Detailed information for compound 28278

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.569 | Formula: C24H36N4O
  • H donors: 3 H acceptors: 1 LogP: 2.23 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCNCCCCNCC1CCN(CC1)C(=O)Cc1cccc2c1cccc2
  • InChi: 1S/C24H36N4O/c25-12-15-26-13-3-4-14-27-19-20-10-16-28(17-11-20)24(29)18-22-8-5-7-21-6-1-2-9-23(21)22/h1-2,5-9,20,26-27H,3-4,10-19,25H2
  • InChiKey: KWVXYIBQDQZSNC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate receptor ionotropic, AMPA Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 888 aa 34.0 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 779 aa 33.4 %
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 Glutamate receptor ionotropic, AMPA   907 aa 959 aa 30.9 %
Schistosoma mansoni glutamate receptor kainate Glutamate receptor ionotropic, AMPA   907 aa 753 aa 33.2 %
Drosophila melanogaster NMDA receptor 2 Glutamate receptor ionotropic, AMPA   907 aa 789 aa 22.1 %
Onchocerca volvulus Glutamate receptor ionotropic, AMPA   907 aa 796 aa 40.5 %
Drosophila melanogaster Glutamate receptor IIB Glutamate receptor ionotropic, AMPA   907 aa 863 aa 27.8 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 886 aa 34.2 %
Echinococcus multilocularis glutamate receptor 2 Glutamate receptor ionotropic, AMPA   907 aa 868 aa 30.4 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 809 aa 33.6 %
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 Glutamate receptor ionotropic, AMPA   907 aa 948 aa 30.6 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 809 aa 34.1 %
Drosophila melanogaster Glutamate receptor IA Glutamate receptor ionotropic, AMPA   907 aa 900 aa 40.6 %
Onchocerca volvulus Putative 39S ribosomal protein L45, mitochondrial Glutamate receptor ionotropic, AMPA   907 aa 799 aa 37.7 %
Echinococcus granulosus glutamate receptor 2 Glutamate receptor ionotropic, AMPA   907 aa 875 aa 30.4 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 779 aa 33.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Tubulin beta 2C chain 0.0194 0.2508 0.2508
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Loa Loa (eye worm) tubulin beta-4 chain 0.0194 0.2508 0.4031
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0414 0.0414
Trypanosoma brucei beta tubulin 0.0159 0.1964 0.7831
Schistosoma mansoni lozenge 0.0054 0.0299 0.0299
Brugia malayi tubulin alpha-2 chain 0.0186 0.2379 0.3824
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0043 0.0049
Brugia malayi alpha-tubulin 0.0186 0.2379 0.3824
Giardia lamblia Gamma tubulin 0.0159 0.1964 0.1741
Treponema pallidum fructose-bisphosphate aldolase 0.0587 0.8713 1
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Brugia malayi Tubulin alpha chain 0.0186 0.2379 0.3824
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2966 0.7463
Echinococcus multilocularis Tubulin beta 2C chain 0.0194 0.2508 0.2508
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Echinococcus multilocularis beta tubulin 0.0194 0.2508 0.2508
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0186 0.2379 0.273
Schistosoma mansoni alpha-glucosidase 0.0146 0.175 0.175
Plasmodium vivax delta tubulin, putative 0.0069 0.0541 0.2158
Giardia lamblia Beta tubulin 0.0194 0.2508 0.2407
Schistosoma mansoni tubulin subunit alpha 0.0186 0.2379 0.2379
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0488 0.1947
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0049
Echinococcus granulosus tubulin alpha 3 chain 0.0186 0.2379 0.2379
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0049
Brugia malayi Tubulin beta-1 chain 0.0194 0.2508 0.4031
Entamoeba histolytica tubulin family protein 0.0194 0.2508 0.2843
Loa Loa (eye worm) hypothetical protein 0.0096 0.0956 0.1537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0414 0.0414
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0018 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Trypanosoma brucei alpha tubulin 0.0186 0.2379 0.9486
Trypanosoma cruzi epsilon tubulin, putative 0.0159 0.1964 0.7831
Trichomonas vaginalis tubulin epsilon chain, putative 0.0069 0.0541 0.0621
Echinococcus granulosus tubulin subunit TubB 0.0186 0.2379 0.2379
Mycobacterium leprae cell division protein FtsZ 0.0069 0.0541 0.1362
Echinococcus multilocularis Protein lozenge 0.0054 0.0299 0.0299
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.3975 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Echinococcus granulosus tubulin beta 1 chain 0.0194 0.2508 0.2508
