TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.605 | Formula: C29H34N4O3
H donors: 2 H acceptors: 2 LogP: 4.02 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](NC(=O)N(c1ccccc1)c1ccccc1)Cc1ccccc1)NCCCN1CCOCC1
InChi: 1S/C29H34N4O3/c34-28(30-17-10-18-32-19-21-36-22-20-32)27(23-24-11-4-1-5-12-24)31-29(35)33(25-13-6-2-7-14-25)26-15-8-3-9-16-26/h1-9,11-16,27H,10,17-23H2,(H,30,34)(H,31,35)/t27-/m0/s1
InChiKey: NHKFTDHGZFSUSG-MHZLTWQESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.0189	0.0337
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0142	0.0261	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	septate junction protein	0.0142	0.0261	0.0946
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus multilocularis	peroxidasin	0.0269	0.0862	0.2565
Echinococcus granulosus	twitchin	0.0659	0.2694	0.2694
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0183	0.0455	0.0455
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0269	0.0862	0.2565
Schistosoma mansoni	vesicular amine transporter	0.0531	0.2093	0.7583
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0142	0.0261	0.0556
Echinococcus multilocularis	Immunoglobulin	0.0142	0.0261	0.0777
Echinococcus multilocularis	titin	0.0128	0.0195	0.058
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	disorganized muscle protein 1	0.0128	0.0195	0.0354
Brugia malayi	Heparan sulfate	0.0142	0.0261	0.0764
Echinococcus multilocularis	hemicentin 1	0.0269	0.0862	0.2565
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0142	0.0261	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0261	0.0556
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0269	0.0862	0.3123
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Echinococcus granulosus	Immunoglobulin	0.0531	0.2093	0.2093
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Brugia malayi	hypothetical protein	0.0531	0.2093	0.6896
Echinococcus multilocularis	titin	0.0128	0.0195	0.058
Brugia malayi	Prion-like-	0.0128	0.0195	0.0542
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Echinococcus granulosus	defective proboscis extension response	0.0531	0.2093	0.2093
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0142	0.0261	0.0946
Schistosoma mansoni	hemicentin	0.0128	0.0195	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Echinococcus granulosus	titin	0.0128	0.0195	0.0195
Schistosoma mansoni	basigin related	0.0142	0.0261	0.0946
Echinococcus multilocularis	Immunoglobulin subtype	0.0142	0.0261	0.0777
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0142	0.0261	0.0764
Echinococcus multilocularis	hemicentin 1	0.0269	0.0862	0.2565
Echinococcus multilocularis	twitchin	0.0128	0.0195	0.058
Onchocerca volvulus	Tyrosine kinase homolog	0.0183	0.0455	0.3901
Loa Loa (eye worm)	animal heme peroxidase	0.0128	0.0195	0.0354
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0103	0.0079	0.0153
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0142	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Brugia malayi	basement membrane proteoglycan precursor	0.0142	0.0261	0.0764
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	TK protein kinase	0.0183	0.0455	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Echinococcus multilocularis	titin	0.0128	0.0195	0.058
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0269	0.0862	0.2565
Brugia malayi	Immunoglobulin domain containing protein	0.0142	0.0261	0.0764
Schistosoma mansoni	nephrin related	0.0128	0.0195	0.0706
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0128	0.0195	0.058
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0269	0.0862	0.2387
Brugia malayi	Immunoglobulin domain containing protein	0.0142	0.0261	0.0764
Echinococcus multilocularis	neuroglian	0.0269	0.0862	0.2565
Echinococcus granulosus	lachesin	0.0269	0.0862	0.0862
Echinococcus granulosus	roundabout 2	0.0269	0.0862	0.0862
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	basigin related	0.0142	0.0261	0.0946
Echinococcus granulosus	titin	0.0128	0.0195	0.0195
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.0142	0.0261	0.0261
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0269	0.0862	0.2387
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0269	0.0862	0.0862
Echinococcus multilocularis	Immunoglobulin	0.0142	0.0261	0.0777
Schistosoma mansoni	nephrin related	0.0142	0.0261	0.0946
Schistosoma mansoni	titin	0.0269	0.0862	0.3123
Echinococcus granulosus	tyrosine protein kinase otk	0.0269	0.0862	0.0862
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Schistosoma mansoni	roundabout	0.0269	0.0862	0.3123
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0128	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0142	0.0261	0.0777
Brugia malayi	basement membrane proteoglycan	0.0142	0.0261	0.0764
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0142	0.0261	0.0777
Schistosoma mansoni	cell adhesion molecule	0.0269	0.0862	0.3123
