Detailed information for compound 275768

Basic information

Technical information
  • TDR Targets ID: 275768
  • Name: 1-phenethyl-4-[3-[5-(1,2,4-triazol-4-yl)-1H-i ndol-3-yl]propyl]piperazin-2-one
  • MW: 428.529 | Formula: C25H28N6O
  • H donors: 1 H acceptors: 3 LogP: 3.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CN(CCCc2c[nH]c3c2cc(cc3)n2cnnc2)CCN1CCc1ccccc1
  • InChi: 1S/C25H28N6O/c32-25-17-29(13-14-30(25)12-10-20-5-2-1-3-6-20)11-4-7-21-16-26-24-9-8-22(15-23(21)24)31-18-27-28-19-31/h1-3,5-6,8-9,15-16,18-19,26H,4,7,10-14,17H2
  • InChiKey: FVUNSWROPFFXFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenethyl-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]-2-piperazinone
  • 1-(2-phenylethyl)-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazin-2-one
  • 1-(2-phenylethyl)-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]-2-piperazinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.078 0.078
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0046 0.0348
Brugia malayi GnHR receptor homolog 0.0268 0.1507 0.4182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0022 0.0037
Onchocerca volvulus 0.0268 0.1507 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.002 0.0546
Onchocerca volvulus 0.0015 0.002 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0126
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.002 0.0678
Toxoplasma gondii hypothetical protein 0.0019 0.0047 0.1918
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0177 0.1354
Loa Loa (eye worm) hypothetical protein 0.0162 0.0882 0.2449
Loa Loa (eye worm) adenylyl cyclase 3 0.0184 0.1014 0.2814
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.026 0.0721
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0228 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0182 0.7371
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.002 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0215 0.0596
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.002 0.0546
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0126 0.0349
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.1507 0.3799
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.0362
Giardia lamblia DINP protein human, muc B family 0.0019 0.0046 0.2818
Loa Loa (eye worm) TYRA-2 protein 0.0268 0.1507 0.4182
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0017 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Echinococcus granulosus orexin receptor type 2 0.0268 0.1507 0.246
Schistosoma mansoni histamine h1 receptor 0.0268 0.1507 0.3799
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0153 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.1507 0.3799
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0046 0.1563
Brugia malayi AMP-binding enzyme family protein 0.0015 0.002 0.0055
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.002 0.1083
Schistosoma mansoni single-minded 0.0048 0.0216 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0052
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0177 0.1354
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.3966 0.3966
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0369
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0228 1
Schistosoma mansoni hypothetical protein 0.0033 0.0126 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Schistosoma mansoni amine GPCR 0.0268 0.1507 0.3799
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Echinococcus multilocularis geminin 0.0168 0.0919 0.0919
Brugia malayi G-protein coupled receptor 0.0268 0.1507 0.4182
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0316 0.1788 0.4961
Onchocerca volvulus 0.0268 0.1507 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0228 0.0632
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi Adenylyl cyclase protein 0.0078 0.0391 0.1084
Echinococcus granulosus dna polymerase kappa 0.0019 0.0046 0.0074
Entamoeba histolytica hypothetical protein 0.0035 0.0136 0.5992
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.00000034511 0.0000026328
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0141 0.6071
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi Muscleblind-like protein 0.0316 0.1788 0.4961
Onchocerca volvulus 0.0027 0.009 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.1534 0.1534
Schistosoma mansoni hypothetical protein 0.0268 0.1507 0.3799
Onchocerca volvulus 0.005 0.0228 0.1511
Schistosoma mansoni survival motor neuron protein 0.0056 0.026 0.0655
Loa Loa (eye worm) hypothetical protein 0.0078 0.0391 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0292 0.0735
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.002 0.0453
Schistosoma mansoni biogenic amine receptor 0.0268 0.1507 0.3799
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0046 0.1563
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0268 0.1507 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0242
Loa Loa (eye worm) hypothetical protein 0.005 0.0228 0.0632
Echinococcus multilocularis g protein coupled receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Schistosoma mansoni neuropeptide f receptor 76f 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0022 0.0062
Echinococcus granulosus 7tm_1 domain containing protein 0.0268 0.1507 0.246
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0092 0.0698
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0581 0.3341 0.9273
Echinococcus granulosus muscleblind protein 0.0316 0.1788 0.2919
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0369
Echinococcus granulosus tachykinin peptides receptor 99D 0.0268 0.1507 0.246
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0177 0.6086
