TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 854.011 | Formula: C40H63N13O8
H donors: 11 H acceptors: 9 LogP: -0.57 Rotable bonds: 30
Rule of 5 violations (Lipinski): 3
SMILES: CNCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)N)Cc1nc[nH]c1)C(CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
InChi: 1S/C40H63N13O8/c1-6-23(4)33(38(60)50-29(18-25-19-45-21-47-25)39(61)53-16-8-10-30(53)34(41)56)52-36(58)28(17-24-11-13-26(54)14-12-24)49-37(59)32(22(2)3)51-35(57)27(48-31(55)20-44-5)9-7-15-46-40(42)43/h11-14,19,21-23,27-30,32-33,44,54H,6-10,15-18,20H2,1-5H3,(H2,41,56)(H,45,47)(H,48,55)(H,49,59)(H,50,60)(H,51,57)(H,52,58)(H4,42,43,46)
InChiKey: WDJJHCAFCXYZLZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0194	0.067	0.0783
Trypanosoma cruzi	hypothetical protein, conserved	0.0194	0.067	0.0632
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	mbt repeat family protein	0.0053	0.0095	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0014	0.0025
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.0215	0.0251
Brugia malayi	Tachykinin-like peptides receptor 99D	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus granulosus	histone acetyltransferase MYST2	0.006	0.0125	0.0138
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0194	0.067	0.0783
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.004	0.0015
Mycobacterium tuberculosis	Conserved protein	0.0194	0.067	0.1092
Mycobacterium ulcerans	beta-lactamase	0.0194	0.067	0.0621
Echinococcus granulosus	allatostatin A receptor	0.007	0.0167	0.0187
Onchocerca volvulus		0.0097	0.0276	0.2973
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1361	0.5419	0.6326
Echinococcus multilocularis	Chromobox protein 3	0.0036	0.0027	0.0024
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0133	0.0423	0.4562
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.007	0.0167	0.0291
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.007	0.0167	0.0195
Loa Loa (eye worm)	helicase	0.0036	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0167	0.0187
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.1461	0.5825	0.6809
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.004	0.0015
Schistosoma mansoni	chromobox protein	0.0221	0.078	0.0913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0053	0.0095	0.0112
Trichomonas vaginalis	D-aminoacylase, putative	0.0194	0.067	0.0754
Onchocerca volvulus		0.007	0.0167	0.1797
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0132	0.023
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0014	0.0007
Schistosoma mansoni	kinase	0.0052	0.0092	0.0107
Plasmodium vivax	hypothetical protein, conserved	0.0194	0.067	0.0774
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.007	0.0167	0.0187
Onchocerca volvulus		0.009	0.0247	0.2661
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.007	0.0167	0.0291
Echinococcus multilocularis	tumor protein p63	0.0366	0.137	0.1596
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0146	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0103	0.0301	0.0345
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2131	0.8551	1
Echinococcus granulosus	fmrfamide receptor	0.007	0.0167	0.0187
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0132	0.0154
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Brugia malayi	PHD-finger family protein	0.0032	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus granulosus	chromobox protein 1	0.0221	0.078	0.0905
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.004	0.0015
Trypanosoma cruzi	polo-like protein kinase, putative	0.0102	0.0297	0.0257
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0036	0.0027	0.0022
Echinococcus granulosus	orexin receptor type 2	0.007	0.0167	0.0187
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0148	0.0173
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0132	0.0147
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.006	0.0125	0.0218
Brugia malayi	M-phase phosphoprotein, mpp8	0.0036	0.0027	0.0032
Echinococcus multilocularis	neuropeptide receptor	0.007	0.0167	0.0187
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0102	0.0297	0.0339
Brugia malayi	AKH receptor	0.007	0.0167	0.0195
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.0167	0.0195
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.2131	0.8551	0.5
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0053	0.0095	0.0104
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.0167	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0194	0.067	0.0783
Trypanosoma cruzi	polo-like protein kinase, putative	0.0102	0.0297	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0237	0.0246
Schistosoma mansoni	opsin-like receptor	0.007	0.0167	0.0195
Onchocerca volvulus		0.0053	0.0095	0.1028
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.004	0.0047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	somatostatin receptor	0.007	0.0167	0.0187
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2131	0.8551	1
Echinococcus multilocularis	fmrfamide receptor	0.007	0.0167	0.0187
