Detailed information for compound 286527

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 804.223 | Formula: C32H31Cl3N3O7S4+
  • H donors: 4 H acceptors: 7 LogP: 6.11 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)CSc1cc(C)[n+](c(c1)CCc1ccc(s1)Cl)CC[C@H](C(=O)O)O)CSc1cc(Cl)ccc1Cl
  • InChi: 1S/C32H30Cl3N3O7S4/c1-16-10-21(12-19(3-4-20-5-7-25(35)49-20)37(16)9-8-23(39)31(42)43)46-13-17-14-48-30-27(29(41)38(30)28(17)32(44)45)36-26(40)15-47-24-11-18(33)2-6-22(24)34/h2,5-7,10-12,23,27,30,39H,3-4,8-9,13-15H2,1H3,(H2-,36,40,42,43,44,45)/p+1/t23-,27-,30-/m1/s1
  • InChiKey: GDYFMKXQLUYZSU-CMSWSFRRSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0102 0.0204
Schistosoma mansoni zinc finger protein 0.0025 0.0147 0.0286
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0643 0.137
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0148 0.0419
Loa Loa (eye worm) hypothetical protein 0.0494 0.513 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0102 0.0102
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.033 0.0663
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0127 0.0254
Echinococcus granulosus orexin receptor type 2 0.0021 0.0102 0.0204
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0041 0.0319 0.0641
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0041 0.0319 0.0542
Schistosoma mansoni neuropeptide receptor 0.0021 0.0102 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0258
Echinococcus granulosus dnaJ subfamily B 0.048 0.4986 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0102 0.0102
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0078 0.0153
Schistosoma mansoni amine GPCR 0.0021 0.0102 0.0198
Brugia malayi MH2 domain containing protein 0.0073 0.0662 0.2184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0643 0.1253
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0078 0.0153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0102 0.0198
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0102 0.0102
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0054 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0059 0.0512 0.0998
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0102 0.0102
Schistosoma mansoni bromodomain containing protein 0.0076 0.0692 0.1349
Brugia malayi Dopamine receptor protein 2 0.0021 0.0102 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Echinococcus granulosus microtubule associated protein 2 0.0467 0.4852 0.9732
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0129 0.0252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0075 0.0677 0.0677
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Onchocerca volvulus 0.0021 0.0102 0.0296
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0067 0.0142
Onchocerca volvulus 0.0021 0.0102 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0106 0.3307
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0075 0.0677 0.1319
Echinococcus granulosus glutamate receptor 2 0.0023 0.0127 0.0254
Schistosoma mansoni myosin xvIII 0.0021 0.0102 0.0198
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0257 0.0515
Schistosoma mansoni hypothetical protein 0.0018 0.0073 0.0142
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0168 0.1671 0.3083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0642 0.1252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0103 0.02
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0102 0.0198
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0157
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0039 0.0296 0.0837
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0106 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0068
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0319 1
Brugia malayi CXXC zinc finger family protein 0.0034 0.024 0.0793
Echinococcus multilocularis dnaJ subfamily B 0.048 0.4986 0.4986
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0102 0.0114
Plasmodium falciparum glutathione reductase 0.0032 0.0223 0.6966
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0102 0.0204
Schistosoma mansoni hypothetical protein 0.0021 0.0102 0.0198
Schistosoma mansoni copper/topaquinone oxidase 0.0059 0.0512 0.0998
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0041 0.0319 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0078 0.0153
Trypanosoma cruzi ISWI complex protein 0.0018 0.0073 0.2282
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0081 0.0745 0.1589
Onchocerca volvulus 0.0021 0.0102 0.0296
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0023 0.0127 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0236 0.2393 0.7898
Onchocerca volvulus 0.0034 0.024 0.2049
Onchocerca volvulus 0.0021 0.0102 0.0296
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0078 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0102 0.0102
Echinococcus multilocularis somatostatin receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0045
Onchocerca volvulus 0.0021 0.0102 0.0296
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0319 1
Schistosoma mansoni opsin-like receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0039 0.0296 0.0837
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0102 0.0102
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Brugia malayi RE18450p 0.0041 0.0319 0.1054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0157
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0148 0.4643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0041 0.0319 0.0622
Loa Loa (eye worm) hypothetical protein 0.0045 0.0361 0.0623
Echinococcus granulosus sex peptide receptor 0.0021 0.0102 0.0204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0102 0.0204
Brugia malayi latrophilin 2 splice variant baaae 0.0161 0.1599 0.5276
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0184 0.0184
