TDR Targets

Basic information

Technical information

TDR Targets ID: 273645
Name: 2-(2-bromophenyl)-3,1-benzoxazin-4-one
MW: 302.123 | Formula: C14H8BrNO2
H donors: 0 H acceptors: 1 LogP: 3.62 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccccc1c1nc2ccccc2c(=O)o1
InChi: 1S/C14H8BrNO2/c15-11-7-3-1-5-9(11)13-16-12-8-4-2-6-10(12)14(17)18-13/h1-8H
InChiKey: RYRROGBSEYPKTN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

SMR000504992
2-(2-Bromo-phenyl)-benzo[d][1,3]oxazin-4-one
BAS 00129538
ZINC00070198
STK300106
MLS001210119

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	complement component 1, r subcomponent	Starlite/ChEMBL	No references
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	hypothetical protein	0.0176	0.2168	0.2325
Echinococcus granulosus	nuclear receptor nhr 48	0.0333	0.4272	0.4264
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.1671	0.1661
Toxoplasma gondii	transporter, cation channel family protein	0.0021	0.0082	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	serotonin transporter	0.0069	0.0729	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	hypothetical protein	0.0373	0.4808	0.5172
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0705	0.9284	0.9284
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.0133	0.0146
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0091	0.102	0.1009
Wolbachia endosymbiont of Brugia malayi	glutamine synthetase	0.0191	0.2371	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0395	0.0383
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0333	0.4272	0.4264
Echinococcus multilocularis	neuropeptide s receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Schistosoma mansoni	glutamine synthetase bacteria	0.0191	0.2371	0.2361
Schistosoma mansoni	glutamine synthetase 1 2 (glutamate-amonia ligase) (gs)	0.0758	1	1
Echinococcus multilocularis	glutamine synthetase	0.0758	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.1671	0.1661
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0825	0.0876
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0333	0.4272	0.4264
Echinococcus granulosus	Tolloid protein 1	0.0021	0.0076	0.0064
Schistosoma mansoni	growth hormone secretagogue receptor	0.0139	0.1671	0.1661
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	g protein coupled receptor	0.0139	0.1671	0.1661
Brugia malayi	tailless protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Echinococcus multilocularis	Tolloid protein 1	0.0021	0.0076	0.0064
Brugia malayi	nuclear hormone receptor	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0039	0.032	0.0331
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0044	0.0004
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0705	0.9284	0.9284
Mycobacterium ulcerans	thioesterase	0.0025	0.0133	0.0146
Echinococcus granulosus	neuropeptides capa receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	7tm_1 domain containing protein	0.0139	0.1671	0.1661
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0139	0.1671	0.1661
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.02	0.0276
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0091	0.102	0.1009
Brugia malayi	G-protein coupled receptor	0.0139	0.1671	0.1789
Mycobacterium ulcerans	glutamine synthetase	0.0488	0.6359	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.02	0.0253
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0091	0.102	0.1009
Brugia malayi	Nuclear hormone receptor-like 1	0.0373	0.4808	0.5172
Brugia malayi	latrophilin 2 splice variant baaae	0.0078	0.0848	0.0902
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0139	0.1671	0.1661
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0705	0.9284	0.9284
Onchocerca volvulus		0.0139	0.1671	0.1789
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0705	0.9284	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0139	0.1671	0.1661
Mycobacterium leprae	PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II)	0.0488	0.6359	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	hypothetical protein	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0139	0.1671	0.1789
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0139	0.1671	0.1661
Entamoeba histolytica	glutamine synthetase, putative	0.0191	0.2371	0.5
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Brugia malayi	conserved hypotetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Brugia malayi	glutamine synthetase	0.0271	0.3437	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0705	0.9284	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.0225	0.0315
Loa Loa (eye worm)	nuclear hormone receptor	0.0333	0.4272	0.4593
Echinococcus multilocularis	voltage dependent calcium channel	0.0091	0.102	0.1009
Brugia malayi	nuclear receptor RXR	0.0333	0.4272	0.4593
Onchocerca volvulus		0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.0562	0.0593
Loa Loa (eye worm)	fatty acid synthase	0.003	0.0195	0.0196
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0333	0.4272	0.4593
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0091	0.102	0.1009
Loa Loa (eye worm)	G-protein coupled receptor	0.0139	0.1671	0.1789
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0705	0.9284	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.02	0.0276
Schistosoma mansoni	hypothetical protein	0.0036	0.0283	0.0271
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0021	0.0082	0.0074
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.0121	0.0128
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0283	0.0271
