TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.402 | Formula: C23H20O5
H donors: 3 H acceptors: 3 LogP: 5.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(O)c(c2c1c1ccc(c(c1cc2)OC)O)Cc1ccc(cc1)O
InChi: 1S/C23H20O5/c1-27-21-12-20(26)18(11-13-3-5-14(24)6-4-13)16-7-8-17-15(22(16)21)9-10-19(25)23(17)28-2/h3-10,12,24-26H,11H2,1-2H3
InChiKey: FTRCSQQUXKTUOD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0272	0.2382	0.6304
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	biogenic amine receptor	0.0103	0.073	0.07
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0407	0.3707	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Onchocerca volvulus		0.0048	0.0185	0.0758
Loa Loa (eye worm)	G-protein coupled receptor	0.0103	0.073	0.1297
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0103	0.073	0.07
Schistosoma mansoni	amine GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	neuropeptide s receptor	0.0103	0.073	0.073
Echinococcus granulosus	neuropeptide receptor A26	0.0103	0.073	0.073
Brugia malayi	sulfakinin receptor protein	0.0103	0.073	0.1297
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0056	0.014
Loa Loa (eye worm)	transcriptional regulator	0.0272	0.2382	0.4331
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	hypothetical protein	0.0103	0.073	0.07
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.0523	0.1121
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Plasmodium falciparum	plasmepsin V	0.0056	0.0271	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Onchocerca volvulus		0.0048	0.019	0.0785
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0103	0.073	0.1297
Plasmodium vivax	hypothetical protein, conserved	0.0082	0.0523	0.2431
Schistosoma mansoni	chromatin regulatory protein sir2	0.0407	0.3707	0.3688
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	Melatonin receptor type 1A	0.0103	0.073	0.1297
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.2029	0.2029
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0357	0.3214	0.8623
Onchocerca volvulus		0.0103	0.073	0.3453
Brugia malayi	proprotein convertase 2	0.0369	0.3332	0.6076
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0121	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	G-protein coupled receptor	0.0103	0.073	0.1297
Onchocerca volvulus		0.0103	0.073	0.3453
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0103	0.073	0.1297
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0056	0.0271	0.0455
Plasmodium vivax	aspartyl protease, putative	0.0056	0.0271	0.1184
Schistosoma mansoni	chromatin regulatory protein sir2	0.0272	0.2382	0.2358
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0032	0.0032
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.081	0.7655	0.7647
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0103	0.073	0.07
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Brugia malayi	Dopamine receptor protein 1	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Echinococcus multilocularis	g protein coupled receptor	0.0103	0.073	0.07
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Echinococcus multilocularis	Furin 1	0.0139	0.1077	0.1049
Schistosoma mansoni	hypothetical protein	0.0114	0.0831	0.0802
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0082	0.0523	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0142	0.1112	0.1084
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	proprotein convertase 2	0.0139	0.1077	0.1935
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0357	0.3214	0.3214
Schistosoma mansoni	biogenic amine receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0357	0.3214	0.3192
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0272	0.2382	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0103	0.073	0.1297
Brugia malayi	Serotonin receptor	0.0103	0.073	0.1297
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0238	0.2053	0.5386
Echinococcus multilocularis	neuropeptide receptor	0.0103	0.073	0.07
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus granulosus	tm gpcr rhodopsin	0.0103	0.073	0.073
Plasmodium vivax	aspartyl protease, putative	0.0056	0.0271	0.1184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0612	0.0582
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0103	0.073	0.1297
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0082	0.0523	0.181
Echinococcus granulosus	Furin 1	0.0139	0.1077	0.1077
Trichomonas vaginalis	hypothetical protein	0.0114	0.0831	0.198
Brugia malayi	Pre-SET motif family protein	0.0032	0.0032	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Plasmodium falciparum	plasmepsin VIII, putative	0.0056	0.0271	0.0461
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Echinococcus multilocularis	neuropeptide receptor A26	0.0103	0.073	0.07
Plasmodium vivax	SET domain protein, putative	0.0065	0.0351	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	C type lectin domian containing protein	0.0048	0.0185	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0357	0.3214	0.8623
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.0523	0.1121
