TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.378 | Formula: C18H22N2O5
H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C(c1cn(c2c1cccc2)C(=O)OCC)CNC(=O)C
InChi: 1S/C18H22N2O5/c1-4-24-17(22)14(10-19-12(3)21)15-11-20(18(23)25-5-2)16-9-7-6-8-13(15)16/h6-9,11,14H,4-5,10H2,1-3H3,(H,19,21)
InChiKey: GVGIXMDLOUUUEL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-tubulin, identical	0.0088	0.1307	0.1307
Leishmania major	oxidoreductase-like protein	0.0059	0.0709	0.0709
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0709
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Loa Loa (eye worm)	tubulin beta-4 chain	0.0088	0.1307	0.1307
Plasmodium vivax	hypothetical protein, conserved	0.0197	0.3527	0.3527
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin alpha chain, putative	0.0031	0.0139	0.0139
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0031	0.0139	0.0139
Echinococcus granulosus	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Echinococcus granulosus	cytochrome b5 reductase 4	0.0059	0.0709	0.0709
Schistosoma mansoni	alpha tubulin	0.0054	0.0616	0.0616
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Schistosoma mansoni	diflavin oxidoreductase	0.0256	0.4719	0.4719
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Trypanosoma brucei	nitrate reductase, putative	0.0059	0.0709	0.0578
Onchocerca volvulus		0.0031	0.0139	0.1963
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0578
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0059	0.0709	0.0709
Echinococcus multilocularis	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0516	1	1
Leishmania major	cytochrome P450 reductase, putative	0.0457	0.8808	0.8808
Echinococcus multilocularis	tubulin alpha chain	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Echinococcus granulosus	peroxisome assembly protein 26	0.0054	0.0616	0.0616
Onchocerca volvulus		0.0059	0.0709	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Trichomonas vaginalis	tubulin alpha chain, putative	0.0031	0.0139	0.0139
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0516	1	1
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0709
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0516	1	1
Leishmania major	p450 reductase, putative	0.0516	1	1
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0031	0.0139	0.0139
Leishmania major	gamma-tubulin	0.0054	0.0616	0.0616
Giardia lamblia	Nitric oxide synthase, inducible	0.0457	0.8808	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0197	0.3527	0.3527
Loa Loa (eye worm)	BEN-1 protein	0.0088	0.1307	0.1307
Treponema pallidum	flavodoxin	0.0197	0.3527	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0059	0.0709	0.0709
Echinococcus granulosus	tubulin subunit TubB	0.0054	0.0616	0.0616
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0139	0.0139
Echinococcus multilocularis	tubulin alpha chain	0.0054	0.0616	0.0616
Loa Loa (eye worm)	flavodoxin family protein	0.0197	0.3527	0.3527
Schistosoma mansoni	cytochrome B5	0.0059	0.0709	0.0709
Trichomonas vaginalis	sulfite reductase, putative	0.0516	1	1
Trypanosoma cruzi	nitrate reductase, putative	0.0059	0.0709	0.0099
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Plasmodium vivax	tubulin epsilon chain, putative	0.0054	0.0616	0.0616
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Echinococcus granulosus	methionine synthase reductase	0.0319	0.599	0.599
Toxoplasma gondii	beta tubulin	0.0088	0.1307	0.2769
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Plasmodium falciparum	alpha tubulin 1	0.0054	0.0616	0.0616
Loa Loa (eye worm)	alpha-tubulin	0.0054	0.0616	0.0616
Schistosoma mansoni	tubulin subunit alpha	0.0054	0.0616	0.0616
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0059	0.0709	0.1503
Entamoeba histolytica	type A flavoprotein, putative	0.0197	0.3527	1
Trypanosoma cruzi	beta tubulin, putative	0.0088	0.1307	0.0736
Giardia lamblia	Hypothetical protein	0.0457	0.8808	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0031	0.0139	0.0139
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Entamoeba histolytica	tubulin gamma chain	0.0054	0.0616	0.1747
Brugia malayi	Tubulin alpha-2 chain	0.0054	0.0616	0.0616
Brugia malayi	FAD binding domain containing protein	0.0319	0.599	0.599
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0054	0.0616	0.1306
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0059	0.0709	0.0578
Echinococcus granulosus	beta tubulin	0.0088	0.1307	0.1307
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0054	0.0616	0.0616
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Echinococcus granulosus	alpha tubulin	0.0054	0.0616	0.0616
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0197	0.3527	0.3102
Leishmania major	reductase, putative	0.0059	0.0709	0.0709
Plasmodium vivax	tubulin beta chain, putative	0.0088	0.1307	0.1307
