Detailed information for compound 273663

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.018 | Formula: C28H32ClN2O3-
  • H donors: 1 H acceptors: 2 LogP: 4.87 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)[C@H](N(C(=O)C(c1ccccc1)c1ccccc1)C)CN1CC[C@H](C1)O.[Cl-]
  • InChi: 1S/C28H32N2O3.ClH/c1-29(28(32)27(22-9-5-3-6-10-22)23-11-7-4-8-12-23)26(20-30-18-17-24(31)19-30)21-13-15-25(33-2)16-14-21;/h3-16,24,26-27,31H,17-20H2,1-2H3;1H/p-1/t24-,26+;/m0./s1
  • InChiKey: QTUGKWDVJADLDG-ZFGDHOEWSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.068 0.1115
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Schistosoma mansoni lamin 0.0019 0.0175 0.0231
Echinococcus multilocularis SWI:SNF matrix associated 0.0143 0.2084 0.2069
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0441 0.471
Brugia malayi glutathione reductase 0.0069 0.0937 0.1485
Schistosoma mansoni thyroid hormone receptor 0.0402 0.6105 0.8044
Plasmodium falciparum phosphodiesterase delta, putative 0.0037 0.0441 0.1835
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0175 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0242 0.1482
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.1081
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0402 0.6105 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0076 0.1054 0.1678
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0247 0.0325
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0051 0.066 0.1029
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0336 0.2628
Entamoeba histolytica recQ family helicase, putative 0.0016 0.0121 0.1673
Schistosoma mansoni fusion 0.0051 0.066 0.087
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0264 0.3967 0.6499
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.1835
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0441 0.1835
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Trypanosoma cruzi WLM domain containing protein, putative 0.0051 0.066 0.7047
Brugia malayi PHD-finger family protein 0.0021 0.02 0.0271
Schistosoma mansoni P2X receptor subunit 0.0058 0.0778 0.1026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0247 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Schistosoma mansoni hypothetical protein 0.0024 0.0247 0.0326
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0336 0.0495
Schistosoma mansoni hypothetical protein 0.0024 0.0247 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0441 0.118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0156 0.2298 0.8921
Onchocerca volvulus 0.019 0.2813 0.4482
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0247 0.0301
Brugia malayi nuclear hormone receptor 0.0402 0.6105 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0247 0.0349
Brugia malayi Nuclear hormone receptor E75 0.019 0.2813 0.4577
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0242 0.2585
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0175 0.0231
Brugia malayi ecdysone receptor 0.019 0.2813 0.4577
Brugia malayi conserved hypotetical protein 0.019 0.2813 0.4577
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0051 0.066 0.1029
Plasmodium vivax thioredoxin reductase, putative 0.0069 0.0937 0.4494
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0051 0.066 0.7047
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.1081
Echinococcus granulosus thyroid hormone receptor alpha 0.019 0.2813 0.3691
Brugia malayi SWIB/MDM2 domain containing protein 0.0143 0.2084 0.3376
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0402 0.6105 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0336 0.0486
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0242 0.0846
Echinococcus granulosus bloom syndrome protein 0.0016 0.0121 0.0135
Echinococcus multilocularis p2X purinoceptor 4 0.0058 0.0778 0.0761
Echinococcus granulosus GPCR family 2 0.0024 0.0247 0.0301
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.0327
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0385 0.0483
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0402 0.6105 0.6097
Entamoeba histolytica hypothetical protein 0.0055 0.0725 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0441 0.0723
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0242 0.2585
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0441 0.3923
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0037 0.0441 0.0423
Schistosoma mansoni hypothetical protein 0.016 0.236 0.311
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Brugia malayi Steroid receptor seven-up type 2 0.0402 0.6105 1
Schistosoma mansoni hypothetical protein 0.0143 0.2084 0.2746
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0336 0.0317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Echinococcus multilocularis bloom syndrome protein 0.0016 0.0121 0.0102
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0121 0.0268
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0242 0.0846
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0037 0.0441 0.0669
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0242 0.0534
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6608
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0242 0.1482
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0139 0.1915
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0139 0.1196
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0037 0.0441 0.0557
