Detailed information for compound 267984

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.445 | Formula: C21H28O4
  • H donors: 2 H acceptors: 3 LogP: 5.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1cc(O)c2c(c1)OC([C@H]1C2CC(=CC1)C(=O)O)(C)C
  • InChi: 1S/C21H28O4/c1-4-5-6-7-13-10-17(22)19-15-12-14(20(23)24)8-9-16(15)21(2,3)25-18(19)11-13/h8,10-11,15-16,22H,4-7,9,12H2,1-3H3,(H,23,24)/t15?,16-/m1/s1
  • InChiKey: OGXXAQFMAFTSRU-OEMAIJDKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0947 0.4152 0.4152
Mycobacterium leprae conserved hypothetical protein 0.0123 0.0471 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0146 0.0572 0.0572
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0123 0.0471 0.0522
Schistosoma mansoni cpg binding protein 0.0071 0.0237 0.0279
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0123 0.0471 0.0522
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1914 0.8469 0.8469
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0572 0.0572
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0042 0.0013
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0123 0.0471 0.0471
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0146 0.0572 0.0642
Echinococcus granulosus geminin 0.0198 0.0804 0.0804
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Leishmania major calcium channel protein, putative,ion transporter, putative 0.2257 1 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0146 0.0572 0.0675
Schistosoma mansoni hypothetical protein 0.0123 0.0471 0.0557
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0146 0.0572 0.0656
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0123 0.0471 0.0471
Echinococcus granulosus voltage gated potassium channel 0.0146 0.0572 0.0572
Brugia malayi cation channel family protein 0.0146 0.0572 0.0656
Echinococcus granulosus two pore calcium channel protein 2 0.0146 0.0572 0.0572
Echinococcus multilocularis dnaJ subfamily B 0.0956 0.4189 0.4189
Toxoplasma gondii transporter, cation channel family protein 0.0146 0.0572 0.0867
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0146 0.0572 0.0867
Echinococcus granulosus dnaJ subfamily B 0.0956 0.4189 0.4189
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0522
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0031 0.0016
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1522 0.672 0.7927
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0042 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0642 0.2787 0.3276
Loa Loa (eye worm) voltage-gated calcium channel 0.0146 0.0572 0.0655
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0146 0.0572 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.0985 0.1131
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Echinococcus granulosus TRP transient receptor potential channel 0.0146 0.0572 0.0572
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0362 0.1537 0.1785
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1524 0.6727 0.7935
Echinococcus multilocularis two pore calcium channel protein 1 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0362 0.1537 0.1797
Schistosoma mansoni voltage-gated cation channel 0.0146 0.0572 0.0675
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1914 0.8469 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0493 0.0741
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0522
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0146 0.0572 0.0867
Echinococcus granulosus two pore calcium channel protein 1 0.0146 0.0572 0.0572
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0123 0.0471 0.0557
Trypanosoma cruzi target of rapamycin kinase 3 0.1524 0.6727 0.7935
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0123 0.0471 0.0471
Echinococcus granulosus hypothetical protein 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.4536 0.5339
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Echinococcus multilocularis geminin 0.0198 0.0804 0.0804
Schistosoma mansoni 60S ribosomal protein L21 0.0146 0.0572 0.0675
Entamoeba histolytica hypothetical protein 0.0042 0.0108 0.0091
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0123 0.0471 0.0522
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.007 0.0047
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0146 0.0572 0.0656
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.0471 0.0557
Toxoplasma gondii FATC domain-containing protein 0.0362 0.1537 0.2411
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0146 0.0572 0.0656
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Leishmania major phosphatidylinositol 3-kinase, putative 0.0642 0.2787 0.2765
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0146 0.0572 0.0656
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1132 0.4977 0.5862
Echinococcus multilocularis shaker cognate 0.0146 0.0572 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0403 0.1721 0.2004
Echinococcus multilocularis two pore calcium channel protein 2 0.0146 0.0572 0.0572
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0146 0.0572 0.0572
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0146 0.0572 0.0572
Echinococcus multilocularis voltage gated potassium channel 0.0146 0.0572 0.0572
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1914 0.8469 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0471 0.0706
Giardia lamblia Hypothetical protein 0.0123 0.0471 0.0522
Brugia malayi RNA, U transporter 1 0.0096 0.0348 0.0391
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0146 0.0572 0.0656
Echinococcus multilocularis hyperpolarization activated cyclic 0.0146 0.0572 0.0572
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0146 0.0572 0.0572
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0146 0.0572 0.0572
Toxoplasma gondii target of rapamycin (TOR), putative 0.1424 0.6278 1
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0146 0.0572 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.2787 0.3266
Echinococcus granulosus importin subunit beta 1 0.0034 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.0123 0.0471 0.0522