Onchocerca volvulus 0.0021 0.0102 0.0296
Plasmodium vivax glutathione reductase, putative 0.0032 0.0223 0.6966
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0223 0.0474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0127 0.0254
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0148 0.0419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Schistosoma mansoni opsin-like receptor 0.0021 0.0102 0.0198
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0102 0.0204
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0102 0.0102
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0168 0.1671 0.3257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0103 0.02
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0102 0.0204
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0044 0.0088
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0103 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0129 0.2009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0045
Schistosoma mansoni biogenic amine receptor 0.0021 0.0102 0.0198
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0106 0.0106
Brugia malayi PHD-finger family protein 0.0031 0.0213 0.0704
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0039 0.0296 0.0632
Onchocerca volvulus 0.0021 0.0102 0.0296
Echinococcus granulosus tumor protein p63 0.0397 0.4098 0.822
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.044
Mycobacterium tuberculosis Probable dehydrogenase 0.0073 0.0659 0.1404
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0075 0.0677 0.1357
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0319 0.0623
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0102 0.0198
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0044 0.0085
Schistosoma mansoni adenoreceptor 0.0021 0.0102 0.0198
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0102 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Onchocerca volvulus 0.0021 0.0102 0.0296
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0129 0.0252
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0102 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0078 0.0258
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0319 0.0381
Brugia malayi AKH receptor 0.0021 0.0102 0.0336
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0044 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0078 0.0258
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0067 0.2086
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0319 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Mycobacterium tuberculosis Probable reductase 0.0073 0.0659 0.1404
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0102 0.0198
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0044 0.0144
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0041 0.0319 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0236 0.2393 0.4619
Brugia malayi ORL1-like opioid receptor 0.0021 0.0102 0.0336
Schistosoma mansoni fad oxidoreductase 0.0041 0.0319 0.0623
Toxoplasma gondii hypothetical protein 0.0041 0.0319 0.497
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0078 0.0078
Toxoplasma gondii exonuclease III APE 0.0021 0.0106 0.1644
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0041 0.0319 0.0623
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0319 1
Schistosoma mansoni NAD dehydrogenase 0.0041 0.0319 0.0623
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0102 0.0204
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0081 0.0745 0.1233
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0258
Echinococcus granulosus cpg binding protein 0.0038 0.0285 0.0571
Echinococcus multilocularis microtubule associated protein 2 0.0467 0.4852 0.4852
Echinococcus multilocularis neuropeptide s receptor 0.0332 0.3415 0.3415
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0041 0.0319 0.0319
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0129 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0078 0.0153
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0102 0.0204
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0078
Brugia malayi larval opioid receptor 0.0021 0.0102 0.0336
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0078 0.0153
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0044 0.0085
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0041 0.0319 0.497
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0095 0.0185
Echinococcus multilocularis geminin 0.0111 0.1059 0.1059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0157
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0041 0.0319 0.497
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0106 0.0206
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0102 0.0336
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0102 0.0198
Echinococcus multilocularis nmda type glutamate receptor 0.0169 0.1682 0.1682
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0102 0.0102
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0103 0.0206
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0044 0.0351 0.0713
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0102 0.0114
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0102 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0078 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Trypanosoma brucei trypanothione reductase 0.0032 0.0223 0.6966
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0102 0.0102
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0102 0.0204
Brugia malayi Thioredoxin reductase 0.0032 0.0223 0.0734
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0129 0.0068
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0067 0.2086
Brugia malayi putative neuropeptide receptor 0.0021 0.0102 0.0336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0257 0.0257