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0037 0.0441 0.0581
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0402 0.6105 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Echinococcus multilocularis lamin dm0 0.0019 0.0175 0.0156
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus granulosus nuclear receptor nhr 48 0.019 0.2813 0.3691
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0402 0.6105 0.8039
Echinococcus multilocularis GPCR, family 2 0.0024 0.0247 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0402 0.6105 0.8044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0242 0.1162
Loa Loa (eye worm) hypothetical protein 0.0099 0.1404 0.2299
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0051 0.066 0.7047
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0037 0.0441 0.471
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0212 0.3166 0.4171
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Onchocerca volvulus 0.0191 0.2832 0.4514
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0247 0.0349
Brugia malayi photoreceptor-specific nuclear receptor 0.0402 0.6105 1
Echinococcus multilocularis nuclear receptor nhr 48 0.019 0.2813 0.2799
Schistosoma mansoni hypothetical protein 0.0055 0.0725 0.0956
Onchocerca volvulus Huntingtin homolog 0.0099 0.1404 0.212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0037 0.0441 0.3923
Brugia malayi nuclear hormone receptor family member odr-7 0.019 0.2813 0.4577
Echinococcus multilocularis ecdysone induced protein 78C 0.0402 0.6105 0.6097
Plasmodium falciparum glutathione reductase 0.0024 0.0242 0.0846
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0144 0.018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0402 0.6105 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0242 0.1162
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0301 0.4535 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.019 0.2813 0.3707
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0402 0.6105 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0441 0.471
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.066 0.7047
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.019 0.2813 0.4577
Brugia malayi nuclear receptor NHR-88 0.019 0.2813 0.4577
Brugia malayi Nuclear hormone receptor-like 1 0.0212 0.3166 0.5157
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0441 0.0557
Loa Loa (eye worm) PDE1B protein 0.0037 0.0441 0.0723
Echinococcus granulosus geminin 0.016 0.236 0.3092
Echinococcus multilocularis microtubule associated protein 2 0.0498 0.7589 0.7584
Onchocerca volvulus 0.0402 0.6105 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus granulosus lysine specific demethylase 5A 0.0025 0.0268 0.0329
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0156 0.2298 0.8921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0402 0.6105 0.8044
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6608
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Chlamydia trachomatis DNA topoisomerase I 0.0143 0.2084 1
Loa Loa (eye worm) DR-78 0.019 0.2813 0.4608
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Brugia malayi hypothetical protein 0.0212 0.3166 0.5157
Brugia malayi tailless protein 0.019 0.2813 0.4577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0199
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0144 0.018
Mycobacterium tuberculosis Probable oxidoreductase 0.0174 0.2569 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0242 0.2585
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0069 0.0937 0.3492
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0247 0.0228
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0402 0.6105 0.8044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0402 0.6105 1
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.0725 0.0956
Toxoplasma gondii thioredoxin reductase 0.0069 0.0937 0.2066
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0247 0.0544
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0402 0.6105 0.6097
Schistosoma mansoni DNA helicase recq5 0.0016 0.0121 0.016
Schistosoma mansoni zinc finger protein 0.0051 0.066 0.087
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0441 0.0423
Leishmania major trypanothione reductase 0.0069 0.0937 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.471
Loa Loa (eye worm) hypothetical protein 0.0036 0.0433 0.0709
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0402 0.6105 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0143 0.2084 0.4596
Loa Loa (eye worm) RecQ helicase 0.0016 0.0121 0.0199
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.019 0.2813 0.3707
Echinococcus multilocularis neuropeptide s receptor 0.0375 0.5693 0.5685
Loa Loa (eye worm) hypothetical protein 0.0019 0.0175 0.0287
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0441 0.1835
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0016 0.0121 0.0102
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis SWI:SNF matrix associated 0.0143 0.2084 0.2069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0402 0.6105 0.6097
Schistosoma mansoni zinc finger protein 0.019 0.2813 0.3707
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0336 0.0442
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Schistosoma mansoni coup transcription factor 0.0402 0.6105 0.8044
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0264 0.3967 0.5216
