Detailed information for compound 226912

Basic information

Technical information
  • TDR Targets ID: 226912
  • Name: 5-[(E)-[phenyl(pyrimidin-2-yl)methylidene]ami no]oxypentanoic acid
  • MW: 299.324 | Formula: C16H17N3O3
  • H donors: 1 H acceptors: 4 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCCO/N=C(/c1ncccn1)\c1ccccc1
  • InChi: 1S/C16H17N3O3/c20-14(21)9-4-5-12-22-19-15(13-7-2-1-3-8-13)16-17-10-6-11-18-16/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,21)/b19-15+
  • InChiKey: NRRRQGIXMAKNPZ-XDJHFCHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(E)-[phenyl(pyrimidin-2-yl)methylene]amino]oxypentanoic acid
  • 5-[(E)-[phenyl(2-pyrimidinyl)methylene]amino]oxypentanoic acid
  • 5-[(E)-[phenyl(2-pyrimidyl)methylene]amino]oxyvaleric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.0221 0.0734
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.0918
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.005 0.016
Schistosoma mansoni smad1 5 8 and 0.0009 0.0032 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0032 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0102 0.0352
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0227 0.0812
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0227 0.0593
Schistosoma mansoni hypothetical protein 0.0017 0.0136 0.0136
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0014 0.0093 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.002 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0306 0.4375 0.4366
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.001 0.0043 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Leishmania major phosphoglycerate kinase B, cytosolic 0.0112 0.1532 0.5552
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0043 0.0024
Trichomonas vaginalis importin beta-1, putative 0.0011 0.0051 0.0167
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0495 0.3064
Trypanosoma brucei phosphoglycerate kinase, putative 0.0041 0.0495 0.3064
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0112 0.1532 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0306 0.4375 0.4375
Brugia malayi beta-lactamase family protein 0.0054 0.0681 0.1779
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0032 0.0032
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0013 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0126 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.002 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0227 0.1273
Giardia lamblia Phosphoglycerate kinase 0.0112 0.1532 0.3447
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0142 0.1974 0.4489
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.002 0.0006
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0495 0.3064
Echinococcus multilocularis phosphoglycerate kinase 1 0.0112 0.1532 0.1518
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.001 0.0043 0.0043
Trichomonas vaginalis ran, putative 0.001 0.0037 0.0113
Onchocerca volvulus 0.0054 0.0681 0.2259
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0209 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.002 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0966 0.0951
Schistosoma mansoni coup transcription factor 0.0009 0.002 0.002
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0014 0.0093 0.0208
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0227 0.1235
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0037 0.0439 0.0423
Echinococcus multilocularis GTP binding nuclear protein Ran 0.001 0.0037 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0123 0.058
Trypanosoma brucei unspecified product 0.0023 0.0227 0.1273
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0439 0.2689
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0209 0.1154
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0136 0.0272
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.002 0.0003
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0269 0.3829 0.3819
Loa Loa (eye worm) histone methyltransferase 0.001 0.0047 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0043 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.001 0.0043 0.0024
Plasmodium vivax phosphodiesterase gamma, putative 0.0037 0.0439 0.1493
Echinococcus granulosus FTZ F1 alpha 0.0009 0.002 0.0003
Echinococcus granulosus importin subunit beta 1 0.0013 0.0088 0.0072
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0194 0.273 0.6208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Schistosoma mansoni nuclear hormone receptor 0.0009 0.002 0.002
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0439 0.0423
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0013 0.008 0.0273
Leishmania major hypothetical protein, conserved 0.0037 0.0439 0.1493
Schistosoma mansoni ran 0.001 0.0037 0.0037
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0024 0.0246 0.0817
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0439 0.1493
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0269 0.3829 0.3819
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Mycobacterium tuberculosis Probable lipase LipE 0.0054 0.0681 0.1306
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0681 0.2393
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0054 0.0681 0.0681
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0037 0.0439 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.002 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.002 0.0006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni phosphoglycerate kinase 0.0112 0.1532 0.1532
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0439 0.1146
Brugia malayi Phosphoglycerate kinase 0.0041 0.0495 0.1292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.002 0.0006
Echinococcus multilocularis GPCR, family 2 0.0017 0.0136 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Mycobacterium tuberculosis Conserved protein 0.0054 0.0681 0.1306
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1923 0.4373
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0123 0.058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.0966 0.2523
Echinococcus granulosus Smad4 0.0009 0.0032 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.002 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0227 0.1235
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0102 0.0352
Trichomonas vaginalis esterase, putative 0.0054 0.0681 0.2479
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.001 0.0043 0.0043
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0037 0.0439 0.1493
