Detailed information for compound 254999

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 854.011 | Formula: C40H63N13O8
  • H donors: 11 H acceptors: 9 LogP: -0.57 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: CNCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)N)Cc1nc[nH]c1)C(CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
  • InChi: 1S/C40H63N13O8/c1-6-23(4)33(38(60)50-29(18-25-19-45-21-47-25)39(61)53-16-8-10-30(53)34(41)56)52-36(58)28(17-24-11-13-26(54)14-12-24)49-37(59)32(22(2)3)51-35(57)27(48-31(55)20-44-5)9-7-15-46-40(42)43/h11-14,19,21-23,27-30,32-33,44,54H,6-10,15-18,20H2,1-5H3,(H2,41,56)(H,45,47)(H,48,55)(H,49,59)(H,50,60)(H,51,57)(H,52,58)(H4,42,43,46)
  • InChiKey: WDJJHCAFCXYZLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0167 0.0291
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0167 0.0291
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0167 0.0187
Onchocerca volvulus 0.007 0.0167 0.1797
Trichomonas vaginalis chromobox protein, putative 0.0221 0.078 0.0883
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0167 0.0291
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0038 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0027 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0043 0.005
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Schistosoma mansoni alpha glucosidase 0.0039 0.004 0.0047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0167 0.0195
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Brugia malayi jmjC domain containing protein 0.0103 0.0301 0.0352
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0095 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.067 0.0783
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0009 0.001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0167 0.0291
Schistosoma mansoni alpha-glucosidase 0.0153 0.0502 0.0587
Echinococcus multilocularis tumor protein p63 0.0366 0.137 0.1596
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis chromobox protein 1 0.0221 0.078 0.0905
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0343 0.1277 0.2364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0095 0.1028
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0148 0.0108
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0059 0.0061
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0247 0.0281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.0602 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.067 0.0632
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0027 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0167 0.0291
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0015
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0691 0.2693 0.2664
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0027 0.0022
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0167 0.0291
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2131 0.8551 0.8545
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.0297 0.0316
Brugia malayi neuropeptide F receptor 0.007 0.0167 0.0195
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0175
Echinococcus granulosus tar DNA binding protein 0.0062 0.0132 0.0147
Brugia malayi CHD4 protein 0.0038 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Brugia malayi putative neuropeptide receptor 0.007 0.0167 0.0195
Echinococcus granulosus neuropeptide receptor A26 0.007 0.0167 0.0187
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0167 0.0187
Echinococcus multilocularis somatostatin receptor 0.007 0.0167 0.0187
Onchocerca volvulus 0.0054 0.0098 0.106
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0043 0.005
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0042 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0167 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Brugia malayi TAR-binding protein 0.0062 0.0132 0.0154
Schistosoma mansoni chromobox protein 0.0221 0.078 0.0913
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.067 0.2606 0.5145
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1361 0.5419 0.6335
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0027 0.0022
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0167 0.0187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus multilocularis muscleblind protein 0.0316 0.1165 0.1356
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0167 0.0195
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0167 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0167 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0167 0.0187
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0043 0.0042
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0027 0.0024
Onchocerca volvulus 0.007 0.0167 0.1797
Mycobacterium ulcerans esterase/lipase LipP 0.0194 0.067 0.0621
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0055 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0237 0.0246
Mycobacterium ulcerans lipoprotein LpqF 0.0343 0.1277 0.1344
Brugia malayi AKH receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Onchocerca volvulus 0.0036 0.0027 0.0296
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0167 0.0187
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.067 0.2606 1
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0167 0.0187
Echinococcus granulosus orexin receptor type 2 0.007 0.0167 0.0187
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.004 0.007
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Brugia malayi G-protein coupled receptor 0.007 0.0167 0.0195
Echinococcus multilocularis serotonin receptor 0.007 0.0167 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Brugia malayi PHD-finger family protein 0.0032 0.0009 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0194 0.067 0.0621
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0167 0.0187
Schistosoma mansoni myosin xvIII 0.007 0.0167 0.0195
Schistosoma mansoni chromobox protein 0.0221 0.078 0.0913
Brugia malayi beta-lactamase family protein 0.0194 0.067 0.0783
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0167 0.0195
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0167 0.0195
Brugia malayi mbt repeat family protein 0.0053 0.0095 0.0112
Echinococcus multilocularis muscleblind protein 1 0.0316 0.1165 0.1356
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0769 0.3012 0.3522
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.0297 0.0347
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0098 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0423 0.0464
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Loa Loa (eye worm) hypothetical protein 0.0316 0.1165 0.2031
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0407 0.0709
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2131 0.8551 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Loa Loa (eye worm) hypothetical protein 0.0097 0.0276 0.0481
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2131 0.8551 0.5
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0343 0.1277 0.3138
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1361 0.5419 0.6335