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Echinococcus multilocularis	beta tubulin	0.0088	0.1307	0.1307
Echinococcus granulosus	tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin epsilon chain	0.0054	0.0616	0.0616
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0059	0.0709	0.0709
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin alpha	0.0054	0.0616	0.0616
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0197	0.3527	0.3527
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin, putative	0.0031	0.0139	0.0139
Brugia malayi	diaphorase	0.0059	0.0709	0.0709
Trypanosoma brucei	alpha tubulin	0.0054	0.0616	0.0484
Plasmodium vivax	tubulin alpha chain, putative	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin alpha chain, putative	0.0054	0.0616	0.0616
Plasmodium vivax	tubulin alpha chain, putative	0.0054	0.0616	0.0616
Schistosoma mansoni	NADPH flavin oxidoreductase	0.026	0.4799	0.4799
Loa Loa (eye worm)	tubulin alpha 2	0.0031	0.0139	0.0139
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0516	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0088	0.1307	0.1307
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0059	0.0709	0.1184
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0197	0.3527	0.3527
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Entamoeba histolytica	type A flavoprotein, putative	0.0197	0.3527	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0516	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0088	0.1307	0.1307
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus multilocularis	tubulin beta 1 chain	0.0088	0.1307	0.1307
Schistosoma mansoni	tubulin subunit epsilon	0.0054	0.0616	0.0616
Plasmodium vivax	flavodoxin domain containing protein	0.0457	0.8808	0.8808
Trypanosoma brucei	epsilon tubulin	0.0054	0.0616	0.0484
Mycobacterium tuberculosis	Probable monooxygenase	0.0059	0.0709	1
Echinococcus multilocularis	tubulin alpha chain	0.0054	0.0616	0.0616
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0457	0.8808	0.8808
Brugia malayi	Tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0059	0.0709	0.0709
Mycobacterium tuberculosis	Probable oxidoreductase	0.0059	0.0709	1
Echinococcus multilocularis	tubulin subunit beta	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin gamma chain, putative	0.0088	0.1307	0.1307
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0578
Leishmania major	cytochrome-b5 reductase, putative	0.0059	0.0709	0.0709
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Entamoeba histolytica	tubulin alpha-1 chain	0.0054	0.0616	0.1747
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0031	0.0139	0.0139
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0709
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Trypanosoma cruzi	p450 reductase, putative	0.0059	0.0709	0.0099
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.0139	0.0139
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Entamoeba histolytica	tubulin family protein	0.0088	0.1307	0.3705
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin gamma chain, putative	0.0054	0.0616	0.0616
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0059	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0516	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0088	0.1307	0.1307
Plasmodium falciparum	nitric oxide synthase, putative	0.0516	1	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0059	0.0709	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Echinococcus multilocularis	tubulin subunit TubB	0.0054	0.0616	0.0616
Giardia lamblia	Beta tubulin	0.0088	0.1307	0.0843
Entamoeba histolytica	type A flavoprotein, putative	0.0197	0.3527	1
Echinococcus multilocularis	tubulin alpha	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin, putative	0.0031	0.0139	0.0139
Chlamydia trachomatis	sulfite reductase	0.0319	0.599	1
Trypanosoma cruzi	reductase, putative	0.0059	0.0709	0.0099
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Brugia malayi	tubulin alpha chain - mouse	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin alpha 1C chain	0.0054	0.0616	0.0616
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0516	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin alpha chain, putative	0.0088	0.1307	0.1307
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0516	1	1
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0059	0.0709	1
Trypanosoma brucei	epsilon tubulin	0.0054	0.0616	0.0484
Schistosoma mansoni	tubulin subunit alpha	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0059	0.0709	0.0113
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0709
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0059	0.0709	0.0578
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Echinococcus granulosus	tubulin alpha chain	0.0054	0.0616	0.0616
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Echinococcus multilocularis	tubulin epsilon chain	0.0054	0.0616	0.0616