Loa Loa (eye worm) hypothetical protein 0.0301 0.4535 0.7428
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0037 0.0441 0.0581
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0049 0.0632 0.0614
Loa Loa (eye worm) hypothetical protein 0.0099 0.1404 0.2299
Loa Loa (eye worm) hypothetical protein 0.0076 0.1054 0.1726
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0228
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.1482
Brugia malayi Bloom's syndrome protein homolog 0.0016 0.0121 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0402 0.6105 0.6097
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0242 0.0319
Loa Loa (eye worm) brahma associated protein 0.0143 0.2084 0.3414
Plasmodium falciparum thioredoxin reductase 0.0069 0.0937 0.4297
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0402 0.6105 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0051 0.066 0.7047
Echinococcus granulosus PHD finger protein rhinoceros 0.0021 0.02 0.0238
Schistosoma mansoni brg-1 associated factor 0.0143 0.2084 0.2746
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0941 0.0924
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0336 0.0418
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Brugia malayi intermediate filament protein 0.0019 0.0175 0.0231
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0051 0.066 0.0847
Onchocerca volvulus Huntingtin homolog 0.0099 0.1404 0.212
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus granulosus intermediate filament protein 0.0019 0.0175 0.0206
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0175 0.0287
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0336 0.0418
Onchocerca volvulus Bile acid receptor homolog 0.0402 0.6105 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0242 0.0223
Onchocerca volvulus 0.0051 0.066 0.0874
Schistosoma mansoni nuclear receptor 0.019 0.2813 0.3707
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.1835
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0441 0.471
Echinococcus multilocularis ring and YY1 binding protein 0.0051 0.066 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0402 0.6105 1
Brugia malayi Nuclear hormone receptor-like 1 0.0212 0.3166 0.5157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0139 0.1915
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0121 0.1295
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0037 0.0441 0.0423
Brugia malayi Thioredoxin reductase 0.0069 0.0937 0.1485
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0943 0.122
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0242 0.0294
Mycobacterium tuberculosis Probable reductase 0.0156 0.2298 0.8921
Loa Loa (eye worm) hypothetical protein 0.0212 0.3166 0.5185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0402 0.6105 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0301 0.4535 0.4524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0385 0.0508
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.3923
Brugia malayi steroid hormone receptor 0.0402 0.6105 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0212 0.3166 0.4171
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0242 0.1482
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Schistosoma mansoni hypothetical protein 0.0143 0.2084 0.2746
Onchocerca volvulus Alhambra homolog 0.0021 0.02 0.0102
Echinococcus granulosus ring and YY1 binding protein 0.0051 0.066 0.0847
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0076 0.1054 0.1726
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0051 0.066 0.0642
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0242 0.0446
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.0937 0.1534
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0156 0.2298 0.8921
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0441 0.0557
Echinococcus granulosus p2X purinoceptor 4 0.0058 0.0778 0.1003
Echinococcus granulosus FTZ F1 alpha 0.0402 0.6105 0.8039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Loa Loa (eye worm) hypothetical protein 0.0024 0.0247 0.0405
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0402 0.6105 0.8044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0441 0.0723
Loa Loa (eye worm) steroid hormone receptor 0.0402 0.6105 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0336 0.4627
Schistosoma mansoni hypothetical protein 0.0024 0.0247 0.0326
Schistosoma mansoni nuclear hormone receptor 0.019 0.2813 0.3707
Schistosoma mansoni hypothetical protein 0.0024 0.0247 0.0326
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0441 0.0669
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0037 0.0441 0.0557
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0021 0.02 0.0263
Brugia malayi orphan nuclear receptor NR2E1 0.019 0.2813 0.4577
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0168 0.2473 0.405
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0247 0.0228
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0228
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0441 0.3923
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0139 0.1196
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0143 0.2084 0.2728
Loa Loa (eye worm) hypothetical protein 0.0037 0.0441 0.0723
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0632 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0336 0.0317
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.019 0.2813 0.4482
