Detailed information for compound 264331

Basic information

Technical information
  • TDR Targets ID: 264331
  • Name: 8-methyl-6-(1,2,4-triazol-4-yl)-1H-quinolin-2 -one
  • MW: 226.234 | Formula: C12H10N4O
  • H donors: 1 H acceptors: 4 LogP: 1.7 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(n1)c(C)cc(c2)n1cnnc1
  • InChi: 1S/C12H10N4O/c1-8-4-10(16-6-13-14-7-16)5-9-2-3-11(17)15-12(8)9/h2-7H,1H3,(H,15,17)
  • InChiKey: KJHQKMKVNPPNHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-methyl-6-(1,2,4-triazol-4-yl)carbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0097 0.0461 0.1235
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0043 0.0487
Echinococcus multilocularis expressed conserved protein 0.0189 0.1024 0.1014
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0043 0.0089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0312 0.5895
Echinococcus multilocularis heat shock protein 0.0035 0.0082 0.0071
Echinococcus multilocularis protein patched 0.0086 0.0397 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0075 0.0119
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0163 0.095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.083
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0312 0.5795
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0035 0.0082 0.0827
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0626 0.3699 0.3692
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0035 0.0082 0.5
Echinococcus multilocularis snurportin 1 0.0282 0.1594 0.1584
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0066 0.0258
Trichomonas vaginalis pyruvate kinase, putative 0.0106 0.0516 0.3435
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0082 0.0222
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0043 0.0487
Plasmodium vivax endoplasmin, putative 0.0035 0.0082 0.1061
Plasmodium vivax pyruvate kinase 2, putative 0.0054 0.0201 0.3511
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0066 0.0098
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0082 0.037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0287 0.5171
Echinococcus multilocularis heat shock protein 90 0.0035 0.0082 0.0071
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0163 0.1084
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Trypanosoma cruzi hypothetical protein 0.0023 0.0012 0.0031
Schistosoma mansoni multidrug resistance protein 0.003 0.0055 0.0065
Leishmania major developmentally regulated phosphoprotein-like protein 0.0626 0.3699 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.032 0.0852
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.021 0.0484
Onchocerca volvulus Pyruvate kinase homolog 0.0106 0.0516 0.3242
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0043 0.0487
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.003 0.0055 0.0148
Echinococcus multilocularis pyruvate kinase 0.0054 0.0201 0.019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0154 0.0404
Mycobacterium leprae Probable pyruvate kinase PykA 0.0106 0.0516 1
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Schistosoma mansoni pyruvate dehydrogenase 0.0591 0.3486 0.9325
Plasmodium falciparum pyruvate kinase 2 0.0054 0.0201 0.3511
Chlamydia trachomatis pyruvate kinase 0.0106 0.0516 1
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0771 0.2074
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0125 0.0305
Leishmania major mitochondrial DNA topoisomerase II 0.0035 0.0082 0.0222
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0163 0.2724
Echinococcus multilocularis microtubule associated protein 2 0.0632 0.3736 0.3729
Schistosoma mansoni pyruvate kinase 0.0054 0.0201 0.046
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.1627 0.4337
Echinococcus granulosus GPCR family 2 0.0047 0.0154 0.0384
Brugia malayi hypothetical protein 0.0483 0.2823 0.763
Loa Loa (eye worm) multidrug resistance-associated protein 0.0024 0.0013 0.0021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0287 0.0276
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0082 0.037
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0055 0.0498
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0035 0.0082 0.0546
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0032 0.0065 0.0161
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0043 0.0255
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0066 0.0179
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0066 0.0179
Schistosoma mansoni hypothetical protein 0.0083 0.0378 0.0937
Brugia malayi ABC transporter transmembrane region family protein 0.003 0.0055 0.0134
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0031 0.0019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0066 0.0055
Giardia lamblia Pyruvate kinase 0.0054 0.0201 0.3194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0125 0.0256
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.018 0.0973 0.2621
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0134
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0035 0.0082 0.0827
Brugia malayi heat shock protein 90 0.0035 0.0082 0.0208
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.013
