Detailed information for compound 273963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 801.254 | Formula: C28H19F6I2NO4
  • H donors: 1 H acceptors: 3 LogP: 7.5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1Cc2cc(I)c(c(c2CN1C(=O)/C=C/c1ccccc1C(F)(F)F)I)OCc1cccc(c1)C(F)(F)F
  • InChi: 1S/C28H19F6I2NO4/c29-27(30,31)18-6-3-4-15(10-18)14-41-25-21(35)11-17-12-22(26(39)40)37(13-19(17)24(25)36)23(38)9-8-16-5-1-2-7-20(16)28(32,33)34/h1-11,22H,12-14H2,(H,39,40)/b9-8+/t22-/m0/s1
  • InChiKey: XIVZILSLPOQNRA-UVIRAJKCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1326 0.1326
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0579 0.795 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0178 0.0446
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0368 0.0835
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Trypanosoma brucei trypanothione reductase 0.0039 0.0301 0.0672
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0079 0.0079
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0092 0.0726
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0494 0.1145
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1821 0.4383
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1914 0.1914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0349 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0951 0.1544
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.2197
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.1002 0.1232
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0276 0.0612
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.01 0.0794
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0092 0.0162
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0167 0.0167
Schistosoma mansoni DNA helicase recq5 0.0029 0.0167 0.0167
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1326 0.3287
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0502 0.1163
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0106 0.1256 0.1553
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0693
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0008 0.0008
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0579 0.795 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Brugia malayi MAP kinase sur-1 0.0052 0.0494 0.0802
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1141 0.1408
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0288 0.0288
Onchocerca volvulus 0.0072 0.0774 0.1255
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0092 0.3039
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0708 0.0708
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0084
Loa Loa (eye worm) hypothetical protein 0.0085 0.0956 0.1552
Loa Loa (eye worm) hypothetical protein 0.0029 0.0167 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3981 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0951 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0494 0.0494
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1326 0.1326
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0956 0.0956
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0079 0.0079
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0951 0.0951
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1821 0.4383
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0092 0.0162
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0082 0.0911 0.1478
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0604 0.0604
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0951 0.1544
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1141 0.1408
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0494 0.3933
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0708 0.1667
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0041
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1326 0.3174
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0488 0.0488
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1256 0.1553
Schistosoma mansoni hypothetical protein 0.0021 0.0052 0.0052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0276 0.0448
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0288 0.0665
Schistosoma mansoni bromodomain containing protein 0.0065 0.0669 0.0669
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3981 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1326 0.1641
Loa Loa (eye worm) hypothetical protein 0.0084 0.0935 0.1517
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0494 0.1145
Brugia malayi Bromodomain containing protein 0.0039 0.0307 0.0498
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0178 0.5718
Brugia malayi Bromodomain containing protein 0.0077 0.0838 0.136
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0349 0.0875
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.1002 0.1158
Schistosoma mansoni alpha-glucosidase 0.0143 0.1782 0.1782
Onchocerca volvulus 0.0084 0.0935 0.1516
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0301 0.0488
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0494 0.1145
Echinococcus granulosus bloom syndrome protein 0.0042 0.0349 0.0349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1256 0.1553
Brugia malayi Thioredoxin reductase 0.0039 0.0301 0.0487
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0311 1
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.4122 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0708 0.1149
Leishmania major trypanothione reductase 0.0039 0.0301 0.0672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Echinococcus multilocularis zinc finger protein 0.002 0.0036 0.0036
Plasmodium falciparum glutathione reductase 0.0039 0.0301 0.9656
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0494 0.1145
Echinococcus multilocularis tumor protein p63 0.0355 0.4771 0.4771
Echinococcus granulosus muscleblind protein 0.0153 0.1914 0.1914
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0951 0.0951
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0708 0.1726
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1326 0.157
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.1002 0.1232
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0301 0.0347
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0579 0.795 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0494 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0 0.0001
Echinococcus granulosus zinc finger protein 0.002 0.0036 0.0036
Brugia malayi C1-like domain containing protein 0.0082 0.0911 0.1478
Loa Loa (eye worm) hypothetical protein 0.0153 0.1914 0.3107
Brugia malayi 6-phosphofructokinase 0.0111 0.1326 0.2151
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0009 0.0014
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.0271
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0494 0.0494
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1819 0.2263
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.211 0.211
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.1002 0.1232
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0 0.0001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0178 0.1415
Schistosoma mansoni alpha-glucosidase 0.0143 0.1782 0.1782
Loa Loa (eye worm) aspartyl protease 6 0.0017 0 0.0001
Mycobacterium ulcerans hypothetical protein 0.0106 0.1256 0.1553
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0167 0.5375
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0167 0.0167
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0025
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0494 0.1185
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0236
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Plasmodium falciparum thioredoxin reductase 0.0039 0.0301 0.9656
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0708 0.0708
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Onchocerca volvulus 0.0052 0.0488 0.0791
Loa Loa (eye worm) hypothetical protein 0.0042 0.0343 0.0556
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1141 0.1408
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0301 0.0672
Brugia malayi phosphofructokinase 0.0111 0.1326 0.2151
Loa Loa (eye worm) hypothetical protein 0.0072 0.0776 0.126
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0349 0.0349
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0205 0.0454
Brugia malayi Muscleblind-like protein 0.0153 0.1914 0.3107
Brugia malayi jmjC domain containing protein 0.006 0.0604 0.098
Trypanosoma brucei protein kinase, putative 0.0052 0.0494 0.1145
Loa Loa (eye worm) hypothetical protein 0.0153 0.1914 0.3107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0632 0.0632
Schistosoma mansoni DNA helicase recq1 0.0029 0.0167 0.0167
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1326 0.2152
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3981 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4122 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0092 0.0084
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0632 0.0632
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.1002 0.1232
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0301 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.1002 0.1232
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0092 0.0726
