Detailed information for compound 286428

Basic information

Technical information
  • TDR Targets ID: 286428
  • Name: 1-[6-(benzenesulfonamido)-6-oxohexyl]-5-[(2,6 -dichlorophenyl)methoxy]indole-2-carboxylic a cid
  • MW: 589.487 | Formula: C28H26Cl2N2O6S
  • H donors: 2 H acceptors: 5 LogP: 5.96 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NS(=O)(=O)c1ccccc1)CCCCCn1c(cc2c1ccc(c2)OCc1c(Cl)cccc1Cl)C(=O)O
  • InChi: 1S/C28H26Cl2N2O6S/c29-23-10-7-11-24(30)22(23)18-38-20-13-14-25-19(16-20)17-26(28(34)35)32(25)15-6-2-5-12-27(33)31-39(36,37)21-8-3-1-4-9-21/h1,3-4,7-11,13-14,16-17H,2,5-6,12,15,18H2,(H,31,33)(H,34,35)
  • InChiKey: KIAIASJQUQJQDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[6-(benzenesulfonamido)-6-oxo-hexyl]-5-[(2,6-dichlorophenyl)methoxy]indole-2-carboxylic acid
  • 1-[6-(benzenesulfonamido)-6-oxohexyl]-5-[(2,6-dichlorophenyl)methoxy]-2-indolecarboxylic acid
  • 5-[(2,6-dichlorophenyl)methoxy]-1-[6-oxo-6-(phenylsulfonylamino)hexyl]indole-2-carboxylic acid
  • 1-[6-(benzenesulfonamido)-6-keto-hexyl]-5-(2,6-dichlorobenzyl)oxy-indole-2-carboxylic acid
  • 5-[(2,6-dichlorophenyl)methoxy]-1-[6-oxo-6-(phenylsulfonylamino)hexyl]-2-indolecarboxylic acid
  • 5-(2,6-dichlorobenzyl)oxy-1-[6-keto-6-(phenylsulfonylamino)hexyl]indole-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0059 0.1454 0.4156
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus solute carrier family 22 0.0012 0.0195 0.0195
Echinococcus multilocularis lysyl tRNA synthetase 0.0019 0.0386 0.0386
Echinococcus multilocularis serotonin receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus geminin 0.0099 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0016 0.0308 0.0764
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0461 0.0461
Echinococcus granulosus neuroglian 0.0005 0.0004 0.0004
Toxoplasma gondii lysine-tRNA ligase 0.0019 0.0386 0.0602
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Brugia malayi Sugar transporter family protein 0.0012 0.0195 0.0483
Trichomonas vaginalis glucose transporter, putative 0.0012 0.0195 0.0583
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Brugia malayi Glutathione S-transferase 4 0.0009 0.0108 0.0268
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0386 0.337
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0156 0.4035 0.4035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.002 0.0411 0.1019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Plasmodium falciparum protein kinase 7 0.0245 0.6412 0.6616
Onchocerca volvulus 0.0012 0.0195 0.0268
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0027 0.0588 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Brugia malayi Serotonin receptor 0.0022 0.0461 0.1143
Schistosoma mansoni adenoreceptor 0.0022 0.0461 0.0461
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis glutathione S transferase 0.0012 0.0179 0.0179
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni hypothetical protein 0.0042 0.1004 0.1004
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.0678 0.5924
Echinococcus granulosus prostaglandin H2 D isomerase 0.0051 0.1235 0.1235
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0461 0.1089
Brugia malayi Dopamine receptor 0.0022 0.0461 0.1143
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.0195 0.0195
Brugia malayi putative neuropeptide receptor 0.0022 0.0461 0.1143
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0026 0.0563 0.1684
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0461 0.0461
Schistosoma mansoni sugar transporter 0.0012 0.0195 0.0195
Brugia malayi Dopamine receptor protein 1 0.0022 0.0461 0.1143
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0027 0.0589 0.0918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.1004 0.1004
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0096
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0016 0.0308 0.0308
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0012 0.0195 0.1703
Schistosoma mansoni hypothetical protein 0.0099 0.2519 0.2519
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0587 0.1753
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus glutathione S transferase Mu 1 0.0012 0.0179 0.0179
Echinococcus multilocularis geminin 0.0099 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis glutathione S transferase 0.0039 0.0926 0.0926
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0042 0.1004 0.2487
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0461 0.0461
Schistosoma mansoni glutathione-S-transferase 0.0012 0.0179 0.0179
Schistosoma mansoni histamine h1 receptor 0.0022 0.0461 0.0461
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0461 0.1143
Toxoplasma gondii kringle domain-containing protein 0.002 0.0411 0.0641
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0461 0.0461
Schistosoma mansoni protein kinase 0.0027 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Plasmodium vivax glutathione S-transferase, putative 0.0051 0.1235 0.1274