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.0242 0.0274
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Onchocerca volvulus 0.0024 0.0247 0.0181
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0139 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Schistosoma mansoni lamin 0.0019 0.0175 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.2813 0.2799
Onchocerca volvulus 0.0019 0.0175 0.0061
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Loa Loa (eye worm) nuclear hormone receptor 0.019 0.2813 0.4608
Leishmania major hypothetical protein, conserved 0.0037 0.0441 0.3923
Echinococcus multilocularis FTZ F1 alpha 0.0402 0.6105 0.6097
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.3923
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0247 0.0325
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0242 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.019 0.2813 0.4608
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0264 0.3967 0.6478
Echinococcus granulosus neuropeptide s receptor 0.0375 0.5693 0.7495
Echinococcus granulosus Nuclear hormone receptor HR96 0.019 0.2813 0.3691
Brugia malayi Pre-SET motif family protein 0.0024 0.0247 0.0348
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.2117
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.066 0.6608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0402 0.6105 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0247 0.0405
Entamoeba histolytica hypothetical protein 0.0055 0.0725 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0385 0.0508
Echinococcus multilocularis geminin 0.016 0.236 0.2345
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0264 0.3967 0.3956
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0441 0.471
Trypanosoma cruzi WLM domain containing protein, putative 0.0051 0.066 0.7047
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.2117
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0937 1
Brugia malayi nuclear receptor RXR 0.019 0.2813 0.4577
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0037 0.0441 0.0669
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0016 0.0121 0.0135
Onchocerca volvulus Protein ultraspiracle homolog 0.0402 0.6105 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.3166 0.5185
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0035 0.0058
Treponema pallidum NADH oxidase 0.0024 0.0242 1
Schistosoma mansoni nuclear receptor nhr-48 0.019 0.2813 0.3707
Plasmodium vivax SET domain protein, putative 0.0024 0.0247 0.1183
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.3923
Plasmodium vivax hypothetical protein, conserved 0.0143 0.2084 1
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Echinococcus granulosus microtubule associated protein 2 0.0498 0.7589 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0336 0.0791
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0336 0.0418
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0301 0.4535 0.5965
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0441 0.0669
Onchocerca volvulus 0.0051 0.066 0.0874
Echinococcus granulosus Zinc finger RanBP2 type 0.0051 0.066 0.0847
Brugia malayi Nuclear hormone receptor-like 1 0.0402 0.6105 1
Onchocerca volvulus 0.0051 0.066 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0402 0.6105 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0118
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0143 0.2084 1
Brugia malayi nuclear receptor NHR-88 0.0402 0.6105 1
Brugia malayi ecdysteroid receptor 0.0402 0.6105 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0174 0.2569 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0016 0.0121 0.0246
Echinococcus multilocularis SWI:SNF matrix associated 0.0143 0.2084 0.2069
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0385 0.0483
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0143 0.2084 0.3414
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0247 0.0301
Schistosoma mansoni retinoic acid receptor RXR 0.0402 0.6105 0.8044
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0242 0.3039
Brugia malayi brahma associated protein 60 kDa 0.0143 0.2084 0.3376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0402 0.6105 0.8039
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0037 0.0441 0.0669
Loa Loa (eye worm) hypothetical protein 0.0122 0.1761 0.2884
Loa Loa (eye worm) hypothetical protein 0.0212 0.3166 0.5185
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0139 0.0171
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0233 0.0282
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0016 0.0121 0.0102
Mycobacterium ulcerans hypothetical protein 0.0017 0.0139 0.1196
Leishmania major cAMP-specific phosphodiesterase, putative 0.0037 0.0441 0.3923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0385 0.0508
Brugia malayi Pre-SET motif family protein 0.0168 0.2473 0.4016
Plasmodium falciparum glutathione reductase 0.0069 0.0937 0.4297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0402 0.6105 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0247 0.03
Schistosoma mansoni jumonji domain containing protein 0.0055 0.0722 0.0951
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0242 0.0341
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.0725 0.0933
Toxoplasma gondii aldehyde dehydrogenase 0.0049 0.0632 0.1394
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6608