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Echinococcus multilocularis calcium activated potassium channel 0.0146 0.0572 0.0572
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0123 0.0471 0.0471
Echinococcus multilocularis sodium channel protein 0.2257 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.0471 0.0522
Loa Loa (eye worm) phosphatidylinositol 3 0.0123 0.0471 0.0536
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0123 0.0471 0.0471
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0123 0.0471 0.0471
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.007 0.007
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0146 0.0572 0.0656
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0123 0.0471 0.0522
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0146 0.0572 0.0572
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0905 0.3963 0.466
Brugia malayi Pre-SET motif family protein 0.0036 0.0082 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.1914 0.8469 1
Brugia malayi cation channel family protein 0.0146 0.0572 0.0656
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0062
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Echinococcus multilocularis hyperpolarization activated cyclic 0.0146 0.0572 0.0572
Brugia malayi hypothetical protein 0.0146 0.0572 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.0471 0.0522
Schistosoma mansoni hypothetical protein 0.0198 0.0804 0.0949
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0471 0.0522
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0146 0.0572 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.0471 0.0522
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0642 0.2787 0.3266
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0123 0.0471 0.0471
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0522
Echinococcus granulosus serine protein kinase ATM 0.0362 0.1537 0.1537
Echinococcus granulosus calcium activated potassium channel 0.0146 0.0572 0.0572
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0146 0.0572 0.0656
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0082 0.0083
Toxoplasma gondii transporter, cation channel family protein 0.0146 0.0572 0.0867
Onchocerca volvulus 0.0067 0.022 0.1272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0097
Loa Loa (eye worm) phosphatidylinositol 3 0.0123 0.0471 0.0536
Plasmodium vivax hypothetical protein 0.0123 0.0471 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0146 0.0572 0.0572
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0146 0.0572 0.0675
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0362 0.1537 0.1815
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0146 0.0572 0.0572
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0123 0.0471 1
Schistosoma mansoni hypothetical protein 0.028 0.117 0.1381
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0146 0.0572 0.0642
Loa Loa (eye worm) hypothetical protein 0.039 0.1662 0.1945
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0123 0.0471 0.0557
Plasmodium vivax hypothetical protein, conserved 0.0123 0.0471 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Leishmania major hypothetical protein, unknown function 0.0123 0.0471 0.0442
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0146 0.0572 0.0675
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.007 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.4536 0.5339
Echinococcus multilocularis conserved hypothetical protein 0.0146 0.0572 0.0572
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0146 0.0572 0.0675
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0123 0.0471 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0146 0.0572 0.0655
Leishmania major hypothetical protein, conserved 0.0146 0.0572 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.1132 0.4977 0.5862
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1524 0.6727 0.6717
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0572 0.0572
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0362 0.1537 0.1537
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0642 0.2787 0.3266
Echinococcus granulosus short transient receptor potential channel 6 0.0146 0.0572 0.0572
Loa Loa (eye worm) ryanodine receptor 0.0146 0.0572 0.0655
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0123 0.0471 0.0522
Loa Loa (eye worm) phosphatidylinositol kinase 0.0123 0.0471 0.0536
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0471 0.0522
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1914 0.8469 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.022 0.0238
Entamoeba histolytica protein kinase rad3, putative 0.0362 0.1537 0.1785
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0146 0.0572 0.0642
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0146 0.0572 0.0675
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0642 0.2787 0.3266
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0642 0.2787 0.3266
Onchocerca volvulus 0.0278 0.1163 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0146 0.0572 0.4533
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0146 0.0572 0.0572
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0362 0.1537 0.1785
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0123 0.0471 0.0522
Loa Loa (eye worm) ion channel NompC 0.0146 0.0572 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0123 0.0471 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0442
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0042 0.0013
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0146 0.0572 0.0655
Schistosoma mansoni cpg binding protein 0.0067 0.022 0.0259
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.007 0.0064
Echinococcus multilocularis 0.0123 0.0471 0.0471
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0471 0.0706
Schistosoma mansoni ran 0.0025 0.0031 0.0036
Echinococcus granulosus voltage gated hydrogen channel 1 0.0146 0.0572 0.0572