Loa Loa (eye worm) alpha-tubulin 0.0186 0.2379 0.3824
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0414 0.0666
Leishmania major gamma-tubulin 0.0159 0.1964 0.7831
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0018 0.0018
Loa Loa (eye worm) tubulin beta-2A chain 0.0194 0.2508 0.4031
Echinococcus granulosus tubulin gamma 1 chain 0.0159 0.1964 0.1964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Entamoeba histolytica tubulin alpha chain, putative 0.0186 0.2379 0.2695
Echinococcus granulosus Tubulin beta 2C chain 0.0194 0.2508 0.2508
Echinococcus granulosus glutamate receptor 2 0.0036 0.0018 0.0018
Echinococcus granulosus tubulin alpha 1C chain 0.0186 0.2379 0.2379
Leishmania major beta tubulin 0.0194 0.2508 1
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0488 0.1947
Loa Loa (eye worm) tubulin alpha-2 chain 0.0186 0.2379 0.3824
Echinococcus multilocularis tubulin alpha 0.0159 0.1964 0.1964
Trypanosoma brucei epsilon tubulin 0.0159 0.1964 0.7831
Trichomonas vaginalis tubulin, putative 0.0194 0.2508 0.2878
Schistosoma mansoni tubulin subunit beta 0.0069 0.0541 0.0541
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0414 0.0414
Trypanosoma brucei trypanothione reductase 0.0066 0.0488 0.1947
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Echinococcus multilocularis tubulin alpha 1C chain 0.0186 0.2379 0.2379
Giardia lamblia Alpha-tubulin 0.0186 0.2379 0.2249
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0069 0.0541 0.2158
Trichomonas vaginalis tubulin alpha chain, putative 0.009 0.0872 0.1001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.3975 1
Echinococcus multilocularis tubulin alpha chain 0.0186 0.2379 0.2379
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0043 0.0049
Plasmodium falciparum tubulin delta chain, putative 0.0069 0.0541 0.0262
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2122 0.2122
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0159 0.1964 0.7831
Echinococcus granulosus tubulin alpha chain 0.0186 0.2379 0.2379
Brugia malayi Tubulin gamma chain 0.0159 0.1964 0.3157
Echinococcus multilocularis Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Echinococcus multilocularis nmda type glutamate receptor 0.004 0.008 0.008
Trypanosoma brucei zeta tubulin, putative 0.0069 0.0541 0.2158
Loa Loa (eye worm) tubulin alpha chain 0.0186 0.2379 0.3824
Toxoplasma gondii beta tubulin 0.0194 0.2508 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0069 0.0541 0.5
Leishmania major beta tubulin 0.0194 0.2508 1
Leishmania major beta tubulin 0.0194 0.2508 1
Onchocerca volvulus 0.009 0.0872 0.1402
Echinococcus multilocularis tubulin alpha 1C chain 0.0186 0.2379 0.2379
Plasmodium vivax tubulin alpha chain, putative 0.0186 0.2379 0.9486
Echinococcus multilocularis tubulin gamma 1 chain 0.0159 0.1964 0.1964
Echinococcus granulosus tubulin alpha chain 0.0186 0.2379 0.2379
Echinococcus multilocularis Tubulin beta 2C chain 0.0194 0.2508 0.2508
Echinococcus granulosus Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Echinococcus granulosus Tubulin beta 2C chain 0.0194 0.2508 0.2508
Brugia malayi Tubulin alpha-2 chain 0.0186 0.2379 0.3824
Mycobacterium tuberculosis Cell division protein FtsZ 0.0069 0.0541 0.1362
Brugia malayi Thioredoxin reductase 0.0066 0.0488 0.0785
Mycobacterium ulcerans cell division protein FtsZ 0.0069 0.0541 0.1362
Trypanosoma cruzi tubulin gamma chain 0.0159 0.1964 0.7831
Trypanosoma cruzi tubulin delta chain 0.0069 0.0541 0.2158
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0018 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0414 0.0414
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Loa Loa (eye worm) tubulin alpha chain 0.0186 0.2379 0.3824
Loa Loa (eye worm) tubulin alpha-3 chain 0.0096 0.0956 0.1537
Schistosoma mansoni alpha glucosidase 0.0038 0.0043 0.0043
Onchocerca volvulus 0.0098 0.0995 0.16
Echinococcus granulosus Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Brugia malayi jmjC domain containing protein 0.0061 0.0414 0.0666
Leishmania major beta tubulin 0.0194 0.2508 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0587 0.8713 1
Echinococcus multilocularis tubulin alpha chain 0.0186 0.2379 0.2379
Echinococcus granulosus tubulin alpha 1C chain 0.0186 0.2379 0.2379
Schistosoma mansoni alpha tubulin 0.0186 0.2379 0.2379
Echinococcus granulosus tubulin alpha chain 0.0186 0.2379 0.2379
