Detailed information for compound 272627

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 295.251 | Formula: C11H13N5O5
  • H donors: 5 H acceptors: 8 LogP: -1.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC([C@H]([C@@H]1O)O)Nc1ncnc2c1ncnc2O
  • InChi: 1S/C11H13N5O5/c17-1-4-7(18)8(19)11(21-4)16-9-5-6(13-2-14-9)10(20)15-3-12-5/h2-4,7-8,11,17-19H,1H2,(H,12,15,20)(H,13,14,16)/t4?,7-,8?,11?/m0/s1
  • InChiKey: KNRIBILRNJYSTR-CNFMFTKYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0717 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Onchocerca volvulus 0.0062 0.0219 0.0662
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0044 0.0133
Trichomonas vaginalis ribonuclease H1, putative 0.0424 0.2538 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0022
Onchocerca volvulus 0.0041 0.0085 0.0123
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0085 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0216 0.0851
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0351 0.0952
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0112 0.0542 0.1595
Schistosoma mansoni phosphoglucomutase 0.0424 0.2538 0.251
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0037 0.0064
Onchocerca volvulus Ribonuclease H1 homolog 0.0424 0.2538 1
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0036 0.0055 0.0044
Treponema pallidum ribonuclease H (rnhA) 0.0424 0.2538 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0085 0.0212
Brugia malayi reverse transcriptase 0.0036 0.0055 0.0133
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0351 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.025 0.0984
Brugia malayi hypothetical protein 0.0082 0.0351 0.1021
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0036 0.0055 0.0215
Trypanosoma cruzi target of rapamycin kinase 3 0.0082 0.0346 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Schistosoma mansoni immunophilin 0.006 0.0207 0.0171
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.006 0.0207 0.1932
Onchocerca volvulus 0.0041 0.0085 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0091 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Trypanosoma brucei ingi protein (ORF1) 0.046 0.2768 0.2761
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0091 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0044 0.0173
Entamoeba histolytica hypothetical protein 0.0082 0.0351 0.6677
Mycobacterium tuberculosis Conserved protein 0.0041 0.0085 0.0212
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0096 0.0086
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0036 0.0055 0.0044
Brugia malayi Importin beta-1 subunit 0.0033 0.0037 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0085 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0264 0.104
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0219 0.0634
Loa Loa (eye worm) hypothetical protein 0.0139 0.0712 0.2112
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1028 0.2871
Trypanosoma cruzi ribonuclease H1, putative 0.0424 0.2538 1
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0036 0.0055 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.07
Echinococcus granulosus lamin 0.0062 0.0219 0.0579
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0085 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.048 0.1891
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0103 0.048 0.1858
Brugia malayi reverse transcriptase 0.0036 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0216 0.0851
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.046 0.2768 0.2761
Schistosoma mansoni phosphoglucomutase 0.0424 0.2538 0.251
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.014 0.0717 0.199
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Loa Loa (eye worm) hypothetical protein 0.0551 0.3344 1
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0085 0.0212
Brugia malayi beta-lactamase family protein 0.0041 0.0085 0.0224
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.1492 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.0702
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0091 0.036
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.0717 0.0683
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.006 0.0207 0.0546
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.006 0.0207 0.0197
Leishmania major hypothetical protein, conserved 0.0041 0.0085 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.0702
Onchocerca volvulus Huntingtin homolog 0.0139 0.0712 0.2648
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0085 0.0212
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0037 0.0027
Echinococcus granulosus KRAB A domain containing protein 0.0036 0.0055 0.0113
Schistosoma mansoni phosphoglucomutase 0.0424 0.2538 0.251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.048 0.1891
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0091 0.036
Brugia malayi beta-lactamase family protein 0.0041 0.0085 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0037 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0085 0.0212
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0085 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0216 0.0851
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0091 0.036
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0085 0.0296
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0091 0.036
Brugia malayi hypothetical protein 0.0551 0.3344 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0717 1
Loa Loa (eye worm) FKBP5 protein 0.006 0.0207 0.0599
Brugia malayi Muscleblind-like protein 0.0175 0.0944 0.28
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0085 0.0212
Schistosoma mansoni survival motor neuron protein 0.0112 0.0542 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Loa Loa (eye worm) hypothetical protein 0.0175 0.0944 0.2806
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0091 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Brugia malayi RNase H family protein 0.0424 0.2538 0.758
Brugia malayi hypothetical protein 0.0036 0.0055 0.0133
Schistosoma mansoni protein kinase 0.0036 0.0055 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0085 0.0048
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0103 0.048 0.1858
Schistosoma mansoni alpha glucosidase 0.0042 0.0091 0.0054
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0036 0.0055 0.0215
Trypanosoma brucei ribonuclease H1 0.0424 0.2538 0.253
Echinococcus multilocularis muscleblind protein 0.0175 0.0944 0.2631
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0082 0.0346 0.1329
Brugia malayi RNase H family protein 0.0424 0.2538 0.758
Loa Loa (eye worm) beta-lactamase 0.0041 0.0085 0.0233