Echinococcus granulosus solute carrier family 22 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus glutathione S transferase 0.0009 0.0108 0.0108
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0461 0.0461
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Echinococcus granulosus serotonin receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0461 0.0461
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0461 0.0461
Plasmodium falciparum calcium-dependent protein kinase 4 0.0027 0.0589 0.0607
Onchocerca volvulus 0.0012 0.0195 0.0268
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Schistosoma mansoni hypothetical protein 0.0042 0.1004 0.1004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0461 0.0461
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Brugia malayi hypothetical protein 0.013 0.3341 0.828
Brugia malayi neuropeptide F receptor 0.0022 0.0461 0.1143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0386 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0587 0.1753
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0461 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Onchocerca volvulus 0.0012 0.0195 0.0268
Brugia malayi Cam kinase protein 1 0.0027 0.0588 0.1458
Schistosoma mansoni neuropeptide receptor 0.0022 0.0461 0.0461
Brugia malayi Pre-SET motif family protein 0.0114 0.2925 0.7249
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Schistosoma mansoni hypothetical protein 0.0099 0.2519 0.2519
Loa Loa (eye worm) dihydrofolate reductase 0.0048 0.1145 0.2838
Schistosoma mansoni nephrin 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Plasmodium falciparum protein kinase 6 0.0367 0.9692 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0086 0.2182 0.3403
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0195 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Entamoeba histolytica hypothetical protein 0.0021 0.0432 0.7349
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0026 0.0563 0.1396
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Giardia lamblia Sugar-proton symporter 0.0012 0.0195 0.346
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0009 0.0108 0.0324
Plasmodium vivax SET domain protein, putative 0.0016 0.0308 0.0318
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0461 0.0461
Brugia malayi major facilitator superfamily protein 0.0012 0.0195 0.0483
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Plasmodium vivax sugar transporter, putative 0.0012 0.0195 0.0201
Leishmania major hypothetical protein, conserved 0.0012 0.0195 0.1703
Echinococcus granulosus sex peptide receptor 0.0022 0.0461 0.0461
Schistosoma mansoni biogenic amine receptor 0.0022 0.0461 0.0461
Echinococcus granulosus GPCR family 2 0.0042 0.1004 0.1004
Plasmodium vivax hexose transporter 0.0086 0.2182 0.2251
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0195 0.0583
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Toxoplasma gondii sugar transporter ST2 0.0012 0.0195 0.0304
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus multilocularis glutathione S-transferase 0.0012 0.0179 0.0179
Entamoeba histolytica hypothetical protein 0.0019 0.0386 0.656
Plasmodium falciparum lysine--tRNA ligase 0.0019 0.0386 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi Calcitonin receptor-like protein seb-1 0.0134 0.3453 0.8556
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Leishmania major glucose transporter/membrane transporter D2, putative 0.0027 0.0587 0.5125
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0016 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.0086 0.2182 0.2182
Onchocerca volvulus 0.0012 0.0195 0.0268
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0461 0.1143
Entamoeba histolytica protein kinase, putative 0.0027 0.0588 1
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Trypanosoma cruzi hexose transporter 0.0027 0.0587 0.5125
Schistosoma mansoni hypothetical protein 0.0022 0.0461 0.0461
Echinococcus granulosus glutathione S transferase 0.0039 0.0926 0.0926
Brugia malayi Dopamine receptor protein 2 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Echinococcus multilocularis glutathione S transferase 0.0012 0.0179 0.0179
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis solute carrier family 22 0.0012 0.0195 0.0195
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0461 0.0461
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0027 0.0589 0.0607
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0048 0.1145 1
Brugia malayi Kringle domain containing protein 0.002 0.0411 0.1019
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0461 0.1143
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0012 0.0195 0.1703
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0587 0.5125
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0027 0.0589 0.0918