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.004	0.0015
Echinococcus granulosus	chromobox protein 1	0.0221	0.078	0.0905
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.004	0.0015
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.004	0.0039
Schistosoma mansoni	biogenic amine receptor	0.007	0.0167	0.0195
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.004	0.0015
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.007	0.0167	0.0195
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Onchocerca volvulus	Alhambra homolog	0.0032	0.0009	0.0094
Echinococcus granulosus	peregrin	0.0032	0.0009	0.0002
Brugia malayi	mbt repeat family protein	0.0053	0.0095	0.0112
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.007	0.0167	0.0195
Mycobacterium ulcerans	lipoprotein LpqF	0.0343	0.1277	0.1344
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0237	0.0246
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.0167	0.0195
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0043	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0385	0.0671
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0691	0.2693	0.2664
Schistosoma mansoni	myelin transcription factor 1 myt1	0.006	0.0125	0.0146
Schistosoma mansoni	hypothetical protein	0.0036	0.0027	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0194	0.067	0.0632
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0009	0.001
Echinococcus granulosus	serotonin receptor	0.007	0.0167	0.0187
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0769	0.3012	0.3501
Echinococcus multilocularis	microtubule associated protein 2	0.0748	0.2924	0.3414
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Onchocerca volvulus		0.007	0.0167	0.1797
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.006	0.0125	0.0138
Trichomonas vaginalis	penicillin-binding protein, putative	0.0194	0.067	0.0754
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0194	0.067	0.1092
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0167	0.0187
Echinococcus multilocularis	sex peptide receptor	0.007	0.0167	0.0187
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2131	0.8551	0.8545
Loa Loa (eye worm)	hypothetical protein	0.1361	0.5419	0.9445
Loa Loa (eye worm)	TYRA-2 protein	0.007	0.0167	0.0291
Onchocerca volvulus		0.007	0.0167	0.1797
Schistosoma mansoni	cpg binding protein	0.0031	0.0007	0.0008
Echinococcus multilocularis	neuropeptide receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2487	1	1
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.2131	0.8551	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0691	0.2693	0.2664
Schistosoma mansoni	myosin xvIII	0.007	0.0167	0.0195
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0208	0.0728	0.0844
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.004	0.0015
Brugia malayi	RNA binding protein	0.0062	0.0132	0.0154
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0036	0.0034
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0148	0.0165
Echinococcus multilocularis	polycomb protein SCMH1	0.0053	0.0095	0.0104
Brugia malayi	Associated with TFs and helicases family protein	0.0036	0.0027	0.0032
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.0167	0.0291
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	serotonin receptor	0.007	0.0167	0.0187
Schistosoma mansoni	hypothetical protein	0.0032	0.0009	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Schistosoma mansoni	chromobox protein	0.0221	0.078	0.0913
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0148	0.0165
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.0167	0.0187
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0208	0.0728	0.0844
Brugia malayi	larval opioid receptor	0.007	0.0167	0.0195
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0148	0.0108
Echinococcus granulosus	g protein coupled receptor	0.007	0.0167	0.0187
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0148	0.0163
Schistosoma mansoni	opsin-like receptor	0.007	0.0167	0.0195
Brugia malayi	RE15519p	0.007	0.0167	0.0195
Echinococcus multilocularis	geminin	0.0171	0.0574	0.0664
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0098	0.0115
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0014	0.0009
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0053	0.0095	0.1028
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0691	0.2693	0.2664
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.2131	0.8551	1
Brugia malayi	follicle stimulating hormone receptor	0.007	0.0167	0.0195
Schistosoma mansoni	neuropeptide receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Brugia malayi	ORL1-like opioid receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0547	0.0953
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0167	0.0195
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Trichomonas vaginalis	D-aminoacylase, putative	0.0194	0.067	0.0754
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	G protein coupled receptor 139	0.007	0.0167	0.0187
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2131	0.8551	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0014	0.0017