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0439 0.2689
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Trypanosoma brucei phosphoglycerate kinase 0.0112 0.1532 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Toxoplasma gondii t-complex protein beta subunit 0.0013 0.008 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0681 0.4311
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0112 0.1532 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0947 0.0947
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0344 0.4927 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0136 0.0119
Onchocerca volvulus 0.0034 0.039 0.1294
Trypanosoma brucei unspecified product 0.0016 0.0123 0.058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0439 0.1589
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.001 0.0043 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Mycobacterium ulcerans hypothetical protein 0.0054 0.0681 0.4286
Leishmania major cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.1493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.002 0.0003
Onchocerca volvulus 0.0054 0.0681 0.2259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0966 0.0966
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0037 0.0439 0.0439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0966 0.0951
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Leishmania major DNA polymerase kappa, putative 0.0023 0.0227 0.0706
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0418 0.109
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0136 0.0355
Loa Loa (eye worm) PDE1B protein 0.0037 0.0439 0.0967
Loa Loa (eye worm) hypothetical protein 0.0022 0.0221 0.0468
Brugia malayi Heterochromatin protein 1 0.004 0.0479 0.125
Loa Loa (eye worm) hypothetical protein 0.0213 0.3016 0.6881
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0032 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.002 0.0003
Echinococcus multilocularis dna polymerase eta 0.004 0.0472 0.0456
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0013 0.008 0.008
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0227 0.0706
Mycobacterium ulcerans esterase/lipase LipP 0.0054 0.0681 0.4286
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.002 0.0003
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0194 0.273 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0112 0.1532 0.5602
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0681 0.2479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0966 0.0951
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0136 0.0119
Onchocerca volvulus Huntingtin homolog 0.0213 0.3016 1
Trichomonas vaginalis chromobox protein, putative 0.004 0.0479 0.1736
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0043 0.0024
Brugia malayi hypothetical protein 0.0014 0.0097 0.0254
Giardia lamblia TCP-1 chaperonin subunit beta 0.0013 0.008 0.01
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Leishmania major macrophage migration inhibitory factor-like protein 0.0194 0.273 1
Mycobacterium tuberculosis Probable esterase LipL 0.0054 0.0681 0.1306
Brugia malayi Phosphoglycerate kinase 0.0112 0.1532 0.4
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0008 0.0017 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0227 0.0376
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0112 0.1532 0.3048
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0439 0.0423
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0242 0.1374
Echinococcus granulosus phosphoglycerate kinase 1 0.0112 0.1532 0.1518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.0966 0.2177
Echinococcus multilocularis importin subunit beta 1 0.0013 0.0088 0.0072
Schistosoma mansoni hypothetical protein 0.0017 0.0136 0.0136
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0439 0.1146
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.002 0.0052
Echinococcus multilocularis smad 0.0009 0.0032 0.0015
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0037 0.0439 0.0423
Schistosoma mansoni hypothetical protein 0.001 0.0035 0.0035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0227 0.0376
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0439 0.1146
Schistosoma mansoni hypothetical protein 0.0036 0.0418 0.0418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.002 0.0003
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.273 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Brugia malayi ecdysteroid receptor 0.0009 0.002 0.0052
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.002 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0227 0.0227
Schistosoma mansoni cpg binding protein 0.0036 0.0418 0.0418
Giardia lamblia Hypothetical protein 0.0037 0.0439 0.0927
Loa Loa (eye worm) Smad1 0.0009 0.0032 0.0032
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0681 0.2479
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.005 0.016
Onchocerca volvulus 0.0054 0.0681 0.2259
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0306 0.4375 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0136 0.0119
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Schistosoma mansoni ap endonuclease 0.001 0.0043 0.0043
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0037 0.0439 0.0423
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0136 0.0119
Loa Loa (eye worm) hypothetical protein 0.0037 0.0439 0.0967
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0221 0.0791
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0227 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.002 0.0006
Brugia malayi Smad1 0.0009 0.0032 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.002 0.0003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0032 0.0015
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.001 0.0037 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.002 0.002
Trypanosoma brucei unspecified product 0.0016 0.0123 0.058
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0209 0.064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Mycobacterium tuberculosis Probable hydrolase 0.0054 0.0681 0.1306
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0194 0.273 0.6225
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0037 0.0439 0.0423
Trichomonas vaginalis penicillin-binding protein, putative 0.0054 0.0681 0.2479
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Brugia malayi nuclear hormone receptor 0.0009 0.002 0.0052
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0242 0.0473
