Detailed information for compound 236252

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 697.818 | Formula: C36H51N5O9
  • H donors: 8 H acceptors: 9 LogP: 2.74 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]([C@H](CC(=O)N[C@H](C(=O)NCc1cccc(c1)C(=O)O)Cc1ccc(cc1)O)O)CC(C)C)C)NC(=O)C)C
  • InChi: 1S/C36H51N5O9/c1-7-21(4)32(39-23(6)42)35(48)38-22(5)33(46)41-28(15-20(2)3)30(44)18-31(45)40-29(17-24-11-13-27(43)14-12-24)34(47)37-19-25-9-8-10-26(16-25)36(49)50/h8-14,16,20-22,28-30,32,43-44H,7,15,17-19H2,1-6H3,(H,37,47)(H,38,48)(H,39,42)(H,40,45)(H,41,46)(H,49,50)/t21?,22-,28-,29-,30-,32-/m0/s1
  • InChiKey: OYUWAAXUJRTVGW-PNPRZBCJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0049 0.0099 0.0271
Echinococcus granulosus neuroglian 0.0119 0.0654 0.0654
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0063 0.021 0.021
Brugia malayi hypothetical protein 0.0109 0.0576 0.0556
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis hemicentin 1 0.0119 0.0654 0.0654
Echinococcus granulosus low density lipoprotein receptor ldl 0.0092 0.0437 0.0437
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0136 0.0792 1
Echinococcus multilocularis roundabout 2 0.0505 0.3752 0.3752
Schistosoma mansoni netrin receptor unc5 0.0092 0.0437 0.0437
Echinococcus granulosus dihydrofolate reductase 0.1286 1 1
Echinococcus multilocularis dihydrofolate reductase 0.1286 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.007 0.0262 0.0262
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0092 0.0437 0.0437
Schistosoma mansoni nephrin related 0.0092 0.0437 0.0437
Echinococcus granulosus tyrosine kinase 0.004 0.0021 0.0021
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.0048 0.0048
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0049 0.0099 0.0099
Echinococcus multilocularis Immunoglobulin 0.0387 0.2802 0.2802
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0092 0.0437 0.0437
Brugia malayi Fibronectin type III domain containing protein 0.0387 0.2802 0.2787
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.0235 0.0235
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0437 0.0417
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1286 1 1
Echinococcus multilocularis tyrosine kinase 0.004 0.0021 0.0021
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1286 1 1
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.002 0.0054
Onchocerca volvulus Putative titin 0.0044 0.0059 0.0497
Brugia malayi Dihydrofolate reductase 0.1286 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus lachesin 0.0119 0.0654 0.0654
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0492 0.3641 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.004 0.0021 0.0021
Echinococcus multilocularis Immunoglobulin 0.0387 0.2802 0.2802
Schistosoma mansoni cell adhesion molecule 0.0119 0.0654 0.0654
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.004 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0485 0.3589 0.3589
Echinococcus granulosus tyrosine protein kinase Lyn 0.0071 0.0269 0.0269
Schistosoma mansoni netrin receptor unc5 0.0092 0.0437 0.0437
Echinococcus multilocularis tyrosine protein kinase Blk 0.0066 0.0235 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Echinococcus multilocularis lachesin 0.0119 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.047 0.3467 0.3453
Schistosoma mansoni dihydrofolate reductase 0.1286 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) TK protein kinase 0.0066 0.0235 0.0215
Schistosoma mansoni nephrin 0.0414 0.3018 0.3018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Echinococcus granulosus tyrosine protein kinase Blk 0.0066 0.0235 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Echinococcus granulosus twitchin 0.0415 0.3025 0.3025
Brugia malayi basement membrane proteoglycan precursor 0.0092 0.0437 0.0417
Echinococcus granulosus fibroblast growth factor receptor 4 0.0779 0.5939 0.5939
Schistosoma mansoni tyrosine kinase 0.0043 0.0048 0.0048
Echinococcus granulosus roundabout 2 0.0505 0.3752 0.3752
Loa Loa (eye worm) hypothetical protein 0.0055 0.0141 0.0121
Echinococcus multilocularis tyrosine protein kinase otk 0.0119 0.0654 0.0654
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Brugia malayi Immunoglobulin domain containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis tyrosine protein kinase Src64B 0.007 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.007 0.0262 0.0262
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0092 0.0437 0.0437