Giardia lamblia GTOR 0.0103 0.048 0.1713
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0154 0.0396
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0036 0.0055 0.0113
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.006 0.0207 1
Schistosoma mansoni alpha-glucosidase 0.0162 0.0861 0.0826
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.014 0.0717 0.199
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.006 0.0207 0.0546
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0091 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0346 0.1362
Giardia lamblia Ribonuclease H 0.0424 0.2538 1
Echinococcus multilocularis survival motor neuron protein 1 0.0551 0.3344 0.943
Leishmania major ribonuclease H1, putative 0.0424 0.2538 1
Mycobacterium leprae Probable lipase LipE 0.0041 0.0085 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.0044 0.011
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1028 0.2871
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0085 0.0335
Echinococcus granulosus importin subunit beta 1 0.0033 0.0037 0.0064
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0044 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.048 0.1408
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.0044 0.0034
Trypanosoma cruzi ribonuclease H1, putative 0.0424 0.2538 1
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.0717 0.0683
Trypanosoma brucei hypothetical protein, conserved 0.046 0.2768 0.2761
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0424 0.2538 0.5
Toxoplasma gondii ABC1 family protein 0.0041 0.0085 0.0296
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0103 0.048 0.1858
Leishmania major fk506-binding protein 1-like protein 0.006 0.0207 0.0779
Echinococcus multilocularis ribonuclease H1 0.0424 0.2538 0.7145
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.006 0.0207 0.0615
Schistosoma mansoni hypothetical protein 0.0582 0.3546 0.3522
Mycobacterium tuberculosis Conserved protein 0.0041 0.0085 0.0212
Schistosoma mansoni hypothetical protein 0.0036 0.0055 0.0017
Brugia malayi hypothetical protein 0.0036 0.0055 0.0133
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0036 0.0055 0.0113
Schistosoma mansoni immunophilin 0.006 0.0207 0.0171
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.006 0.0207 0.0615
Entamoeba histolytica hypothetical protein 0.0082 0.0351 0.6677
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0034 0.0044 0.0034
Loa Loa (eye worm) phosphatidylinositol 3 0.0103 0.048 0.1416
Onchocerca volvulus 0.0109 0.0521 0.1877
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0103 0.048 0.1858
Brugia malayi RNA, U transporter 1 0.0095 0.043 0.1259
Echinococcus multilocularis geminin 0.0582 0.3546 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.006 0.0207 0.0779
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0034 0.0044 0.0083
Onchocerca volvulus Huntingtin homolog 0.0139 0.0712 0.2648
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Echinococcus granulosus survival motor neuron protein 1 0.0551 0.3344 0.943
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0346 0.1362
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.006 0.0207 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Schistosoma mansoni intermediate filament proteins 0.0062 0.0219 0.0182
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0036 0.0076
Trypanosoma brucei unspecified product 0.046 0.2768 0.2761
Trypanosoma brucei glucosidase, putative 0.0042 0.0091 0.0081
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0103 0.048 0.047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0036 0.0084
Brugia malayi RNase H family protein 0.0424 0.2538 0.758
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0044 0.0133
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Brugia malayi Zinc knuckle family protein 0.0036 0.0055 0.0133
Echinococcus granulosus snurportin 1 0.0356 0.2099 0.5904
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1028 0.3059
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0103 0.048 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0085 0.0212
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0085 0.3795
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0036 0.0055 0.0113
Toxoplasma gondii aldehyde dehydrogenase 0.014 0.0717 0.2798
Echinococcus granulosus muscleblind protein 0.0175 0.0944 0.2631
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0037 0.0106
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Schistosoma mansoni lamin 0.0062 0.0219 0.0182
Trichomonas vaginalis reverse transcriptases, putative 0.0036 0.0055 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0384 0.1513
Plasmodium vivax importin-beta 2, putative 0.0033 0.0037 0.1362
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0103 0.048 0.047
Echinococcus granulosus intermediate filament protein 0.0062 0.0219 0.0579
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.006 0.0207 0.2983
Entamoeba histolytica hypothetical protein 0.0082 0.0351 0.6677
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0091 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.0702
Brugia malayi hypothetical protein 0.0036 0.0055 0.0133
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0103 0.048 0.0444
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0055 0.0175
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0036 0.0055 0.0044
Echinococcus multilocularis fk506 binding protein 0.006 0.0207 0.0546
Loa Loa (eye worm) hypothetical protein 0.0061 0.0212 0.0612
Entamoeba histolytica hypothetical protein 0.0082 0.0351 0.6677
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0085 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0044 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0085 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0055 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0085 0.0335
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0717 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0089
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0103 0.048 0.1318
Trichomonas vaginalis immunophilin, putative 0.006 0.0207 0.0816
Schistosoma mansoni hypothetical protein 0.0356 0.2099 0.207
Schistosoma mansoni lamin 0.0062 0.0219 0.0182
Echinococcus multilocularis muscleblind protein 1 0.0175 0.0944 0.2631
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0091 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0346 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0212 0.0836
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0091 0.036
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.07
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.006 0.0207 0.0779