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0041 0.0319 1
Loa Loa (eye worm) glutathione reductase 0.0032 0.0223 0.0352
Plasmodium falciparum thioredoxin reductase 0.0032 0.0223 0.6966
Brugia malayi Dopamine receptor 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Onchocerca volvulus 0.0021 0.0102 0.0296
Brugia malayi hypothetical protein 0.0093 0.0869 0.2868
Brugia malayi cDNA sequence BC016226 0.0041 0.0319 0.1054
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0102 0.0102
Brugia malayi Bromodomain containing protein 0.009 0.0838 0.2766
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0044 0.0044
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0025 0.0148 0.0124
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0041 0.0319 0.1054
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0258
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0041 0.0319 0.0623
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0102 0.0198
Echinococcus granulosus zinc finger protein 0.0025 0.0147 0.0294
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0039 0.0296 0.9281
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Schistosoma mansoni hypothetical protein 0.0024 0.0139 0.0272
Onchocerca volvulus 0.0021 0.0102 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0102 0.0336
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Echinococcus granulosus serotonin receptor 0.0021 0.0102 0.0204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0057 0.0121
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0085
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0106 0.0349
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0344 0.3544 1
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0102 0.0204
Echinococcus multilocularis serotonin receptor 0.0021 0.0102 0.0102
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0044 0.0088
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0184 0.0368
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0643 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0078 0.0068
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0184 0.0358
Onchocerca volvulus 0.0021 0.0102 0.0296
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.0681
Schistosoma mansoni amine GPCR 0.0021 0.0102 0.0198
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0045
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0041 0.0319 0.0381
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0129 0.0252
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0102 0.0102
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0044 0.0351 0.099
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0044 0.0085
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0168 0.1671 0.356
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis sex peptide receptor 0.0021 0.0102 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0129 0.0426
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0102 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0068
Onchocerca volvulus 0.0093 0.0869 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0148 0.0297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0075 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.024 0.0387
Onchocerca volvulus 0.0058 0.0499 0.5321
Loa Loa (eye worm) hypothetical protein 0.0041 0.0319 0.0542
Giardia lamblia Fructose-bisphosphate aldolase 0.0344 0.3544 1
Echinococcus multilocularis tumor protein p63 0.0397 0.4098 0.4098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0296 0.303 0.5872
Schistosoma mansoni hypothetical protein 0.0075 0.0677 0.1319
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0129 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0258
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0102 0.0114
Schistosoma mansoni amine GPCR 0.0021 0.0102 0.0198
Schistosoma mansoni ap endonuclease 0.0021 0.0106 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0223 0.6966
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0102 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis GPCR, family 2 0.0075 0.0677 0.0677
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0129 0.0426
Schistosoma mansoni hypothetical protein 0.0161 0.1599 0.3116
Schistosoma mansoni hypothetical protein 0.0075 0.0677 0.1319
Echinococcus granulosus ubiquitin specific protease 41 0.0025 0.0148 0.0297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0073 0.0659 0.1404
Echinococcus granulosus amiloride sensitive amine oxidase 0.0059 0.0512 0.1026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.059 0.9187
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0102 0.0204
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0102 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0021 0.0102 0.0198
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0041 0.0319 0.3049
Loa Loa (eye worm) hypothetical protein 0.0236 0.2393 0.4619
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0081 0.0745 0.1589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0058 0.0499 0.0895
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0106 0.0298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0102 0.0204
Brugia malayi G protein-coupled receptor 0.0021 0.0102 0.0336
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0044 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0068
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0041 0.0319 0.0623
Leishmania major hypothetical protein, conserved 0.0041 0.0319 0.497
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0083 0.0764 0.1417
Onchocerca volvulus 0.0021 0.0102 0.0296
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0023 0.0127 0.0254
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0102 0.0102
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0344 0.3544 1