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Trypanosoma brucei	beta tubulin	0.0088	0.1307	0.1184
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Entamoeba histolytica	type A flavoprotein, putative	0.0197	0.3527	1
Echinococcus multilocularis	methionine synthase reductase	0.0319	0.599	0.599
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0516	1	1
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0616	0.0616
Entamoeba histolytica	tubulin alpha chain, putative	0.0054	0.0616	0.1747
Leishmania major	cytochrome-b5 reductase, putative	0.0059	0.0709	0.0709
Plasmodium falciparum	tubulin beta chain	0.0088	0.1307	0.1307
Echinococcus multilocularis	hypothetical protein	0.0054	0.0616	0.0616
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0197	0.3527	0.3527
Toxoplasma gondii	beta-tubulin, putative	0.0088	0.1307	0.2769
Schistosoma mansoni	tubulin subunit alpha	0.0054	0.0616	0.0616
Schistosoma mansoni	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Leishmania major	epsilon tubulin, putative	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin alpha 3 chain	0.0054	0.0616	0.0616
Plasmodium falciparum	tubulin epsilon chain, putative	0.0054	0.0616	0.0616
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0319	0.599	0.599
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0059	0.0709	0.0099
Trichomonas vaginalis	tubulin gamma chain, putative	0.0054	0.0616	0.0616
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Echinococcus multilocularis	tubulin gamma 1 chain	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Brugia malayi	tubulin alpha-2 chain	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Loa Loa (eye worm)	tubulin beta-1 chain	0.0088	0.1307	0.1307
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0197	0.3527	0.3527
Echinococcus granulosus	tubulin beta 4A class IVa	0.0088	0.1307	0.1307
Echinococcus granulosus	tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus multilocularis	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Echinococcus multilocularis	tubulin alpha 3 chain	0.0054	0.0616	0.0616
Echinococcus granulosus	beta tubulin	0.0088	0.1307	0.1307
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Echinococcus granulosus	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Echinococcus multilocularis	tubulin alpha 3 chain	0.0054	0.0616	0.0616
Brugia malayi	flavodoxin family protein	0.0197	0.3527	0.3527
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0197	0.3527	0.3102
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0197	0.3527	0.3436
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Trypanosoma brucei	alpha tubulin	0.0054	0.0616	0.0484
Echinococcus multilocularis	tubulin alpha 1C chain	0.0054	0.0616	0.0616
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0516	1	1
Leishmania major	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0709
Echinococcus multilocularis	tubulin alpha 1C chain	0.0054	0.0616	0.0616
Trypanosoma brucei	oxidoreductase-protein, putative	0.0059	0.0709	0.0578
Trypanosoma brucei	tubulin gamma chain	0.0054	0.0616	0.0484
Brugia malayi	Tubulin alpha-2 chain	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin alpha 3 chain	0.0054	0.0616	0.0616
Giardia lamblia	Beta tubulin	0.0088	0.1307	0.0843
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0197	0.3527	0.3527
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Entamoeba histolytica	tubulin family protein	0.0088	0.1307	0.3705
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Toxoplasma gondii	alpha tubulin TUBA1	0.0054	0.0616	0.1306
Echinococcus multilocularis	tubulin alpha chain	0.0054	0.0616	0.0616
Loa Loa (eye worm)	tubulin beta chain	0.0088	0.1307	0.1307
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0319	0.599	0.599
Mycobacterium tuberculosis	Possible oxygenase	0.0059	0.0709	1
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0516	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0054	0.0616	0.0616
Loa Loa (eye worm)	tubulin alpha 2	0.0031	0.0139	0.0139
Trypanosoma brucei	beta tubulin	0.0088	0.1307	0.1184
Trichomonas vaginalis	tubulin, putative	0.0088	0.1307	0.1307
Entamoeba histolytica	type A flavoprotein, putative	0.0197	0.3527	1
Echinococcus multilocularis	beta tubulin	0.0088	0.1307	0.1307
Schistosoma mansoni	alpha tubulin	0.0054	0.0616	0.0616
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0578
Schistosoma mansoni	cytochrome P450 reductase	0.0516	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0054	0.0616	0.0616
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Schistosoma mansoni	tubulin subunit gamma	0.0054	0.0616	0.0616
Trypanosoma brucei	beta tubulin	0.0054	0.0616	0.0484
Brugia malayi	FAD binding domain containing protein	0.0516	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0059	0.0709	0.0099
Leishmania major	nitrate reductase, putative	0.0059	0.0709	0.0709
Loa Loa (eye worm)	BEN-1 protein	0.0088	0.1307	0.1307