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.067 0.0754
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Schistosoma mansoni histamine h1 receptor 0.007 0.0167 0.0195
Brugia malayi MH2 domain containing protein 0.0129 0.0407 0.0476
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0167 0.0291
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0027 0.0022
Brugia malayi beta-lactamase 0.0194 0.067 0.0783
Onchocerca volvulus 0.0257 0.0927 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0691 0.2693 0.2664
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0927 0.1056
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0167 0.0187
Brugia malayi jmjC domain containing protein 0.004 0.0043 0.005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.0297 0.0339
Brugia malayi G-protein coupled receptor 0.007 0.0167 0.0195
Echinococcus granulosus allatostatin A receptor 0.007 0.0167 0.0187
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0167 0.0187
Schistosoma mansoni hypothetical protein 0.0032 0.0009 0.001
Echinococcus granulosus chromobox protein 1 0.0221 0.078 0.0905
Onchocerca volvulus 0.0103 0.0298 0.321
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0125 0.0146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0132 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0125 0.0138
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.0297 0.0517
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi RNA binding protein 0.0062 0.0132 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.004 0.0047
Brugia malayi beta-lactamase family protein 0.0194 0.067 0.0783
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.0297 0.0257
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0148 0.0165
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Toxoplasma gondii ABC1 family protein 0.0194 0.067 0.0774
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0027 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0167 0.0195
Trypanosoma brucei beta lactamase 0.0343 0.1277 0.1242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0194 0.067 0.1092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0194 0.067 0.1168
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Onchocerca volvulus 0.007 0.0167 0.1797
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0167 0.0291
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0167 0.0187
Trypanosoma brucei polo-like protein kinase 0.0102 0.0297 0.0257
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis beta LACTamase domain containing family member 0.0194 0.067 0.0776
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.007 0.0167 0.1797
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0215 0.0251
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Loa Loa (eye worm) CHromoDomain protein family member 0.0038 0.0034 0.006
Brugia malayi GnHR receptor homolog 0.007 0.0167 0.0195
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0167 0.0195
Echinococcus granulosus hypothetical protein 0.007 0.0167 0.0187
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0027 0.0032
Brugia malayi Dopamine receptor 0.007 0.0167 0.0195
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus geminin 0.0171 0.0574 0.0664
Loa Loa (eye worm) hypothetical protein 0.1361 0.5419 0.9445
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0407 0.0709
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0132 0.0154
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Onchocerca volvulus 0.0194 0.067 0.7223
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0194 0.067 0.0783
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni adenoreceptor 0.007 0.0167 0.0195
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0167 0.0187
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) heterochromatin protein 1 0.0221 0.078 0.136
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0167 0.0195
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2131 0.8551 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0167 0.0291
Echinococcus granulosus chromobox protein 2 0.0036 0.0027 0.0024
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1361 0.5419 0.9445
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Brugia malayi Dopamine receptor protein 2 0.007 0.0167 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0162 0.0189
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0801 0.1395
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0167 0.0187
Schistosoma mansoni alpha-glucosidase 0.0153 0.0502 0.0587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Echinococcus granulosus neuropeptide receptor 0.007 0.0167 0.0187
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0043 0.0074
Schistosoma mansoni hypothetical protein 0.0321 0.1188 0.139
Brugia malayi Pre-SET motif family protein 0.0226 0.0801 0.0936
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.0728 0.0844
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0691 0.2693 0.2664
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1439 0.5737 1
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0167 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.007 0.0167 0.1797
Brugia malayi Heterochromatin protein 1 0.0221 0.078 0.0913
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus Alhambra homolog 0.0032 0.0009 0.0094
Brugia malayi sulfakinin receptor protein 0.007 0.0167 0.0195
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0167 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0014 0.0009
Mycobacterium ulcerans hypothetical protein 0.0194 0.067 0.0621
Brugia malayi Bromodomain containing protein 0.0032 0.0009 0.001
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0167 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0059 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0167 0.0187
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.004 0.0015
Echinococcus granulosus muscleblind protein 0.0316 0.1165 0.1356
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0691 0.2693 0.2664
Echinococcus multilocularis fmrfamide receptor 0.007 0.0167 0.0187
Brugia malayi mbt repeat family protein 0.0053 0.0095 0.0112
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0098 0.0171
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.0728 0.0844
Echinococcus granulosus g-protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0095 0.0166
Schistosoma mansoni hypothetical protein 0.0171 0.0574 0.0671
Trichomonas vaginalis chromobox protein, putative 0.0221 0.078 0.0883
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0247 0.0289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0167 0.0195
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0247 0.043
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.004 0.0039
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0167 0.0187
Schistosoma mansoni hypothetical protein 0.0171 0.0574 0.0671
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0167 0.0187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0769 0.3012 0.3501