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.1507 0.246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Echinococcus granulosus somatostatin receptor 0.0268 0.1507 0.246
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0292 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0022 0.0037
Schistosoma mansoni neuropeptide receptor 0.0268 0.1507 0.3799
Echinococcus granulosus dna polymerase eta 0.0019 0.0046 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0757 0.1235
Onchocerca volvulus 0.0268 0.1507 1
Onchocerca volvulus 0.0078 0.0391 0.2593
Brugia malayi G protein-coupled receptor 0.0268 0.1507 0.4182
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.005 0.0228 0.0632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0022 0.0022
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.002 0.0546
Echinococcus granulosus Solute carrier family 22 5 0.1055 0.6125 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0141 0.6071
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.00000034511 0.00000034511
Onchocerca volvulus 0.0268 0.1507 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0268 0.1507 0.246
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0046 0.136
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0182 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.1507 0.4182
Echinococcus granulosus geminin 0.0168 0.0919 0.15
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0268 0.1507 0.246
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0268 0.1507 0.4182
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0046 0.2002
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi Pre-SET motif family protein 0.0206 0.1144 0.3174
Echinococcus multilocularis sex peptide receptor 0.0268 0.1507 0.1507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Echinococcus granulosus neuropeptide receptor 0.0268 0.1507 0.246
Onchocerca volvulus 0.0027 0.009 0.0598
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.002 0.0678
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0007 0.0236
Schistosoma mansoni hypothetical protein 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0046 0.0115
Brugia malayi neuropeptide F receptor 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0625 0.3603 1
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.002 0.0453
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0047 0.1918
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0053 0.0148
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0625 0.3603 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0107 0.0107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.1507 0.246
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0092 0.0254
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.002 0.0868
Brugia malayi PAS domain containing protein 0.0048 0.0216 0.06
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0425
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034511 0.0000026328
Loa Loa (eye worm) hypothetical protein 0.0316 0.1788 0.4961
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0369
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0046 0.0074
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.002 0.0678
Trypanosoma brucei unspecified product 0.0019 0.0046 0.1563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.002 0.0868
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0026 0.0201
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.1507 0.1507
Brugia malayi intermediate filament protein 0.0027 0.009 0.025
Echinococcus multilocularis somatostatin receptor 0.0268 0.1507 0.1507
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0182 0.0298
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0047 0.2085
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0047 0.2935
Entamoeba histolytica hypothetical protein 0.0035 0.0136 0.5992
Mycobacterium ulcerans hypothetical protein 0.005 0.0228 1
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0047 0.2602
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.1507 0.246
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.1507 0.4182
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.1507 0.246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0228 1
Onchocerca volvulus 0.0235 0.1311 0.8699
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0248 0.1888
Echinococcus multilocularis muscleblind protein 1 0.0316 0.1788 0.1788
Loa Loa (eye worm) hypothetical protein 0.003 0.0107 0.0297
Echinococcus multilocularis g-protein coupled receptor 0.0268 0.1507 0.1507
Echinococcus granulosus allatostatin A receptor 0.0268 0.1507 0.246
Echinococcus multilocularis neuropeptide s receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Brugia malayi ORL1-like opioid receptor 0.0268 0.1507 0.4182
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0268 0.1507 0.3799
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0292 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0268 0.1507 0.1507
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0228 0.7756
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.1507 0.246
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0268 0.1507 0.3799
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.1507 0.246
Mycobacterium leprae Possible regulatory protein 0.0013 0.0007 0.0302
Brugia malayi Melatonin receptor type 1A 0.0268 0.1507 0.4182
Brugia malayi AKH receptor 0.0268 0.1507 0.4182
Onchocerca volvulus 0.0268 0.1507 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0371 0.103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Onchocerca volvulus 0.0268 0.1507 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.002 0.0453
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0017 0.0048
Brugia malayi sulfakinin receptor protein 0.0268 0.1507 0.4182