Schistosoma mansoni cpg binding protein 0.0034 0.024 0.0468
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Schistosoma mansoni opsin-like receptor 0.0021 0.0102 0.0198
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0041 0.0319 0.3049
Schistosoma mansoni hypothetical protein 0.0111 0.1059 0.2064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0643 0.1253
Onchocerca volvulus 0.0021 0.0102 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Echinococcus granulosus glutamate receptor NMDA 0.0162 0.1599 0.3207
Echinococcus multilocularis zinc finger protein 0.0025 0.0147 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0647 0.1298
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0106 0.0122
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0073 0.0662 0.1216
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0052 0.0435 0.0768
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0044 0.0085
Loa Loa (eye worm) hypothetical protein 0.0093 0.0869 0.1623
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0129 0.2009
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0078 0.0153
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0148 0.0148
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0102 0.0204
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0102 0.0204
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0102 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Echinococcus granulosus fmrfamide receptor 0.0021 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0075 0.0677 0.2233
Onchocerca volvulus 0.0021 0.0102 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0129 0.0252
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0102 0.0198
Brugia malayi Serotonin receptor 0.0021 0.0102 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0015 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Schistosoma mansoni biogenic amine receptor 0.0021 0.0102 0.0198
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0078 0.0258
Toxoplasma gondii hypothetical protein 0.003 0.02 0.3114
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0102 0.0204
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0148 0.0206
Schistosoma mansoni hypothetical protein 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Schistosoma mansoni hypothetical protein 0.0075 0.0677 0.1319
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0129 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0643 0.1253
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0106 0.3307
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0095 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0106 0.3307
Echinococcus multilocularis neuropeptide receptor A26 0.0332 0.3415 0.3415
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0643 0.1289
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0139 0.0188
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0102 0.0198
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0073 0.0659 0.1059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0116
Mycobacterium ulcerans hypothetical protein 0.0023 0.0129 0.0252
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0102 0.0114
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0148 0.4643
Brugia malayi Latrophilin receptor protein 2 0.0075 0.0677 0.2233
Echinococcus multilocularis cpg binding protein 0.0038 0.0285 0.0285
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0127 0.0127
Schistosoma mansoni neuropeptide receptor 0.0021 0.0102 0.0198
Schistosoma mansoni cpg binding protein 0.0038 0.0285 0.0555
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.303 0.5872
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0157
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0102 0.0198
Brugia malayi G-protein coupled receptor 0.0021 0.0102 0.0336
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0078 0.0153
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.3057
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0078 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0102 0.0102
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0073 0.0659 0.1404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0129 0.0252
Onchocerca volvulus 0.0021 0.0102 0.0296
Echinococcus granulosus GPCR family 2 0.0075 0.0677 0.1357
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0025 0.0148 0.0289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0106 1
Chlamydia trachomatis glutamine binding protein 0.0039 0.0296 0.9281
Echinococcus granulosus thioredoxin glutathione reductase 0.0032 0.0223 0.0446
Treponema pallidum fructose-bisphosphate aldolase 0.0344 0.3544 1
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0041 0.0319 0.0319
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0102 0.0198
Brugia malayi steroid hormone receptor 0.0018 0.0078 0.0258
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0102 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0102 0.0198
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0067 0.2086
Echinococcus multilocularis serotonin receptor 0.0021 0.0102 0.0102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0075 0.0677 0.1357
Loa Loa (eye worm) hypothetical protein 0.0075 0.0677 0.1244
Brugia malayi Bromodomain containing protein 0.0045 0.036 0.1188
Brugia malayi RE15519p 0.0021 0.0102 0.0336
Brugia malayi Melatonin receptor type 1A 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0148 0.0489
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0148 0.4643
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0057 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0067 0.013
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0296 0.303 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0025 0.0148 0.0148
Echinococcus granulosus somatostatin receptor 0.0021 0.0102 0.0204