Schistosoma mansoni	alpha glucosidase	0.0039	0.004	0.0047
Schistosoma mansoni	growth hormone secretagogue receptor	0.007	0.0167	0.0195
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0086	0.0069
Schistosoma mansoni	biogenic amine receptor	0.007	0.0167	0.0195
Echinococcus multilocularis	Chromo domain	0.0036	0.0027	0.0024
Echinococcus granulosus	g protein coupled receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	dro:myosuppressin receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Onchocerca volvulus	Neuropeptide F receptor homolog	0.007	0.0167	0.1797
Echinococcus granulosus	dro:myosuppressin receptor	0.007	0.0167	0.0187
Onchocerca volvulus		0.007	0.0167	0.1797
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0102	0.0297	0.0316
Schistosoma mansoni	alpha-glucosidase	0.0153	0.0502	0.0587
Echinococcus multilocularis	G-protein coupled receptor, putative	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	CHromoDomain protein family member	0.0038	0.0034	0.006
Onchocerca volvulus		0.007	0.0167	0.1797
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0014	0.0009
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.2131	0.8551	0.8545
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0167	0.0187
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2131	0.8551	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	neuropeptide receptor	0.007	0.0167	0.0195
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0014	0.0017
Loa Loa (eye worm)	beta-lactamase	0.0194	0.067	0.1168
Plasmodium falciparum	heterochromatin protein 1	0.0036	0.0027	0.0022
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0009	0.0015
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0194	0.067	0.1092
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.2131	0.8551	1
Brugia malayi	Dopamine receptor	0.007	0.0167	0.0195
Echinococcus multilocularis	orexin receptor type 2	0.007	0.0167	0.0187
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0194	0.067	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Schistosoma mansoni	amine GPCR	0.007	0.0167	0.0195
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.067	0.2606	0.5145
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0167	0.0195
Echinococcus multilocularis	muscleblind protein	0.0316	0.1165	0.1356
Schistosoma mansoni	alpha-glucosidase	0.0153	0.0502	0.0587
Onchocerca volvulus		0.0054	0.0098	0.106
Brugia malayi	neuropeptide F receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus granulosus	tumor protein p63	0.0366	0.137	0.1596
Echinococcus granulosus	g protein coupled receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	G protein-coupled receptor	0.007	0.0167	0.0195
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.007	0.0167	0.0195
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0027	0.0022
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.0602	0.0704
Schistosoma mansoni	hypothetical protein	0.0171	0.0574	0.0671
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	microtubule-associated protein tau	0.0748	0.2924	0.3419
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1361	0.5419	0.9445
Schistosoma mansoni	neuropeptide f receptor 76f	0.007	0.0167	0.0195
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.004	0.0037
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0602	0.0697
Schistosoma mansoni	hypothetical protein	0.007	0.0167	0.0195
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.007	0.0167	0.0187
Brugia malayi	Pre-SET motif family protein	0.0226	0.0801	0.0936
Brugia malayi	TAR-binding protein	0.0062	0.0132	0.0154
Onchocerca volvulus		0.007	0.0167	0.1797
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Onchocerca volvulus		0.007	0.0167	0.1797
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0167	0.0195
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	fmrfamide receptor	0.007	0.0167	0.0187
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0069	0.0162	0.0189
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.124	0.4926	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Onchocerca volvulus		0.0036	0.0027	0.0296
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0132	0.0154
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.0167	0.0187
Echinococcus granulosus	sex peptide receptor	0.007	0.0167	0.0187
Mycobacterium ulcerans	hypothetical protein	0.0194	0.067	0.0621
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	0.8545
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0769	0.3012	0.3522
Echinococcus granulosus	muscleblind protein	0.0316	0.1165	0.1356
Onchocerca volvulus		0.0194	0.067	0.7223
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2131	0.8551	0.8545
Echinococcus granulosus	chromobox protein 2	0.0036	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	beta-lactamase	0.0194	0.067	0.0783
Brugia malayi	Dopamine receptor protein 2	0.007	0.0167	0.0195
Brugia malayi	Serotonin receptor	0.007	0.0167	0.0195
Schistosoma mansoni	chromobox protein	0.0036	0.0027	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0132	0.0147