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0142	0.0261	0.0777
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0142	0.0261	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Schistosoma mansoni	cell adhesion molecule	0.0128	0.0195	0.0706
Brugia malayi	Fibronectin type III domain containing protein	0.0531	0.2093	0.6896
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0269	0.0862	0.2565
Loa Loa (eye worm)	TK/ROR protein kinase	0.0183	0.0455	0.1147
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0183	0.0455	0.1354
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0142	0.0261	0.0946
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Echinococcus multilocularis	neuroglian	0.0659	0.2694	0.8015
Echinococcus granulosus	titin	0.0128	0.0195	0.0195
Brugia malayi	Disorganized muscle protein 1	0.0128	0.0195	0.0542
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0142	0.0261	0.0946
Schistosoma mansoni	septate junction protein	0.0269	0.0862	0.3123
Echinococcus multilocularis	roundabout 2	0.0269	0.0862	0.2565
Echinococcus granulosus	peroxidasin	0.0269	0.0862	0.0862
Echinococcus multilocularis	netrin receptor unc 5	0.0142	0.0261	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Schistosoma mansoni	netrin receptor unc5	0.0142	0.0261	0.0946
Echinococcus multilocularis	roundabout 2	0.08	0.3362	1
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0128	0.0195	0.0706
Brugia malayi	kettin	0.0128	0.0195	0.0542
Schistosoma mansoni	slit	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus multilocularis	Immunoglobulin	0.0531	0.2093	0.6227
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.0189	0.0337
Schistosoma mansoni	cell adhesion molecule	0.0269	0.0862	0.3123
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0269	0.0862	0.2565
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0142	0.0261	0.0261
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus granulosus	down syndrome cell adhesion	0.0128	0.0195	0.0195
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0531	0.2093	0.6896
Schistosoma mansoni	serine/threonine protein kinase	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Brugia malayi	Animal haem peroxidase family protein	0.0128	0.0195	0.0542
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0531	0.2093	0.7583
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus granulosus	Immunoglobulin subtype	0.0142	0.0261	0.0261
Schistosoma mansoni	peroxidasin	0.0142	0.0261	0.0946
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0261	0.0556
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0127	0.0191	0.0191
Brugia malayi	MH2 domain containing protein	0.0126	0.0189	0.0523
Echinococcus multilocularis	roundabout 2	0.0269	0.0862	0.2565
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Schistosoma mansoni	cell adhesion molecule	0.0142	0.0261	0.0946
Echinococcus granulosus	titin	0.0128	0.0195	0.0195
Schistosoma mansoni	basigin related	0.0142	0.0261	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0142	0.0261	0.0777
Loa Loa (eye worm)	hypothetical protein	0.08	0.3362	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Loa Loa (eye worm)	LAD-2 short isoform	0.0142	0.0261	0.0556
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Echinococcus multilocularis	transfer RNA-Phe	0.0128	0.0195	0.058
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Loa Loa (eye worm)	projectin	0.0128	0.0195	0.0354
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0142	0.0261	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Echinococcus granulosus	nephrin	0.0128	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0142	0.0261	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	cell adhesion molecule	0.0128	0.0195	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Echinococcus granulosus	hemicentin 1	0.0269	0.0862	0.0862
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0128	0.0195	0.058
Schistosoma mansoni	nephrin	0.0659	0.2694	0.976
Loa Loa (eye worm)	hypothetical protein	0.0531	0.2093	0.6137
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0261	0.0556
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0128	0.0195	0.0195
Echinococcus granulosus	Immunoglobulin	0.0142	0.0261	0.0261
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0142	0.0261	0.0261
Echinococcus granulosus	contactin	0.0269	0.0862	0.0862
Schistosoma mansoni	cell adhesion molecule	0.0673	0.2761	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0142	0.0261	0.0261
Schistosoma mansoni	nephrin	0.0269	0.0862	0.3123
Brugia malayi	Prion-like-	0.0128	0.0195	0.0542
Schistosoma mansoni	neuroglian	0.0269	0.0862	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Schistosoma mansoni	cell adhesion molecule	0.0128	0.0195	0.0706
Echinococcus multilocularis	insulin growth factor binding	0.0128	0.0195	0.058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Brugia malayi	Immunoglobulin domain containing protein	0.0142	0.0261	0.0764