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Entamoeba histolytica ABC transporter, putative 0.003 0.0055 0.0498
Toxoplasma gondii pyruvate kinase PyKII 0.0054 0.0201 0.1225
Schistosoma mansoni hypothetical protein 0.0098 0.0472 0.119
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0461 0.1235
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0043 0.0116
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0138 0.1839
Trichomonas vaginalis DNA topoisomerase II, putative 0.0035 0.0082 0.0546
Schistosoma mansoni heat shock protein 0.0035 0.0082 0.0139
Brugia malayi Pre-SET motif family protein 0.0234 0.1303 0.3513
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0287 0.0693
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.0461 0.8853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0125 0.0256
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0219 0.1208 0.3266
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0154 0.0143
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0082 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0102
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.1099 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.003 0.0055 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0287 0.0693
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0043 0.0034
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0035 0.0082 0.0189
Loa Loa (eye worm) hypothetical protein 0.0147 0.0771 0.2074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0287 0.5408
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0035 0.0082 0.0546
Entamoeba histolytica pyruvate kinase, putative 0.0074 0.032 0.2911
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0066 0.0147
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0287 0.1847
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0035 0.0082 0.0071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0287 0.5406
Loa Loa (eye worm) hypothetical protein 0.0483 0.2823 0.763
Echinococcus multilocularis pyruvate kinase 0.0106 0.0516 0.0505
Entamoeba histolytica hypothetical protein 0.0114 0.0566 0.5153
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.003 0.0055 0.0134
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0461 0.8853
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.1099 0.2961
Mycobacterium ulcerans pyruvate kinase 0.0106 0.0516 1
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0066 0.0258
Mycobacterium ulcerans two component sensor kinase MprB 0.0035 0.0082 0.0827
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0043 0.0089
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0125 0.0325
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0461 0.1247
Echinococcus granulosus heat shock protein 90 0.0035 0.0082 0.0189
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.0868 0.2259
Onchocerca volvulus 0.0267 0.1501 1
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Echinococcus multilocularis pyruvate kinase 0.0054 0.0201 0.019
Leishmania major DNA topoisomerase ii 0.0035 0.0082 0.0222
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0043 0.0391
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0043 0.0116
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0035 0.0082 0.0208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0125 0.0114
Plasmodium vivax DNA gyrase subunit B, putative 0.0035 0.0082 0.1061
Leishmania major hypothetical protein, conserved 0.0035 0.0082 0.0222
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0069
Plasmodium vivax DNA topoisomerase II, putative 0.0035 0.0082 0.1061
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0055 0.0498
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0043 0.0034
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0106 0.0516 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0134
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0066 0.0055
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0035 0.0082 0.0827
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0287 0.5171
Loa Loa (eye worm) endoplasmin 0.0035 0.0082 0.0208
Onchocerca volvulus 0.0098 0.0472 0.294
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0066 0.0959
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0287 0.5408
Loa Loa (eye worm) hypothetical protein 0.0201 0.1099 0.2961
Toxoplasma gondii pyruvate kinase PyK1 0.0106 0.0516 0.3488
Giardia lamblia MRP-like ABC transporter 0.003 0.0055 0.0033
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.1099 0.292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0287 0.5408
Loa Loa (eye worm) acetyltransferase 0.0163 0.0868 0.2335
Leishmania major pentamidine resistance protein 1 0.003 0.0055 0.0148
Schistosoma mansoni heat shock protein 0.0035 0.0082 0.0139
Echinococcus granulosus heat shock protein 0.0035 0.0082 0.0189
Schistosoma mansoni hypothetical protein 0.0047 0.0154 0.0334
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0035 0.0082 0.0222
Onchocerca volvulus 0.0056 0.021 0.1144
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0043 0.0089
Echinococcus granulosus pyruvate kinase 0.0054 0.0201 0.0508
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0626 0.3699 0.9901
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0035 0.0082 0.0268