Plasmodium falciparum	plasmepsin IV	0.0238	0.2053	1
Brugia malayi	celfurPC protein	0.0474	0.4357	0.7958
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0561	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0082	0.0523	0.5
Toxoplasma gondii	rhoptry neck protein RON1	0.0048	0.0185	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Echinococcus granulosus	allatostatin A receptor	0.0103	0.073	0.073
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.0523	0.1121
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus multilocularis	serotonin receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	furin	0.0587	0.5469	0.5469
Onchocerca volvulus		0.0048	0.0185	0.0758
Echinococcus granulosus	7tm_1 domain containing protein	0.0103	0.073	0.073
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	sex peptide receptor	0.0103	0.073	0.07
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0082	0.0523	0.0493
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0238	0.2053	0.2053
Toxoplasma gondii	histone deacetylase SIR2	0.0082	0.0523	0.2431
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Brugia malayi	Integrin alpha pat-2 precursor	0.0156	0.1245	0.2243
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0103	0.073	0.1297
Loa Loa (eye worm)	G-protein coupled receptor	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0056	0.0271	0.0455
Schistosoma mansoni	biogenic amine receptor	0.0103	0.073	0.07
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0272	0.2382	0.2382
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0114	0.0831	0.198
Brugia malayi	Dopamine receptor	0.0103	0.073	0.1297
Brugia malayi	Serotonin receptor	0.0103	0.073	0.1297
Brugia malayi	follicle stimulating hormone receptor	0.0103	0.073	0.1297
Schistosoma mansoni	neuropeptide receptor	0.0103	0.073	0.07
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Echinococcus granulosus	orexin receptor type 2	0.0103	0.073	0.073
Toxoplasma gondii	rhoptry neck protein RON9	0.0048	0.0185	0.0758
Echinococcus granulosus	g protein coupled receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	endoprotease bli-4	0.0587	0.5469	1
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0272	0.2382	0.4331
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Plasmodium vivax	aspartyl proteinase, putative	0.0056	0.0271	0.1184
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Plasmodium falciparum	plasmepsin II	0.0238	0.2053	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.2904	0.529
Brugia malayi	hypothetical protein	0.0056	0.0271	0.0455
Giardia lamblia	Furin precursor putative serine protease	0.0114	0.0831	0.0968
Echinococcus multilocularis	integrin alpha 3	0.0119	0.0889	0.086
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0082	0.0523	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0917	0.1641
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0103	0.073	0.073
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0139	0.1077	0.1049
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.2054	0.5389
Echinococcus granulosus	fmrfamide receptor	0.0103	0.073	0.073
Echinococcus granulosus	neuroendocrine convertase 2	0.0369	0.3332	0.3332
Echinococcus multilocularis	somatostatin receptor	0.0103	0.073	0.07
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Toxoplasma gondii	aspartyl protease	0.0056	0.0271	0.1184
Echinococcus granulosus	biogenic amine 5HT receptor	0.0103	0.073	0.073
Echinococcus granulosus	neuropeptide receptor	0.0309	0.2742	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0114	0.0831	0.198
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Plasmodium falciparum	plasmepsin I	0.0238	0.2053	1
Loa Loa (eye worm)	integrin alpha pat-2	0.024	0.2071	0.3761
Onchocerca volvulus		0.0048	0.0185	0.0758
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0272	0.2382	0.2358
Brugia malayi	endoprotease bli-4 precursor	0.0587	0.5469	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.105	1	1
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0272	0.2382	1
Schistosoma mansoni	opsin-like receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	neuropeptide Y receptor	0.0103	0.073	0.07
Schistosoma mansoni	chromatin regulatory protein sir2	0.0272	0.2382	0.2358
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0103	0.073	0.07
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0103	0.073	0.07
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0103	0.073	0.07
Echinococcus multilocularis	neuropeptides capa receptor	0.0103	0.073	0.07
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	neuropeptide F receptor	0.0103	0.073	0.1297
Echinococcus granulosus	integrin alpha ps	0.0033	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.023	0.1974	0.3583
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0065	0.0351	0.0321
Plasmodium vivax	plasmepsin V, putative	0.0056	0.0271	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0236	0.2029	0.3683
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0103	0.073	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Echinococcus granulosus	neuropeptide FF receptor 2	0.0103	0.073	0.073