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.002 0.005
Echinococcus granulosus neuropeptide receptor 0.0268 0.1507 0.246
Echinococcus granulosus g-protein coupled receptor 0.0268 0.1507 0.246
Echinococcus multilocularis dro:myosuppressin receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Echinococcus granulosus neuropeptide receptor A26 0.0268 0.1507 0.246
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0292 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0026 0.0201
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0026 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Brugia malayi Tachykinin-like peptides receptor 99D 0.0268 0.1507 0.4182
Leishmania major DNA polymerase kappa, putative 0.0019 0.0046 0.136
Echinococcus multilocularis muscleblind protein 0.0316 0.1788 0.1788
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.00000034511 0.00000087008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0046 0.0126
Echinococcus granulosus single minded 2 0.0036 0.0143 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Echinococcus multilocularis G-protein coupled receptor, putative 0.0268 0.1507 0.1507
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0015
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.002 0.0678
Schistosoma mansoni amine GPCR 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi hypoxia-induced factor 1 0.0149 0.0809 0.2245
Loa Loa (eye worm) acetyltransferase 0.0144 0.078 0.2166
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0007 0.0236
Onchocerca volvulus 0.0013 0.0007 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0107 0.0175
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.002 0.0868
Brugia malayi Cytochrome P450 family protein 0.002 0.0053 0.0148
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.002 0.0799
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Schistosoma mansoni hypothetical protein 0.0268 0.1507 0.3799
Brugia malayi hypothetical protein 0.0035 0.0136 0.0379
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0092 0.0698
Echinococcus multilocularis allatostatin A receptor 0.0268 0.1507 0.1507
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0215 0.0596
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.1507 0.1507
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0046 0.2002
Echinococcus multilocularis g protein coupled receptor 0.0268 0.1507 0.1507
Brugia malayi Serotonin receptor 0.0268 0.1507 0.4182
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0022 0.0062
Loa Loa (eye worm) hypothetical protein 0.0625 0.3603 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0046 0.172
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.025
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.3966 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.005 0.0228 0.0632
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0007 0.0236
Onchocerca volvulus 0.003 0.0107 0.071
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.002 0.0868
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0046 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.1507 0.3799
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0141 0.6071
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0809 0.2245
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0268 0.1507 0.3799
Echinococcus granulosus hypothetical protein 0.0268 0.1507 0.246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Echinococcus multilocularis lamin 0.0027 0.009 0.009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0268 0.1507 0.3799
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0268 0.1507 0.1507
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.002 0.0799
Loa Loa (eye worm) melatonin receptor type 1A 0.0268 0.1507 0.4182
Brugia malayi AMP-binding enzyme family protein 0.005 0.0228 0.0632
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0047 0.2085
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0182 0.7371
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.0391 0.0391
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0101 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0046 0.0126
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.002 0.0055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0228 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.002 0.0055
Toxoplasma gondii hypothetical protein 0.0054 0.0248 1
Echinococcus granulosus g protein coupled receptor 0.0268 0.1507 0.246
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.002 0.0868
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0136 0.0223
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0292 1
Brugia malayi larval opioid receptor 0.0268 0.1507 0.4182
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0228 0.7756
Onchocerca volvulus 0.0015 0.002 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.002 0.1222
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0047 0.1806
Loa Loa (eye worm) CYP4Cod1 0.002 0.0053 0.0148
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0026 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0107 0.027
Echinococcus granulosus fmrfamide receptor 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus granulosus microtubule associated protein 2 0.0687 0.3966 0.6476
Onchocerca volvulus 0.0268 0.1507 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Schistosoma mansoni hypothetical protein 0.0168 0.0919 0.2316
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Brugia malayi Serotonin receptor 0.0268 0.1507 0.4182
Brugia malayi hypothetical protein 0.0162 0.0882 0.2449
Echinococcus granulosus G protein coupled receptor 139 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis fmrfamide receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Brugia malayi Pre-SET motif family protein 0.003 0.0107 0.0297