Schistosoma mansoni hypothetical protein 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Entamoeba histolytica hypothetical protein 0.0021 0.0432 0.7349
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0026 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Onchocerca volvulus Tyrosine kinase homolog 0.0061 0.1491 0.4271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0308 0.0308
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0195 0.0483
Toxoplasma gondii sugar transporter ST3 0.0012 0.0195 0.0304
Echinococcus multilocularis glutathione S transferase 0.0009 0.0108 0.0108
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0026 0.0578 0.1432
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0461 0.1143
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0386 0.0386
Echinococcus granulosus General substrate transporter 0.0074 0.1857 0.1857
Onchocerca volvulus 0.0022 0.0461 0.1089
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0411 0.3592
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0026 0.0563 0.0563
Schistosoma mansoni myosin xvIII 0.0022 0.0461 0.0461
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0563 0.0563
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0461 0.0461
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.013 0.3341 0.828
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0011 0.0155 0.0383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis General substrate transporter 0.0074 0.1857 0.1857
Loa Loa (eye worm) sugar transporter 0.0012 0.0195 0.0483
Onchocerca volvulus 0.0016 0.0308 0.0617
Brugia malayi AKH receptor 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Giardia lamblia Prolyl-tRNA synthetase 0.0026 0.0563 1
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Brugia malayi hypothetical protein 0.0021 0.0432 0.1072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus twitchin 0.0007 0.0059 0.0059
Brugia malayi Sugar transporter family protein 0.0012 0.0195 0.0483
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0461 0.1143
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis solute carrier family 22 0.0012 0.0195 0.0195
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0461 0.0461
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0461 0.0461
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0461 0.0461
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0048 0.1145 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0461 0.0461
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.0588 0.1758
Schistosoma mansoni neuropeptide receptor 0.0022 0.0461 0.0461
Onchocerca volvulus 0.0022 0.0461 0.1089
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0026 0.0563 0.1396
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis glutathione s transferase mu 0.0012 0.0179 0.0179
Schistosoma mansoni sugar transporter 0.0012 0.0195 0.0195
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0012 0.0195 0.1703
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0461 0.1089
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0262 0.2287
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0461 0.1143
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0017 0.0322 0.0963
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0587 0.1753
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0134 0.3453 0.8556
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0019 0.0386 0.1153
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.1004 0.1004
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0461 0.0461
Schistosoma mansoni neuropeptide receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Echinococcus multilocularis neuroglian 0.0005 0.0004 0.0004
Brugia malayi dihydrofolate reductase family protein 0.0048 0.1145 0.2838
Leishmania major lysyl-tRNA synthetase, putative 0.0019 0.0386 0.337
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0027 0.0588 0.1458
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0016 0.0308 0.0481
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0012 0.0195 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0461 0.0461
Leishmania major glucose transporter, lmgt3 0.0027 0.0587 0.5125
Echinococcus granulosus roundabout 2 0.0006 0.0039 0.0039
Echinococcus granulosus g protein coupled receptor 0.0022 0.0461 0.0461
Onchocerca volvulus 0.0022 0.0461 0.1089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0461 0.0461
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0461 0.0461
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0461 0.0461
Plasmodium falciparum hexose transporter 0.0086 0.2182 0.2251
Brugia malayi map kinase activated protein kinase protein 2 0.0156 0.4035 1
Schistosoma mansoni microtubule-associated protein tau 0.0379 1 1
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0411 0.0424
Brugia malayi Sugar transporter family protein 0.0086 0.2182 0.5406
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0065 0.1606 0.3979