Entamoeba histolytica DNA topoisomerase II, putative 0.0035 0.0082 0.0746
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0055 0.0498
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0154 0.0143
Echinococcus granulosus microtubule associated protein 2 0.0632 0.3736 1
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0626 0.3699 0.3692
Schistosoma mansoni hypothetical protein 0.0114 0.0566 0.1446
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0043 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0461 0.4198
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0461 0.8853
Entamoeba histolytica hypothetical protein 0.0114 0.0566 0.5153
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.003 0.0055 0.0148
Trichomonas vaginalis sensor histidine kinase, putative 0.0035 0.0082 0.0546
Toxoplasma gondii DNA topoisomerase 2, putative 0.0035 0.0082 0.037
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0043 0.0255
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0035 0.0082 0.0268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0287 0.5171
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0075 0.0317
Brugia malayi RNA, U transporter 1 0.0075 0.0328 0.0875
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0066 0.0166
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0461 0.8853
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.1099 0.1089
Mycobacterium ulcerans two component regulator - sensor kinase 0.0035 0.0082 0.0827
Trypanosoma brucei p-glycoprotein 0.003 0.0055 0.0066
Trichomonas vaginalis pyruvate kinase, putative 0.0106 0.0516 0.3435
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0043 0.0487
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0066 0.0055
Schistosoma mansoni pyruvate dehydrogenase 0.0591 0.3486 0.9325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0125 0.0256
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0075 0.0063
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0035 0.0082 0.0268
Echinococcus granulosus multidrug resistance associated protein 1 0.003 0.0055 0.0116
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0287 0.0777
Loa Loa (eye worm) pyruvate kinase 0.0106 0.0516 0.1382
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0043 0.0116
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0219 0.1208 0.8468
Loa Loa (eye worm) hypothetical protein 0.018 0.0973 0.2621
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0066 0.0097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0102
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0035 0.0082 0.0222
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0066 0.0055
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0043 0.0033
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0082 0.014
Echinococcus granulosus tumor protein p63 0.038 0.2197 0.5868
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0082 0.1061
Loa Loa (eye worm) hypothetical protein 0.0097 0.0461 0.1235
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0035 0.0082 0.0827
Loa Loa (eye worm) hypothetical protein 0.0101 0.0486 0.1301
Loa Loa (eye worm) hypothetical protein 0.018 0.0973 0.2621
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0082 0.1061
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0287 0.074
Plasmodium falciparum DNA topoisomerase 2 0.0035 0.0082 0.1061
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.0461 0.8909
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Trypanosoma brucei DNA topoisomerase ii 0.0035 0.0082 0.014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0106 0.0516 0.1394
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0082 0.0546
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0163 0.0406
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0461 0.1235
Giardia lamblia Pyruvate kinase 0.0106 0.0516 1
Schistosoma mansoni microtubule-associated protein tau 0.0632 0.3736 1
Mycobacterium ulcerans hypothetical protein 0.0097 0.0461 0.8853
Loa Loa (eye worm) hypothetical protein 0.0047 0.0154 0.0404
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0461 0.1247
Schistosoma mansoni hypothetical protein 0.0083 0.0378 0.0937
Schistosoma mansoni hypothetical protein 0.0083 0.0378 0.0937
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0461 0.1247
Echinococcus granulosus multidrug resistance associated protein 7 0.003 0.0055 0.0116
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0035 0.0082 0.1274
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0035 0.0082 0.0827
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0771 0.2074
Entamoeba histolytica multidrug resistance protein, putative 0.003 0.0055 0.0498
Echinococcus granulosus pyruvate kinase 0.0106 0.0516 0.1353
Entamoeba histolytica hypothetical protein 0.003 0.0055 0.0498
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.083
Schistosoma mansoni pyruvate dehydrogenase 0.0626 0.3699 0.99
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0035 0.0082 0.1274
Brugia malayi kinase, mitochondrial precursor 0.0626 0.3699 1
Brugia malayi CHE-14 protein 0.0086 0.0397 0.106
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0397 0.0386