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.004 0.0015
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0385 0.0419
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0148 0.0173
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.0097 0.0276 0.2973
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0014 0.0007
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Schistosoma mansoni cpg binding protein 0.0031 0.0007 0.0008
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1461 0.5825 0.6809
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0247 0.0289
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0133 0.0423 0.4562
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0095 0.0104
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0036 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.0167 0.1797
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0167 0.0187
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0715 0.2791 0.3146
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0125 0.0138
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0027 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0194 0.067 0.1092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0015
Echinococcus multilocularis sex peptide receptor 0.007 0.0167 0.0187
Echinococcus multilocularis Chromo domain 0.0036 0.0027 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0014 0.0009
Brugia malayi ORL1-like opioid receptor 0.007 0.0167 0.0195
Brugia malayi SET domain containing protein 0.0038 0.0035 0.0041
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Echinococcus granulosus microtubule associated protein 2 0.0748 0.2924 0.3414
Onchocerca volvulus 0.007 0.0167 0.1797
Onchocerca volvulus 0.007 0.0167 0.1797
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Leishmania major hypothetical protein, conserved 0.0194 0.067 0.0632
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0167 0.0195
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.0167 0.0187
Echinococcus multilocularis chromobox protein 2 0.0036 0.0027 0.0024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0167 0.0187
Echinococcus granulosus neuropeptide s receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0015
Echinococcus multilocularis serotonin receptor 0.007 0.0167 0.0187
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0423 0.0464
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0025
Brugia malayi Protein cec-1. 0.0036 0.0027 0.0032
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0027 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Brugia malayi G protein-coupled receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1361 0.5419 0.6326
Brugia malayi Pre-SET motif family protein 0.0033 0.0014 0.0017
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Echinococcus granulosus beta LACTamase domain containing family member 0.0194 0.067 0.0776
Mycobacterium ulcerans beta-lactamase 0.0194 0.067 0.0621
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0167 0.0187
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0148 0.0165
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0167 0.0291
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0715 0.2791 0.5532
Schistosoma mansoni hypothetical protein 0.0036 0.0027 0.0032
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) MBCTL1 0.006 0.0125 0.0218
Brugia malayi larval opioid receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.0297 0.0339
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0038 0.0034 0.0032
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptide s receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.0053 0.0095 0.0166
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Brugia malayi RE15519p 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0164 0.0547 0.0953
Echinococcus multilocularis orexin receptor type 2 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni chromobox protein 0.0036 0.0027 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0132 0.0147
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0194 0.067 0.0774
Trichomonas vaginalis esterase, putative 0.0194 0.067 0.0754
Brugia malayi Serotonin receptor 0.007 0.0167 0.0195
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2131 0.8551 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0148 0.0163
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Echinococcus multilocularis neuropeptide receptor 0.007 0.0167 0.0187
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.0167 0.1797
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0316 0.1165 0.2031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.067 0.0783
Echinococcus granulosus fmrfamide receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1439 0.5737 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1361 0.5419 0.9445
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0015
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2131 0.8551 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis chromobox protein 1 0.0221 0.078 0.0905
Brugia malayi follicle stimulating hormone receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.0164 0.0547 0.5893
Brugia malayi hypothetical protein 0.0164 0.0547 0.0639
Schistosoma mansoni kinase 0.0052 0.0092 0.0107
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0148 0.0173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0297 0.0347
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Echinococcus granulosus Chromobox protein 3 0.0036 0.0027 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.067 0.0754
Onchocerca volvulus 0.0194 0.067 0.7223
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0167 0.0195
Brugia malayi neuropeptide F receptor 0.007 0.0167 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.0022
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.004 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0086 0.0069
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0167 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.0748 0.2924 0.3414
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus sex peptide receptor 0.007 0.0167 0.0187
Onchocerca volvulus 0.009 0.0247 0.2661
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0027 0.0032
Echinococcus multilocularis peregrin 0.0032 0.0009 0.0002
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2131 0.8551 1
Echinococcus multilocularis allatostatin A receptor 0.007 0.0167 0.0187
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0027 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) beta-lactamase 0.0194 0.067 0.1168
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0237 0.0246
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0194 0.067 0.1092
Echinococcus granulosus chromobox protein 1 0.0221 0.078 0.0905
Echinococcus multilocularis fmrfamide receptor 0.007 0.0167 0.0187
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0014 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0167 0.0187
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis geminin 0.0171 0.0574 0.0664
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2131 0.8551 1