Echinococcus granulosus dihydrofolate reductase 0.0048 0.1145 0.1145
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0432 0.0432
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0195 0.0483
Trypanosoma cruzi hexose transporter, putative 0.0012 0.0195 0.1703
Echinococcus multilocularis dihydrofolate reductase 0.0048 0.1145 0.1145
Plasmodium falciparum glutathione S-transferase 0.0012 0.0179 0.0185
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0461 0.0461
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0461 0.1143
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Echinococcus granulosus glutathione S transferase 0.0012 0.0179 0.0179
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0386 0.337
Onchocerca volvulus 0.0012 0.0195 0.0268
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0461 0.0461
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0461 0.0461
Brugia malayi Dihydrofolate reductase 0.0048 0.1145 0.2838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0016 0.0308 0.2691
Echinococcus granulosus allatostatin A receptor 0.0022 0.0461 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni amine GPCR 0.0022 0.0461 0.0461
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0027 0.0589 0.0607
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0587 0.1753
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Echinococcus multilocularis calcium dependent protein kinase 0.0025 0.0534 0.0534
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0448 0.1111
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0461 0.0461
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0461 0.0461
Schistosoma mansoni sugar transporter 0.0012 0.0195 0.0195
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni cell adhesion molecule 0.0005 0.0012 0.0012
Loa Loa (eye worm) sugar transporter 0.0086 0.2182 0.5406
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0009 0.0115 0.1004
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0156 0.4035 0.4035
Schistosoma mansoni opsin-like receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0016 0.0308 0.2691
Schistosoma mansoni amine GPCR 0.0022 0.0461 0.0461
Trypanosoma cruzi sugar transporter, putative 0.0012 0.0195 0.1703
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi G-protein coupled receptor 0.0022 0.0461 0.1143
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0678 0.5924
Chlamydia trachomatis proline--tRNA ligase 0.0009 0.0115 0.1004
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0678 0.5924
Loa Loa (eye worm) hypothetical protein 0.0012 0.0179 0.0444
Onchocerca volvulus 0.002 0.0411 0.0936
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0027 0.0588 0.1458
Loa Loa (eye worm) hypothetical protein 0.0092 0.2319 0.5747
Chlamydia trachomatis dihydrofolate reductase 0.0048 0.1145 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni hypothetical protein 0.0021 0.0432 0.0432
Brugia malayi latrophilin 2 splice variant baaae 0.0092 0.2319 0.5747
Schistosoma mansoni opsin-like receptor 0.0022 0.0461 0.0461
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0027 0.0588 0.5138
Entamoeba histolytica hypothetical protein 0.0021 0.0432 0.7349
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis survival motor neuron protein 1 0.013 0.3341 0.3341
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0048 0.1145 0.1182
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0461 0.0461
Schistosoma mansoni hypothetical protein 0.0042 0.1004 0.1004
Trichomonas vaginalis sugar transport protein, putative 0.0012 0.0195 0.0583
Schistosoma mansoni hypothetical protein 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0114 0.2925 0.7249
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0308 0.0308
Echinococcus multilocularis microtubule associated protein 2 0.0379 1 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0026 0.0563 0.9577
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0461 0.1143
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.014 0.3616 0.3731
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0411 0.0424
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0587 0.5125
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni hypothetical protein 0.002 0.0411 0.0411
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni neuropeptide receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Onchocerca volvulus 0.0022 0.0461 0.1089
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0461 0.0461
Brugia malayi lysyl-tRNA synthetase 0.0019 0.0386 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0587 0.5125
Entamoeba histolytica hypothetical protein 0.0021 0.0432 0.7349
Trichomonas vaginalis glucose transporter, putative 0.0027 0.0587 0.1753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0461 0.0461
Schistosoma mansoni amine GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0461 0.0461
Onchocerca volvulus 0.0012 0.0195 0.0268