Onchocerca volvulus		0.0103	0.073	0.3453
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2053	0.3727
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0103	0.073	0.07
Schistosoma mansoni	memapsin-2 (A01 family)	0.0056	0.0271	0.024
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0075	0.0095
Plasmodium vivax	apical sushi protein, putative	0.0048	0.0185	0.0758
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0103	0.073	0.1297
Brugia malayi	aspartic protease BmAsp-2, identical	0.0056	0.0271	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0103	0.073	0.07
Echinococcus multilocularis	integrin alpha ps	0.0033	0.0047	0.0015
Echinococcus multilocularis	integrin alpha ps	0.007	0.0403	0.0373
Brugia malayi	Sushi domain	0.0048	0.0185	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	dro:myosuppressin receptor	0.0103	0.073	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Brugia malayi	larval opioid receptor	0.0103	0.073	0.1297
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0091	0.0612	0.0582
Schistosoma mansoni	neuropeptide F-like receptor	0.0103	0.073	0.07
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Onchocerca volvulus		0.0103	0.073	0.3453
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	g protein coupled receptor	0.0103	0.073	0.07
Schistosoma mansoni	myosin xvIII	0.0103	0.073	0.07
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0103	0.073	0.073
Schistosoma mansoni	hypothetical protein	0.0103	0.073	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0238	0.2053	0.2028
Brugia malayi	putative neuropeptide receptor	0.0103	0.073	0.1297
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0082	0.0523	0.0917
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0407	0.3707	1
Schistosoma mansoni	integrin alpha	0.0156	0.1245	0.1217
Schistosoma mansoni	survival motor neuron protein	0.0048	0.019	0.0159
Echinococcus multilocularis	g-protein coupled receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0048	0.0185	0.0296
Onchocerca volvulus		0.0103	0.073	0.3453
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Plasmodium falciparum	plasmepsin VI	0.0238	0.2053	1
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus multilocularis	fmrfamide receptor	0.0103	0.073	0.07
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0272	0.2382	0.2358
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus granulosus	serotonin receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	G protein coupled receptor 139	0.0309	0.2742	0.2719
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0103	0.073	0.3453
Echinococcus granulosus	neuropeptide receptor	0.0103	0.073	0.073
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0121	0.009
Brugia malayi	putative neuropeptide receptor NPR1	0.0103	0.073	0.1297
Onchocerca volvulus		0.0048	0.0185	0.0758
Leishmania major	silent information regulator 2, putative	0.0272	0.2382	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0103	0.073	0.07
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0103	0.073	0.07
Onchocerca volvulus		0.0048	0.0185	0.0758
Schistosoma mansoni	amine GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0047	0.0043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0103	0.073	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Echinococcus multilocularis	neuropeptide s receptor	0.0103	0.073	0.07
Plasmodium vivax	plasmepsin IV, putative	0.0238	0.2053	1
Giardia lamblia	Hypothetical protein	0.0272	0.2382	0.5838
Schistosoma mansoni	amine GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	neuroendocrine convertase 2	0.0369	0.3332	0.3311
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.1112	0.1084
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0103	0.073	0.07
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0103	0.073	0.07
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0103	0.073	0.07
Onchocerca volvulus		0.0048	0.0185	0.0758
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0121	0.0414
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0103	0.073	0.07
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0082	0.0523	0.1778
Brugia malayi	hypothetical protein	0.0236	0.2029	0.3683
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0103	0.073	0.07
Echinococcus granulosus	g protein coupled receptor	0.0103	0.073	0.073
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0272	0.2382	1
Loa Loa (eye worm)	TYRA-2 protein	0.0103	0.073	0.1297
Schistosoma mansoni	cathepsin D (A01 family)	0.0703	0.66	0.6589
Echinococcus granulosus	neuropeptides capa receptor	0.0103	0.073	0.073
Echinococcus granulosus	biogenic amine 5HT receptor	0.0103	0.073	0.073
Giardia lamblia	High cysteine membrane protein Group 2	0.0218	0.1856	0.4185
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Schistosoma mansoni	neuropeptide receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0271	0.0455
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0103	0.073	0.07
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Schistosoma mansoni	chromatin regulatory protein sir2	0.0272	0.2382	0.2358