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Echinococcus multilocularis jumonji domain containing protein 0.0029 0.0327 0.0309
Mycobacterium tuberculosis Probable dehydrogenase 0.0156 0.2298 0.8921
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0385 0.0631
Echinococcus granulosus lamin dm0 0.0019 0.0175 0.0206
Echinococcus multilocularis Nuclear hormone receptor HR96 0.019 0.2813 0.2799
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0118
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0242 0.0722
Brugia malayi nuclear hormone receptor 0.019 0.2813 0.4577
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Schistosoma mansoni nuclear receptor 0.019 0.2813 0.3707
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0143 0.2084 1
Echinococcus granulosus neuropeptide receptor A26 0.0375 0.5693 0.7495
Brugia malayi jmjC domain containing protein 0.0069 0.0941 0.1493
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0037 0.0441 0.0581
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0336 0.2628
Schistosoma mansoni hypothetical protein 0.016 0.236 0.311
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0016 0.0121 0.0199
Schistosoma mansoni RNA binding protein 0.0051 0.066 0.087
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0441 0.0669
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.1081
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0441 0.3923
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0143 0.2084 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.2813 0.3691
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0051 0.066 0.6608
Echinococcus multilocularis p2X purinoceptor 4 0.0058 0.0778 0.0761
Brugia malayi nuclear receptor NHR-67 0.019 0.2813 0.4577
Brugia malayi brahma associated protein 60 kDa 0.0143 0.2084 0.3376
Schistosoma mansoni P2X receptor subunit 0.0058 0.0778 0.1026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0385 0.0576
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0118
Echinococcus multilocularis thyroid hormone receptor alpha 0.0402 0.6105 0.6097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.019 0.2813 0.2799
Echinococcus granulosus p2X purinoceptor 4 0.0058 0.0778 0.1003
Plasmodium falciparum phosphodiesterase gamma, putative 0.0037 0.0441 0.1835
Schistosoma mansoni hypothetical protein 0.0021 0.02 0.0263
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Schistosoma mansoni hypothetical protein 0.0051 0.066 0.087
Brugia malayi latrophilin 2 splice variant baaae 0.0052 0.068 0.1063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0247 0.0325
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0139 0.1196
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0336 0.0317
Trichomonas vaginalis set domain proteins, putative 0.0191 0.2832 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0156 0.2298 0.8887
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Toxoplasma gondii ran binding protein 0.0051 0.066 0.1456
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0301 0.4535 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0174 0.2569 1
Onchocerca volvulus 0.0122 0.1761 0.2719
Schistosoma mansoni hypothetical protein 0.0143 0.2084 0.2746
Brugia malayi hypothetical protein 0.0099 0.1404 0.2254
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Onchocerca volvulus 0.0019 0.0175 0.0061
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0212 0.3166 0.5185
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0242 0.0446
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.0072 0.0345
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0016 0.0121 0.0135
Echinococcus multilocularis zinc finger protein Ran binding 0.0051 0.066 0.0642
Echinococcus granulosus ecdysone induced protein 78C 0.0402 0.6105 0.8039
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0441 0.0423
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0037 0.0441 0.0557
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6608
Schistosoma mansoni steroid hormone receptor ad4bp 0.0402 0.6105 0.8044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0402 0.6105 0.6097
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0051 0.066 0.7047
Echinococcus granulosus peregrin 0.0021 0.02 0.0238
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0441 0.471
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0441 0.118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0632 1
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.066 0.6608
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0268 0.0354
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0242 0.1482
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0547 0.0896
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0402 0.6105 0.8039
Loa Loa (eye worm) glutathione reductase 0.0069 0.0937 0.1534
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0336 0.0791
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0049 0.0632 0.6264
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0242 0.3039
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0037 0.0441 0.0723
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis peregrin 0.0021 0.02 0.0181
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0301 0.4535 0.5975
Loa Loa (eye worm) hypothetical protein 0.0051 0.066 0.1081
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Brugia malayi Calcitonin receptor-like protein seb-1 0.0076 0.1054 0.1678