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0117	0.0145	0.0526
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0673	0.2761	0.2761
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus granulosus	roundabout 2	0.0269	0.0862	0.0862
Echinococcus multilocularis	Immunoglobulin	0.0531	0.2093	0.6227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0728	0.3021	1
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0128	0.0195	0.0542
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0142	0.0261	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0673	0.2761	0.8169
Echinococcus multilocularis	down syndrome cell adhesion	0.0128	0.0195	0.058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0142	0.0261	0.0764
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0269	0.0862	0.3123
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0728	0.3021	0.8962
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Echinococcus multilocularis		0.0128	0.0195	0.058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0142	0.0261	0.0764
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0531	0.2093	0.7583
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.08	0.3362	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0127	0.0191	0.0567
Brugia malayi	Prion-like-	0.0128	0.0195	0.0542
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0142	0.0261	0.0777
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.0455	0.1413
Echinococcus granulosus	titin	0.0128	0.0195	0.0195
Schistosoma mansoni	myosin-binding protein-related	0.0128	0.0195	0.0706
Brugia malayi	Prion-like-	0.0269	0.0862	0.2775
Schistosoma mansoni	cell adhesion molecule	0.0269	0.0862	0.3123
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0128	0.0195	0.0195
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus granulosus	roundabout 2	0.08	0.3362	0.3362
Loa Loa (eye worm)	CAMK protein kinase	0.0128	0.0195	0.0354
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Schistosoma mansoni	septate junction protein	0.0142	0.0261	0.0946
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0269	0.0862	0.2387
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0269	0.0862	0.2387
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0128	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus granulosus	neuroglian	0.0269	0.0862	0.0862
Echinococcus multilocularis	titin	0.0128	0.0195	0.058
Schistosoma mansoni	titin	0.0128	0.0195	0.0706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0862	0.2775
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0531	0.2093	0.6227
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387
Brugia malayi	protein unc-22	0.0128	0.0195	0.0542
Schistosoma mansoni	serine/threonine protein kinase	0.0128	0.0195	0.0706
Schistosoma mansoni	septate junction protein	0.0269	0.0862	0.3123
Echinococcus multilocularis	lachesin	0.0269	0.0862	0.2565
Brugia malayi	hypothetical protein	0.0142	0.0261	0.0764
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0128	0.0195	0.0195
Brugia malayi	Leucine Rich Repeat family protein	0.0128	0.0195	0.0542
Echinococcus granulosus	insulin growth factor binding	0.0128	0.0195	0.0195
Echinococcus multilocularis	tyrosine protein kinase otk	0.0269	0.0862	0.2565
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0261	0.0556
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Echinococcus granulosus	netrin receptor unc 5	0.0142	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0261	0.0556
Echinococcus granulosus	neuroglian	0.0659	0.2694	0.2694
Schistosoma mansoni	cell adhesion molecule	0.0142	0.0261	0.0946
Schistosoma mansoni	netrin receptor unc5	0.0142	0.0261	0.0946
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0269	0.0862	1
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0128	0.0195	0.058
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0191	0.0341
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Brugia malayi	Peroxidasin	0.0269	0.0862	0.2775
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0269	0.0862	0.2565
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.0195	0.0354
Schistosoma mansoni	hypothetical protein	0.0142	0.0261	0.0946
Schistosoma mansoni	tyrosine kinase	0.0325	0.1123	0.4066
Echinococcus granulosus	Immunoglobulin	0.0142	0.0261	0.0261
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.0195	0.0542
Loa Loa (eye worm)	one IG domain family member	0.0128	0.0195	0.0354
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0195	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0862	0.2387

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 3 uM	Bindining affinity for human tachykinin receptor 2 was measured by using [125I]-NKA as radio ligand	ChEMBL.	15664817
Ki (binding)	> 3 uM	Bindining affinity for human tachykinin receptor 2 was measured by using [125I]-NKA as radio ligand	ChEMBL.	15664817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 319194