TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.791 | Formula: C15H12ClN3O4S
H donors: 2 H acceptors: 5 LogP: 2.06 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)S(=O)(=O)N(C(=C2O)C(=O)Nc1ccccn1)C
InChi: 1S/C15H12ClN3O4S/c1-19-13(15(21)18-12-4-2-3-7-17-12)14(20)10-6-5-9(16)8-11(10)24(19,22)23/h2-8,20H,1H3,(H,17,18,21)
InChiKey: PVDSDDBBKGXOOL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Plasmodium falciparum	plasmepsin III	0.0023	0.0144	0.0144
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0369	0.4107	0.4107
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0748	0.8439	0.8439
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Echinococcus multilocularis	cathepsin L	0.0011	0.0014	0.0014
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0369	0.4107	0.4107
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0135	0.0135
Plasmodium vivax	vivapain-3	0.0011	0.0014	0.0014
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0748	0.8439	0.8439
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0885	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Echinococcus granulosus	cathepsin l1	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0369	0.4107	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0023	0.0144	0.0144
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.024	0.2629	0.2629
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0052	0.0052
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0023	0.0144	0.0144
Loa Loa (eye worm)	fibroinase	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0022	0.0135	0.033
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0369	0.4107	0.4107
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0014	0.0014
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0014	0.0014
Echinococcus granulosus	ras gtpase	0.0595	0.668	0.668
Toxoplasma gondii	hypothetical protein	0.0379	0.4217	0.4217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0052	0.0052
Brugia malayi	Ras protein let-60	0.0595	0.668	0.668
Loa Loa (eye worm)	hypothetical protein	0.0748	0.8439	0.8439
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0023	0.0144	0.0144
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0011	0.0014	0.0014
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Giardia lamblia	Rab geranylgeranyltransferase	0.0369	0.4107	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0983	0.0983
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0748	0.8439	0.8439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0885	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.0135	0.0135
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0885	1	1
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Onchocerca volvulus		0.0023	0.0144	0.0351
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0885	1	1
Plasmodium vivax	plasmepsin V, putative	0.0023	0.0144	0.0144
Brugia malayi	Ras-related protein R-Ras2	0.0595	0.668	0.668
Brugia malayi	aspartic protease BmAsp-2, identical	0.0023	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0015	0.0052	0.0128
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.0135	0.0135
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0135	0.0122
Plasmodium falciparum	plasmepsin IX	0.0023	0.0144	0.0144
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0748	0.8439	0.8439
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0369	0.4107	0.4107
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Plasmodium falciparum	plasmepsin VI	0.0096	0.0983	0.0983
Plasmodium falciparum	geranylgeranyltransferase, putative	0.024	0.2629	0.2629
Trypanosoma cruzi	lanosterol synthase, putative	0.0766	0.8642	0.864
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0885	1	1
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.024	0.2629	0.2629
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Toxoplasma gondii	hypothetical protein	0.0369	0.4107	0.4107
Plasmodium falciparum	plasmepsin VIII, putative	0.0023	0.0144	0.0144
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0885	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0135	0.0135
Schistosoma mansoni	cathepsin D (A01 family)	0.0283	0.3123	0.3123
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0885	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0052	0.0052
Plasmodium vivax	aspartyl proteinase, putative	0.0096	0.0983	0.0983
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.0135	0.0135
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0135	0.0135
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.0135	0.0135
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0748	0.8439	0.8439
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0748	0.8439	0.8439
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Plasmodium falciparum	plasmepsin VII	0.0023	0.0144	0.0144
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0023	0.0144	0.0351
Plasmodium vivax	aspartyl protease, putative	0.0023	0.0144	0.0144
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0135	0.033
Loa Loa (eye worm)	hypothetical protein	0.024	0.2629	0.2629
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.024	0.2629	0.2629
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0369	0.4107	0.4099
Toxoplasma gondii	aspartyl protease ASP3	0.0023	0.0144	0.0144
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0369	0.4107	0.4107
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0096	0.0983	0.0983
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0052	0.0052
Trichomonas vaginalis	rheb, putative	0.0595	0.668	0.668
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0135	0.0135
Plasmodium vivax	aspartyl protease, putative	0.0023	0.0144	0.0144