Brugia malayi hypothetical protein 0.0012 0.0195 0.0483
Echinococcus granulosus calcium dependent protein kinase 0.0025 0.0534 0.0534
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0461 0.0461
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0134 0.3453 0.8556
Schistosoma mansoni sugar transporter 0.0012 0.0195 0.0195
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0005 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0042 0.1004 0.1004
Echinococcus multilocularis serotonin receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0026 0.0563 0.1396
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.1004 0.2487
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0096
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0461 0.0461
Plasmodium falciparum proline--tRNA ligase 0.003 0.0678 0.07
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Echinococcus granulosus orexin receptor type 2 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0461 0.0461
Treponema pallidum prolyl-tRNA synthetase 0.0009 0.0115 1
Echinococcus granulosus hypothetical protein 0.0022 0.0461 0.0461
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0461 0.0461
Toxoplasma gondii sugar transporter ST1 0.0012 0.0195 0.0304
Schistosoma mansoni hypothetical protein 0.0026 0.0578 0.0578
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Plasmodium falciparum calcium-dependent protein kinase 5 0.0027 0.0589 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0433 0.1074
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0461 0.0461
Schistosoma mansoni biogenic amine receptor 0.0022 0.0461 0.0461
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0461 0.0461
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0587 0.5125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi RE15519p 0.0022 0.0461 0.1143
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0026 0.0563 0.1396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0086 0.2182 0.2182
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0563 0.0563
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0461 0.0461
Giardia lamblia Lysyl-tRNA synthetase 0.0019 0.0386 0.6849
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0048 0.1145 0.1182
Echinococcus multilocularis roundabout 2 0.0006 0.0039 0.0039
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0461 0.0461
Brugia malayi sulfakinin receptor protein 0.0022 0.0461 0.1143
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis solute carrier family 22 0.0012 0.0195 0.0195
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0461 0.0461
Brugia malayi GnHR receptor homolog 0.0022 0.0461 0.1143
Leishmania major glucose transporter, lmgt1 0.0027 0.0587 0.5125
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0461 0.0461
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0587 0.1753
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0195 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.4035 0.4035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0461 0.0461
Toxoplasma gondii protein kinase, putative 0.0245 0.6412 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.003 0.0678 0.1058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0461 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Echinococcus multilocularis GPCR, family 2 0.0042 0.1004 0.1004
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0386 0.337
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0432 0.0432
Echinococcus granulosus lysyl tRNA synthetase 0.0019 0.0386 0.0386
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Onchocerca volvulus 0.0012 0.0195 0.0268
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni biogenic amine receptor 0.0022 0.0461 0.0461
Chlamydia trachomatis lysine--tRNA ligase 0.0019 0.0386 0.337
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0048 0.1145 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0195 0.0483
Plasmodium vivax CDK-related protein kinase 6, putative 0.0367 0.9692 1
Echinococcus granulosus solute carrier family 22 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni glucose transport protein 0.0086 0.2182 0.2182
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0587 0.5125
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0461 0.0461
Echinococcus granulosus glutathione s transferase mu 0.0012 0.0179 0.0179
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0048 0.1145 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0461 0.1143
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0026 0.0563 0.4921
Onchocerca volvulus 0.0012 0.0195 0.0268
Echinococcus granulosus fmrfamide receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0019 0.0386 0.337
Schistosoma mansoni dihydrofolate reductase 0.0048 0.1145 0.1145
Onchocerca volvulus Putative transporter 0.0012 0.0195 0.0268
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0461 0.0461
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0195 0.0304