Schistosoma mansoni d-amino acid oxidase 0.0494 0.513 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0157
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0078 0.0157
Loa Loa (eye worm) hypothetical protein 0.0262 0.2664 0.5152
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0296 0.303 0.5907
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0102 0.0336
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0041 0.0319 0.0641
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0148 0.0297
Brugia malayi neuropeptide F receptor 0.0021 0.0102 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0258
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0025 0.0148 0.0419
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0745 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0102 0.0204
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0319 1
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0044 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0078 0.0157
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0127 0.0127
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0102 0.0336
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0106 0.0225
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0102 0.0114
Toxoplasma gondii thioredoxin reductase 0.0032 0.0223 0.3462
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0095 0.019
Brugia malayi ecdysteroid receptor 0.0018 0.0078 0.0258
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0129 0.0275
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0102 0.0102
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0319 0.0681
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis thioredoxin glutathione reductase 0.0032 0.0223 0.0223
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0102 0.0114
Echinococcus granulosus neuropeptide s receptor 0.0332 0.3415 0.6849
Onchocerca volvulus 0.0023 0.0129 0.0643
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0073 0.0659 0.1404
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0041 0.0319 1
Schistosoma mansoni histamine h1 receptor 0.0021 0.0102 0.0198
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0223 0.6966
Schistosoma mansoni hypothetical protein 0.0111 0.1059 0.2064
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0127 0.0127
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0102 0.0296
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0078 0.0153
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0106 0.0298
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0025 0.0148 0.0289
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0102 0.0102
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0041 0.0319 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0102 0.0204
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0102 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0494 0.513 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Schistosoma mansoni hypothetical protein 0.0035 0.0257 0.0501
Echinococcus granulosus g protein coupled receptor 0.0021 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0041 0.0319 0.0542
Schistosoma mansoni hypothetical protein 0.0021 0.0102 0.0198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0106 0.3307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0452 0.4693 1
Schistosoma mansoni cpg binding protein 0.0038 0.0285 0.0555
Schistosoma mansoni glutamate receptor NMDA 0.0185 0.1844 0.3594
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0025 0.0148 0.2308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0157
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0106 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0129 0.2009
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0102 0.0204
Schistosoma mansoni zinc finger protein 0.0018 0.0073 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Leishmania major trypanothione reductase 0.0032 0.0223 0.3462
Echinococcus granulosus geminin 0.0111 0.1059 0.2124
Echinococcus granulosus allatostatin A receptor 0.0021 0.0102 0.0204
Trypanosoma brucei ISWI complex protein 0.0018 0.0073 0.2282
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0041 0.0319 0.0623
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0041 0.0319 0.1054
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0039 0.0296 0.0578
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0223 0.0352
Brugia malayi Dopamine receptor protein 1 0.0021 0.0102 0.0336
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0059 0.0512 0.0512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0102 0.0198
Echinococcus granulosus nmda type glutamate receptor 0.0169 0.1682 0.3374
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0102 0.0198
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0102 0.0198
Brugia malayi Serotonin receptor 0.0021 0.0102 0.0336
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0319 1
Schistosoma mansoni microtubule-associated protein tau 0.0467 0.4852 0.9458
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0129 0.0275
Schistosoma mansoni coup transcription factor 0.0018 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0168
Brugia malayi glutathione reductase 0.0032 0.0223 0.0734
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0106 0.3307
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0257 0.0501
Brugia malayi neuropeptide F receptor 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0102 0.0102
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0106 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0236 0.2393 0.7898
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0078 0.0258
Brugia malayi GnHR receptor homolog 0.0021 0.0102 0.0336
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0102 0.0102
Schistosoma mansoni biogenic amine receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0106 0.0212