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	MH2 domain containing protein	0.0129	0.0407	0.0476
Brugia malayi	Melatonin receptor type 1A	0.007	0.0167	0.0195
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.0167	0.0291
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.009	0.0247	0.0289
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0095	0.0112
Onchocerca volvulus		0.007	0.0167	0.1797
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0167	0.0187
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0036	0.0027	0.0032
Brugia malayi	GnHR receptor homolog	0.007	0.0167	0.0195
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0036	0.0027	0.0024
Onchocerca volvulus		0.007	0.0167	0.1797
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0132	0.023
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0407	0.0709
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0124	0.0385	0.4149
Schistosoma mansoni	amine GPCR	0.007	0.0167	0.0195
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Echinococcus multilocularis	chromobox protein 2	0.0036	0.0027	0.0024
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0036	0.0027	0.0022
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	neuropeptide s receptor	0.007	0.0167	0.0187
Giardia lamblia	Kinase, PLK	0.0102	0.0297	0.0337
Echinococcus granulosus	Chromobox protein 3	0.0036	0.0027	0.0024
Echinococcus granulosus	hypothetical protein	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0276	0.0481
Echinococcus granulosus	g-protein coupled receptor	0.007	0.0167	0.0187
Brugia malayi	beta-lactamase family protein	0.0194	0.067	0.0783
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.007	0.0167	0.0195
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0167	0.0187
Trichomonas vaginalis	penicillin-binding protein, putative	0.0194	0.067	0.0754
Loa Loa (eye worm)	hypothetical protein	0.009	0.0247	0.043
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Echinococcus multilocularis	peregrin	0.0032	0.0009	0.0002
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0036	0.0027	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0124	0.0385	0.0419
Schistosoma mansoni	adenoreceptor	0.007	0.0167	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Brugia malayi	SET domain containing protein	0.0038	0.0035	0.0041
Brugia malayi	hypothetical protein	0.0164	0.0547	0.0639
Brugia malayi	neuropeptide F receptor	0.007	0.0167	0.0195
Echinococcus granulosus	neuropeptide FF receptor 2	0.007	0.0167	0.0187
Echinococcus granulosus	neuropeptide receptor	0.007	0.0167	0.0187
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Echinococcus granulosus	somatostatin receptor	0.007	0.0167	0.0187
Onchocerca volvulus		0.0194	0.067	0.7223
Schistosoma mansoni	neuropeptide receptor	0.007	0.0167	0.0195
Plasmodium vivax	heterochromatin protein 1, putative	0.0036	0.0027	0.0022
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.006	0.0125	0.0138
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.007	0.0167	0.0187
Echinococcus granulosus	beta LACTamase domain containing family member	0.0194	0.067	0.0776
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.0602	0.0697
Schistosoma mansoni	neuropeptide receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.007	0.0167	0.0291
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0316	0.1165	0.2031
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0132	0.0154
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.0167	0.0187
Trypanosoma brucei	polo-like protein kinase	0.0102	0.0297	0.0257
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2487	1	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0036	0.0027	0.0032
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0038	0.0034	0.0032
Schistosoma mansoni	cpg binding protein	0.0031	0.0007	0.0008
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1361	0.5419	0.6335
Echinococcus granulosus	G protein coupled receptor 139	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.004	0.0015
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.2131	0.8551	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0095	0.0112
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.2131	0.8551	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0167	0.0195
Onchocerca volvulus		0.0194	0.067	0.7223
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0112	0.0121
Echinococcus granulosus	L aminoadipate semialdehyde	0.009	0.0247	0.0281
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.007	0.0167	0.0291
Trypanosoma brucei	beta lactamase	0.0343	0.1277	0.1242
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2131	0.8551	0.8545
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0691	0.2693	0.2664
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Onchocerca volvulus		0.0164	0.0547	0.5893
Onchocerca volvulus		0.007	0.0167	0.1797
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0148	0.0173
Brugia malayi	chromobox protein homolog 3	0.0124	0.0385	0.045
Brugia malayi	Dopamine receptor protein 1	0.007	0.0167	0.0195