Echinococcus granulosus	allatostatin A receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0139	0.1671	0.1661
Brugia malayi	ecdysone receptor	0.0333	0.4272	0.4593
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.0121	0.0128
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	neuropeptide receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Echinococcus multilocularis	FTZ F1 alpha	0.0705	0.9284	0.9284
Brugia malayi	ecdysteroid receptor	0.0705	0.9284	1
Brugia malayi	ORL1-like opioid receptor	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0705	0.9284	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0139	0.1671	0.1661
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.1671	0.1661
Schistosoma mansoni	hypothetical protein	0.0036	0.0283	0.0271
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0373	0.4808	0.4802
Schistosoma mansoni	nuclear receptor nhr-48	0.0333	0.4272	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4808	0.5172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4808	0.5172
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0139	0.1671	0.1789
Mycobacterium ulcerans	glutamine synthetase GlnA1	0.0488	0.6359	1
Mycobacterium ulcerans	polyketide synthase Pks9	0.002	0.0063	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	adenoreceptor	0.0139	0.1671	0.1661
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.0225	0.0258
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	neuropeptide f receptor 76f	0.0139	0.1671	0.1661
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0044	0.0031
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0283	0.0271
Onchocerca volvulus		0.0052	0.05	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0002
Schistosoma mansoni	amine GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0333	0.4272	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0225	0.0293
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0091	0.102	0.1009
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0333	0.4272	0.4593
Brugia malayi	RNA binding protein	0.0076	0.0825	0.0876
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0333	0.4272	0.4264
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4808	0.5172
Onchocerca volvulus		0.0139	0.1671	0.1789
Onchocerca volvulus		0.0139	0.1671	0.1789
Echinococcus multilocularis	allatostatin A receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	norepinephrine transporter	0.0069	0.0729	0.0773
Onchocerca volvulus		0.0139	0.1671	0.1789
Brugia malayi	putative neuropeptide receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0705	0.9284	0.9284
Toxoplasma gondii	glutamine synthetase, type I, putative	0.0488	0.6359	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0705	0.9284	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0114	0.1336	0.1427
Entamoeba histolytica	glutamine synthetase, putative	0.0191	0.2371	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0139	0.1671	0.1789
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.02	0.0253
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0139	0.1671	0.1661
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0139	0.1671	0.1789
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0091	0.102	0.1009
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0139	0.1671	0.1789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.0058	0.0091
Onchocerca volvulus		0.0139	0.1671	0.1789
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.0525	0.0552
Echinococcus granulosus	neuropeptide FF receptor 2	0.0139	0.1671	0.1661
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.02	0.0253
Brugia malayi	neuropeptide F receptor	0.0139	0.1671	0.1789
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0139	0.1671	0.1661
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0191	0.0234
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0705	0.9284	1
Onchocerca volvulus		0.0139	0.1671	0.1789
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.0133	0.0111
Schistosoma mansoni	myosin xvIII	0.0139	0.1671	0.1661
Echinococcus multilocularis	nuclear receptor nhr 48	0.0333	0.4272	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4808	0.5172
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	neuropeptide receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0705	0.9284	1
Brugia malayi	nuclear receptor RXR	0.0373	0.4808	0.5172
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.004	0.003
Loa Loa (eye worm)	hypothetical protein	0.0373	0.4808	0.5172
Echinococcus granulosus	somatostatin receptor	0.0139	0.1671	0.1661
Trypanosoma brucei	glutamine synthetase, putative	0.0758	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0333	0.4272	0.4264
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0069	0.0729	0.0773
Schistosoma mansoni	amine GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0705	0.9284	1
Loa Loa (eye worm)	calcium channel	0.0091	0.102	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0139	0.1671	0.1789
Schistosoma mansoni	amine GPCR	0.0139	0.1671	0.1661
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0056	0.0555	0.0517
Echinococcus multilocularis	neuropeptide receptor	0.0139	0.1671	0.1661
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0225	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	Nuclear hormone receptor E75	0.0333	0.4272	0.4593
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.004	0.0337	0.0324
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.1671	0.1661
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0705	0.9284	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	thyroid hormone receptor	0.0705	0.9284	0.9284