Schistosoma mansoni GST class-mu 0.0012 0.0179 0.0179
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0461 0.0461
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0051 0.1235 0.1235
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0461 0.0461
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Leishmania major myo-inositol/proton symporter (MIT) 0.0012 0.0195 0.1703
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0461 0.0461
Mycobacterium ulcerans sugar transporter 0.0012 0.0195 0.1703
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0461 0.0461
Schistosoma mansoni hypothetical protein 0.0092 0.2319 0.2319
Echinococcus granulosus somatostatin receptor 0.0022 0.0461 0.0461
Brugia malayi larval opioid receptor 0.0022 0.0461 0.1143
Schistosoma mansoni survival motor neuron protein 0.0026 0.0578 0.0578
Trichomonas vaginalis glucose transporter, putative 0.0027 0.0587 0.1753
Brugia malayi major facilitator superfamily protein 0.0012 0.0195 0.0483
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0461 0.0461
Schistosoma mansoni protein kinase 0.0027 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0308 0.0308
Brugia malayi Protein kinase domain containing protein 0.0021 0.0421 0.1043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0051 0.1235 0.1235
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi Pre-SET motif family protein 0.0016 0.0308 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0195 0.0583
Giardia lamblia Hexose transporter 0.0012 0.0195 0.346
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Echinococcus multilocularis glutathione S transferase 0.0009 0.0108 0.0108
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Plasmodium vivax lysine--tRNA ligase, putative 0.0019 0.0386 0.0398
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0461 0.1143
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0461 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0027 0.0588 0.0588
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0308 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0019 0.0386 0.337
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.1606 0.3979
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0461 0.1143
Trypanosoma brucei glucose transporter, putative 0.0027 0.0587 0.5125
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0027 0.0589 0.0918
Plasmodium falciparum calcium-dependent protein kinase 1 0.0027 0.0589 0.0607
Trypanosoma cruzi glucose transporter, putative 0.0012 0.0195 0.1703
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0012 0.0195 0.1703
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.0678 0.5924
Brugia malayi G protein-coupled receptor 0.0022 0.0461 0.1143
Schistosoma mansoni glucose transporter 0.0012 0.0195 0.0195
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0461 0.1143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0195 0.0583
Echinococcus granulosus g protein coupled receptor 0.0022 0.0461 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0588 0.0588
Entamoeba histolytica protein kinase, putative 0.0027 0.0588 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0027 0.0589 0.0607
Loa Loa (eye worm) hypothetical protein 0.0027 0.0588 0.1458
Brugia malayi Melatonin receptor type 1A 0.0022 0.0461 0.1143
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.2182 0.6518
Trypanosoma brucei sugar transporter, putative 0.0012 0.0195 0.1703
Onchocerca volvulus 0.0012 0.0195 0.0268
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0308 0.0308
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0461 0.0461
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0195 0.0483
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0461 0.0461
Schistosoma mansoni protein kinase 0.0027 0.0588 0.0588
Echinococcus multilocularis somatostatin receptor 0.0022 0.0461 0.0461
Echinococcus granulosus neuropeptide receptor 0.0022 0.0461 0.0461
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Leishmania major protein kinase, putative 0.0027 0.0588 0.5138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Leishmania major glucose transporter, lmgt2 0.0027 0.0587 0.5125
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0012 0.0195 0.1703
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0461 0.0461
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.1004 0.1004
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Brugia malayi hypothetical protein 0.0012 0.0195 0.0483
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0195 0.0583
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Onchocerca volvulus 0.0022 0.0461 0.1089
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0461 0.0461
Trichomonas vaginalis myo-inositol transporter, putative 0.0012 0.0195 0.0583
Plasmodium falciparum mitogen-activated protein kinase 2 0.014 0.3616 0.3731
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0016 0.0308 0.2691
Echinococcus granulosus g protein coupled receptor 0.0022 0.0461 0.0461