Trichomonas vaginalis	D-aminoacylase, putative	0.0194	0.067	0.0754
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0102	0.0297	0.0339
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0043	0.005
Loa Loa (eye worm)	melatonin receptor type 1A	0.007	0.0167	0.0291
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	0.8545
Onchocerca volvulus		0.007	0.0167	0.1797
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0297	0.0316
Brugia malayi	G-protein coupled receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0098	0.0171
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0194	0.067	0.0621
Schistosoma mansoni	chromobox protein	0.0036	0.0027	0.0032
Brugia malayi	putative neuropeptide receptor	0.007	0.0167	0.0195
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2131	0.8551	0.8545
Mycobacterium tuberculosis	Probable lipase LipE	0.0194	0.067	0.1092
Echinococcus granulosus	7TM GPCR rhodopsin	0.007	0.0167	0.0187
Trichomonas vaginalis	esterase, putative	0.0194	0.067	0.0754
Echinococcus multilocularis	chromobox protein 1	0.0221	0.078	0.0905
Trichomonas vaginalis	chromobox protein, putative	0.0221	0.078	0.0883
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2131	0.8551	1
Schistosoma mansoni	amine GPCR	0.007	0.0167	0.0195
Onchocerca volvulus		0.0103	0.0298	0.321
Echinococcus multilocularis	muscleblind protein 1	0.0316	0.1165	0.1356
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0036	0.0027	0.0022
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Brugia malayi	Serotonin receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0043	0.0074
Onchocerca volvulus		0.007	0.0167	0.1797
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.007	0.0167	0.0291
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0102	0.0297	0.0517
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	0.8545
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.0167	0.0291
Echinococcus multilocularis	neuropeptide receptor A26	0.007	0.0167	0.0187
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0343	0.1277	0.3138
Schistosoma mansoni	hypothetical protein	0.007	0.0167	0.0195
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0132	0.0154
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1361	0.5419	0.6326
Echinococcus granulosus	tachykinin peptides receptor 99D	0.007	0.0167	0.0187
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2487	1	1
Mycobacterium ulcerans	lipase LipD	0.0194	0.067	0.0621
Brugia malayi	hypothetical protein	0.0036	0.0027	0.0032
Mycobacterium tuberculosis	Conserved protein	0.0194	0.067	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0009	0.0015
Brugia malayi	G-protein coupled receptor	0.007	0.0167	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.007	0.0167	0.0195
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Trypanosoma brucei	hypothetical protein, conserved	0.0194	0.067	0.0632
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0132	0.0154
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0043	0.0055	0.0032
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2131	0.8551	0.8545
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1361	0.5419	0.9445
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	opsin-like receptor	0.007	0.0167	0.0195
Echinococcus granulosus	Chromo domain	0.0036	0.0027	0.0024
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0167	0.0187
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.007	0.0167	0.0187
Echinococcus multilocularis	neuropeptide FF receptor 2	0.007	0.0167	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0038	0.0034	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0042	0.0017
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.004	0.0039
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0038	0.0034	0.0032
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0036	0.0027	0.0022
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.004	0.0015
Echinococcus multilocularis	g-protein coupled receptor	0.007	0.0167	0.0187
Echinococcus granulosus	neuropeptide receptor A26	0.007	0.0167	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0014	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0014	0.0017
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0691	0.2693	0.315
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.0167	0.0187
Brugia malayi	Heterochromatin protein 1	0.0221	0.078	0.0913
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0194	0.067	0.1092
Loa Loa (eye worm)	heterochromatin protein 1	0.0221	0.078	0.136
Mycobacterium tuberculosis	Probable esterase LipL	0.0194	0.067	0.1092
Loa Loa (eye worm)	MBCTL1	0.006	0.0125	0.0218
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.006	0.0125	0.0146
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.007	0.0167	0.0195
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	0.8545
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1439	0.5737	1
Brugia malayi	sulfakinin receptor protein	0.007	0.0167	0.0195
Brugia malayi	putative neuropeptide receptor NPR1	0.007	0.0167	0.0195