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0146 0.0572 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.1522 0.672 0.7927
Echinococcus multilocularis potassium large conductance calcium activated 0.0146 0.0572 0.0572
Entamoeba histolytica hypothetical protein 0.0042 0.0108 0.0091
Loa Loa (eye worm) calcium channel 0.0146 0.0572 0.0655
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0123 0.0471 0.0557
Schistosoma mansoni voltage-dependent calcium channel 0.0146 0.0572 0.0675
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0123 0.0471 0.0522
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0642 0.2787 0.2765
Loa Loa (eye worm) phosphatidylinositol 3 0.1914 0.8469 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0471 0.0522
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0522
Schistosoma mansoni transient receptor potential channel 4 0.0146 0.0572 0.0675
Echinococcus granulosus ryanodine receptor 44f 0.0146 0.0572 0.0572
Brugia malayi Importin beta-1 subunit 0.0034 0.007 0.0063
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.028 0.117 0.117
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Loa Loa (eye worm) voltage-dependent calcium channel 0.0146 0.0572 0.0655
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Brugia malayi olfactory channel protein osm-9 0.0146 0.0572 0.0656
Brugia malayi Pre-SET motif family protein 0.0245 0.1012 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.2787 0.3266
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.1032 0.4529 0.5331
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0362 0.1537 0.1785
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0572 0.0572
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0146 0.0572 0.0572
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0082 0.0097
Brugia malayi ion channel NompC 0.0146 0.0572 0.0656
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0146 0.0572 0.0656
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0642 0.2787 0.2787
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0042 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0123 0.0471 0.0538
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0572 0.0572
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Brugia malayi Transient-receptor-potential like protein 0.0146 0.0572 0.0656
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0146 0.0572 0.0572
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0146 0.0572 0.0572
Entamoeba histolytica hypothetical protein 0.0123 0.0471 0.0522
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0123 0.0471 0.0471
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0362 0.1537 0.1798
Schistosoma mansoni transient receptor potential channel 0.0146 0.0572 0.0675
Loa Loa (eye worm) hypothetical protein 0.0403 0.1721 0.2015
Giardia lamblia GTOR 0.1914 0.8469 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0097
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0123 0.0471 0.0471
Schistosoma mansoni two-pore calcium channel 0.0146 0.0572 0.0675
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0362 0.1537 0.1785
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0956 0.4189 0.4946
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0572 0.0572
Brugia malayi FAT domain containing protein 0.028 0.117 0.1364
Trichomonas vaginalis PIKK family atypical protein kinase 0.1144 0.5028 0.5922
Schistosoma mansoni fkbp-rapamycin associated protein 0.0362 0.1537 0.1815
Loa Loa (eye worm) voltage-gated potassium channel 0.0146 0.0572 0.0655
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0146 0.0572 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.1522 0.672 0.7927
Echinococcus granulosus shaker cognate 0.0146 0.0572 0.0572
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1914 0.8469 0.8469
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0123 0.0471 1
Plasmodium falciparum importin beta, putative 0.0034 0.007 0.0901
Entamoeba histolytica hypothetical protein 0.0042 0.0108 0.0091
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0536
Schistosoma mansoni hypothetical protein 0.0146 0.0572 0.0675
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0146 0.0572 0.0675
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0146 0.0572 0.0572
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis set domain proteins, putative 0.0278 0.1163 0.1341
Echinococcus multilocularis serine protein kinase ATM 0.0362 0.1537 0.1537
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0146 0.0572 0.0572
Onchocerca volvulus 0.0123 0.0471 0.3603
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0362 0.1537 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.5654 0.6665
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.1012 0.1176
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0471 0.0522
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0123 0.0471 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0146 0.0572 0.0656
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0146 0.0572 0.0655
Echinococcus multilocularis ryanodine receptor 44f 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1144 0.5028 0.5922
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.028 0.117 0.1363
Loa Loa (eye worm) hypothetical protein 0.0239 0.0985 0.1144
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0146 0.0572 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.4536 0.5339
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0146 0.0572 0.0572
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.0471 0.0557
Echinococcus multilocularis sodium leak channel non selective protein 0.0146 0.0572 0.0572
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0146 0.0572 0.0572
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0239 0.0985 0.1131
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0795 0.3471 0.4077
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Echinococcus multilocularis importin subunit beta 1 0.0034 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0123 0.0471 0.0522