Brugia malayi MH2 domain containing protein 0.0009 0.0032 0.0083
Schistosoma mansoni flap endonuclease-1 0.0012 0.0074 0.0074
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0439 0.2689
Echinococcus granulosus dna polymerase kappa 0.0023 0.0227 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.2689
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.002 0.0052
Schistosoma mansoni hypothetical protein 0.069 1 1
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0246 0.0883
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0037 0.0439 0.0423
Leishmania major T-complex protein 1, beta subunit, putative 0.0013 0.008 0.0161
Schistosoma mansoni hypothetical protein 0.0017 0.0136 0.0136
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.039 0.0855
Echinococcus granulosus beta LACTamase domain containing family member 0.0054 0.0681 0.0666
Onchocerca volvulus 0.0018 0.0151 0.0499
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0013 0.008 0.029
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0269 0.3829 1
Brugia malayi MH1 domain containing protein 0.0009 0.0032 0.0083
Brugia malayi MH2 domain containing protein 0.0139 0.1923 0.5021
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.002 0.0006
Plasmodium falciparum importin beta, putative 0.0013 0.0088 0.0191
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0439 0.2689
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Entamoeba histolytica Flap nuclease, putative 0.0014 0.0093 0.0208
Loa Loa (eye worm) hypothetical protein 0.004 0.0472 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0047 0.003
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Schistosoma mansoni smad1 5 8 and 0.0009 0.0032 0.0032
Plasmodium falciparum phosphodiesterase delta, putative 0.0037 0.0439 0.1493
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0472 0.2913
Brugia malayi CXXC zinc finger family protein 0.0034 0.039 0.1019
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0306 0.4375 0.4366
Toxoplasma gondii exonuclease III APE 0.001 0.0043 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.066 0.1724
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.002 0.0003
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1493
Trichomonas vaginalis chaperonin, putative 0.0013 0.008 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Schistosoma mansoni ap endonuclease 0.001 0.0043 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0136 0.0355
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.002 0.002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0037 0.0439 0.1146
Mycobacterium ulcerans lipase LipD 0.0054 0.0681 0.4286
Brugia malayi Bm-MIF-1, identical 0.0194 0.273 0.7129
Trypanosoma brucei importin beta-1 subunit, putative 0.0013 0.0088 0.0344
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0032 0.0015
Trichomonas vaginalis chromobox protein, putative 0.004 0.0479 0.1736
Loa Loa (eye worm) hypothetical protein 0.0306 0.4375 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0013 0.008 0.0161
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.002 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0041 0.0495 0.3064
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0037 0.0439 0.0423
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Schistosoma mansoni phosphoglycerate kinase 0.0112 0.1532 0.1532
Giardia lamblia hypothetical protein 0.0037 0.0439 0.0927
Brugia malayi exodeoxyribonuclease III family protein 0.001 0.0043 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0054 0.0681 0.2479
Brugia malayi Importin beta-1 subunit 0.0013 0.0088 0.023
Giardia lamblia Flap structure-specific endonuclease 0.0014 0.0093 0.0129
Schistosoma mansoni thyroid hormone receptor 0.0009 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0035 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Leishmania major DNA polymerase eta, putative 0.004 0.0472 0.1617
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0054 0.0681 0.1306
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0051 0.0167
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Leishmania major phosphoglycerate kinase C, glycosomal 0.0112 0.1532 0.5552
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0054 0.0681 0.1779
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.002 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.002 0.0003
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0112 0.1532 0.3447
Echinococcus multilocularis chromobox protein 1 0.004 0.0479 0.0463
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus granulosus chromobox protein 1 0.004 0.0479 0.0463
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1493
Echinococcus multilocularis geminin 0.069 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0037 0.0439 0.1146
Plasmodium vivax flap endonuclease 1, putative 0.0014 0.0093 0.0208
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Schistosoma mansoni cpg binding protein 0.0036 0.0418 0.0418
Plasmodium falciparum phosphodiesterase gamma, putative 0.0037 0.0439 0.1493
Toxoplasma gondii HEAT repeat-containing protein 0.0013 0.0088 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0013 0.008 0.008
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Schistosoma mansoni cpg binding protein 0.0034 0.039 0.039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0047 0.003
Leishmania major DNA polymerase eta, putative 0.0024 0.0242 0.0763
Schistosoma mansoni hypothetical protein 0.0017 0.0136 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus granulosus smad 0.0009 0.0032 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0054 0.0681 0.1523
Brugia malayi nuclear receptor NHR-88 0.0009 0.002 0.0052
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0041 0.0495 0.3064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.002 0.0003
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0269 0.3829 0.8748
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0227 0.1273
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0013 0.008 0.0064
Brugia malayi chromobox protein homolog 3 0.0022 0.0221 0.0578
Schistosoma mansoni ran 0.001 0.0037 0.0037
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Brugia malayi hypothetical protein 0.0213 0.3016 0.7875
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0037 0.0439 0.2689
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.002 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.002 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.002 0.0052
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0227 0.0211