Loa Loa (eye worm) TOPoisomerase family member 0.0035 0.0082 0.0208
Leishmania major p-glycoprotein e 0.003 0.0055 0.0148
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0043 0.0031
Loa Loa (eye worm) pyruvate kinase-PB 0.0074 0.032 0.0852
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0082 0.0222
Mycobacterium ulcerans putative regultory protein 0.0035 0.0082 0.0827
Trypanosoma brucei pyruvate kinase 1, putative 0.0106 0.0516 0.1322
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0055 0.0066
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0082 0.0546
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0035 0.0082 0.5
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0035 0.0082 0.014
Echinococcus granulosus importin subunit beta 1 0.0026 0.0031 0.0051
Echinococcus multilocularis GPCR, family 2 0.0047 0.0154 0.0143
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0082 0.0222
Mycobacterium leprae Probable two-component sensor kinase 0.0035 0.0082 0.0827
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0035 0.0082 0.1274
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0035 0.0082 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0075 0.0119
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0312 0.5795
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0397 0.1034
Echinococcus granulosus pyruvate kinase 0.0054 0.0201 0.0508
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0566 0.149
Schistosoma mansoni survival motor neuron protein 0.0098 0.0472 0.119
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0254 0.1421 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.0461 0.8853
Schistosoma mansoni hypothetical protein 0.0047 0.0154 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0397 0.2644
Schistosoma mansoni DNA topoisomerase II 0.0035 0.0082 0.0139
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0154 0.0404
Plasmodium vivax pyruvate kinase, putative 0.0106 0.0516 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0125 0.0305
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0461 0.1235
Echinococcus granulosus expressed conserved protein 0.0189 0.1024 0.272
Brugia malayi multidrug resistance related protein 1 0.003 0.0055 0.0134
Schistosoma mansoni pyruvate kinase 0.0106 0.0516 0.1309
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0461 0.4198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Brugia malayi Pre-SET motif family protein 0.0034 0.0075 0.0188
Brugia malayi Probable DNA topoisomerase II 0.0035 0.0082 0.0208
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0035 0.0082 0.0827
Brugia malayi Pyruvate kinase, muscle isozyme 0.0106 0.0516 0.1382
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0066 0.0738
Schistosoma mansoni pyruvate kinase 0.0106 0.0516 0.1309
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0035 0.0082 0.1274
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0472 0.1263
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0075 0.0063
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0082 0.0222
Toxoplasma gondii hypothetical protein 0.018 0.0973 0.678
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0219 0.1208 0.3209
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0397 0.106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0125 0.0114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0461 0.8909
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Giardia lamblia Pms1-like protein 0.0035 0.0082 0.0624
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0043 0.0286
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0055 0.0066
Loa Loa (eye worm) pyruvate kinase 0.0106 0.0516 0.1382
Onchocerca volvulus 0.0097 0.0461 0.287
Trypanosoma cruzi pyruvate kinase 2, putative 0.0106 0.0516 0.1394
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.0868 0.2335
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0082 0.0222
Trypanosoma cruzi DNA topoisomerase II, putative 0.0035 0.0082 0.0222
Onchocerca volvulus Pyruvate kinase homolog 0.0106 0.0516 0.3242
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0163 0.095
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0043 0.0116
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0082 0.014
Plasmodium falciparum endoplasmin, putative 0.0035 0.0082 0.1061
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0397 0.1034
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0055 0.0033
Trichomonas vaginalis receptor histidine kinase, putative 0.0035 0.0082 0.0546
Schistosoma mansoni hypothetical protein 0.0101 0.0486 0.1228
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0055 0.0148
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0035 0.0082 0.037
Loa Loa (eye worm) pyruvate kinase 0.0106 0.0516 0.1382
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.084 0.2223
Brugia malayi Pyruvate kinase, M2 isozyme 0.0106 0.0516 0.1382
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0035 0.0082 0.1274
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0043 0.0487
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Trichomonas vaginalis receptor histidine kinase, putative 0.0035 0.0082 0.0546