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0402 0.6105 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Onchocerca volvulus 0.019 0.2813 0.4482
Onchocerca volvulus 0.0143 0.2084 0.3261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0268 0.0354
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0051 0.066 0.2923
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0156 0.2298 0.8921
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0139 0.031
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0336 0.3583
Schistosoma mansoni DNA helicase recq1 0.0016 0.0121 0.016
Brugia malayi hypothetical protein 0.019 0.2813 0.4577
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0051 0.066 0.1456
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0139 0.1196
Echinococcus granulosus SWI:SNF matrix associated 0.0143 0.2084 0.2728
Schistosoma mansoni thyroid hormone receptor 0.0402 0.6105 0.8044
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.02 0.0327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0632 1
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0632 0.0833
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Echinococcus multilocularis lysine specific demethylase 5A 0.0025 0.0268 0.025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0402 0.6105 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0402 0.6105 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0242 0.1482
Echinococcus granulosus lamin 0.0019 0.0175 0.0206
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.019 0.2813 0.4482
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0242 0.1482
Giardia lamblia Hypothetical protein 0.0037 0.0441 0.0725
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Brugia malayi nuclear receptor RXR 0.0212 0.3166 0.5157
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.0121 0.0246
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0051 0.066 0.1029
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0037 0.0441 0.0423
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0402 0.6105 0.6097
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0247 0.0228
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0051 0.066 0.0874
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0051 0.066 0.1029
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Chlamydia trachomatis SWIB complex protein 0.0143 0.2084 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0049 0.0632 0.2277
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Echinococcus multilocularis neuropeptide receptor A26 0.0375 0.5693 0.5685
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Schistosoma mansoni nuclear hormone receptor 0.019 0.2813 0.3707
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0402 0.6105 0.8044
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.066 0.7047
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0441 0.471
Giardia lamblia hypothetical protein 0.0037 0.0441 0.0725
Schistosoma mansoni P2X receptor subunit 0.0058 0.0778 0.1026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0212 0.3166 0.5185
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0336 0.0791
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.0725 0.0707
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0212 0.3166 0.4156
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0441 0.0581
Leishmania major hypothetical protein, conserved 0.0037 0.0441 0.3923
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.019 0.2813 0.2799
Brugia malayi hypothetical protein 0.0212 0.3166 0.5157
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0139 0.0216
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0943 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0402 0.6105 1
Entamoeba histolytica hypothetical protein 0.0055 0.0725 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.118
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0441 0.471
Plasmodium vivax glutathione reductase, putative 0.0069 0.0937 0.4494
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0268 0.044
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0301 0.4535 0.4524
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0139 0.1196
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0402 0.6105 0.8039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0941 0.1218
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0051 0.066 0.7047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0121 0.0142
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0143 0.2084 0.2069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0139 0.1915
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0441 0.2117
Schistosoma mansoni microtubule-associated protein tau 0.0498 0.7589 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0121 0.0268
Schistosoma mansoni hypothetical protein 0.0052 0.068 0.0897
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0441 0.0557
Brugia malayi nuclear hormone receptor family member nhr-6 0.019 0.2813 0.4577
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0242 0.3039
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0242 0.0534
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0143 0.2084 0.4596
Onchocerca volvulus 0.0051 0.066 0.0874
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0139 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Brugia malayi hypothetical protein 0.0122 0.1761 0.2843
