Detailed information for compound 273963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 801.254 | Formula: C28H19F6I2NO4
  • H donors: 1 H acceptors: 3 LogP: 7.5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1Cc2cc(I)c(c(c2CN1C(=O)/C=C/c1ccccc1C(F)(F)F)I)OCc1cccc(c1)C(F)(F)F
  • InChi: 1S/C28H19F6I2NO4/c29-27(30,31)18-6-3-4-15(10-18)14-41-25-21(35)11-17-12-22(26(39)40)37(13-19(17)24(25)36)23(38)9-8-16-5-1-2-7-20(16)28(32,33)34/h1-11,22H,12-14H2,(H,39,40)/b9-8+/t22-/m0/s1
  • InChiKey: XIVZILSLPOQNRA-UVIRAJKCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0301 0.0672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Trypanosoma brucei trypanothione reductase 0.0039 0.0301 0.0672
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0617 0.0617
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0167 0.0167
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0072 0.0774 0.1256
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4122 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0951 0.0951
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0082 0.0911 0.1478
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0349 0.0565
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0092 0.2934
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0951 0.0951
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1821 0.4383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Echinococcus multilocularis muscleblind protein 0.0153 0.1914 0.1914
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0579 0.795 1
Echinococcus granulosus zinc finger protein 0.002 0.0036 0.0036
Schistosoma mansoni bromodomain containing protein 0.0065 0.0669 0.0669
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0579 0.795 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Schistosoma mansoni zinc finger protein 0.002 0.0036 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0063
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0073 0.0784 0.1273
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0494 0.0494
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.1002 0.1232
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0349 0.0875
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0349 0.0875
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1821 0.4383
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0041
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0178 0.5718
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.1002 0.1232
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0153 0.1914 0.3107
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0178 0.1415
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0494 0.0494
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0494 0.1185
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Onchocerca volvulus 0.0096 0.1116 0.1812
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.01 0.0794
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0951 0.1544
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0167 0.0167
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.211 0.211
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0774 0.1256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0079 0.0079
Plasmodium falciparum glutathione reductase 0.0039 0.0301 0.9656
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0084
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0956 0.0956
Onchocerca volvulus 0.0052 0.0488 0.0791
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0311 1
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0308 0.0501
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.2197
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0301 0.0347
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3981 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.09 0.1461
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0288 0.0467
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0052 0.0084
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1326 0.2152
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0276 0.0612
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0092 0.0084
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0494 0.1145
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1326 0.3174
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.211 0.211
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0178 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.1002 0.1232
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0833
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.211 0.3425
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0199
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0951 0.0951
Loa Loa (eye worm) aspartyl protease 6 0.0017 0 0.0001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0579 0.795 1
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0301 0.0488
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0167 0.0359
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0138 0.0138
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0178 0.5718
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0092 0.0162
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1821 0.4383
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0205 0.0454
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0632 0.0632
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1819 0.2263
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0804
Loa Loa (eye worm) hypothetical protein 0.0085 0.0951 0.1544
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0092 0.3039
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0306 0.0306
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1326 0.1641
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0079 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0178 0.5922
Plasmodium falciparum thioredoxin reductase 0.0039 0.0301 0.9656
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0178 0.0386
Brugia malayi glutathione reductase 0.0039 0.0301 0.0487
Loa Loa (eye worm) hypothetical protein 0.0042 0.0343 0.0556
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0368 0.0835
Onchocerca volvulus 0.0081 0.09 0.1461
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Brugia malayi MAP kinase sur-1 0.0052 0.0494 0.0802
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0502 0.1163
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0167 0.5375
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0708 0.1667
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Mycobacterium ulcerans hypothetical protein 0.0106 0.1256 0.1553
Brugia malayi C1-like domain containing protein 0.0082 0.0911 0.1478
Echinococcus multilocularis tumor protein p63 0.0355 0.4771 0.4771
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0632 0.1025
Echinococcus multilocularis zinc finger protein 0.002 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.005 0.0458 0.3643
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0288 0.0665
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0178 0.0386
Schistosoma mansoni lozenge 0.0057 0.0557 0.0557
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0092 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.0084 0.0935 0.1517
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1914 0.1914
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0708 0.1726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.1002 0.1232
Schistosoma mansoni memapsin-2 (A01 family) 0.0435 0.5905 0.5905
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1326 0.1326
Plasmodium vivax glutathione reductase, putative 0.0039 0.0301 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1141 0.1408
Echinococcus multilocularis Protein lozenge 0.0057 0.0557 0.0557
Brugia malayi jmjC domain containing protein 0.0062 0.0632 0.1025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0236
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0724 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1256 0.1553
Schistosoma mansoni microtubule-associated protein tau 0.0724 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1141 0.1335
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0723
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0494 0.1145
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Schistosoma mansoni jumonji domain containing protein 0.006 0.0604 0.0604
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0494 0.0494
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0167 0.0167
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0276 0.0693
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.133
Brugia malayi jmjC domain containing protein 0.006 0.0604 0.098
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0632 0.0632
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3981 1
Brugia malayi Bromodomain containing protein 0.0039 0.0307 0.0498