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0496 0.2845 0.7894
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0268 0.1507 0.4182
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0268 0.1507 0.1507
Echinococcus granulosus lamin dm0 0.0027 0.009 0.0147
Leishmania major cytochrome p450-like protein 0.002 0.0053 0.1632
Entamoeba histolytica hypothetical protein 0.0035 0.0136 0.5992
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0053 0.2342
Echinococcus granulosus serotonin receptor 0.0268 0.1507 0.246
Onchocerca volvulus 0.0268 0.1507 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0182 0.1392
Brugia malayi Cytochrome P450 family protein 0.002 0.0053 0.0148
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.002 0.0868
Onchocerca volvulus 0.0268 0.1507 1
Echinococcus multilocularis neuropeptide receptor A26 0.0268 0.1507 0.1507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Echinococcus multilocularis adenylate cyclase type IX 0.0109 0.0576 0.0576
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0047 0.2085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0022 0.0022
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.002 0.0868
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.078 0.2166
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.1507 0.1507
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0026 0.0201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0136 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.0268 0.1507 0.4182
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.002 0.0678
Echinococcus granulosus neuropeptide s receptor 0.0268 0.1507 0.246
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.002 0.0546
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.002 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0228 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0625 0.3603 0.9085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.1507 0.246
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0268 0.1507 0.246
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.002 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0292 0.2224
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0268 0.1507 0.4182
Onchocerca volvulus 0.0268 0.1507 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0228 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Schistosoma mansoni amine GPCR 0.0268 0.1507 0.3799
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.002 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Schistosoma mansoni neuropeptide receptor 0.0268 0.1507 0.3799
Echinococcus multilocularis fmrfamide receptor 0.0268 0.1507 0.1507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Plasmodium vivax SET domain protein, putative 0.003 0.0107 0.5861
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.1507 0.3799
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0053 0.1829
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Leishmania major DNA polymerase eta, putative 0.0019 0.0046 0.136
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) oxidoreductase 0.0015 0.002 0.0055
Schistosoma mansoni hypothetical protein 0.0035 0.0136 0.0344
Toxoplasma gondii hypothetical protein 0.0019 0.0047 0.1918
Onchocerca volvulus 0.0268 0.1507 1
Onchocerca volvulus 0.0015 0.002 0.0131
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0268 0.1507 0.246
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0268 0.1507 0.4182
Brugia malayi Dopamine receptor protein 1 0.0268 0.1507 0.4182
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Onchocerca volvulus 0.0268 0.1507 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.009 0.0227
Brugia malayi hypothetical protein 0.0273 0.1534 0.4257
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0228 1
Echinococcus multilocularis neuropeptide receptor 0.0268 0.1507 0.1507
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0053 0.1829
Trypanosoma brucei cytochrome P450, putative 0.002 0.0053 0.1829
Schistosoma mansoni opsin-like receptor 0.0268 0.1507 0.3799
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0268 0.1507 0.1507
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0017
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0153 0.9478
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.002 0.0546
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.1507 0.246
Onchocerca volvulus 0.0268 0.1507 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0092 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0046 0.2002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0268 0.1507 0.1507
Treponema pallidum DNA ligase (lig) 0.0011 0 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0228 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0215 0.0596
Schistosoma mansoni lamin 0.0027 0.009 0.0227
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.1534 0.2505
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0136 0.0344
Onchocerca volvulus 0.0268 0.1507 1
Onchocerca volvulus 0.0268 0.1507 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.002 0.0151
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0143 0.0143
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0055
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.002 0.0546
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0026 0.0201
Schistosoma mansoni adenoreceptor 0.0268 0.1507 0.3799
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0153 0.84
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Schistosoma mansoni neuropeptide receptor 0.0268 0.1507 0.3799
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0268 0.1507 0.4182
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0369
