugia malayi	intermediate filament protein	0.0028	0.0066	0.0062
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0188	0.2868
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0004	0.0004
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0027	0.0023
Echinococcus granulosus	cpg binding protein	0.0031	0.0079	0.0079
Plasmodium falciparum	purine nucleoside phosphorylase	0.0028	0.0067	0.0244
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0188	0.0188
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0027	0.0023
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0027	0.0027
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0098	0.0098
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.0242	0.0242
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0136	0.0451	0.9126
Loa Loa (eye worm)	D-ets-2 protein	0.0011	0.0007	0.0007
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0025	0.0021
Echinococcus granulosus	ETS transcription factor Elf 1	0.0011	0.0007	0.0007
Trypanosoma brucei	Aph-1 protein, putative	0.0115	0.0379	1
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0028	0.0067	0.1142
Schistosoma mansoni	hypothetical protein	0.0011	0.0007	0.0003
Echinococcus granulosus	gamma secretase subunit aph 1	0.0296	0.1023	0.1023
Schistosoma mansoni	ets-related	0.0234	0.0803	0.0799
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0086	0.0274	0.7016
Schistosoma mansoni	hypothetical protein	0.0348	0.1208	0.1205
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0274	0.2138
Onchocerca volvulus		0.2811	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0098	0.0317
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0477	0.167	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.2811	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0004	0.0004
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0091	0.0087
Schistosoma mansoni	hypothetical protein	0.0037	0.0098	0.0094
Echinococcus multilocularis	musashi	0.0028	0.0066	0.0066
Plasmodium falciparum	amino acid transporter, putative	0.0477	0.167	1
Brugia malayi	Ets-domain containing protein	0.0011	0.0007	0.0003
Brugia malayi	DNA-binding protein D-ETS-3	0.0011	0.0007	0.0003
Brugia malayi	CXXC zinc finger family protein	0.003	0.0073	0.0069
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0477	0.167	0.167
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0004	0.0004
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0086	0.0274	0.7016
Brugia malayi	Ets-domain containing protein	0.0077	0.0242	0.0239
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0028	0.0067	0.0067
Loa Loa (eye worm)	norepinephrine transporter	0.2811	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0004	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.2811	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0011	0.0007	0.0007
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0066	0.0062
Loa Loa (eye worm)	hypothetical protein	0.2811	1	1
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0004	0.0004
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0136	0.0451	0.0447
Schistosoma mansoni	sodium/chloride dependent transporter	0.0477	0.167	0.1667
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0004	0.0004
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0188	0.0978
Echinococcus granulosus	ETS transcription factor Elf 5	0.0011	0.0007	0.0007
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0028	0.0067	0.1142
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0004	0.0004
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0477	0.167	0.1667
Toxoplasma gondii	phosphorylase family protein	0.0028	0.0067	0.0244
Schistosoma mansoni	sodium/chloride dependent transporter	0.0477	0.167	0.1667
Echinococcus multilocularis	microtubule associated protein 2	0.0735	0.2589	0.2589
Brugia malayi	hypothetical protein	0.0477	0.167	0.1667
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0477	0.167	0.1667
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.002	0.002
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Brugia malayi	gamma-secretase subunit aph-1	0.0296	0.1023	0.1019
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0011	0.0007	0.0007
Brugia malayi	MTAP	0.0028	0.0067	0.0063
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0148	0.0145
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0027	0.0027
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0066	0.0066
Echinococcus multilocularis	dnaJ subfamily B	0.0423	0.1478	0.1478
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0007	0.0007
Entamoeba histolytica	hypothetical protein	0.0037	0.0098	0.0317
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0066	0.0066
Echinococcus multilocularis	lamin	0.0028	0.0066	0.0066
Onchocerca volvulus		0.0477	0.167	0.1667
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0086	0.0274	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0025	0.0025
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0028	0.0067	0.0063
Schistosoma mansoni	cpg binding protein	0.003	0.0073	0.0069
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0188	0.0188
Schistosoma mansoni	sodium/chloride dependent transporter	0.2811	1	1
Onchocerca volvulus		0.0028	0.0066	0.0062
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0477	0.167	0.1667
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0298	0.1033	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0013	0.0013
Echinococcus granulosus	protein C ets 2	0.0011	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0035	0.0091	0.0087
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0027	0.0027
Echinococcus granulosus	dnaJ subfamily B	0.0423	0.1478	0.1478
Toxoplasma gondii	phosphorylase family protein	0.0028	0.0067	0.0244
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Echinococcus granulosus	sodium and chloride dependent glycine	0.0477	0.167	0.167
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.0379	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0168	0.0858
