Detailed information for compound 279940

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 285.298 | Formula: C15H15N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(c(c1)OC)c1nc2c(n1)cc[nH]c2
  • InChi: 1S/C15H15N3O3/c1-19-9-6-12(20-2)14(13(7-9)21-3)15-17-10-4-5-16-8-11(10)18-15/h4-8,16H,1-3H3
  • InChiKey: OTNRFTYRHJOIGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Loa Loa (eye worm) cysteine protease 0.0016 0.0071 0.0098
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Echinococcus multilocularis musashi 0.0026 0.0222 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.0347
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0565 0.0836
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0691 0.0682
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0565 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0195 0.5182
Loa Loa (eye worm) hypothetical protein 0.0049 0.0559 0.0867
Leishmania major glucose transporter, lmgt1 0.0034 0.0339 0.4363
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0565 0.0513
Brugia malayi hypothetical protein 0.0025 0.0196 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0174 0.0119
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0691 0.064
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0058 0.0047
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Onchocerca volvulus 0.0016 0.0058 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0339 0.223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.1486 0.1477
Onchocerca volvulus 0.0016 0.0058 0.0075
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0355 1
Echinococcus granulosus single minded 2 0.0035 0.0355 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0174 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0016 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus multilocularis cysteine protease 0.0016 0.0071 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0157 0.0235
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0691 0.0682
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0071 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0565 0.0556
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0058 0.0004
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0149 0.0941
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0046
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2044 0.3207
Leishmania major hypothetical protein, conserved 0.0016 0.0058 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi nuclear receptor NHR-88 0.0049 0.0565 0.0836
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0029 0.0032
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0174 0.0216
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0055 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Schistosoma mansoni zinc finger protein 0.0023 0.0174 0.0119
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0323 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi hypothetical protein 0.0016 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0354 0.0344
Toxoplasma gondii protein kinase, putative 0.0313 0.4521 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0265 0.0403
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0565 0.0556
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0565 0.0556
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi hypothetical protein 0.0026 0.0216 0.0283
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni lamin 0.0026 0.0222 0.0167
Leishmania major protein kinase, putative 0.0034 0.0333 0.4277
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0294
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0323 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0058 0.0047
Onchocerca volvulus 0.0016 0.0058 0.0075
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0174 0.0119
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0301 0.0291
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Brugia malayi N-terminal motif family protein 0.0177 0.2486 0.3876
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0333 0.0407
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0011
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0265 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0565 0.0556
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0174 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Onchocerca volvulus 0.0026 0.0222 0.0333
Schistosoma mansoni intermediate filament proteins 0.0026 0.0222 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.2081 0.2073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0055 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0565 0.0513
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0216 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Echinococcus granulosus lamin 0.0026 0.0222 0.0211
Entamoeba histolytica protein kinase, putative 0.0034 0.0333 0.9241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0565 0.0877
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0565 0.0513
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0339 0.223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0333 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0565 0.0836
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0076
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0268 0.0214
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0058 0.032
Plasmodium falciparum hexose transporter 0.0111 0.1486 0.2097
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0565 0.0556
Echinococcus multilocularis lamin dm0 0.0026 0.0222 0.0211
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Schistosoma mansoni netrin receptor unc5 0.0029 0.0265 0.0211
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0354 0.0301
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0323 0.0452
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0174 0.0163
Schistosoma mansoni lozenge 0.0055 0.0643 0.0591
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0195 0.0205
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0333 0.0407
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0489
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0489
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0174 0.0119
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0565 0.0513
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Echinococcus multilocularis Ankyrin 0.003 0.0268 0.0258
Onchocerca volvulus 0.0049 0.0565 0.0875
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0071 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0565 0.0877
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0071 0.0802
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0174 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0071 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0594
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0058 0.5
Onchocerca volvulus 0.0023 0.0174 0.0257
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0565 0.0836
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0106 0.1264
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0323 1
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Brugia malayi major facilitator superfamily protein 0.0016 0.0058 0.0033
Brugia malayi jmjC domain containing protein 0.0058 0.0691 0.1035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0559 0.0867
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0333 0.0407
Onchocerca volvulus 0.0016 0.0058 0.0075