Echinococcus granulosus tyrosine protein kinase Fps85D 0.004 0.0021 0.0021
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0514 0.3824 0.3811
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0119 0.0654 0.0654
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0092 0.0437 0.0437
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0049 0.0099 0.0078
Brugia malayi Tyrosine-protein kinase abl-1 0.0043 0.0048 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0092 0.0437 0.0437
Giardia lamblia Kinase, NEK 0.0154 0.0941 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0109 0.0576 0.0576
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0485 0.3589 0.3575
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0092 0.0437 0.0437
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0055 0.0141 0.0388
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0154 0.0941 0.2584
Echinococcus granulosus roundabout 2 0.0119 0.0654 0.0654
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Schistosoma mansoni cell adhesion molecule 0.0092 0.0437 0.0437
Trypanosoma cruzi polo-like protein kinase, putative 0.0049 0.0099 0.0271
Echinococcus multilocularis c src tyrosine kinase 0.0043 0.0048 0.0048
Echinococcus multilocularis roundabout 2 0.0119 0.0654 0.0654
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Schistosoma mansoni septate junction protein 0.0092 0.0437 0.0437
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0779 0.5939 0.5939
Trichomonas vaginalis AGC family protein kinase 0.0154 0.0941 1
Schistosoma mansoni hypothetical protein 0.0044 0.0059 0.0059
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0055 0.0141 0.0388
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0141 0.0121
Schistosoma mansoni basigin related 0.0092 0.0437 0.0437
Schistosoma mansoni tyrosine kinase 0.004 0.0021 0.0021
Echinococcus multilocularis Immunoglobulin subtype 0.0092 0.0437 0.0437
Onchocerca volvulus 0.0044 0.0059 0.0497
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Loa Loa (eye worm) hypothetical protein 0.0478 0.3535 0.3521
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0779 0.5939 0.5939
Schistosoma mansoni tyrosine kinase 0.007 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Echinococcus granulosus tyrosine protein kinase ABL1 0.004 0.0021 0.0021
Brugia malayi protein-tyrosine kinase 0.0066 0.0235 0.0215
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0055 0.0141 0.0141
Schistosoma mansoni vesicular amine transporter 0.0387 0.2802 0.2802
Plasmodium falciparum NIMA related kinase 1 0.0154 0.0941 0.2584
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0119 0.0661 0.0641
Onchocerca volvulus 0.0044 0.0059 0.0497
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0119 0.0654 0.0634
Brugia malayi Immunoglobulin domain containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.007 0.0262 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Giardia lamblia Kinase, NEK 0.0154 0.0941 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.007 0.0262 0.0262
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0387 0.2802 0.2802
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0092 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0417
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0055 0.0141 0.0141
Loa Loa (eye worm) SRC-1 0.007 0.0262 0.0242
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1286 1 1
Schistosoma mansoni basigin related 0.0092 0.0437 0.0437
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Echinococcus granulosus neuroglian 0.0414 0.3018 0.3018
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0119 0.0654 0.0654
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis Immunoglobulin 0.0092 0.0437 0.0437
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni roundabout 0.0119 0.0654 0.0654
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus contactin 0.0136 0.0792 0.0792
Brugia malayi basement membrane proteoglycan 0.0092 0.0437 0.0417
Brugia malayi hypothetical protein 0.0387 0.2802 0.2787
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0043 0.0048 0.0048
Echinococcus multilocularis tyrosine protein kinase Abl 0.0043 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0505 0.3752 0.3739
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis Immunoglobulin 0.0092 0.0437 0.0437
Schistosoma mansoni titin 0.0136 0.0792 0.0792
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni cell adhesion molecule 0.0092 0.0437 0.0437