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.1507 0.246
Echinococcus multilocularis dna polymerase eta 0.0019 0.0046 0.0046
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis neuropeptide receptor 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0062
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.1507 0.4182
Schistosoma mansoni biogenic amine (5HT) receptor 0.0268 0.1507 0.3799
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.1563
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.1507 0.246
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0007 0.0236
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0292 0.0292
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0025
Echinococcus granulosus 7TM GPCR rhodopsin 0.0268 0.1507 0.246
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.078 0.1968
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0046 0.0115
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.002 0.0868
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0228 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0046 0.0115
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.1507 0.3799
Onchocerca volvulus 0.0075 0.0371 0.2464
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0046 0.1563
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.002 0.0546
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0369
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.1507 0.3799
Onchocerca volvulus 0.0056 0.026 0.1725
Schistosoma mansoni alpha-1 adrenergic receptor 0.0268 0.1507 0.3799
Echinococcus multilocularis G protein coupled receptor 139 0.0268 0.1507 0.1507
Echinococcus granulosus lamin 0.0027 0.009 0.0147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Onchocerca volvulus 0.0015 0.002 0.0131
Onchocerca volvulus 0.0268 0.1507 1
Schistosoma mansoni hypothetical protein 0.0056 0.026 0.0655
Schistosoma mansoni biogenic amine (5HT) receptor 0.0268 0.1507 0.3799
Brugia malayi G protein-coupled receptor F59B2.13 0.0268 0.1507 0.4182
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0143 0.6269
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.002 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0292 1
Toxoplasma gondii propionate-CoA ligase 0.0015 0.002 0.0799
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0118 0.0328
Schistosoma mansoni biogenic amine receptor 0.0268 0.1507 0.3799
Echinococcus multilocularis serotonin receptor 0.0268 0.1507 0.1507
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.1507 0.1507
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0053 0.0148
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0056
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0007 0.0448
Loa Loa (eye worm) hypothetical protein 0.0033 0.0126 0.0349
Brugia malayi Dopamine receptor 0.0268 0.1507 0.4182
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0292 0.2224
Brugia malayi neuropeptide F receptor 0.0268 0.1507 0.4182
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0007 0.0236
Brugia malayi Cytochrome P450 family protein 0.0031 0.0118 0.0328
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0268 0.1507 0.246
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0052
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0228 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0162 0.7103
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0153 0.6732
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0292 0.2224
Echinococcus granulosus GPCR family 2 0.0015 0.0022 0.0037
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0268 0.1507 0.1507
Echinococcus granulosus adenylate cyclase type IX 0.0109 0.0576 0.0941
Echinococcus multilocularis serotonin receptor 0.0268 0.1507 0.1507
Loa Loa (eye worm) intermediate filament protein 0.0027 0.009 0.025
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.002 0.0546
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.002 0.0868
Schistosoma mansoni hypothetical protein 0.0268 0.1507 0.3799
Echinococcus granulosus g protein coupled receptor 0.0268 0.1507 0.246
Echinococcus multilocularis orexin receptor type 2 0.0268 0.1507 0.1507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0107 0.027
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0292 0.0476
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0141 0.6071
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034511 0.0000026328
Schistosoma mansoni amine GPCR 0.0268 0.1507 0.3799
Schistosoma mansoni opsin-like receptor 0.0268 0.1507 0.3799
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus granulosus peptide allatostatin:somatostatin 0.0268 0.1507 0.246
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.002 0.0868
Schistosoma mansoni biogenic amine receptor 0.0268 0.1507 0.3799
Echinococcus granulosus dro:myosuppressin receptor 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0425
Schistosoma mansoni opsin-like receptor 0.0268 0.1507 0.3799
Echinococcus granulosus alpha 1A adrenergic receptor 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1144 0.3174
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0047 0.1806
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0007 0.0236
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.002 0.0546
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Echinococcus granulosus intermediate filament protein 0.0027 0.009 0.0147
Onchocerca volvulus 0.0036 0.0143 0.0947
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0162 1
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.0391 0.2593
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0078 0.0391 0.2593
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0046 0.0348
Echinococcus granulosus biogenic amine 5HT receptor 0.0268 0.1507 0.246