Echinococcus granulosus voltage gated potassium channel 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1914 0.8469 1
Echinococcus multilocularis voltage dependent calcium channel 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0123 0.0471 0.0522
Echinococcus multilocularis transfer RNA-Gly 0.0146 0.0572 0.0572
Echinococcus granulosus transient receptor potential gamma protein 0.0146 0.0572 0.0572
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0123 0.0471 0.0522
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1914 0.8469 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0018 0.0018
Onchocerca volvulus 0.0123 0.0471 0.3603
Trichomonas vaginalis PIKK family atypical protein kinase 0.1634 0.7219 0.8519
Entamoeba histolytica hypothetical protein 0.0362 0.1537 0.1785
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0146 0.0572 0.4533
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0642 0.2787 0.2787
Leishmania major hypothetical protein, unknown function 0.0146 0.0572 0.0543
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.0471 0.0522
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0471 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.1144 0.5028 0.5922
Schistosoma mansoni hypothetical protein 0.036 0.1526 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.1522 0.672 0.7927
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0362 0.1537 0.1537
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.028 0.117 0.135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0642 0.2787 0.3277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0985 0.1131
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.547 0.6446
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0123 0.0471 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.2787 0.3266
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0146 0.0572 0.0656
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0123 0.0471 0.0522
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Plasmodium vivax SET domain protein, putative 0.0036 0.0082 0.117
Toxoplasma gondii hypothetical protein 0.0146 0.0572 0.0867
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0146 0.0572 0.0675
Entamoeba histolytica hypothetical protein 0.0123 0.0471 0.0522
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0146 0.0572 0.0572
Toxoplasma gondii hypothetical protein 0.0146 0.0572 0.0867
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0123 0.0471 0.0471
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0123 0.0471 0.0471
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0123 0.0471 0.0522
Leishmania major phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0442
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0572 0.0572
Schistosoma mansoni transient receptor potential channel 0.0146 0.0572 0.0675
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0031 0.0015
Echinococcus multilocularis cpg binding protein 0.0071 0.0237 0.0237
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0514 0.2214 0.2587
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0123 0.0471 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.0471 0.0557
Echinococcus granulosus potassium large conductance calcium activated 0.0146 0.0572 0.0572
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0146 0.0572 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0082 0.0082
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.2257 1 1
Onchocerca volvulus 0.0146 0.0572 0.4533
Trichomonas vaginalis PIKK family atypical protein kinase 0.1032 0.4529 0.5331
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0146 0.0572 0.0675
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0642 0.2787 0.3291
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0146 0.0572 0.0572
Echinococcus granulosus voltage dependent calcium channel 0.0146 0.0572 0.0572
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0108 0.0108
Echinococcus granulosus voltage dependent calcium channel 0.0146 0.0572 0.0572
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0144 0.0561 0.0663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0471 0.0538
Echinococcus granulosus sodium leak channel non selective protein 0.0146 0.0572 0.0572
Plasmodium vivax importin-beta 2, putative 0.0034 0.007 0.0901
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0146 0.0572 0.0572
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0471 0.0706
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0471 0.0706
Brugia malayi voltage-dependent calcium channel 0.0146 0.0572 0.0656
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0123 0.0471 0.0471
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 0.1526 0.1784
Echinococcus granulosus short transient receptor potential channel 6 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.2787 0.3266
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0146 0.0572 0.0675
Brugia malayi Cyclic-nucleotide gated cation channel 0.0146 0.0572 0.0656
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1914 0.8469 1
Entamoeba histolytica hypothetical protein 0.0042 0.0108 0.0091
Schistosoma mansoni importin beta-1 0.0034 0.007 0.0083
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0572 0.0642
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Echinococcus granulosus hyperpolarization activated cyclic 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0123 0.0471 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0146 0.0572 0.0572
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0471 0.0522
Schistosoma mansoni calcium-activated potassium channel 0.0146 0.0572 0.0675
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0123 0.0471 0.0471
Echinococcus multilocularis short transient receptor potential channel 6 0.0146 0.0572 0.0572
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0146 0.0572 0.0572
Schistosoma mansoni hypothetical protein 0.0042 0.0108 0.0127
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.028 0.117 0.117
Leishmania major hypothetical protein, conserved 0.0123 0.0471 0.0442
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0123 0.0471 0.0522