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0306 0.4375 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Mycobacterium ulcerans beta-lactamase 0.0054 0.0681 0.4286
Brugia malayi RNA, U transporter 1 0.0038 0.0448 0.1169
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0681 0.4311
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0209 0.1154
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0439 0.0423
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0209 0.0398
Echinococcus granulosus flap endonuclease 1 0.0014 0.0093 0.0076
Brugia malayi T-complex protein 1, beta subunit 0.0013 0.008 0.0209
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0227 0.0706
Echinococcus multilocularis Smad4 0.0009 0.0032 0.0015
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0013 0.008 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0681 0.2479
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Onchocerca volvulus Huntingtin homolog 0.0213 0.3016 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Leishmania major importin beta-1 subunit, putative 0.0011 0.0051 0.0054
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.2689
Loa Loa (eye worm) hypothetical protein 0.0052 0.066 0.1475
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Schistosoma mansoni smad 0.0009 0.0032 0.0032
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0194 0.273 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0112 0.1532 1
Loa Loa (eye worm) beta-lactamase 0.0054 0.0681 0.1523
Treponema pallidum phosphoglycerate kinase 0.0112 0.1532 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni smad1 5 8 and 0.0009 0.0032 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0054 0.0681 0.1306
Echinococcus multilocularis cpg binding protein 0.0036 0.0418 0.0402
Loa Loa (eye worm) heterochromatin protein 1 0.004 0.0479 0.1058
Brugia malayi Flap endonuclease-1 0.0014 0.0093 0.0243
Mycobacterium tuberculosis Conserved protein 0.0054 0.0681 0.1306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0151 0.0305
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0008 0.0017 0.0017
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0439 0.0423
Mycobacterium tuberculosis Conserved protein 0.0054 0.0681 0.1306
Brugia malayi MH1 domain containing protein 0.0009 0.0032 0.0083
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0112 0.1532 0.3447
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.002 0.0066
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.001 0.0037 0.0096
Plasmodium falciparum flap endonuclease 1 0.0014 0.0093 0.0208
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.002 0.0052
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0227 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0017 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1923 0.4373
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0013 0.008 0.0064
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0083 0.1103 0.2492
Echinococcus granulosus GPCR family 2 0.0017 0.0136 0.0119
Echinococcus granulosus cpg binding protein 0.0036 0.0418 0.0402
Brugia malayi steroid hormone receptor 0.0009 0.002 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0439 0.1589
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0439 0.1589
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0054 0.0681 0.0681
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.002 0.0003
Echinococcus granulosus GTP binding nuclear protein Ran 0.001 0.0037 0.002
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0013 0.008 0.029
Loa Loa (eye worm) flap endonuclease-1 0.0014 0.0093 0.0173
Schistosoma mansoni importin beta-1 0.0013 0.0088 0.0088
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0041 0.0495 0.3064
Brugia malayi hypothetical protein 0.0022 0.0209 0.0546
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0439 0.1493
Schistosoma mansoni DNA polymerase eta 0.004 0.0472 0.0472
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0013 0.008 0.0161
Chlamydia trachomatis phosphoglycerate kinase 0.0112 0.1532 0.5
Trypanosoma brucei phosphoglycerate kinase 0.0041 0.0495 0.3064
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0306 0.4375 0.4366
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.002 0.002
Loa Loa (eye worm) T-complex protein 1 0.0013 0.008 0.0144
Entamoeba histolytica hypothetical protein 0.0011 0.0051 0.0054
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0227 0.0481
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0093 0.0319
Echinococcus multilocularis beta LACTamase domain containing family member 0.0054 0.0681 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0221 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.002 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Toxoplasma gondii ABC1 family protein 0.0054 0.0681 0.1486
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0037 0.0439 0.2689
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0439 0.2689
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0834 0.1839
Echinococcus multilocularis chromobox protein 1 0.004 0.0479 0.0463
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0227 0.1273
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Brugia malayi beta-lactamase family protein 0.0054 0.0681 0.1779
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0227 0.0211
Leishmania major macrophage migration inhibitory factor-like protein 0.0194 0.273 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1493
Schistosoma mansoni thyroid hormone receptor 0.0009 0.002 0.002
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Trypanosoma brucei importin beta-1 subunit, putative 0.0013 0.0088 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0227 0.1273
Echinococcus multilocularis flap endonuclease 1 0.0014 0.0093 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0136 0.0272
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0054 0.0681 0.4286
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0043 0.0137
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0014 0.0093 0.0129
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0439 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.002 0.0052
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0246 0.0883
Brugia malayi CHD4 protein 0.0008 0.0017 0.0046
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0037 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.001 0.0043 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.002 0.0052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.002 0.002