Brugia malayi AMP-binding enzyme family protein 0.0015 0.002 0.0055
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0228 1
Echinococcus granulosus adenylate cyclase 9 0.0078 0.0391 0.0638
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0046 0.1563
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0092 0.0231
Onchocerca volvulus Neuropeptide F receptor homolog 0.0268 0.1507 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0268 0.1507 0.1507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0107 0.027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0268 0.1507 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0047 0.2085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0425
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.002 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0107 0.027
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0248 0.1888
Echinococcus multilocularis musashi 0.0027 0.009 0.009
Entamoeba histolytica hypothetical protein 0.0035 0.0136 0.5992
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Brugia malayi G-protein coupled receptor 0.0268 0.1507 0.4182
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0046 0.1563
Echinococcus multilocularis g protein coupled receptor 0.0268 0.1507 0.1507
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0007 0.0007
Echinococcus granulosus sex peptide receptor 0.0268 0.1507 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0092 0.0149
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.002 0.0868
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0092 0.0254
Echinococcus granulosus g protein coupled receptor 0.0268 0.1507 0.246
Brugia malayi hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1311 1
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.1507 0.3799
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0153 0.6617
Echinococcus granulosus replication factor c subunit 1 0.0011 0.00000034511 0.00000056347
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0092 0.0698
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0026 0.0201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0268 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni lamin 0.0027 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0268 0.1507 0.1507
Brugia malayi RE15519p 0.0268 0.1507 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0056
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.009 0.025
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0007 0.0011
Schistosoma mansoni growth hormone secretagogue receptor 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0017
Brugia malayi AMP-binding enzyme family protein 0.005 0.0228 0.0632
Brugia malayi Dopamine receptor protein 2 0.0268 0.1507 0.4182
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0268 0.1507 0.4182
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0216 0.0545
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0132
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0107 0.4321
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0026 0.0201
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0143 0.0396
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0228 0.7756
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Schistosoma mansoni amine GPCR 0.0268 0.1507 0.3799
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0022 0.0062
Brugia malayi follicle stimulating hormone receptor 0.0496 0.2845 0.7894
Echinococcus multilocularis lamin dm0 0.0027 0.009 0.009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.009 0.025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.1507 0.1507
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0168 0.0919 0.2316
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.1507 0.3799
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.002 0.0868
Echinococcus granulosus neuropeptide FF receptor 2 0.0268 0.1507 0.246
Brugia malayi AMP-binding enzyme family protein 0.0015 0.002 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0046 0.172
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.002 0.0678
Schistosoma mansoni neuropeptide receptor 0.0268 0.1507 0.3799
Loa Loa (eye worm) hypothetical protein 0.0268 0.1507 0.4182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0254
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0268 0.1507 0.4182
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0273 0.1534 0.4257
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0228 1
Schistosoma mansoni myosin xvIII 0.0268 0.1507 0.3799
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.002 0.0546
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0292 0.2224
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.002 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0248 0.1888
Brugia malayi putative neuropeptide receptor 0.0268 0.1507 0.4182
Onchocerca volvulus 0.0268 0.1507 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.1507 0.1507
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0292 0.2224
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0182 0.1392
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0007 0.0019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 nM Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells ChEMBL. 10052976
IC50 (binding) = 5.2 nM Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells ChEMBL. 10052976
IC50 (binding) = 78 nM Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells. ChEMBL. 10052976
IC50 (binding) = 78 nM Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells. ChEMBL. 10052976
Selectivity (binding) = 15 Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor ChEMBL. 10052976

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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