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0058 0.0627
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Onchocerca volvulus 0.0016 0.0058 0.0075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0565 0.0513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0179 0.251 0.3597
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Brugia malayi conserved hypotetical protein 0.0023 0.0174 0.0216
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0055 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0565 0.0556
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0535 0.0788
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Brugia malayi hypothetical protein 0.0232 0.3311 0.5182
Brugia malayi ecdysteroid receptor 0.0049 0.0565 0.0836
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0405 0.0513
Onchocerca volvulus 0.0023 0.0174 0.0257
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.6643 0.664
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Echinococcus multilocularis lamin 0.0026 0.0222 0.0211
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0058 0.0047
Trypanosoma cruzi hexose transporter 0.0034 0.0339 0.4363
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Toxoplasma gondii sugar transporter ST3 0.0016 0.0058 0.0006
Echinococcus multilocularis General substrate transporter 0.0095 0.1252 0.1243
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0071 0.0061
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0139 1
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0333 0.2186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0214 0.0324
Brugia malayi nuclear hormone receptor 0.0023 0.0174 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0058 0.1623
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0046
Brugia malayi major facilitator superfamily protein 0.0016 0.0058 0.0033
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0405 0.0513
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Brugia malayi Cam kinase protein 1 0.0034 0.0333 0.0468
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0058 0.1623
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0222 0.0336
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0501
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0195 0.2447
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Leishmania major glucose transporter, lmgt2 0.0034 0.0339 0.4363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0565 0.0877
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3311 0.3304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0565 0.0556
Leishmania major protein kinase, putative 0.0015 0.0042 0.0421
Echinococcus granulosus phd:f box containing protein 0.0015 0.0055 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Schistosoma mansoni hypothetical protein 0.0166 0.2323 0.228
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0222 0.0336
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0565 0.0513
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0354 0.0344
Loa Loa (eye worm) runx1 0.0055 0.0643 0.1
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0565 0.0836
Onchocerca volvulus 0.0035 0.0355 0.0543
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0691 0.064
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0323 0.0495
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.6643 0.664
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Onchocerca volvulus 0.0016 0.0058 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0565 0.0836
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0565 0.0877
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0489
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0691 0.0682
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0071 0.0802
Brugia malayi ecdysone receptor 0.0023 0.0174 0.0216
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0559 0.0826
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Brugia malayi jmjC domain containing protein 0.0058 0.0691 0.1035
Loa Loa (eye worm) hypothetical protein 0.0435 0.6355 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0333 0.0468
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0498 0.073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0565 0.0836
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Trypanosoma brucei glucose transporter 1E 0.0034 0.0339 0.4007
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0195 0.5493
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0535 0.0483
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.047 0.6879 1
Echinococcus granulosus Ankyrin 0.003 0.0268 0.0258
Echinococcus granulosus geminin 0.0166 0.2323 0.2315
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0265 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0071 0.0095
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0056 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0098
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0541 0.0489
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.1486 0.3205
Schistosoma mansoni single-minded 0.0048 0.0541 0.0489
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0355 0.0345
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0071 0.0095
Onchocerca volvulus Putative transporter 0.0016 0.0058 0.0075
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0323 0.0313
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0055 0.0045
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0333 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0565 0.0836
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus granulosus lamin dm0 0.0026 0.0222 0.0211
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0565 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus 0.0435 0.6355 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) sugar transporter 0.0111 0.1486 0.2328
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus multilocularis GPCR, family 2 0.0015 0.0056 0.0046
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Onchocerca volvulus 0.0016 0.0071 0.0095
Brugia malayi nuclear hormone receptor 0.0049 0.0565 0.0836
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0195 0.0141
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0333 0.0407
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0339 0.4363
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.2486 0.3903
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0058 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0071 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Brugia malayi PAS domain containing protein 0.0048 0.0541 0.0798
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0333 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Onchocerca volvulus 0.0016 0.0071 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0139 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0216 0.0161
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0333 0.0511
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Onchocerca volvulus 0.0016 0.0058 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi hypoxia-induced factor 1 0.0148 0.2044 0.3177
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Echinococcus granulosus death domain containing protein 0.0029 0.0265 0.0255
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0195 0.5912
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0265 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus 0.0016 0.0071 0.0095