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.024	0.2629	0.2629
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0135	0.0122
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.024	0.2629	0.2629
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0	0.5
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.024	0.2629	0.2629
Entamoeba histolytica	ras-1, putative	0.0595	0.668	0.668
Toxoplasma gondii	cathepsin CPL	0.0022	0.0135	0.0135
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0011	0.0014	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0096	0.0983	0.0983
Onchocerca volvulus		0.0022	0.0135	0.033
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0645	0.7256	0.7256
Trypanosoma cruzi	hypothetical protein, conserved	0.0369	0.4107	0.4099
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.024	0.2629	0.2629
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0096	0.0983	0.0983
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.0135	0.0135
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.024	0.2629	0.2629
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0766	0.8642	1
Echinococcus granulosus	cathepsin L	0.0011	0.0014	0.0014
Leishmania major	lanosterol synthase, putative	0.0526	0.5898	0.5898
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0885	1	1
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0748	0.8439	0.8439
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0011	0.0014	0.0014
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0369	0.4107	0.4099
Trypanosoma cruzi	hypothetical protein, conserved	0.0369	0.4107	0.4099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Schistosoma mansoni	cathepsin D (A01 family)	0.0283	0.3123	0.3123
Trypanosoma cruzi	hypothetical protein, conserved	0.024	0.2629	0.2618
Brugia malayi	cathepsin L-like precursor	0.0015	0.0052	0.0052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0135	0.0135
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0015	0.0052	0.0039
Plasmodium falciparum	plasmepsin I	0.0096	0.0983	0.0983
Loa Loa (eye worm)	aspartyl protease 6	0.0023	0.0144	0.0144
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Entamoeba histolytica	cysteine protease, putative	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trypanosoma brucei	hypothetical protein, conserved	0.0369	0.4107	0.4099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Trypanosoma cruzi	lanosterol synthase, putative	0.0766	0.8642	0.864
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0135	0.0135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Leishmania major	geranylgeranyltransferase, putative	0.024	0.2629	0.2629
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0369	0.4107	0.4099
Echinococcus multilocularis	ras gtpase	0.0595	0.668	0.668
Plasmodium vivax	aspartyl proteinase, putative	0.0023	0.0144	0.0144
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0369	0.4107	0.4107
Plasmodium vivax	vivapain-2	0.0022	0.0135	0.0135
Plasmodium falciparum	plasmepsin II	0.0096	0.0983	0.0983
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0135	0.0122
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0135	0.0122
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.024	0.2629	0.2629
Trypanosoma brucei	lanosterol synthase	0.0766	0.8642	0.864
Entamoeba histolytica	Ras family GTPase	0.0595	0.668	0.668
Brugia malayi	hypothetical protein	0.0023	0.0144	0.0144
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0595	0.668	0.668
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Entamoeba histolytica	cysteine proteinase 2	0.0011	0.0014	0.0014
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0135	0.0135
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0135	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0096	0.0983	0.0983
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0369	0.4107	0.4099
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.024	0.2629	0.2629
Giardia lamblia	Prenyltransferase	0.0885	1	1
Leishmania major	farnesyltransferase beta subunit	0.0885	1	1
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.024	0.2629	0.2629
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0135	0.033
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.024	0.2629	0.2629
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0135	0.0135
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.0135	0.033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Brugia malayi	Pepsin A precursor	0.0023	0.0144	0.0144
Plasmodium vivax	aspartyl protease, putative	0.0023	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0052	0.0052
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.024	0.2629	0.2629
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0748	0.8439	0.8439
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0023	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0052	0.0052
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0096	0.0983	0.0983
Brugia malayi	Papain family cysteine protease containing protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	cysteine protease	0.0022	0.0135	0.0135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Trichomonas vaginalis	dexras1, putative	0.0595	0.668	0.668
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0369	0.4107	0.4107
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0023	0.0144	0.0144
Onchocerca volvulus		0.0022	0.0135	0.033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Plasmodium falciparum	plasmepsin X	0.0023	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0595	0.668	0.668
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0135	0.0135
Leishmania major	cathepsin L-like protease	0.0022	0.0135	0.0135