Echinococcus granulosus hypothetical protein 0.0021 0.0102 0.0204
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0102 0.0204
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.033 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0102 0.0198
Trypanosoma cruzi ISWI complex protein 0.0018 0.0073 0.2282
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0102 0.0204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0057 0.0121
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0258
Onchocerca volvulus 0.0021 0.0102 0.0296
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Echinococcus granulosus neuropeptide receptor A26 0.0332 0.3415 0.6849
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0078 0.0068
Echinococcus granulosus neuropeptide receptor 0.0021 0.0102 0.0204
Schistosoma mansoni ap endonuclease 0.0021 0.0106 0.0206
Brugia malayi nuclear hormone receptor 0.0018 0.0078 0.0258
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0102 0.0102
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0102 0.0114
Echinococcus granulosus neuropeptide receptor 0.0021 0.0102 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0258
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Loa Loa (eye worm) latrophilin receptor protein 2 0.0075 0.0677 0.1244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Echinococcus granulosus g protein coupled receptor 0.0021 0.0102 0.0204
Onchocerca volvulus Putative fad oxidoreductase 0.0041 0.0319 0.3049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0127 0.0254
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0102 0.0114
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0102 0.0102
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0073 0.0659 0.1404
Loa Loa (eye worm) MH2 domain-containing protein 0.0073 0.0662 0.1216
Brugia malayi hypothetical protein 0.0035 0.0257 0.0848
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0102 0.0102
Echinococcus multilocularis nmda type glutamate receptor 0.0216 0.2175 0.2175
Schistosoma mansoni neuropeptide receptor 0.0021 0.0102 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0068
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0044 0.0044
Brugia malayi nuclear receptor NHR-88 0.0018 0.0078 0.0258
Brugia malayi hypothetical protein 0.0021 0.0102 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0102 0.0102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.0041 0.0319 0.497
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0102 0.0102
Brugia malayi sulfakinin receptor protein 0.0021 0.0102 0.0336
Leishmania major hypothetical protein, conserved 0.0018 0.0073 0.1134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0102 0.0336
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0078
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0044 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0344 0.3544 1
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0044 0.0085
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0095 0.0095
Chlamydia trachomatis D-amino acid dehydrogenase 0.0041 0.0319 1
Schistosoma mansoni hypothetical protein 0.0021 0.0102 0.0198
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0102 0.0114
Echinococcus granulosus nmda type glutamate receptor 0.0216 0.2175 0.4363
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0499 0.0973
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0494 0.513 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0258
Schistosoma mansoni neuropeptide receptor 0.0021 0.0102 0.0198
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0129 0.0252
Schistosoma mansoni fad oxidoreductase 0.0041 0.0319 0.0623
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0044 0.0044
Echinococcus multilocularis NMDA receptor 0.0015 0.0044 0.0044
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0044 0.0044
Schistosoma mansoni amine GPCR 0.0021 0.0102 0.0198
Echinococcus granulosus g protein coupled receptor 0.0021 0.0102 0.0204
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0041 0.0319 0.0623
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0643 0.1253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0068
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0129 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0643 0.1253
Schistosoma mansoni hypothetical protein 0.048 0.4986 0.9719
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0057 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0078 0.0157
Onchocerca volvulus 0.0021 0.0102 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0102 0.0198
Brugia malayi G-protein coupled receptor 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0114
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0102 0.0204
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0044 0.0088
Echinococcus multilocularis glutamate receptor NMDA 0.0162 0.1599 0.1599
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0148 0.0419
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0078 0.0153
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0148 0.0148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0102 0.0204
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0041 0.0319 0.0542

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 8 U ml-1 Minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus (MRSA) A27223 ChEMBL. 11277523
MIC (functional) = 8 U ml-1 Minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus (MRSA) A27223 in the presence of 50% calf serum. ChEMBL. 11277523
PD50 (functional) > 23 mg kg-1 Dose required for acute toxic activity against methicillin-resistant Staphylococcus aureus (MRSA) A27223 in mouse following i.v. administration. ChEMBL. 11277523

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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