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0071 0.0098
Onchocerca volvulus 0.0047 0.0535 0.0827
Schistosoma mansoni nuclear receptor 0.0023 0.0174 0.0119
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0565 0.0556
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0565 0.0836
Loa Loa (eye worm) hypothetical protein 0.0232 0.3311 0.5203
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0195 0.2447
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.2486 0.3902
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0565 0.0877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0174 0.0163
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0323 0.0269
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Echinococcus granulosus cathepsin l1 0.0016 0.0071 0.0061
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0333 0.0623
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0071 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Plasmodium vivax vivapain-2 0.0016 0.0071 0.0023
Entamoeba histolytica hypothetical protein 0.0025 0.0195 0.4377
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0174 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni glucose transporter 0.0016 0.0058 0.0002
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0323 0.8878
Loa Loa (eye worm) hypothetical protein 0.0025 0.0196 0.0295
Plasmodium falciparum protein kinase 6 0.047 0.6879 1
Plasmodium vivax vivapain-2 0.0016 0.0071 0.0023
Brugia malayi nuclear receptor RXR 0.0026 0.0216 0.0283
Onchocerca volvulus 0.0016 0.0071 0.0095
Brugia malayi hypothetical protein 0.0023 0.0174 0.0216
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.0409
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0216 0.0283
Mycobacterium ulcerans sugar transporter 0.0016 0.0058 0.1623
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0333 0.0623
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0565 0.0556
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Onchocerca volvulus 0.0016 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0765 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi hypothetical protein 0.0035 0.0354 0.0502
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0326 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0333 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Brugia malayi Sugar transporter family protein 0.0016 0.0058 0.0033
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0265 0.0401
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0058 0.032
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0333 0.0407
Schistosoma mansoni hypothetical protein 0.0111 0.1486 0.1439
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0058 0.032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0565 0.0513
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0565 0.0556
Onchocerca volvulus 0.0016 0.0071 0.0095
Schistosoma mansoni lamin 0.0026 0.0222 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3311 0.3304
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0333 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Brugia malayi nuclear receptor NHR-67 0.0023 0.0174 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0691 0.1076
Plasmodium vivax hexose transporter 0.0111 0.1486 0.2097
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0355 0.0503
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus multilocularis Protein lozenge 0.0055 0.0643 0.0634
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0174 0.026
Leishmania major hypothetical protein, conserved 0.0025 0.0196 0.2456
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0683 0.8918
Loa Loa (eye worm) hypothetical protein 0.0034 0.0333 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0174 0.0163
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.2456
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0323 0.2116
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0174 0.0257
Schistosoma mansoni hypothetical protein 0.0166 0.2323 0.228
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0071 0.0095
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Brugia malayi intermediate filament protein 0.0026 0.0222 0.0292
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0037 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0405 0.0784
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0196 0.1979
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.4934
Brugia malayi tailless protein 0.0023 0.0174 0.0216
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.6643 0.664
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0058 0.0077
Loa Loa (eye worm) ctsf protein 0.0016 0.0071 0.0098
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0174 0.026
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0174 0.0216
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0174 0.0257
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0216 0.0205
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0339 0.223
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0195 0.025
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0174 0.0216
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0058 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi hypothetical protein 0.016 0.2231 0.3472
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0565 0.0875
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0195 0.0185
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0265 0.0255
Leishmania major glucose transporter, lmgt3 0.0034 0.0339 0.4363
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Toxoplasma gondii sugar transporter ST2 0.0016 0.0058 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.001 0.0003
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0174 0.0163
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0058 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0056 0.0031
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0195 0.1251
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0195 0.197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0565 0.0877
Onchocerca volvulus 0.0016 0.0071 0.0095
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0055 0.0594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Schistosoma mansoni survival motor neuron protein 0.0047 0.0535 0.0483
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.2456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0489
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trypanosoma brucei sugar transporter, putative 0.0016 0.0058 0.0035
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0071 0.0061
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0058 0.0077
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0216 0.0205
Echinococcus granulosus GPCR family 2 0.0015 0.0056 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0265 0.036
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1486 1
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0055 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0565 0.0875
Brugia malayi Sugar transporter family protein 0.0016 0.0058 0.0033
Brugia malayi hypothetical protein 0.0023 0.0174 0.0216
Brugia malayi Sugar transporter family protein 0.0111 0.1486 0.2294
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0058 0.0627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0565 0.0836
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0565 0.0513