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.0167	0.0195
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2131	0.8551	0.8545
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0101	0.0175
Schistosoma mansoni	alpha-1 adrenergic receptor	0.007	0.0167	0.0195
Plasmodium vivax	SET domain protein, putative	0.0033	0.0014	0.0007
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0715	0.2791	0.5532
Schistosoma mansoni	amine GPCR	0.007	0.0167	0.0195
Brugia malayi	G protein-coupled receptor F59B2.13	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Mycobacterium tuberculosis	Probable hydrolase	0.0194	0.067	0.1092
Schistosoma mansoni	histamine h1 receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2131	0.8551	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0132	0.023
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0027	0.0022
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.2131	0.8551	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.007	0.0167	0.0187
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0009	0.0002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.007	0.0167	0.0187
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0027	0.0022
Schistosoma mansoni	amine GPCR	0.007	0.0167	0.0195
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0043	0.005
Onchocerca volvulus		0.007	0.0167	0.1797
Onchocerca volvulus		0.007	0.0167	0.1797
Leishmania major	hypothetical protein, conserved	0.0194	0.067	0.0632
Echinococcus granulosus	neuropeptide s receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0095	0.0166
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0715	0.2791	0.3146
Brugia malayi	Protein cec-1.	0.0036	0.0027	0.0032
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0102	0.0297	0.0347
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.067	0.2606	1
Schistosoma mansoni	hypothetical protein	0.007	0.0167	0.0195
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2131	0.8551	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0167	0.0187
Toxoplasma gondii	ABC1 family protein	0.0194	0.067	0.0774
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.007	0.0167	0.0187
Echinococcus multilocularis	serotonin receptor	0.007	0.0167	0.0187
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0343	0.1277	0.2364
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Brugia malayi	jmjC domain containing protein	0.004	0.0043	0.005
Brugia malayi	Bromodomain containing protein	0.0032	0.0009	0.001
Schistosoma mansoni	hypothetical protein	0.0171	0.0574	0.0671
Echinococcus granulosus	peptide allatostatin:somatostatin	0.007	0.0167	0.0187
Loa Loa (eye worm)	mbt repeat family protein	0.0053	0.0095	0.0166
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2131	0.8551	0.8545
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0086	0.0069
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.0167	0.0291
Echinococcus granulosus	SAM and MBT domain containing protein	0.0053	0.0095	0.0104
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.004	0.0015
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0602	0.0697
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0014	0.0009
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.009	0.0247	0.0289
Echinococcus multilocularis	histone acetyltransferase MYST2	0.006	0.0125	0.0138
Echinococcus granulosus	7tm_1 domain containing protein	0.007	0.0167	0.0187
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0407	0.0709
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Onchocerca volvulus		0.0069	0.0162	0.1744
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.007	0.0167	0.0195
Echinococcus multilocularis	chromobox protein 1	0.0221	0.078	0.0905
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1361	0.5419	0.6335
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.2131	0.8551	1
Onchocerca volvulus		0.0036	0.0027	0.0296
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0132	0.0154
Schistosoma mansoni	biogenic amine receptor	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0027	0.0048
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.0801	0.1395
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1439	0.5737	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0194	0.067	0.0621
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.0167	0.0187
Echinococcus multilocularis	L aminoadipate semialdehyde	0.009	0.0247	0.0281
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.007	0.0167	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0194	0.067	0.1168
Onchocerca volvulus		0.007	0.0167	0.1797
Trichomonas vaginalis	chromobox protein, putative	0.0221	0.078	0.0883
Echinococcus granulosus	geminin	0.0171	0.0574	0.0664
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0102	0.0297	0.0257
Schistosoma mansoni	hypothetical protein	0.007	0.0167	0.0195
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.007	0.0167	0.0187
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2131	0.8551	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.007	0.0167	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0316	0.1165	0.2031