Echinococcus granulosus tyrosine protein kinase Srms 0.004 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0417
Schistosoma mansoni nephrin 0.0119 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Echinococcus granulosus roundabout 2 0.0119 0.0654 0.0654
Loa Loa (eye worm) TK/ROR protein kinase 0.0063 0.021 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0099 0.0857
Schistosoma mansoni septate junction protein 0.0119 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Onchocerca volvulus Netrin receptor homolog 0.0044 0.0059 0.0497
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.0048 0.0048
Brugia malayi serine/threonine-protein kinase plk-2 0.0049 0.0099 0.0078
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0119 0.0654 0.0654
Toxoplasma gondii hypothetical protein 0.0039 0.002 0.0054
Echinococcus granulosus Immunoglobulin 0.0387 0.2802 0.2802
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0119 0.0654 0.0654
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis hemicentin 1 0.0136 0.0792 0.0792
Echinococcus granulosus Immunoglobulin subtype 0.0092 0.0437 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0141 0.1322
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0437 0.0417
Toxoplasma gondii hypothetical protein 0.0039 0.002 0.0054
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0417
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0514 0.3824 0.3811
Schistosoma mansoni tyrosine kinase 0.007 0.0262 0.0262
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0092 0.0437 0.0437
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0492 0.3641 1
Schistosoma mansoni septate junction protein 0.0092 0.0437 0.0437
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0492 0.3641 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni peroxidasin 0.0092 0.0437 0.0437
Echinococcus granulosus tyrosine protein kinase HCK 0.0063 0.0207 0.0207
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0119 0.0654 0.0654
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0492 0.3641 1
Echinococcus granulosus hemicentin 1 0.0136 0.0792 0.0792
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0099 0.0099
Echinococcus multilocularis netrin receptor unc 5 0.0092 0.0437 0.0437
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0092 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.043 0.3151 0.3137
Echinococcus granulosus basement membrane specific heparan sulfate 0.0092 0.0437 0.0437
Brugia malayi Heparan sulfate 0.0092 0.0437 0.0417
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0119 0.0654 0.0654
Echinococcus granulosus peroxidasin 0.0119 0.0654 0.0654
Schistosoma mansoni tyrosine kinase 0.0779 0.5939 0.5939
Echinococcus multilocularis peroxidasin 0.0119 0.0654 0.0654
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0492 0.3641 1
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0092 0.0437 0.0437
Echinococcus granulosus Immunoglobulin 0.0092 0.0437 0.0437
Trichomonas vaginalis STE family protein kinase 0.0154 0.0941 1
Schistosoma mansoni tyrosine kinase 0.004 0.0021 0.0021
Schistosoma mansoni septate junction protein 0.0119 0.0654 0.0654
Brugia malayi Immunoglobulin I-set domain containing protein 0.0806 0.6156 0.6148
Brugia malayi Peroxidasin 0.0119 0.0654 0.0634
Echinococcus granulosus netrin receptor unc 5 0.0092 0.0437 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0437 0.0417
Trypanosoma cruzi polo-like protein kinase, putative 0.0049 0.0099 0.0271
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0066 0.0235 0.0235
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0092 0.0437 0.0417
Chlamydia trachomatis dihydrofolate reductase 0.1286 1 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0066 0.0235 0.0235
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.007 0.0262 0.0262
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0049 0.0099 0.0099
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni cell adhesion molecule 0.0119 0.0654 0.0654
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0417
Echinococcus granulosus tyrosine protein kinase Src64B 0.007 0.0262 0.0262
Onchocerca volvulus Serine\/threonine kinase homolog 0.0049 0.0099 0.1007
Trypanosoma brucei polo-like protein kinase 0.0049 0.0099 0.0271
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0154 0.0941 0.2544
Echinococcus granulosus Immunoglobulin 0.0092 0.0437 0.0437
Brugia malayi Prion-like- 0.0119 0.0654 0.0634
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0141 0.0388
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0055 0.0141 0.0141