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0705	0.9284	0.9284
Brugia malayi	sulfakinin receptor protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0705	0.9284	0.9284
Schistosoma mansoni	voltage-gated cation channel	0.0091	0.102	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0705	0.9284	0.9284
Schistosoma mansoni	hypothetical protein	0.0078	0.0848	0.0837
Echinococcus multilocularis	neuropeptide Y receptor	0.0139	0.1671	0.1661
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0139	0.1671	0.1789
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.02	0.0202
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0373	0.4808	0.4802
Echinococcus multilocularis	somatostatin receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	7TM GPCR rhodopsin	0.0139	0.1671	0.1661
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.0225	0.0293
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0191	0.0152
Echinococcus granulosus	voltage dependent calcium channel	0.0021	0.0082	0.0069
Onchocerca volvulus		0.0139	0.1671	0.1789
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0021	0.0076	0.0068
Brugia malayi	Nuclear hormone receptor-like 1	0.0373	0.4808	0.5172
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	nuclear receptor NHR-88	0.0333	0.4272	0.4593
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0191	0.0234
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0395	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0475	0.0499
Echinococcus granulosus	ecdysone induced protein 78C	0.0705	0.9284	0.9284
Brugia malayi	G protein-coupled receptor F59B2.13	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Trypanosoma cruzi	glutamine synthetase, putative	0.0758	1	1
Echinococcus multilocularis	sex peptide receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0333	0.4272	0.4593
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	nuclear receptor	0.0333	0.4272	0.4264
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0705	0.9284	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0191	0.0234
Brugia malayi	G protein-coupled receptor	0.0139	0.1671	0.1789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0139	0.1671	0.1661
Brugia malayi	Dopamine receptor	0.0139	0.1671	0.1789
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0013	0.002
Schistosoma mansoni	coup transcription factor	0.0705	0.9284	0.9284
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.004	0.003
Trichomonas vaginalis	glutamine synthetase, putative	0.0191	0.2371	1
Mycobacterium ulcerans	hypothetical protein	0.0191	0.2371	0.3689
Brugia malayi	GnHR receptor homolog	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	G protein coupled receptor 139	0.0139	0.1671	0.1661
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Echinococcus granulosus	fmrfamide receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0373	0.4808	0.4802
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Echinococcus multilocularis	fmrfamide receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0114	0.1336	0.1427
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0114	0.1336	0.1427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0139	0.1671	0.1661
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.0121	0.0092
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0333	0.4272	0.4593
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	photoreceptor-specific nuclear receptor	0.0705	0.9284	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0139	0.1671	0.1661
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.02	0.0218
Loa Loa (eye worm)	G-protein coupled receptor	0.0139	0.1671	0.1789
Echinococcus multilocularis	fmrfamide receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0044	0.0034
Echinococcus multilocularis	serotonin receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0091	0.102	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus granulosus	orexin receptor type 2	0.0139	0.1671	0.1661
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0333	0.4272	0.4264
Onchocerca volvulus		0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2168	0.2325
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0283	0.0271
Brugia malayi	Melatonin receptor type 1A	0.0139	0.1671	0.1789
Echinococcus multilocularis	g-protein coupled receptor	0.0139	0.1671	0.1661
Treponema pallidum	sodium- and chloride- dependent transporter	0.0069	0.0729	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0139	0.1671	0.1661
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0091	0.102	0.1087
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.0173	0.0234
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0825	0.0813
Echinococcus multilocularis	dro:myosuppressin receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	ecdysone induced protein 78C	0.0705	0.9284	0.9284
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0283	0.0292
Echinococcus multilocularis	sodium channel protein	0.004	0.0337	0.0324
Schistosoma mansoni	biogenic amine receptor	0.0139	0.1671	0.1661
Mycobacterium ulcerans	polyketide synthase	0.003	0.02	0.0253
Brugia malayi	follicle stimulating hormone receptor	0.0139	0.1671	0.1789
Brugia malayi	putative neuropeptide receptor NPR1	0.0139	0.1671	0.1789
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0825	0.0876
Loa Loa (eye worm)	TYRA-2 protein	0.0139	0.1671	0.1789
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0018	0.0044	0.0029
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0825	0.0876
Brugia malayi	hypothetical protein	0.0029	0.0191	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0705	0.9284	0.9284