Schistosoma mansoni	hypothetical protein	0.0321	0.1188	0.139
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.007	0.0167	0.1797
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Onchocerca volvulus		0.0257	0.0927	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.004	0.0015
Brugia malayi	hypothetical protein	0.007	0.0167	0.0195
Brugia malayi	beta-lactamase family protein	0.0194	0.067	0.0783
Onchocerca volvulus		0.007	0.0167	0.1797
Mycobacterium tuberculosis	Probable lipase LipD	0.0194	0.067	0.1092
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.0927	0.1056
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0103	0.0301	0.0345
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0036	0.0027	0.0032
Mycobacterium tuberculosis	Conserved protein	0.0194	0.067	0.1092
Trichomonas vaginalis	chromobox protein, putative	0.0133	0.0423	0.0464
Brugia malayi	CHD4 protein	0.0038	0.0034	0.004
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0102	0.0297	0.32
Schistosoma mansoni	serine/threonine protein kinase	0.0102	0.0297	0.0347
Onchocerca volvulus		0.007	0.0167	0.1797
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0043	0.0055	0.0032
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.004	0.007
Echinococcus granulosus	polycomb protein SCMH1	0.0053	0.0095	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0194	0.067	0.1168
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.2131	0.8551	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.007	0.0167	0.0187
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.0167	0.0187
Brugia malayi	Valyl-tRNA synthetase	0.0036	0.0027	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.0167	0.0187
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.0167	0.0195
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2131	0.8551	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.007	0.0167	0.0195
Brugia malayi	Muscleblind-like protein	0.0316	0.1165	0.1363
Loa Loa (eye worm)	hypothetical protein	0.007	0.0167	0.0291
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0043	0.0055	0.0032
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0139	0.0163
Trichomonas vaginalis	chromobox protein, putative	0.0133	0.0423	0.0464
Echinococcus multilocularis	allatostatin A receptor	0.007	0.0167	0.0187
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0059	0.0061
Echinococcus granulosus	alpha 1A adrenergic receptor	0.007	0.0167	0.0187
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.0167	0.0187
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.004	0.0042	0.0017
Brugia malayi	jmjC domain containing protein	0.0103	0.0301	0.0352
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0059	0.0061
Echinococcus granulosus	neuropeptide receptor	0.007	0.0167	0.0187
Trichomonas vaginalis	conserved hypothetical protein	0.0124	0.0385	0.0419
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0039	0.004	0.0015
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.007	0.0167	0.0195
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0036	0.0027	0.0024
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0691	0.2693	0.2664
Echinococcus granulosus	microtubule associated protein 2	0.0748	0.2924	0.3414
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.0602	0.1049

Activities

Activity type	Activity value	Assay description	Source	Reference
Concentration (functional)	= 0.0001 M	Concentration required by the compound to pocesses agonistic activity in isolated rabbit aorta assay.	ChEMBL.	2918497
Concentration (functional)	= 60 ug min-1 kg-1	Concentration at which compound antagonizes increase in arterial pressure produced by angiotensin II	ChEMBL.	2918497
Control (functional)	= 6 %	Variation in mean arterial pressure, produced by angiotensin II upon administration of the compound at 60 ug/kg/min in rats; 6/3	ChEMBL.	2918497
Control (functional)	= 50 %	Variation in mean arterial pressure produced by angiotensin II, 5 min after administration of the compound (dose: 60 ug/kg/min) in rats; 50/5	ChEMBL.	2918497
Control (functional)	= 61 %	Variation in mean arterial pressureproduced by angiotensin II, 10 min after administration of the compound (dose: 60 ug/kg/min) in rats; 61/5	ChEMBL.	2918497
Control (functional)	= 78 %	Variation in mean arterial pressure produced by angiotensin II, 20 min after administration of the compound (dose: 60 ug/kg/min) in rats; 78/5	ChEMBL.	2918497
Control (functional)	= 91 %	Variation in mean arterial pressure produced by angiotensin II, 40 min after administration of the compound (dose: 60 ug/kg/min) in rats; 91/4	ChEMBL.	2918497
Control (functional)	= 91 %	Variation in mean arterial pressure produced by angiotensin II, 60 min after administration of the compound (dose: 60 ug/kg/min) in rats; 91/5	ChEMBL.	2918497
pA2 (functional)	= 7.63	Tested for antagonist activity in rabbit aortic rings, pA2 values were determined from Schild plots.	ChEMBL.	2918497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 348309

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 254999