Brugia malayi tubulin alpha chain - mouse 0.0186 0.2379 0.3824
Plasmodium vivax tubulin epsilon chain, putative 0.0159 0.1964 0.7831
Schistosoma mansoni tubulin subunit epsilon 0.0159 0.1964 0.1964
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0069 0.0541 0.2158
Trypanosoma brucei tubulin gamma chain 0.0159 0.1964 0.7831
Leishmania major beta tubulin 0.0194 0.2508 1
Loa Loa (eye worm) glutathione reductase 0.0066 0.0488 0.0785
Plasmodium falciparum tubulin gamma chain 0.0159 0.1964 0.7307
Schistosoma mansoni tubulin subunit alpha 0.0186 0.2379 0.2379
Leishmania major beta tubulin 0.0194 0.2508 1
Echinococcus granulosus Tubulin beta 2C chain 0.0194 0.2508 0.2508
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0414 0.0414
Leishmania major beta tubulin 0.0194 0.2508 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0194 0.2508 0.2878
Schistosoma mansoni tubulin subunit delta 0.0069 0.0541 0.0541
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Trypanosoma brucei epsilon tubulin 0.0159 0.1964 0.7831
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0043 0.0049
Loa Loa (eye worm) tubulin gamma chain 0.0159 0.1964 0.3157
Trypanosoma cruzi beta tubulin, putative 0.0194 0.2508 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0587 0.8713 1
Leishmania major beta tubulin 0.0194 0.2508 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0488 0.1229
Trichomonas vaginalis tubulin gamma chain, putative 0.0069 0.0541 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0541 0.0621
Loa Loa (eye worm) BEN-1 protein 0.0194 0.2508 0.4031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.2122 0.3412
Trypanosoma cruzi alpha tubulin, putative 0.0186 0.2379 0.9486
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0159 0.1964 0.2254
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.009 0.0872 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0541 0.0621
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Echinococcus granulosus peroxisome assembly protein 26 0.0186 0.2379 0.2379
Loa Loa (eye worm) tubulin beta chain 0.0194 0.2508 0.4031
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.017
Schistosoma mansoni tubulin subunit alpha 0.0186 0.2379 0.2379
Leishmania major trypanothione reductase 0.0066 0.0488 0.1947
Echinococcus granulosus nmda type glutamate receptor 0.004 0.008 0.008
Brugia malayi jmjC domain containing protein 0.0061 0.0414 0.0666
Giardia lamblia Beta tubulin 0.0194 0.2508 0.2407
Loa Loa (eye worm) hypothetical protein 0.0186 0.2379 0.3824
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0488 0.0785
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.1287 0.2069
Leishmania major beta tubulin 0.0194 0.2508 1
Plasmodium falciparum tubulin beta chain 0.0194 0.2508 1
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Loa Loa (eye worm) BEN-1 protein 0.0194 0.2508 0.4031
Echinococcus multilocularis tubulin beta 1 chain 0.0194 0.2508 0.2508
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0049
Toxoplasma gondii alpha-tubulin I, putative 0.0186 0.2379 0.9486
Entamoeba histolytica tubulin family protein 0.0194 0.2508 0.2843
Echinococcus multilocularis hypothetical protein 0.0186 0.2379 0.2379
Leishmania major zeta tubulin, putative 0.0069 0.0541 0.2158
Echinococcus granulosus beta tubulin 0.0194 0.2508 0.2508
Loa Loa (eye worm) alpha-tubulin 0.0186 0.2379 0.3824
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.004 0.008 0.008
Echinococcus granulosus tubulin subunit beta 0.0194 0.2508 0.2508
Loa Loa (eye worm) runx1 0.0054 0.0299 0.0481
Trypanosoma brucei alpha tubulin 0.0186 0.2379 0.9486
Trypanosoma brucei beta tubulin 0.0194 0.2508 1
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Brugia malayi Tubulin beta chain 0.0069 0.0541 0.087
Brugia malayi Tubulin alpha chain 0.0069 0.0541 0.087
Echinococcus multilocularis Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Trypanosoma brucei tubulin delta chain 0.0069 0.0541 0.2158
Brugia malayi beta-tubulin, identical 0.0194 0.2508 0.4031
Trichomonas vaginalis tubulin gamma chain, putative 0.0159 0.1964 0.2254
Trypanosoma brucei alpha tubulin 0.0186 0.2379 0.9486
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.3975 1
Echinococcus multilocularis tubulin alpha chain 0.0186 0.2379 0.2379
Echinococcus granulosus tubulin alpha 3 chain 0.0186 0.2379 0.2379
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0043 0.017