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0103 0.048 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Brugia malayi beta-lactamase 0.0041 0.0085 0.0224
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0091 0.032
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1028 0.3053
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0091 0.036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0351 0.0952
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0049 0.0134 0.0124
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.006 0.0207 0.059
Plasmodium falciparum importin beta, putative 0.0033 0.0037 0.1362
Onchocerca volvulus 0.0062 0.0219 0.0662
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Echinococcus multilocularis RNA directed DNA polymerase 0.0036 0.0055 0.0113
Toxoplasma gondii ribonuclease HI protein 0.0424 0.2538 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0219 0.0634
Brugia malayi hypothetical protein 0.0139 0.0712 0.2105
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0219 0.0625
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0091 0.0251
Echinococcus granulosus RNA directed DNA polymerase 0.0036 0.0055 0.0113
Echinococcus granulosus ribonuclease H1 0.0424 0.2538 0.7145
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0085 0.02
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.014 0.0717 0.2798
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.006 0.0207 0.0779
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Toxoplasma gondii target of rapamycin (TOR), putative 0.0076 0.0312 0.1193
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.014 0.0717 0.4613
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Brugia malayi intermediate filament protein 0.0062 0.0219 0.0625
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.0702
Echinococcus multilocularis lamin 0.0062 0.0219 0.0579
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0034 0.0044 0.0007
Leishmania major peptidylprolyl isomerase-like protein 0.006 0.0207 0.0779
Loa Loa (eye worm) hypothetical protein 0.0177 0.0957 0.2845
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.006 0.0207 0.0779
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0082 0.0346 0.0336
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0085 0.0224
Loa Loa (eye worm) hypothetical protein 0.0175 0.0944 0.2806
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0085 0.0212
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0036 0.0055 0.0113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0441
Trichomonas vaginalis reverse transcriptases, putative 0.0036 0.0055 0.0215
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0036 0.0055 0.0113
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.2099 0.6269
Trypanosoma brucei RNA helicase, putative 0.1592 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0034 0.0044 0.0133
Onchocerca volvulus 0.0112 0.0542 0.1963
Brugia malayi reverse transcriptase 0.0036 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.048 0.1891
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0034 0.0044 0.0083
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0103 0.048 0.1318
Echinococcus multilocularis lamin dm0 0.0062 0.0219 0.0579
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0219 0.0634
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.006 0.0207 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.006 0.0207 0.0816
Echinococcus granulosus lamin dm0 0.0062 0.0219 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0044 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0312 0.1229
Trypanosoma brucei ingi protein (ORF1) 0.046 0.2768 0.2761
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0091 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0085 0.0335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0044 0.0101
Brugia malayi Zinc knuckle family protein 0.0036 0.0055 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0085 0.0296
Trichomonas vaginalis fk506-binding protein, putative 0.006 0.0207 0.0816
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0085 0.0075
Echinococcus multilocularis snurportin 1 0.0356 0.2099 0.5904
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0036 0.0055 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0346 0.1362
Brugia malayi hypothetical protein 0.0036 0.0055 0.0133
Brugia malayi hypothetical protein 0.0177 0.0957 0.2838
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.006 0.0207 0.0546
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0091 0.032
Trichomonas vaginalis esterase, putative 0.0041 0.0085 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0178 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0212 0.0836
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.006 0.0207 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0044 0.0173
Brugia malayi Pao retrotransposon peptidase family protein 0.0036 0.0055 0.0133
Schistosoma mansoni hypothetical protein 0.0082 0.0351 0.0315
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0154 0.0396
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0091 0.0217
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.006 0.0207 0.0197
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.006 0.0207 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0044 0.0173
Schistosoma mansoni immunophilin 0.0052 0.0154 0.0118
Echinococcus multilocularis musashi 0.0062 0.0219 0.0579
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1028 0.2871
Onchocerca volvulus 0.0177 0.0957 0.3633
Schistosoma mansoni hypothetical protein 0.0112 0.0542 0.0507
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0085 0.0212
Schistosoma mansoni alpha-glucosidase 0.0162 0.0861 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0346 0.1362
Echinococcus granulosus geminin 0.0582 0.3546 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.006 0.0207 0.0171
Schistosoma mansoni hypothetical protein 0.0582 0.3546 0.3522
Schistosoma mansoni hypothetical protein 0.0036 0.0055 0.0017
Onchocerca volvulus 0.0041 0.0085 0.0123
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.006 0.0207 0.2983
Loa Loa (eye worm) hypothetical protein 0.0139 0.0712 0.2112

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 98.2 % Effect of the compound on de novo purine biosynthesis when [14C]-formate was incorporated to WI-L2 cells at 50 uM with preincubation time of 8 h ChEMBL. 2918511
Control (functional) = 105.9 % Effect of the compound on de novo purine biosynthesis when [14C]-formate was incorporated to WI-L2 media at 50 uM with preincubation time of 8 h ChEMBL. 2918511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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