Trypanosoma cruzi multidrug resistance protein E, putative 0.003 0.0055 0.0148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0312 0.5685
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.0461 0.8853
Echinococcus granulosus snurportin 1 0.0282 0.1594 0.4249
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0035 0.0082 0.1274
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Echinococcus multilocularis multidrug resistance associated protein 7 0.003 0.0055 0.0043
Brugia malayi isocitrate dehydrogenase 0.0032 0.0066 0.0166
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Schistosoma mansoni endoplasmin 0.0035 0.0082 0.0139
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0035 0.0082 0.0208
Mycobacterium tuberculosis Probable two component sensor kinase 0.0035 0.0082 0.1274
Echinococcus granulosus pyruvate kinase 0.0106 0.0516 0.1353
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0035 0.0082 0.1274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0075 0.0119
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0282 0.1594 0.4301
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0486 0.1301
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0035 0.0082 0.0546
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.1627 0.1617
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0035 0.0082 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0075 0.0188
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0035 0.0082 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0461 0.8853
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0043 0.0116
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Schistosoma mansoni multidrug resistance protein 0.003 0.0055 0.0065
Brugia malayi Endoplasmin precursor 0.0035 0.0082 0.0208
Loa Loa (eye worm) hypothetical protein 0.0086 0.0397 0.106
Trypanosoma brucei heat shock protein, putative 0.0035 0.0082 0.014
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0043 0.0116
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0035 0.0082 0.037
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0082 0.0624
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0082 0.0546
Mycobacterium ulcerans DNA gyrase subunit B 0.0035 0.0082 0.0827
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.0461 0.4198
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0055 0.0173
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0066 0.0166
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0154 0.0384
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0566 0.0555
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0043 0.0116
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.1303 0.3513
Loa Loa (eye worm) hypothetical protein 0.0097 0.0461 0.1235
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0626 0.3699 1
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.2823 0.2815
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0043 0.0102
Loa Loa (eye worm) hypothetical protein 0.018 0.0973 0.2621
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0082 0.0746
Loa Loa (eye worm) hypothetical protein 0.0106 0.0516 0.1382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0771 0.2074
Mycobacterium tuberculosis Possible two component sensor kinase 0.0035 0.0082 0.1274
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0055 0.0498
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0102
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0035 0.0082 0.0827
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0125 0.0325
Echinococcus multilocularis pyruvate kinase 0.0083 0.0379 0.0368
Onchocerca volvulus 0.0033 0.007 0.0182
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.1274
Brugia malayi hypothetical protein 0.0114 0.0566 0.1519
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.0554
Schistosoma mansoni hypothetical protein 0.0282 0.1594 0.4219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0208
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0035 0.0082 0.0827
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.003 0.0055 0.0148
Schistosoma mansoni endoplasmin 0.0035 0.0082 0.0139
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0566 0.1446
Loa Loa (eye worm) hypothetical protein 0.0106 0.0516 0.1382
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0066 0.0055
Plasmodium falciparum DNA gyrase subunit B 0.0035 0.0082 0.1061
Entamoeba histolytica hypothetical protein 0.0114 0.0566 0.5153
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0035 0.0082 0.1274
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0035 0.0082 0.5
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0035 0.0082 0.5
Plasmodium vivax SET domain protein, putative 0.0034 0.0075 0.0909
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.0868 0.0857
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0066 0.0738
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0043 0.0487
Trypanosoma brucei multidrug resistance protein E 0.003 0.0055 0.0066
Mycobacterium leprae Probable two component sensor kinase MprB 0.0035 0.0082 0.0827
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.003 0.0055 0.0148
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0055 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.2823 0.755