Mycobacterium tuberculosis Probable esterase LipL 0.0194 0.067 0.1092
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0194 0.067 0.0632
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Brugia malayi Muscleblind-like protein 0.0316 0.1165 0.1363
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptide receptor 0.007 0.0167 0.0187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0167 0.0187
Mycobacterium ulcerans lipase LipD 0.0194 0.067 0.0621
Onchocerca volvulus 0.0036 0.0027 0.0296
Mycobacterium tuberculosis Probable hydrolase 0.0194 0.067 0.1092
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Loa Loa (eye worm) hypothetical protein 0.0124 0.0385 0.0671
Giardia lamblia Kinase, PLK 0.0102 0.0297 0.0337
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0167 0.0195
Echinococcus granulosus serotonin receptor 0.007 0.0167 0.0187
Echinococcus granulosus tumor protein p63 0.0366 0.137 0.1596
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0297 0.0257
Onchocerca volvulus 0.0194 0.067 0.7223
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0095 0.0112
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0167 0.0195
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.0297 0.32
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0301 0.0345
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0055 0.0032
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0015
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0095 0.0104
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0691 0.2693 0.315
Onchocerca volvulus 0.007 0.0167 0.1797
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0112 0.0121
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.004 0.0039
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0139 0.0163
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0167 0.0195
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0167 0.0187
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0247 0.0281
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2131 0.8551 0.5
Schistosoma mansoni cpg binding protein 0.0031 0.0007 0.0008
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0167 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Mycobacterium tuberculosis Probable lipase LipE 0.0194 0.067 0.1092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0167 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.067 0.0632
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0125 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0167 0.0195
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0095 0.0112
Loa Loa (eye worm) RNA binding protein 0.0062 0.0132 0.023
Schistosoma mansoni microtubule-associated protein tau 0.0748 0.2924 0.3419
Brugia malayi hypothetical protein 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0125 0.0218
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0132 0.023
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0167 0.0187
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Brugia malayi Dopamine receptor protein 1 0.007 0.0167 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Plasmodium vivax SET domain protein, putative 0.0033 0.0014 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0009 0.0015
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0027 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0385 0.0419
Echinococcus granulosus somatostatin receptor 0.007 0.0167 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0086 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Brugia malayi chromobox protein homolog 3 0.0124 0.0385 0.045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0167 0.0187
Mycobacterium tuberculosis Possible penicillin-binding protein 0.124 0.4926 1
Schistosoma mansoni chromobox protein 0.0036 0.0027 0.0032
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0167 0.0187
Echinococcus granulosus Chromo domain 0.0036 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0125 0.0146
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0691 0.2693 0.2664
Brugia malayi Serotonin receptor 0.007 0.0167 0.0195
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0095 0.0112
Loa Loa (eye worm) helicase 0.0036 0.0027 0.0048
Echinococcus granulosus peregrin 0.0032 0.0009 0.0002
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0042 0.0017
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2131 0.8551 1
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0167 0.0187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1361 0.5419 0.6326
Onchocerca volvulus 0.0069 0.0162 0.1744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0297 0.0257
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.0602 0.1049
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0095 0.0104
Echinococcus granulosus neuropeptide receptor 0.007 0.0167 0.0187
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0124 0.0385 0.4149
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0301 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0146 0.0254
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0167 0.0195
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0194 0.067 0.1092
Onchocerca volvulus 0.0053 0.0095 0.1028
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi Melatonin receptor type 1A 0.007 0.0167 0.0195
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0125 0.0138

Activities

Activity type Activity value Assay description Source Reference
Concentration (functional) = 0.0001 M Concentration required by the compound to pocesses agonistic activity in isolated rabbit aorta assay. ChEMBL. 2918497
Concentration (functional) = 60 ug min-1 kg-1 Concentration at which compound antagonizes increase in arterial pressure produced by angiotensin II ChEMBL. 2918497
Control (functional) = 6 % Variation in mean arterial pressure, produced by angiotensin II upon administration of the compound at 60 ug/kg/min in rats; 6/3 ChEMBL. 2918497
Control (functional) = 50 % Variation in mean arterial pressure produced by angiotensin II, 5 min after administration of the compound (dose: 60 ug/kg/min) in rats; 50/5 ChEMBL. 2918497
Control (functional) = 61 % Variation in mean arterial pressureproduced by angiotensin II, 10 min after administration of the compound (dose: 60 ug/kg/min) in rats; 61/5 ChEMBL. 2918497
Control (functional) = 78 % Variation in mean arterial pressure produced by angiotensin II, 20 min after administration of the compound (dose: 60 ug/kg/min) in rats; 78/5 ChEMBL. 2918497
Control (functional) = 91 % Variation in mean arterial pressure produced by angiotensin II, 40 min after administration of the compound (dose: 60 ug/kg/min) in rats; 91/4 ChEMBL. 2918497
Control (functional) = 91 % Variation in mean arterial pressure produced by angiotensin II, 60 min after administration of the compound (dose: 60 ug/kg/min) in rats; 91/5 ChEMBL. 2918497
pA2 (functional) = 7.63 Tested for antagonist activity in rabbit aortic rings, pA2 values were determined from Schild plots. ChEMBL. 2918497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.