Echinococcus multilocularis microtubule associated protein 2 0.0724 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0288 0.0467
Loa Loa (eye worm) hypothetical protein 0.0072 0.0774 0.1256
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0178 0.0386
Echinococcus granulosus tumor protein p63 0.0355 0.4771 0.4771
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0288 0.0288
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0178 0.1415
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0956 0.0956
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1819 0.2263
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0708 0.1667
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1326 0.1326
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.133
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.211 0.3425
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1821 0.4383
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0494 0.0494
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0276 0.0693
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0604 0.0604
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0951 0.0951
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.211 0.211
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0073 0.0784 0.1273
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0041
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0951 0.0951
Treponema pallidum licC protein (licC) 0.0106 0.1256 0.3112
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0494 0.0802
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1326 0.1641
Echinococcus multilocularis Protein lozenge 0.0057 0.0557 0.0557
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0178 0.1415
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0604 0.0604
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0723
Onchocerca volvulus 0.0085 0.0956 0.1551
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1326 0.2152
Loa Loa (eye worm) RecQ helicase 0.0042 0.0349 0.0566
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0306 0.0306
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.4122 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0306 0.0306
Brugia malayi jmjC domain containing protein 0.0062 0.0632 0.1025
Loa Loa (eye worm) hypothetical protein 0.0453 0.6161 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3981 1
Loa Loa (eye worm) glutathione reductase 0.0039 0.0301 0.0488
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1326 0.3329
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1326 0.1326
Schistosoma mansoni lozenge 0.0057 0.0557 0.0557
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0205 0.0438
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0288 0.0665
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0167 0.0359
Loa Loa (eye worm) hypothetical protein 0.0453 0.6161 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0774 0.1256
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Loa Loa (eye worm) hypothetical protein 0.0052 0.0488 0.0792
Schistosoma mansoni zinc finger protein 0.002 0.0036 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2055 0.2561
Loa Loa (eye worm) runx1 0.0057 0.0557 0.0904
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1326 0.3174
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0693
Toxoplasma gondii hypothetical protein 0.005 0.0458 0.3643
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1141 0.1335
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0632 0.1025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.133
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0956 0.1551
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0205 0.0514
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0052 0.0084
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0082 0.0911 0.1478
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0084
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0199
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0708 0.0708
Mycobacterium tuberculosis Probable reductase 0.0088 0.1002 0.1232
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0617 0.0617
Trypanosoma brucei glucosidase, putative 0.0037 0.0276 0.0612
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0494 0.1145
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Schistosoma mansoni protein kinase C mu 0.0082 0.0911 0.0911
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0108 0.3591
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0956 0.0956
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0288 0.0288
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0804
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.211 0.211
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0276 0.0693
Loa Loa (eye worm) hypothetical protein 0.0038 0.0288 0.0468
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Toxoplasma gondii thioredoxin reductase 0.0039 0.0301 0.239
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0063
Schistosoma mansoni jumonji domain containing protein 0.006 0.0604 0.0604
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0044 0.037 0.0601
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0167 0.0167
Onchocerca volvulus 0.0081 0.09 0.1461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4122 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0833
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0349 0.0875
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0178 0.5922
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0039 0.0308 0.0501
Mycobacterium ulcerans hypothetical protein 0.0106 0.1256 0.1553
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1326 0.3174
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0079 0.0079
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0178 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0178 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0494 0.1145
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Onchocerca volvulus 0.0096 0.1116 0.1812
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0178 0.0386
Loa Loa (eye worm) hypothetical protein 0.0081 0.09 0.1461
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0288 0.0642
Schistosoma mansoni microtubule-associated protein tau 0.0724 1 1
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0106 0.1256 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0178 0.0386
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0178 0.5718
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0368 0.0835
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0288 0.0288
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0494 0.1145
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0708 0.115
Schistosoma mansoni alpha glucosidase 0.0037 0.0276 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0723
Brugia malayi glutathione reductase 0.0039 0.0301 0.0487
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0579 0.795 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.211 0.3425
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0178 0.5922
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0092 0.0084
Brugia malayi hypothetical protein 0.0453 0.6161 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0301 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0167 0.0167
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0138 0.0138
Brugia malayi 6-phosphofructokinase 0.0111 0.1326 0.2151
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0494 0.1241
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0167 0.0272
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0167 0.0271
Mycobacterium ulcerans hypothetical protein 0.0163 0.2055 0.2561
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1326 0.2152
Schistosoma mansoni memapsin-2 (A01 family) 0.0435 0.5905 0.5905
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0092 0.0167
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1819 0.2198
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0063
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0951 0.1544
Schistosoma mansoni hypothetical protein 0.0085 0.0951 0.0951
Onchocerca volvulus 0.0453 0.6161 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0178 0.0446
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0693
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0951 0.0951
Echinococcus multilocularis muscleblind protein 0.0153 0.1914 0.1914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Brugia malayi PHD-finger family protein 0.0025 0.0114 0.0184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0092 0.2934
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0276 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3981 1
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1326 0.3287
Entamoeba histolytica hypothetical protein 0.0024 0.0092 0.0167
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0617 0.0617

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 36 uM Compound was measured for its inhibitory activity against Cell division cycle 25B ChEMBL. 10762045
IC50 (binding) = 36 uM Compound was measured for its inhibitory activity against Cell division cycle 25B ChEMBL. 10762045

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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