Trypanosoma cruzi importin beta-1 subunit, putative 0.0011 0.0051 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.002 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1493
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Giardia lamblia Macrophage migration inhibitory factor 0.0194 0.273 0.6208
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0194 0.273 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.001 0.0043 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0123 0.058
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0472 0.1233
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0472 0.2913
Onchocerca volvulus 0.0009 0.002 0.0066
Entamoeba histolytica exodeoxyribonuclease III, putative 0.001 0.0043 0.0024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Leishmania major hypothetical protein, conserved 0.0037 0.0439 0.1493
Giardia lamblia DINP protein human, muc B family 0.0023 0.0227 0.0439
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0037 0.0439 0.0439
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.002 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.002 0.0003
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0083 0.1103 0.2492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0037 0.0439 0.1146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0966 0.0966
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0054 0.0681 0.1306
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.002 0.0003
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.002 0.0052
Mycobacterium tuberculosis Probable lipase LipD 0.0054 0.0681 0.1306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0966 0.0966
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0227 0.0812
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0032 0.0032
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0306 0.4375 0.4366
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.001 0.0043 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0051 0.0167
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0439 0.0423
Echinococcus multilocularis snurportin 1 0.0142 0.1974 0.196
Schistosoma mansoni hypothetical protein 0.0142 0.1974 0.1974
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Brugia malayi beta-lactamase 0.0054 0.0681 0.1779
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0681 0.4311
Loa Loa (eye worm) hypothetical protein 0.0037 0.0439 0.0967
Echinococcus granulosus dna polymerase eta 0.004 0.0472 0.0456
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Schistosoma mansoni Smad4 0.0009 0.0032 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.002 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0213 0.3016 0.6881
Loa Loa (eye worm) hypothetical protein 0.0022 0.0209 0.044
Echinococcus granulosus chromobox protein 1 0.004 0.0479 0.0463
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Plasmodium vivax importin-beta 2, putative 0.0013 0.0088 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0041 0.013
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0014 0.0093 0.0376
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0495 0.1701
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.066 0.1475
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.002 0.0052
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0112 0.1532 1
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0209 0.064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0439 0.0967
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.002 0.0066
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0008 0.0017 0.0001
Plasmodium falciparum macrophage migration inhibitory factor 0.0194 0.273 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0032 0.0015
Loa Loa (eye worm) hypothetical protein 0.0112 0.1532 0.3476
Entamoeba histolytica phosphoglycerate kinase, putative 0.0112 0.1532 0.5552
Schistosoma mansoni chromobox protein 0.004 0.0479 0.0479
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0112 0.1532 0.5602
Leishmania major hypothetical protein, conserved 0.0054 0.0681 0.2393
Brugia malayi MH2 domain containing protein 0.0009 0.0032 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.002 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0045 0.0118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.002 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Mycobacterium ulcerans phosphoglycerate kinase 0.0112 0.1532 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0439 0.1589
Echinococcus granulosus snurportin 1 0.0142 0.1974 0.196
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0439 0.2689
Trypanosoma brucei phosphoglycerate kinase 0.0112 0.1532 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0035 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0126 0.044
Brugia malayi T-complex protein 1, beta subunit 0.0013 0.008 0.0209
Schistosoma mansoni hypothetical protein 0.069 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0209 0.064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.0162
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0439 0.2689
Plasmodium falciparum phosphoglycerate kinase 0.0112 0.1532 0.5552
Schistosoma mansoni chromobox protein 0.004 0.0479 0.0479
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.066 0.1724
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0037 0.0439 0.0439
Leishmania major hypothetical protein, conserved 0.0022 0.0209 0.064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0439 0.1589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0966 0.0951
Plasmodium vivax phosphoglycerate kinase, putative 0.0112 0.1532 0.5552
Loa Loa (eye worm) hypothetical protein 0.0054 0.0681 0.1523
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0439 0.1589
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0439 0.0927

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3 uM TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets ChEMBL. 8831771
IC50 (functional) = 3 uM TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets ChEMBL. 8831771
IC50 (binding) > 100 uM TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid ChEMBL. 8831771
IC50 (binding) > 100 uM TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid ChEMBL. 8831771
Inhibition (functional) = 0 % In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM ChEMBL. 8831771
Inhibition (functional) = 0 % In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM ChEMBL. 8831771

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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