Trypanosoma brucei developmentally regulated phosphoprotein 0.0626 0.3699 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0043 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0075 0.0119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0067 0.0149
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0066 0.0179
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0138 0.2219
Plasmodium falciparum pyruvate kinase 0.0106 0.0516 1
Entamoeba histolytica hypothetical protein 0.0114 0.0566 0.5153
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0035 0.0082 0.0827
Giardia lamblia ABC transporter, putative 0.003 0.0055 0.0033
Echinococcus multilocularis pyruvate kinase 0.0054 0.0201 0.019
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0043 0.0487
Schistosoma mansoni hypothetical protein 0.0083 0.0378 0.0937
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0287 0.5408
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.083
Schistosoma mansoni patched 1 0.0086 0.0397 0.0989
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0043 0.0487
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0035 0.0082 0.1274
Leishmania major pyruvate kinase 0.0106 0.0516 0.1394
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0066 0.0098
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0035 0.0082 0.1274
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0154 0.0404
Leishmania major pyruvate kinase 0.0106 0.0516 0.1394
Trichomonas vaginalis set domain proteins, putative 0.0267 0.1501 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.1118 0.2935
Loa Loa (eye worm) oxidoreductase 0.0028 0.0043 0.0102
Schistosoma mansoni multidrug resistance protein 0.003 0.0055 0.0065
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0035 0.0082 0.1061
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0043 0.0487
Schistosoma mansoni multidrug resistance protein 0.003 0.0055 0.0065
Schistosoma mansoni hypothetical protein 0.0047 0.0154 0.0334
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0075 0.0169
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0082 0.0208
Onchocerca volvulus Pyruvate kinase homolog 0.0106 0.0516 0.3242
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0043 0.0487
Schistosoma mansoni hypothetical protein 0.0047 0.0154 0.0334
Echinococcus multilocularis protein dispatched 1 0.0098 0.0471 0.046
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0043 0.0102
Echinococcus granulosus pyruvate kinase 0.0054 0.0201 0.0508
Leishmania major ABC-thiol transporter 0.003 0.0055 0.0148
Brugia malayi Importin beta-1 subunit 0.0026 0.0031 0.0069
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0055 0.0148
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0035 0.0082 0.1274
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0043 0.0286
Loa Loa (eye worm) hypothetical protein 0.0626 0.3699 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0138 0.1257
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0035 0.0082 0.014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0163 0.1084
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0035 0.0082 0.0546
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0219 0.1208 0.3266
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0461 0.8853
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0312 0.5296
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0082 0.0746
Leishmania major heat shock protein 83-1 0.0035 0.0082 0.0222
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0035 0.0082 0.0827
Trypanosoma cruzi DNA topoisomerase II, putative 0.0035 0.0082 0.0222
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0154 0.0384
Plasmodium falciparum heat shock protein 90 0.0035 0.0082 0.1061
Echinococcus multilocularis pyruvate kinase 0.0106 0.0516 0.0505
Trypanosoma brucei pyruvate kinase 1 0.0106 0.0516 0.1322
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.0461 0.8853
Loa Loa (eye worm) hypothetical protein 0.0072 0.0312 0.083
Onchocerca volvulus 0.0034 0.0075 0.0218
Echinococcus multilocularis tumor protein p63 0.038 0.2197 0.2188
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0035 0.0082 0.0222
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0082 0.0222

Activities

Activity type Activity value Assay description Source Reference
Decrease in QA interval (functional) = 15 ms Compound was examined for effects on cardiac contractility after oral administration of 0.25 mg/Kg to conscious dogs for 1 hr ChEMBL. 2537423
Decrease in QA interval (functional) = 17 ms Compound was examined for effects on cardiac contractility to decrease in QA interval after oral administration of 0.25 mg/Kg to conscious dogs for 3h ChEMBL. 2537423
Increase in dP/dt max (functional) = 68 % Compound was tested for cardiotonic activity after intravenous administration of 50 ug/Kg to anesthetized dogs ChEMBL. 2537423
Relative inotropic potency (functional) = 2.3 Relative inotropic potency compared with 4-[4-[2-(1,1-dioxo-2-isothiazolidinyl)ethyl]-1-piperidinyl]-6,7-dimethoxyquinazoline at 50 ug/kg after administration at 25 ug/kg intravenously to anesthetized dogs ChEMBL. 2537423

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.