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0333	0.4272	0.4264
Echinococcus granulosus	neuropeptide receptor A26	0.0139	0.1671	0.1661
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.0447	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0139	0.1671	0.1661
Mycobacterium tuberculosis	Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I)	0.0191	0.2371	0.3703
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1336	0.1427
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0705	0.9284	0.9284
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0028	0.0173	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0848	0.0902
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.02	0.0253
Schistosoma mansoni	opsin-like receptor	0.0139	0.1671	0.1661
Brugia malayi	hypothetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0002
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0139	0.1671	0.1789
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.0173	0.0174
Onchocerca volvulus		0.0139	0.1671	0.1789
Brugia malayi	steroid hormone receptor	0.0705	0.9284	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0139	0.1671	0.1789
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.1671	0.1661
Echinococcus granulosus	dro:myosuppressin receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	voltage dependent calcium channel	0.0091	0.102	0.1009
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0139	0.1671	0.1661
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0044	0.0069
Trypanosoma cruzi	glutamine synthetase, putative	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0825	0.0813
Echinococcus granulosus	neuropeptides capa receptor	0.0139	0.1671	0.1661
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0013	0.002
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0018	0.0044	0.0004
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0056	0.0555	0.0517
Schistosoma mansoni	hypothetical protein	0.0036	0.0283	0.0271
Onchocerca volvulus		0.0139	0.1671	0.1789
Echinococcus multilocularis	serotonin receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0139	0.1671	0.1661
Brugia malayi	nuclear hormone receptor family member odr-7	0.0333	0.4272	0.4593
Schistosoma mansoni	hypothetical protein	0.0036	0.0283	0.0271
Brugia malayi	larval opioid receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	hypothetical protein	0.0139	0.1671	0.1661
Schistosoma mansoni	nuclear receptor	0.0333	0.4272	0.4264
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0044	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0191	0.0152
Echinococcus granulosus	hypothetical protein	0.0139	0.1671	0.1661
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.0225	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Toxoplasma gondii	hypothetical protein	0.0016	0.0014	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Brugia malayi	Nuclear hormone receptor E75	0.0333	0.4272	0.4593
Brugia malayi	Serotonin receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0139	0.1671	0.1789
Echinococcus granulosus	g protein coupled receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0705	0.9284	0.9284
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0021	0.0076	0.0064
Echinococcus granulosus	g protein coupled receptor	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0139	0.1671	0.1789
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0139	0.1671	0.1661
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.0133	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0283	0.0271
Echinococcus granulosus	g-protein coupled receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Trichomonas vaginalis	glutamine synthetase-bacteria, putative	0.0191	0.2371	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0044	0.0031
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0333	0.4272	0.4264
Schistosoma mansoni	neuropeptide F-like receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0333	0.4272	0.4264
Schistosoma mansoni	zinc finger protein	0.0333	0.4272	0.4264
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0044	0.0031
Brugia malayi	Dopamine receptor protein 1	0.0139	0.1671	0.1789
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.004	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0705	0.9284	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0333	0.4272	0.4264
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0139	0.1671	0.1661
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0139	0.1671	0.1661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0705	0.9284	1
Schistosoma mansoni	opsin-like receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	DR-78	0.0333	0.4272	0.4593
Echinococcus granulosus	neuropeptide Y receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0139	0.1671	0.1661
Echinococcus granulosus	thyroid hormone receptor alpha	0.0333	0.4272	0.4264
Loa Loa (eye worm)	neuropeptide F receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	neuropeptide receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	neuropeptide receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0705	0.9284	0.9284
Schistosoma mansoni	nuclear hormone receptor	0.0705	0.9284	0.9284
Brugia malayi	neuropeptide F receptor	0.0139	0.1671	0.1789
Brugia malayi	Nuclear hormone receptor-like 1	0.0705	0.9284	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0705	0.9284	1
Onchocerca volvulus		0.0139	0.1671	0.1789
Echinococcus granulosus	neuropeptide s receptor	0.0139	0.1671	0.1661
Echinococcus granulosus	FTZ F1 alpha	0.0705	0.9284	0.9284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0705	0.9284	1