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0195 0.0583
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni glucose transport protein 0.0086 0.2182 0.2182
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0461 0.0461
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis sex peptide receptor 0.0022 0.0461 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0461 0.0461
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0156 0.4035 1
Trichomonas vaginalis set domain proteins, putative 0.013 0.3347 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0048 0.1145 0.1786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni glucose transport protein 0.0086 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0386 0.0956
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0461 0.1143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Leishmania major hypothetical protein, conserved 0.002 0.0411 0.3592
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0461 0.0461
Echinococcus granulosus neuropeptide receptor 0.0022 0.0461 0.0461
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0048 0.1145 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.014 0.3616 0.564
Onchocerca volvulus 0.0012 0.0195 0.0268
Schistosoma mansoni amine GPCR 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Brugia malayi hypothetical protein 0.0022 0.0461 0.1143
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0012 0.0195 0.0483
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0461 0.0461
Echinococcus granulosus solute carrier family 22 0.0012 0.0195 0.0195
Trypanosoma brucei glucose transporter 2A 0.0027 0.0587 0.5125
Loa Loa (eye worm) hypothetical protein 0.0134 0.3453 0.8556
Plasmodium falciparum calcium-dependent protein kinase 3 0.0027 0.0589 0.0607
Schistosoma mansoni opsin-like receptor 0.0022 0.0461 0.0461
Brugia malayi hypothetical protein 0.0012 0.0195 0.0483
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0048 0.1145 1
Brugia malayi ORL1-like opioid receptor 0.0022 0.0461 0.1143
Echinococcus granulosus Sugar transporter ERD6 protein 0.0012 0.0195 0.0195
Plasmodium vivax proline--tRNA ligase, putative 0.003 0.0678 0.07
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0022 0.0461 0.1089
Schistosoma mansoni amine GPCR 0.0022 0.0461 0.0461
Onchocerca volvulus 0.013 0.3347 1
Echinococcus granulosus survival motor neuron protein 1 0.013 0.3341 0.3341
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0012 0.0195 0.0268
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0587 0.5125
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0027 0.0589 0.0607
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0461 0.0461
Brugia malayi neuropeptide F receptor 0.0022 0.0461 0.1143
Brugia malayi G-protein coupled receptor 0.0022 0.0461 0.1143
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0012 0.0195 0.0195
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0461 0.1143
Onchocerca volvulus 0.0026 0.0578 0.145
Mycobacterium ulcerans integral membrane transport protein 0.0012 0.0195 0.1703
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0461 0.1143
Plasmodium vivax calcium-dependent protein kinase, putative 0.0027 0.0589 0.0607
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.0195 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0461 0.0461
Trypanosoma brucei glucose transporter 1E 0.0027 0.0587 0.5125
Echinococcus multilocularis solute carrier family 22 0.0012 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0009 0.0108 0.0268
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0012 0.0195 0.0195
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.0678 0.5924
Brugia malayi Latrophilin receptor protein 2 0.0042 0.1004 0.2487
Echinococcus multilocularis glutathione S transferase 0.0012 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni hypothetical protein 0.0022 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0016 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0461 0.1143
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0461 0.0461
Brugia malayi Serotonin receptor 0.0022 0.0461 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0195 0.0583
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0461 0.1143
Brugia malayi glutathione transferase 0.0012 0.0179 0.0444
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0461 0.0461
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.1004 0.2487

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.046 uM Inhibitory activity against Streptococcus pneumoniae Beta-ketoacyl-ACP synthase III (FabH) (initiator of the fatty acid synthesis) ChEMBL. 12502353
IC50 (binding) = 4.6 uM Inhibitory activity against Escherichia coli Beta-ketoacyl-ACP synthase III (FabH) (initiator of the fatty acid synthesis) ChEMBL. 12502353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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