Plasmodium falciparum	ferredoxin--NADP reductase	0.0059	0.0709	0.0709
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0059	0.0709	0.0709
Echinococcus granulosus	tubulin gamma 1 chain	0.0054	0.0616	0.0616
Echinococcus granulosus	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Brugia malayi	Tubulin beta chain	0.0031	0.0139	0.0139
Echinococcus granulosus	tubulin subunit beta	0.0088	0.1307	0.1307
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0516	1	1
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0059	0.0709	0.0709
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0059	0.0709	0.0099
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0516	1	1
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0059	0.0709	0.0709
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0059	0.0709	0.0099
Brugia malayi	Tubulin beta-1 chain	0.0088	0.1307	0.1307
Brugia malayi	Tubulin gamma chain	0.0054	0.0616	0.0616
Trichomonas vaginalis	tubulin beta chain, putative	0.0054	0.0616	0.0616
Plasmodium vivax	tubulin gamma chain, putative	0.0054	0.0616	0.0616
Echinococcus granulosus	cytochrome b5 reductase 4	0.0059	0.0709	0.0709
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Loa Loa (eye worm)	tubulin gamma chain	0.0054	0.0616	0.0616
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0059	0.0709	0.0578
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0516	1	1
Leishmania major	beta tubulin	0.0088	0.1307	0.1307
Loa Loa (eye worm)	beta-tubulin	0.0088	0.1307	0.1307
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0516	1	1
Leishmania major	alpha tubulin	0.0054	0.0616	0.0616
Toxoplasma gondii	flavodoxin domain-containing protein	0.0256	0.4719	1
Toxoplasma gondii	flavodoxin domain-containing protein	0.0256	0.4719	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0054	0.0616	0.0616
Loa Loa (eye worm)	tubulin alpha chain	0.0054	0.0616	0.0616
Echinococcus multilocularis	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Trichomonas vaginalis	tubulin beta chain, putative	0.0088	0.1307	0.1307
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0197	0.3527	0.3102
Echinococcus multilocularis	Tubulin beta 2C chain	0.0088	0.1307	0.1307
Plasmodium falciparum	alpha tubulin 2	0.0054	0.0616	0.0616
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0059	0.0709	0.0099
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Toxoplasma gondii	alpha-tubulin I, putative	0.0054	0.0616	0.1306
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0059	0.0709	0.1503
Leishmania major	hypothetical protein, conserved	0.0197	0.3527	0.3527
Trypanosoma brucei	alpha tubulin	0.0054	0.0616	0.0484
Giardia lamblia	Beta tubulin	0.0088	0.1307	0.0843
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0054	0.0616	0.0616
Trypanosoma cruzi	p450 reductase, putative	0.0516	1	1
Trypanosoma brucei	alpha tubulin	0.0054	0.0616	0.0484
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0059	0.0709	0.0709
Schistosoma mansoni	tubulin subunit beta	0.0088	0.1307	0.1307
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0516	1	1
Trypanosoma brucei	epsilon tubulin	0.0054	0.0616	0.0484
Brugia malayi	alpha-tubulin	0.0054	0.0616	0.0616
Echinococcus multilocularis	tubulin alpha chain	0.0054	0.0616	0.0616
Plasmodium falciparum	tubulin gamma chain	0.0054	0.0616	0.0616
Toxoplasma gondii	beta-1 tubulin, putative	0.0088	0.1307	0.2769
Trypanosoma brucei	beta tubulin	0.0088	0.1307	0.1184
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0059	0.0709	0.0099
Echinococcus granulosus	tubulin alpha 1C chain	0.0054	0.0616	0.0616
Loa Loa (eye worm)	alpha-tubulin	0.0054	0.0616	0.0616
Echinococcus granulosus	tubulin beta 1 chain	0.0088	0.1307	0.1307
Trypanosoma brucei	beta tubulin	0.0088	0.1307	0.1184
Echinococcus granulosus	tubulin alpha chain	0.0054	0.0616	0.0616
Loa Loa (eye worm)	diaphorase	0.0059	0.0709	0.0709

Activities

Activity type	Activity value	Assay description	Source	Reference
BP (functional)	= -49 mmHg	Change in blood pressure in normotensive anesthetized cat.	ChEMBL.	7097726
BP (functional)	= -22 mmHg	Antihypertensive activity in renal hypertensive rats 6 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= -18 mmHg	Antihypertensive activity in renal hypertensive rats 4 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= -18 mmHg	Antihypertensive activity in renal hypertensive rats 8 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= -3 mmHg	Antihypertensive activity in renal hypertensive rats 1 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= -3 mmHg	Antihypertensive activity in renal hypertensive rats 2 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 135 mmHg	Decrease in blood pressure in normotensive anesthetized cat at dose 10 mg/Kg iv	ChEMBL.	7097726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL164523

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 278046