Entamoeba histolytica	hypothetical protein	0.0037	0.0098	0.0317
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0025	0.0025
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0298	0.1033	1
Onchocerca volvulus		0.0477	0.167	0.1667
Echinococcus granulosus	lamin dm0	0.0028	0.0066	0.0066
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0477	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0015	0.0015
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0098	0.0098
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.0425	0.0425
Schistosoma mansoni	purine nucleoside phosphorylase	0.0136	0.0451	0.0447
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0188	0.2868
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0136	0.0451	0.3974
Echinococcus granulosus	microtubule associated protein 2	0.0735	0.2589	0.2589
Loa Loa (eye worm)	ets-domain-containing protein	0.0011	0.0007	0.0007
Plasmodium falciparum	transporter, putative	0.0477	0.167	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0004	0.0004
Loa Loa (eye worm)	uridine phosphorylase	0.0028	0.0067	0.0067
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0098	0.0094
Echinococcus multilocularis	uridine phosphorylase 1	0.0028	0.0067	0.0067
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0136	0.0451	0.3974
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0028	0.0067	0.0244
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0025	0.0025
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0004	0.0004
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0011	0.0007	0.0007
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0107	0.0351	0.0351
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0011	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0016	0.0025	0.0021
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0027	0.0027
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0477	0.167	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0188	0.6518
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0027	0.0027
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0028	0.0067	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0091	0.0091
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0136	0.0451	0.9126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0004	0.0004
Toxoplasma gondii	hypothetical protein	0.0477	0.167	1
Brugia malayi	Ets-domain containing protein	0.0077	0.0242	0.0239
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0086	0.0274	0.7016
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0011	0.0007	0.0003
Echinococcus granulosus	geminin	0.0348	0.1208	0.1208
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0477	0.167	0.1667
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0188	0.349
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0004	0.0004
Schistosoma mansoni	microtubule-associated protein tau	0.0735	0.2589	0.2586
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Plasmodium vivax	amine transporter, putative	0.0477	0.167	1
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0296	0.1023	0.1023
Brugia malayi	hypothetical protein	0.0037	0.0098	0.0094
Giardia lamblia	Rrm3p helicase	0.0086	0.0274	0.2138
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0004	0.0004
Onchocerca volvulus		0.0477	0.167	0.1667
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0004	0.0004
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0146	0.0488	1
Loa Loa (eye worm)	serotonin transporter b	0.2811	1	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0298	0.1033	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0079	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0202	0.0202
Schistosoma mansoni	hypothetical protein	0.0011	0.0007	0.0003
Schistosoma mansoni	hypothetical protein	0.0086	0.0274	0.027
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0025	0.0021
Leishmania major	nucleoside phosphorylase-like protein	0.0028	0.0067	0.1628
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0107	0.0351	0.0351
Schistosoma mansoni	hypothetical protein	0.0016	0.0025	0.0021
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0027	0.0027
Brugia malayi	transcription factor E74 isoform	0.0011	0.0007	0.0003
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0477	0.167	0.167
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.0348	0.1208	0.1205
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0025	0.0025
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.0274	0.2138
Schistosoma mansoni	hypothetical protein	0.0016	0.0025	0.0021
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0477	0.167	0.167
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0148	0.0148
Echinococcus multilocularis	ets variant gene 4	0.0011	0.0007	0.0007
Treponema pallidum	fructose-bisphosphate aldolase	0.0298	0.1033	0.0972
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0296	0.1023	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0086	0.0274	0.7016
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0188	0.0184
Schistosoma mansoni	uridine phosphorylase	0.0028	0.0067	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.0007
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0007	0.0007
Entamoeba histolytica	hypothetical protein	0.0037	0.0098	0.0317
Loa Loa (eye worm)	fli-1 protein	0.0234	0.0803	0.0803
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0477	0.167	0.167
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Echinococcus granulosus	ewsr:fli fusion protein type	0.0011	0.0007	0.0007
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0027	0.0023
Schistosoma mansoni	cpg binding protein	0.0031	0.0079	0.0075
Echinococcus multilocularis	geminin	0.0348	0.1208	0.1208
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0146	0.0488	1
Schistosoma mansoni	lamin	0.0028	0.0066	0.0062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0086	0.0274	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.0242	0.0242