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0604 0.0604
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0604 0.0604
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0708 0.0708
Toxoplasma gondii thioredoxin reductase 0.0039 0.0301 0.239
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3981 1
Schistosoma mansoni hypothetical protein 0.0021 0.0052 0.0052
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1326 0.1326
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0106 0.1256 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0723
Onchocerca volvulus 0.0072 0.0774 0.1255
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.0271
Brugia malayi Bromodomain containing protein 0.0077 0.0838 0.136
Mycobacterium ulcerans hypothetical protein 0.0106 0.1256 0.1553
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0276 0.0448
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0951 0.1544
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0693
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1326 0.1326
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0276 0.0693
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0167
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0092 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.211 0.3425
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0178 0.1415
Mycobacterium tuberculosis Probable reductase 0.0088 0.1002 0.1232
Brugia malayi Thioredoxin reductase 0.0039 0.0301 0.0487
Brugia malayi phosphofructokinase 0.0111 0.1326 0.2151
Echinococcus granulosus bloom syndrome protein 0.0042 0.0349 0.0349
Echinococcus granulosus muscleblind protein 0.0153 0.1914 0.1914
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Loa Loa (eye worm) hypothetical protein 0.0153 0.1914 0.3107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1326 0.3287
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0951 0.0951
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1819 0.2198
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1256 0.1553
Onchocerca volvulus 0.0085 0.0956 0.1551
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0178 0.0386
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Leishmania major trypanothione reductase 0.0039 0.0301 0.0672
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0494 0.1145
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.1002 0.1232
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0178 0.1415
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.0272
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0072 0.0776 0.126
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Loa Loa (eye worm) hypothetical protein 0.0038 0.0288 0.0468
Onchocerca volvulus 0.0084 0.0935 0.1516
Brugia malayi Muscleblind-like protein 0.0153 0.1914 0.3107
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0178 1
Loa Loa (eye worm) glutathione reductase 0.0039 0.0301 0.0488
Brugia malayi 6-phosphofructokinase 0.0111 0.1326 0.2151
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0956 0.0956
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.211 0.211
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.4122 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Onchocerca volvulus 0.0453 0.6161 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0494 0.1145
Trypanosoma brucei glucosidase, putative 0.0037 0.0276 0.0612
Loa Loa (eye worm) runx1 0.0057 0.0557 0.0904
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0708 0.0708
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0617 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0 0.0001
Brugia malayi PHD-finger family protein 0.0025 0.0114 0.0184
Schistosoma mansoni protein kinase C mu 0.0082 0.0911 0.0911
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Loa Loa (eye worm) RecQ helicase 0.0042 0.0349 0.0566
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0008 0.0008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0494 0.1145
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0723
Loa Loa (eye worm) hypothetical protein 0.0044 0.037 0.0601
Loa Loa (eye worm) hypothetical protein 0.0453 0.6161 1
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1326 0.2152
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0084
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0009 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0494 0.0802
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.133
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Loa Loa (eye worm) hypothetical protein 0.0453 0.6161 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0092 0.0726
Schistosoma mansoni alpha-glucosidase 0.0143 0.1782 0.1782
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0488 0.0488
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1326 0.3174
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0693
Treponema pallidum licC protein (licC) 0.0106 0.1256 0.3112
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0349 0.0349
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0288 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4122 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0092 0.0726
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1326 0.2152
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0632 0.0632
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0205 0.0514
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0041
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0106 0.1256 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0167 0.0272
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0579 0.795 1
Brugia malayi 6-phosphofructokinase 0.0111 0.1326 0.2151
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0951 0.0951
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0008 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0288 0.0665
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3981 1
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0604 0.0604
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.0271
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1141 0.1408
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0288 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.1002 0.1158
Echinococcus granulosus tumor protein p63 0.0355 0.4771 0.4771
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0494 0.1145
Schistosoma mansoni alpha-glucosidase 0.0143 0.1782 0.1782
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0494 0.1145
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0108 0.3591
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0288 0.0642
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1326 0.3174
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0708 0.1149
Schistosoma mansoni DNA helicase recq1 0.0029 0.0167 0.0167
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0956 0.1551
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Entamoeba histolytica hypothetical protein 0.0024 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0085 0.0956 0.1552
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0494 0.3933
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1326 0.1641
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0708 0.115
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0494 0.0494
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.4122 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0488 0.0792
Schistosoma mansoni alpha glucosidase 0.0037 0.0276 0.0276
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0167 0.0167
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0082 0.0911 0.1478
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0956 0.0956
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0306 0.0306
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1819 0.2263
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0951 0.0951
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0276 0.0448
Trypanosoma brucei protein kinase, putative 0.0052 0.0494 0.1145
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1326 0.157
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0178 0.5922
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1141 0.1408
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0178 0.0446
Brugia malayi hypothetical protein 0.0453 0.6161 1
Mycobacterium ulcerans hypothetical protein 0.0163 0.2055 0.2561
Schistosoma mansoni DNA helicase recq5 0.0029 0.0167 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2055 0.2561

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 36 uM Compound was measured for its inhibitory activity against Cell division cycle 25B ChEMBL. 10762045
IC50 (binding) = 36 uM Compound was measured for its inhibitory activity against Cell division cycle 25B ChEMBL. 10762045

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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