Loa Loa (eye worm) voltage-gated potassium channel 0.0146 0.0572 0.0655
Schistosoma mansoni vesicular amine transporter 0.0146 0.0572 0.0675
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0572 0.0572
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0108 0.0127
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1914 0.8469 0.8464
Leishmania major phosphatidylinositol kinase, putative 0.0123 0.0471 0.0442
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0123 0.0471 0.0522
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0123 0.0471 0.0522
Echinococcus granulosus snurportin 1 0.036 0.1526 0.1526
Schistosoma mansoni voltage-gated ion channel 0.0146 0.0572 0.0675
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0123 0.0471 0.0522
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0642 0.2787 0.3266
Schistosoma mansoni transient receptor potential channel 0.0146 0.0572 0.0675
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0123 0.0471 0.0557
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0362 0.1537 0.1798
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Echinococcus granulosus cpg binding protein 0.0071 0.0237 0.0237
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0146 0.0572 0.0572
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Brugia malayi CXXC zinc finger family protein 0.0067 0.022 0.024
Schistosoma mansoni hypothetical protein 0.0198 0.0804 0.0949
Loa Loa (eye worm) phosphatidylinositol 3 0.0123 0.0471 0.0536
Echinococcus multilocularis transient receptor potential gamma protein 0.0146 0.0572 0.0572
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0146 0.0572 0.0656
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1914 0.8469 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0031 0.0031
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0146 0.0572 0.0675
Brugia malayi hypothetical protein 0.0042 0.0108 0.0107
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.0471 0.5
Echinococcus multilocularis Zinc finger, PHD finger 0.0123 0.0471 0.0471
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1914 0.8469 0.8464
Schistosoma mansoni cpg binding protein 0.0071 0.0237 0.0279
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0471 0.0442
Schistosoma mansoni ran 0.0025 0.0031 0.0036
Echinococcus granulosus hyperpolarization activated cyclic 0.0146 0.0572 0.0572
Echinococcus multilocularis voltage gated potassium channel 0.0146 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1914 0.8469 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0471 0.0522
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0471 0.0706
Schistosoma mansoni ryanodine receptor related 0.0146 0.0572 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0362 0.1537 0.1785
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0123 0.0471 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.1522 0.672 0.7927
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0123 0.0471 0.0522
Giardia lamblia Phosphatidylinositol 4-kinase 0.0123 0.0471 0.0522
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Leishmania major phosphatidylinositol kinase related protein, putative 0.0123 0.0471 0.0442
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0362 0.1537 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.1032 0.4529 0.5331
Echinococcus granulosus transient receptor potential cation channel 0.0146 0.0572 0.0572
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0146 0.0572 0.0572
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0146 0.0572 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.1914 0.8469 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0108 0.0108
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0146 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.4536 0.5339
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0536
Leishmania major importin beta-1 subunit, putative 0.0027 0.0042 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.6278 0.7404
Echinococcus multilocularis transient receptor potential cation channel 0.0146 0.0572 0.0572
Toxoplasma gondii transporter, cation channel family protein 0.0146 0.0572 0.0867
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0572 0.0675
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0146 0.0572 0.0656
Loa Loa (eye worm) hypothetical protein 0.0146 0.0572 0.0655
Entamoeba histolytica hypothetical protein 0.0027 0.0042 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1914 0.8469 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0471 0.0522
Loa Loa (eye worm) phosphatidylinositol 3 0.0123 0.0471 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0097
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0082 0.0082
Echinococcus multilocularis snurportin 1 0.036 0.1526 0.1526
Loa Loa (eye worm) phosphatidylinositol 3 0.0123 0.0471 0.0536
Echinococcus multilocularis voltage dependent calcium channel 0.0146 0.0572 0.0572
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0403 0.1721 0.2706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.0471 0.0522

Activities

Activity type Activity value Assay description Source Reference
No. of rabbits convulsed (functional) = 0 Number of rabbits convulsed at 1 mg/kg,iv out of 3 rabbits tested ChEMBL. 7086846
No. of rabbits convulsed (functional) = 0 Number of rabbits convulsed at 5 mg/kg,iv out of 1 rabbit tested ChEMBL. 7086846
No. of rabbits convulsed (functional) = 0 Number of rabbits convulsed at 10 mg/kg,iv out of 1 rabbit tested ChEMBL. 7086846
No. of rabbits convulsed (functional) = 2 Number of rabbits convulsed at 20 mg/kg,iv out of 2 rabbits tested ChEMBL. 7086846
Relative potency (functional) = 0.3 Capability to induce convulsions in tetrahydrocannabinol-seizure susceptible (THC-SS) rabbit ChEMBL. 7086846
Relative potency (functional) = 0.3 Capability to induce convulsions in tetrahydrocannabinol-seizure susceptible (THC-SS) rabbit ChEMBL. 7086846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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