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0779 0.5939 0.5939
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Echinococcus granulosus tyrosine kinase 0.0066 0.0235 0.0235
Entamoeba histolytica protein kinase, putative 0.0063 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0523 0.389 0.3877
Loa Loa (eye worm) TK protein kinase 0.0063 0.0207 0.0187
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Toxoplasma gondii hypothetical protein 0.0039 0.002 0.0054
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0119 0.0654 0.0654
Schistosoma mansoni memapsin-2 (A01 family) 0.0521 0.3876 0.3876
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus c src tyrosine kinase 0.0043 0.0048 0.0048
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0063 0.021 0.021
Onchocerca volvulus Tyrosine kinase homolog 0.008 0.0348 0.4245
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.007 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0141 0.0388
Schistosoma mansoni tyrosine kinase 0.0155 0.0943 0.0943
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0119 0.0654 0.0654
Echinococcus granulosus tyrosine protein kinase shark 0.004 0.0021 0.0021
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0141 0.0388
Schistosoma mansoni neuroglian 0.0119 0.0654 0.0654
Loa Loa (eye worm) dihydrofolate reductase 0.1286 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus multilocularis tyrosine protein kinase HCK 0.0063 0.0207 0.0207
Brugia malayi SRC-1 0.007 0.0262 0.0242
Echinococcus multilocularis tyrosine protein kinase Fgr 0.007 0.0262 0.0262
Echinococcus multilocularis tyrosine protein kinase shark 0.004 0.0021 0.0021
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0492 0.3641 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0049 0.0099 0.4755
Entamoeba histolytica SH2-protein kinase domain containing protein 0.004 0.0021 0.1006
Schistosoma mansoni cell adhesion molecule 0.0478 0.3535 0.3535
Toxoplasma gondii GAF domain-containing protein 0.0039 0.002 0.0054
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0092 0.0437 0.0437
Echinococcus granulosus tyrosine protein kinase otk 0.0119 0.0654 0.0654
Schistosoma mansoni cell adhesion molecule 0.0119 0.0654 0.0654
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) TK protein kinase 0.0806 0.6156 0.6148
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0387 0.2802 0.2787
Echinococcus multilocularis roundabout 2 0.0119 0.0654 0.0654
Echinococcus granulosus defective proboscis extension response 0.0387 0.2802 0.2802
Schistosoma mansoni tyrosine kinase 0.0043 0.0048 0.0048
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0055 0.0141 0.1322
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0478 0.3535 0.3535
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0485 0.3589 0.3589
Loa Loa (eye worm) hypothetical protein 0.0119 0.0654 0.0634
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0119 0.0654 0.0634
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Schistosoma mansoni basigin related 0.0092 0.0437 0.0437
Echinococcus multilocularis neuroglian 0.0119 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0092 0.0437 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.002 0.002
Loa Loa (eye worm) LAD-2 short isoform 0.0092 0.0437 0.0417
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.007 0.0262 0.0262
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Giardia lamblia Kinase, NEK 0.0154 0.0941 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0092 0.0437 0.0437
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0387 0.2802 0.2802
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0387 0.2802 0.2802
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Brugia malayi Immunoglobulin domain containing protein 0.0092 0.0437 0.0417
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0092 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0092 0.0437 0.0417
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0654 0.0634
Echinococcus multilocularis neuroglian 0.0414 0.3018 0.3018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0387 0.2802 0.2787
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0141 0.1322
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0055 0.0141 0.0141

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 uM Inhibition of human beta-secretase ChEMBL. 14643321

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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