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0565 0.0513
Loa Loa (eye worm) sugar transporter 0.0016 0.0058 0.0077
Brugia malayi hypothetical protein 0.0435 0.6355 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0216 0.0161
Brugia malayi nuclear receptor RXR 0.0023 0.0174 0.0216
Echinococcus multilocularis cysteine protease 0.0016 0.0071 0.0061
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0323 0.0452
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0179 0.251 0.3597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0339 0.223
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0058 0.0002
Schistosoma mansoni hypothetical protein 0.0029 0.0265 0.0211
Plasmodium vivax sugar transporter, putative 0.0016 0.0058 0.0004
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0333 0.3915
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0333 0.0323
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0565 0.0556
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.2081 0.2073
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0174 0.026
Loa Loa (eye worm) fibroinase 0.0016 0.0071 0.0098
Onchocerca volvulus 0.0016 0.0058 0.0075
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0265 0.0403
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0565 0.0556
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0323 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0565 0.0836
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0058 0.1623
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0179 0.251 0.5498
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0055 0.0045
Toxoplasma gondii sugar transporter ST1 0.0016 0.0058 0.0006
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0565 0.0877
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0196 0.0314
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0216 0.0326
Echinococcus granulosus General substrate transporter 0.0095 0.1252 0.1243
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0336
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0563 0.7331
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Brugia malayi nuclear receptor NHR-88 0.0023 0.0174 0.0216
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0333 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0565 0.0836
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0049 0.0565 0.0556
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0071 0.0023
Entamoeba histolytica protein kinase, putative 0.0034 0.0333 0.9241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Treponema pallidum prolyl-tRNA synthetase 0.0012 0 0.5
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0565 0.0836
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0056 0.0076
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0058 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0565 0.0836
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0565 0.0836
Onchocerca volvulus 0.0016 0.0058 0.0075
Brugia malayi steroid hormone receptor 0.0049 0.0565 0.0836
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0195 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0565 0.0877
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus intermediate filament protein 0.0026 0.0222 0.0211
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Brugia malayi Protein kinase domain containing protein 0.0031 0.0296 0.0411
Schistosoma mansoni coup transcription factor 0.0049 0.0565 0.0513
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.0301
Brugia malayi hypothetical protein 0.0026 0.0216 0.0283
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0174 0.0119
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0016 0.0005
Brugia malayi Uncoordinated protein 44 0.0029 0.0265 0.036
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0222 0.0292
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0055 0.0045
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0565 0.0556
Plasmodium falciparum protein kinase 7 0.0313 0.4521 0.6544
Loa Loa (eye worm) hypothetical protein 0.0435 0.6355 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0565 0.0836
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0195 0.5493
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.001 0.0527
Leishmania major protein kinase, putative 0.0018 0.01 0.1183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0323 0.0495
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0071 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0565 0.0513
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0055 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0565 0.0836
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0559 0.0826
Loa Loa (eye worm) DR-78 0.0023 0.0174 0.026
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0565 0.0513
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0265 0.0255
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0195 0.0141
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0055 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.016 0.2231 0.3501
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus granulosus neuropeptide s receptor 0.0454 0.6643 0.664
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0691 0.064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Schistosoma mansoni hypothetical protein 0.0033 0.0326 0.0273
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0333 0.0623
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0174 0.0216
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0195 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0003
Toxoplasma gondii cathepsin CPL 0.0016 0.0071 0.0035
Brugia malayi Death domain containing protein 0.0029 0.0265 0.036
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0691 0.0682
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Schistosoma mansoni nuclear receptor 0.0023 0.0174 0.0119
Echinococcus multilocularis geminin 0.0166 0.2323 0.2315
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus 0.0016 0.0071 0.0095
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0195 0.0313
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0071 0.0016
Brugia malayi Cytochrome P450 family protein 0.0022 0.0157 0.0191
Onchocerca volvulus 0.0016 0.0058 0.0075
Trypanosoma brucei glucose transporter 2A 0.0034 0.0339 0.4007
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0139 0.4121
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0301 0.0291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0055 0.0045
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0498 0.0772
Onchocerca volvulus 0.0026 0.0222 0.0333
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0195 0.0185

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 103 % Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M. ChEMBL. 4009593
Control (functional) = 137 % Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M. ChEMBL. 4009593
ED50 (functional) 0 mg kg-1 Compound tested for contractility in anesthetized dog when administered intravenously; NT = not tested ChEMBL. 4009593
Response ratio (functional) = 0.04 Response ratio = (percent increase to drug)/(percent increase to 10 E-5 M isoproterenol) ChEMBL. 4009593
Response ratio (functional) = 0.51 Response ratio = (percent increase to drug)/(percent increase to 10 E-4 M isoproterenol) ChEMBL. 4009593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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