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0441 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0402 0.6105 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0139 0.1196
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.019 0.2813 0.3691
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0402 0.6105 0.8039
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.1482
Plasmodium vivax hypothetical protein, conserved 0.0021 0.02 0.0959
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0402 0.6105 1
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.066 0.7047
Brugia malayi jmjC domain containing protein 0.0025 0.0268 0.0384
Echinococcus granulosus jumonji domain containing protein 0.0029 0.0327 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0402 0.6105 0.8044
Schistosoma mansoni intermediate filament proteins 0.0019 0.0175 0.0231
Loa Loa (eye worm) nuclear receptor NHR-67 0.019 0.2813 0.4608
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0118
Schistosoma mansoni P2X receptor subunit 0.0058 0.0778 0.1026
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.019 0.2813 0.2799
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0402 0.6105 0.8039
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.02 0.0441
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis PHD finger protein rhinoceros 0.0021 0.02 0.0181
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0278
Loa Loa (eye worm) hypothetical protein 0.0212 0.3166 0.5185
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0121 0.0142
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0139 0.0216
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0242 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Schistosoma mansoni TRABID protein (C64 family) 0.0051 0.066 0.087
Echinococcus granulosus Nuclear hormone receptor HR96 0.019 0.2813 0.3691
Echinococcus multilocularis lamin 0.0019 0.0175 0.0156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0441 0.0973
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0385 0.0367
Loa Loa (eye worm) hypothetical protein 0.0008 0.00000000010205 0.00000000016716
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Echinococcus granulosus p2X purinoceptor 4 0.0058 0.0778 0.1003
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0139 0.0171
Giardia lamblia PHD finger protein 15 0.0021 0.02 0.0178
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0212 0.3166 0.3152
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0072 0.0043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0402 0.6105 0.8044
Echinococcus multilocularis musashi 0.0019 0.0175 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0247 0.0404
Loa Loa (eye worm) hypothetical protein 0.019 0.2813 0.4608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0242 0.2585
Trypanosoma brucei trypanothione reductase 0.0069 0.0937 1
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0632 0.0833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0385 0.0367
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0402 0.6105 0.8039
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0139 0.0171
Brugia malayi Bromodomain containing protein 0.0021 0.02 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0402 0.6105 1
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.2084 0.7242
Brugia malayi hypothetical protein 0.0055 0.0725 0.1137
Schistosoma mansoni RAR-like nuclear receptor 0.0402 0.6105 0.8044
Leishmania major hypothetical protein, conserved 0.0051 0.066 0.6608
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0032
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0037 0.0441 0.3923
Echinococcus multilocularis p2X purinoceptor 4 0.0058 0.0778 0.0761
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0336 0.0442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0247 0.0325
Entamoeba histolytica hypothetical protein 0.0055 0.0725 1
Brugia malayi hypothetical protein 0.019 0.2813 0.4577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0402 0.6105 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0301 0.4535 0.5965
Brugia malayi YY1-associated factor 2 0.0051 0.066 0.1029
Loa Loa (eye worm) hypothetical protein 0.003 0.0336 0.055
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.02 0.0441
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0336 0.3583
Brugia malayi Nuclear hormone receptor E75 0.019 0.2813 0.4577
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0174 0.2569 1
Loa Loa (eye worm) hypothetical protein 0.0402 0.6105 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0051 0.066 0.6608
Plasmodium falciparum phd finger protein, putative 0.0021 0.02 0.0636
Echinococcus granulosus zinc finger protein Ran binding 0.0051 0.066 0.0847
Plasmodium vivax phosphodiesterase gamma, putative 0.0037 0.0441 0.2117
Plasmodium falciparum thioredoxin reductase 0.0024 0.0242 0.0846
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0441 0.118
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0051 0.066 0.0642
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0139 0.1196
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0049 0.0632 0.0809
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0242 0.0846

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7 nM l-1 Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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