Brugia malayi	Dopamine receptor protein 2	0.0139	0.1671	0.1789
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.0225	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0283	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0705	0.9284	0.9284
Echinococcus multilocularis	orexin receptor type 2	0.0139	0.1671	0.1661
Brugia malayi	orphan nuclear receptor NR2E1	0.0333	0.4272	0.4593
Onchocerca volvulus	Glutamine synthetase homolog	0.0488	0.6359	0.6845
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0283	0.0292
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0705	0.9284	0.9284
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0191	0.0152
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0373	0.4808	0.5172
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0091	0.102	0.1087
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	neuropeptide receptor A26	0.0139	0.1671	0.1661
Echinococcus granulosus	voltage dependent calcium channel	0.0091	0.102	0.1009
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.0188	0.0256
Brugia malayi	nuclear receptor NHR-88	0.0705	0.9284	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.0086	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0705	0.9284	1
Mycobacterium tuberculosis	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)	0.0488	0.6359	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0333	0.4272	0.4264
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0705	0.9284	1
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0825	0.0813
Leishmania major	glutamine synthetase, putative	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0173	0.0174
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0825	0.0813
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0825	0.0813
Brugia malayi	Steroid receptor seven-up type 2	0.0705	0.9284	1
Schistosoma mansoni	neuropeptide receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0283	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0229	0.0233
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.04	0.057
Schistosoma mansoni	neuropeptide receptor	0.0139	0.1671	0.1661
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0825	0.0813
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	opsin-like receptor	0.0139	0.1671	0.1661
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0333	0.4272	0.4593
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0191	0.0193
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.02	0.0218
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0705	0.9284	0.9284
Onchocerca volvulus		0.0139	0.1671	0.1789
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0091	0.102	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0729	0.0773
Schistosoma mansoni	glutamine synthetase bacteria	0.0191	0.2371	0.2361
Schistosoma mansoni	nuclear hormone receptor	0.0333	0.4272	0.4264
Brugia malayi	nuclear receptor NHR-67	0.0333	0.4272	0.4593
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.1671	0.1661
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0044	0.0004
Schistosoma mansoni	retinoic acid receptor RXR	0.0705	0.9284	0.9284
Onchocerca volvulus		0.0069	0.0729	0.0773
Onchocerca volvulus		0.0176	0.2168	0.2325
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0139	0.1671	0.1661
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0191	0.0152
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0044	0.0031
Brugia malayi	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	GPCR family 2	0.0036	0.0283	0.0271
Mycobacterium ulcerans	polyketide synthase	0.0032	0.0225	0.0293
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.0084	0.0131
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0705	0.9284	1
Brugia malayi	Cytochrome P450 family protein	0.0018	0.004	0.003
Schistosoma mansoni	hypothetical protein	0.0139	0.1671	0.1661
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0139	0.1671	0.1661
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0139	0.1671	0.1789
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	serotonin transporter b	0.0069	0.0729	0.0773
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.0225	0.0354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0395	0.0383
Plasmodium vivax	glutamine synthetase, putative	0.0488	0.6359	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0139	0.1671	0.1789
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0705	0.9284	0.9284
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0705	0.9284	0.9284
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0044	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0091	0.102	0.1009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0705	0.9284	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0044	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0022	0.001
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0139	0.1671	0.1661
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.0188	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Echinococcus multilocularis	serotonin transporter	0.0069	0.0729	0.0717
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0044	0.0031
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0705	0.9284	0.9284
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0044	0.0004
Echinococcus granulosus	serotonin receptor	0.0139	0.1671	0.1661
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.0225	0.0258
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.002	0.0063	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0729	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0283	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0705	0.9284	1