Echinococcus multilocularis tubulin alpha chain 0.0186 0.2379 0.2379
Brugia malayi Tubulin beta chain 0.009 0.0872 0.1402
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0043 0.0069
Leishmania major beta tubulin 0.0194 0.2508 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2122 0.2122
Leishmania major beta tubulin 0.0194 0.2508 1
Trypanosoma cruzi zeta tubulin, putative 0.0069 0.0541 0.2158
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0018 0.0018
Entamoeba histolytica tubulin alpha-1 chain 0.0186 0.2379 0.2695
Toxoplasma gondii alpha tubulin TUBA1 0.0186 0.2379 0.9486
Schistosoma mansoni alpha tubulin 0.0186 0.2379 0.2379
Echinococcus multilocularis beta tubulin 0.0194 0.2508 0.2508
Trypanosoma brucei alpha tubulin 0.0186 0.2379 0.9486
Echinococcus multilocularis tubulin subunit TubB 0.0186 0.2379 0.2379
Toxoplasma gondii thioredoxin reductase 0.0066 0.0488 0.1947
Echinococcus multilocularis Tubulin beta 2C chain 0.0194 0.2508 0.2508
Echinococcus granulosus beta tubulin 0.0194 0.2508 0.2508
Trichomonas vaginalis tubulin epsilon chain, putative 0.0186 0.2379 0.273
Echinococcus multilocularis tubulin delta chain 0.0069 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0116 0.1287 0.2069
Brugia malayi Tubulin alpha-2 chain 0.0186 0.2379 0.3824
Trypanosoma cruzi zeta tubulin, putative 0.0069 0.0541 0.2158
Trichomonas vaginalis tubulin epsilon chain, putative 0.0194 0.2508 0.2878
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Echinococcus multilocularis tubulin alpha chain 0.0186 0.2379 0.2379
Trypanosoma brucei epsilon tubulin 0.0159 0.1964 0.7831
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0069 0.0541 0.0621
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0488 0.0488
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.2122 0.2122
Echinococcus multilocularis Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Leishmania major beta tubulin 0.0194 0.2508 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0587 0.8713 1
Leishmania major beta tubulin 0.0194 0.2508 1
Trypanosoma brucei glucosidase, putative 0.0038 0.0043 0.017
Leishmania major beta tubulin 0.0194 0.2508 1
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0018 0.0018
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Echinococcus multilocularis peroxisome assembly protein 26 0.0186 0.2379 0.2379
Onchocerca volvulus 0.0429 0.6221 1
Giardia lamblia Alpha-tubulin 0.0186 0.2379 0.2249
Echinococcus granulosus Tubulin beta 2C chain 0.0194 0.2508 0.2508
Leishmania major beta tubulin 0.0194 0.2508 1
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Brugia malayi hypothetical protein 0.0429 0.6221 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0096 0.0956 0.1098
Trypanosoma brucei alpha tubulin, putative 0.009 0.0872 0.3478
Trichomonas vaginalis tubulin alpha chain, putative 0.0194 0.2508 0.2878
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.2122 0.3412
Trypanosoma brucei beta tubulin 0.0194 0.2508 1
Brugia malayi glutathione reductase 0.0066 0.0488 0.0785
Loa Loa (eye worm) tubulin beta chain 0.0069 0.0541 0.087
Entamoeba histolytica tubulin gamma chain 0.0159 0.1964 0.2216
Echinococcus multilocularis tubulin alpha 3 chain 0.0186 0.2379 0.2379
Schistosoma mansoni tubulin subunit alpha 0.0069 0.0541 0.0541
Trichomonas vaginalis tubulin beta chain, putative 0.0194 0.2508 0.2878
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Trichomonas vaginalis tubulin, putative 0.0069 0.0541 0.0621
Plasmodium vivax glutathione reductase, putative 0.0066 0.0488 0.1947
Echinococcus granulosus tubulin alpha 0.0159 0.1964 0.1964
Plasmodium vivax tubulin gamma chain, putative 0.0159 0.1964 0.7831
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0018 0.0018
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0194 0.2508 0.2508
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0043 0.0069
Trichomonas vaginalis tubulin, putative 0.009 0.0872 0.1001
Echinococcus granulosus tubulin alpha chain 0.0186 0.2379 0.2379
Trypanosoma brucei beta tubulin 0.0194 0.2508 1
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Trichomonas vaginalis tubulin, putative 0.009 0.0872 0.1001
Trypanosoma cruzi epsilon tubulin, putative 0.0159 0.1964 0.7831
Trichomonas vaginalis tubulin gamma chain, putative 0.0159 0.1964 0.2254
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0116 0.1287 0.1477
Trichomonas vaginalis tubulin alpha chain, putative 0.009 0.0872 0.1001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0414 0.0414