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0885	1	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0023	0.0144	0.0144
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0748	0.8439	0.8439
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.0052	0.0052
Echinococcus granulosus	cathepsin L cysteine protease	0.0011	0.0014	0.0014
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0885	1	1
Trichomonas vaginalis	ral, putative	0.0595	0.668	0.668
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0135	0.0135
Plasmodium vivax	geranylgeranyltransferase, putative	0.024	0.2629	0.2629
Onchocerca volvulus		0.0022	0.0135	0.033
Trypanosoma cruzi	hypothetical protein, conserved	0.024	0.2629	0.2618
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0022	0.0135	0.033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0144	0.0144
Plasmodium vivax	unspecified product	0.0011	0.0014	0.0014
Giardia lamblia	Rab geranylgeranyltransferase	0.0748	0.8439	0.7882
Loa Loa (eye worm)	cysteine protease	0.0022	0.0135	0.0135
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0885	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0011	0.0014	0.0014
Echinococcus granulosus	cysteine protease	0.0011	0.0014	0.0014
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0369	0.4107	0.4107
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Loa Loa (eye worm)	Ras protein let-60	0.0595	0.668	0.668
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0748	0.8439	0.8439
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Onchocerca volvulus		0.0022	0.0135	0.033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0135	0.0122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Plasmodium vivax	vivapain-1	0.0011	0.0014	0.0014
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.024	0.2629	0.2629
Loa Loa (eye worm)	hypothetical protein	0.024	0.2629	0.2629
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0369	0.4107	0.4099
Echinococcus multilocularis	cysteine protease	0.0022	0.0135	0.0135
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.024	0.2629	0.2618
Loa Loa (eye worm)	ctsf protein	0.0022	0.0135	0.0135
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0369	0.4107	0.4107
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0748	0.8439	0.8439
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0885	1	1
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0595	0.668	0.668
Schistosoma mansoni	memapsin-2 (A01 family)	0.0023	0.0144	0.0144
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.024	0.2629	0.2629
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0096	0.0983	0.0983
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.024	0.2629	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0144	0.0144
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0135	0.0135
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0885	1	1
Plasmodium vivax	vivapain-2	0.0022	0.0135	0.0135
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0885	1	1
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.024	0.2629	0.2629
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0135	0.0135
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0369	0.4107	0.4099
Onchocerca volvulus		0.0022	0.0135	0.033
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.0135	0.0135
Entamoeba histolytica	Ras family GTPase	0.0595	0.668	0.668
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0885	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0011	0.0014	0.0014
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0052	0.0052
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0369	0.4107	0.4107
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0011	0.0014	0.0014
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0135	0.0135
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0014	0.0014
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0369	0.4107	0.4107
Toxoplasma gondii	aspartyl protease	0.0023	0.0144	0.0144
Plasmodium vivax	plasmepsin IV, putative	0.0096	0.0983	0.0983
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.024	0.2629	0.2629
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0885	1	1
Plasmodium falciparum	plasmepsin V	0.0023	0.0144	0.0144
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.024	0.2629	0.2618
Echinococcus granulosus	cathepsin l1	0.0015	0.0052	0.0052
Trichomonas vaginalis	rap1 and, putative	0.0595	0.668	0.668
Plasmodium falciparum	plasmepsin IV	0.0096	0.0983	0.0983
Toxoplasma gondii	aspartyl protease ASP1	0.0096	0.0983	0.0983
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0885	1	1
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0052	0.0052
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.0135	0.0135
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0379	0.4217	0.4217
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0369	0.4107	0.4107

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= -7 %	Inhibition of human Prostaglandin G/H synthase 1 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488
Inhibition (binding)	= 18 %	Inhibition of human Prostaglandin G/H synthase 2 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488
Inhibition (binding)	= 38 %	Inhibition of human Prostaglandin G/H synthase 1 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488
Inhibition (binding)	= 59 %	Inhibition of human Prostaglandin G/H synthase 2 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488
Inhibition (binding)	= 72 %	Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488
Inhibition (binding)	= 77 %	Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production	ChEMBL.	9083488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 392131

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 308554