Loa Loa (eye worm)	Gln-2 protein	0.0488	0.6359	0.6845
Brugia malayi	hypothetical protein	0.0333	0.4272	0.4593
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0139	0.1671	0.1789
Schistosoma mansoni	amine GPCR	0.0139	0.1671	0.1661
Loa Loa (eye worm)	steroid hormone receptor	0.0705	0.9284	1
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.0447	0.0435
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.1671	0.1661
Onchocerca volvulus	Bile acid receptor homolog	0.0705	0.9284	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0705	0.9284	1
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0705	0.9284	0.9284
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0044	0.0034
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.0126	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4272	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0082	0.0074
Brugia malayi	hypothetical protein	0.0019	0.0051	0.0042
Echinococcus granulosus	sex peptide receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0705	0.9284	0.9284
Schistosoma mansoni	thyroid hormone receptor	0.0705	0.9284	0.9284
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.0044	0.0004
Brugia malayi	nuclear hormone receptor	0.0705	0.9284	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0139	0.1671	0.1789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0139	0.1671	0.1661
Plasmodium falciparum	glutamine synthetase, putative	0.0488	0.6359	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0069	0.0729	0.0717
Schistosoma mansoni	amine GPCR	0.0139	0.1671	0.1661
Onchocerca volvulus		0.0139	0.1671	0.1789
Brugia malayi	RE15519p	0.0139	0.1671	0.1789
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.04	0.0535
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.1671	0.1661
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0825	0.0813
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0139	0.1671	0.1661
Schistosoma mansoni	hypothetical protein	0.0139	0.1671	0.1661
Echinococcus granulosus	G protein coupled receptor 139	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0705	0.9284	1
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.04	0.0591
Schistosoma mansoni	biogenic amine receptor	0.0139	0.1671	0.1661
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0705	0.9284	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0705	0.9284	0.9284
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0705	0.9284	0.9284
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0705	0.9284	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Schistosoma mansoni	histamine h1 receptor	0.0139	0.1671	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0825	0.0876
Schistosoma mansoni	sodium/chloride dependent transporter	0.0069	0.0729	0.0717
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.04	0.0591
Onchocerca volvulus	Protein ultraspiracle homolog	0.0705	0.9284	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1671	0.1789
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0069	0.0729	0.0773
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0139	0.1671	0.1661
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0139	0.1671	0.1789
Onchocerca volvulus		0.0139	0.1671	0.1789
Onchocerca volvulus		0.0333	0.4272	0.4593
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0395	0.0413
Schistosoma mansoni	biogenic amine receptor	0.0139	0.1671	0.1661
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0373	0.4808	0.4802
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0076	0.0068
Brugia malayi	Cytochrome P450 family protein	0.0018	0.004	0.003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0139	0.1671	0.1661
Brugia malayi	AKH receptor	0.0139	0.1671	0.1789
Brugia malayi	G-protein coupled receptor	0.0139	0.1671	0.1789
Schistosoma mansoni	nuclear hormone receptor	0.0333	0.4272	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0729	0.0773
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.02	0.0276
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0044	0.0031
Brugia malayi	hypothetical protein	0.0373	0.4808	0.5172
Echinococcus multilocularis	neuropeptides capa receptor	0.0139	0.1671	0.1661
Brugia malayi	TAR-binding protein	0.0076	0.0825	0.0876
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0139	0.1671	0.1661
Brugia malayi	Serotonin receptor	0.0139	0.1671	0.1789
Echinococcus granulosus	neuropeptide receptor	0.0139	0.1671	0.1661
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0705	0.9284	0.9284
Loa Loa (eye worm)	melatonin receptor type 1A	0.0139	0.1671	0.1789
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0191	0.0301

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.5 uM	Inhibition of C1r serine protease	ChEMBL.	No reference
IC50 (binding)	= 9.5 uM	Inhibition of C1r serine protease	ChEMBL.	No reference
IC50 (functional)	13 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	16.1 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	= 32 uM	Inhibitory activity against C1r serine protease	ChEMBL.	No reference
IC50 (binding)	= 32 uM	Inhibitory activity against C1r serine protease	ChEMBL.	No reference
IC50 (binding)	= 46 uM	Inhibitory activity against C1r serine protease	ChEMBL.	No reference
IC50 (binding)	= 46 uM	Inhibitory activity against C1r serine protease	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	30.1313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL158541
PubChem: 695642
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 273645