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0028	0.0067	0.0067
Schistosoma mansoni	gabp alpha	0.0077	0.0242	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Toxoplasma gondii	hypothetical protein	0.0477	0.167	1
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0004	0.0004
Trypanosoma brucei	uridine phosphorylase	0.0028	0.0067	0.1142
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0028	0.0067	0.1142
Schistosoma mansoni	lamin	0.0028	0.0066	0.0062
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	serotonin transporter	0.2811	1	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0477	0.167	0.1667
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Schistosoma mansoni	ets-related	0.0011	0.0007	0.0003
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0086	0.0274	0.0274
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0004	0.0004
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.0425	0.0425
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Onchocerca volvulus		0.0028	0.0066	0.0062
Echinococcus granulosus	serotonin transporter	0.2811	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0027	0.0027
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0007	0.0007
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0477	0.167	0.167
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0477	0.167	0.1667
Schistosoma mansoni	hypothetical protein	0.0128	0.0425	0.0421
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0146	0.0488	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.1033	1
Brugia malayi	Fli-1 protein	0.0234	0.0803	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0477	0.167	0.167
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0025	0.0025
Schistosoma mansoni	thyroid hormone receptor	0.0138	0.0462	0.0458
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0188	0.0184
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0192	0.0188
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Schistosoma mansoni	thyroid hormone receptor	0.0138	0.0462	0.0458
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0004	0.0004
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0086	0.0274	0.7016
Brugia malayi	uridine phosphorylase family protein	0.0028	0.0067	0.0063
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0477	0.167	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0351	0.0351
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0477	0.167	0.1667
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0477	0.167	1
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0086	0.0274	0.0274
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0107	0.0351	0.0351
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0148	0.0145
Schistosoma mansoni	uridine phosphorylase	0.0028	0.0067	0.0063
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0477	0.167	0.1667
Echinococcus granulosus	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0004	0.0004
Leishmania major	methylthioadenosine phosphorylase, putative	0.0028	0.0067	0.1628
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0477	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.2811	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0004	0.0004
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0028	0.0067	0.0872
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0011	0.0007	0.0007
Mycobacterium tuberculosis	Hypothetical protein	0.0028	0.0067	0.0872
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.0015
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0086	0.0274	0.2138
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0477	0.167	0.1667
Echinococcus granulosus	GPCR family 2	0.0016	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0066	0.0066
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0138	0.0462	0.0462
Echinococcus multilocularis	cpg binding protein	0.0031	0.0079	0.0079
Schistosoma mansoni	hypothetical protein	0.0423	0.1478	0.1475
Schistosoma mansoni	ets	0.0011	0.0007	0.0003
Schistosoma mansoni	elf1	0.0011	0.0007	0.0003
Echinococcus multilocularis	lamin dm0	0.0028	0.0066	0.0066
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0028	0.0067	0.1142
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Plasmodium vivax	hypothetical protein, conserved	0.0477	0.167	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0477	0.167	0.167
Echinococcus granulosus	lamin	0.0028	0.0066	0.0066
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0028	0.0067	0.0063
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0028	0.0067	0.0244
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0004	0.0004
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Schistosoma mansoni	purine nucleoside phosphorylase	0.0136	0.0451	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0477	0.167	0.167
Schistosoma mansoni	hypothetical protein	0.0016	0.0025	0.0021
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0073	0.0073
Echinococcus granulosus	uridine phosphorylase 1	0.0028	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0064	0.0064
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0011	0.0007	0.0007
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0477	0.167	0.1667
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0028	0.0067	0.1142
Echinococcus granulosus	intermediate filament protein	0.0028	0.0066	0.0066
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0028	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0136	0.0451	0.0451
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0477	0.167	0.1667
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0296	0.1023	0.1019

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.58 uM	Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.	ChEMBL.	12643944
IC50 (functional)	= 0.58 uM	Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.	ChEMBL.	12643944

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 22418