Brugia malayi Cell division protein ftsZ 0.0069 0.0541 0.087
Loa Loa (eye worm) hypothetical protein 0.0429 0.6221 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0043 0.017
Echinococcus granulosus Tubulin alpha 1 chain 0.0186 0.2379 0.2379
Trichomonas vaginalis tubulin epsilon chain, putative 0.0186 0.2379 0.273
Schistosoma mansoni alpha-glucosidase 0.0146 0.175 0.175
Loa Loa (eye worm) hypothetical protein 0.0429 0.6221 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0116 0.1287 0.2069
Plasmodium falciparum tubulin epsilon chain, putative 0.0159 0.1964 0.7307
Trichomonas vaginalis tubulin gamma chain, putative 0.0194 0.2508 0.2878
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Leishmania major beta tubulin 0.0194 0.2508 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0194 0.2508 0.2508
Giardia lamblia Beta tubulin 0.0194 0.2508 0.2407
Echinococcus multilocularis Tubulin beta 2C chain 0.0194 0.2508 0.2508
Toxoplasma gondii beta-tubulin, putative 0.0194 0.2508 1
Leishmania major delta tubulin, putative 0.0069 0.0541 0.2158
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0414 0.0414
Plasmodium vivax tubulin beta chain, putative 0.0194 0.2508 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0194 0.2508 0.2508
Echinococcus granulosus tubulin alpha chain 0.0186 0.2379 0.2379
Echinococcus granulosus tubulin epsilon chain 0.0159 0.1964 0.1964
Trypanosoma brucei zeta tubulin 0.0069 0.0541 0.2158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Trypanosoma brucei beta tubulin 0.0194 0.2508 1
Echinococcus granulosus alpha tubulin 0.0186 0.2379 0.2379
Plasmodium falciparum alpha tubulin 1 0.0186 0.2379 0.9362
Leishmania major beta tubulin 0.0194 0.2508 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0049
Toxoplasma gondii beta-1 tubulin, putative 0.0194 0.2508 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0043 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0488 0.0488
Echinococcus multilocularis tubulin epsilon chain 0.0159 0.1964 0.1964
Echinococcus multilocularis tubulin subunit beta 0.0194 0.2508 0.2508
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0043 0.0043
Schistosoma mansoni tubulin subunit gamma 0.0159 0.1964 0.1964
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.1287 0.2069
Echinococcus granulosus tubulin delta chain 0.0069 0.0541 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.8713 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0018 0.0018
Trichomonas vaginalis tubulin beta chain, putative 0.009 0.0872 0.1001
Trypanosoma cruzi tubulin delta chain 0.0069 0.0541 0.2158
Loa Loa (eye worm) tubulin beta-1 chain 0.0194 0.2508 0.4031
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Schistosoma mansoni alpha tubulin 0.0186 0.2379 0.2379
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0018 0.0018
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Plasmodium falciparum alpha tubulin 2 0.0186 0.2379 0.9362
Plasmodium vivax tubulin alpha chain, putative 0.0186 0.2379 0.9486
Trichomonas vaginalis tubulin alpha chain, putative 0.009 0.0872 0.1001
Schistosoma mansoni tubulin subunit beta 0.0194 0.2508 0.2508
Loa Loa (eye worm) beta-tubulin 0.0194 0.2508 0.4031
Leishmania major alpha tubulin 0.0186 0.2379 0.9486
Leishmania major beta tubulin 0.0194 0.2508 1
Trichomonas vaginalis tubulin beta chain, putative 0.0186 0.2379 0.273
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0018 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0018 0.0018
Leishmania major epsilon tubulin, putative 0.0159 0.1964 0.7831
Echinococcus multilocularis tubulin alpha 3 chain 0.0186 0.2379 0.2379
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0043 0.0043
Leishmania major alpha tubulin 0.0186 0.2379 0.9486

Activities

Activity type Activity value Assay description Source Reference
Delta SBP (functional) = -50 mmHg Change in systolic blood pressure(SBP) after intravenous administration of 3 mg/kg in rats compared with SBP before dosing ChEMBL. 11392532
IC50 (functional) = 0.33 uM Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expressed in Xenopus oocytes by injection of rat brain mRNA ChEMBL. 11392532
IC50 (functional) = 0.33 uM Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expressed in Xenopus oocytes by injection of rat brain mRNA ChEMBL. 11392532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.