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0238	0.2053	0.2028
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0103	0.073	0.07
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0082	0.0523	0.0917
Echinococcus multilocularis	g protein coupled receptor	0.0103	0.073	0.07
Plasmodium falciparum	plasmepsin IX	0.0056	0.0271	0.0461
Echinococcus multilocularis	neuropeptide receptor	0.0309	0.2742	0.2719
Schistosoma mansoni	opsin-like receptor	0.0103	0.073	0.07
Echinococcus granulosus	dro:myosuppressin receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	chromatin regulatory protein sir2	0.0082	0.0523	0.0493
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0082	0.0523	0.181
Brugia malayi	RE15519p	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0091	0.0612	0.0612
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0091	0.0612	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0032	0.0015
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.0951	0.0922
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	cathepsin D (A01 family)	0.0703	0.66	0.6589
Loa Loa (eye worm)	hypothetical protein	0.0587	0.5469	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Trypanosoma brucei	unspecified product	0.0034	0.0056	0.014
Schistosoma mansoni	hypothetical protein	0.0048	0.019	0.0159
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0103	0.073	0.1297
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0056	0.0271	0.0455
Schistosoma mansoni	c4b-binding protein beta chain	0.0048	0.0185	0.0154
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.1112	0.1084
Echinococcus granulosus	sex peptide receptor	0.0103	0.073	0.073
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.2029	0.2004
Onchocerca volvulus		0.0048	0.0185	0.0758
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0103	0.073	0.073
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0082	0.0523	0.0523
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.0951	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0103	0.073	0.07
Brugia malayi	G-protein coupled receptor	0.0103	0.073	0.1297
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0103	0.073	0.07
Onchocerca volvulus		0.0103	0.073	0.3453
Schistosoma mansoni	opsin-like receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0271	0.0455
Plasmodium falciparum	plasmepsin X	0.0056	0.0271	0.0461
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0272	0.2382	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0103	0.073	0.07
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0103	0.073	0.07
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0082	0.0523	0.1778
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus granulosus	G protein coupled receptor 139	0.0103	0.073	0.073
Echinococcus multilocularis	fmrfamide receptor	0.0103	0.073	0.07
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0103	0.073	0.1297
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0103	0.073	0.1297
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0082	0.052	0.049
Plasmodium vivax	aspartyl protease, putative	0.0056	0.0271	0.1184
Toxoplasma gondii	aspartyl protease ASP1	0.0238	0.2053	1
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Plasmodium falciparum	SET domain protein, putative	0.0065	0.0351	0.089
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0103	0.073	0.07
Echinococcus multilocularis		0.0474	0.4357	0.4339
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Echinococcus granulosus	C type lectin domian containing protein	0.0048	0.0185	0.0185
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.105	1	1
Loa Loa (eye worm)	transcriptional regulator	0.0082	0.0523	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	neuroendocrine convertase 1 precursor	0.0369	0.3332	0.6076
Echinococcus granulosus	g protein coupled receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0103	0.073	0.1297
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0103	0.073	0.07
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0056	0.0271	0.024
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Onchocerca volvulus		0.0048	0.0185	0.0758
Echinococcus granulosus	neuropeptide Y receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus multilocularis	allatostatin A receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	aspartyl protease 6	0.0056	0.0271	0.0455
Brugia malayi	G protein-coupled receptor	0.0103	0.073	0.1297
Echinococcus multilocularis	neuropeptides capa receptor	0.0103	0.073	0.07
Echinococcus granulosus	neuropeptides capa receptor	0.0103	0.073	0.073
Brugia malayi	Pepsin A precursor	0.0056	0.0271	0.0455
Brugia malayi	pregnancy-associated plasma protein-A	0.0048	0.0185	0.0296
Brugia malayi	Pre-SET motif family protein	0.021	0.1773	0.3213
Schistosoma mansoni	neuropeptide receptor	0.0103	0.073	0.07
Schistosoma mansoni	adenoreceptor	0.0103	0.073	0.07
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0407	0.3707	1
Brugia malayi	GnHR receptor homolog	0.0103	0.073	0.1297
Echinococcus multilocularis	orexin receptor type 2	0.0103	0.073	0.07
Echinococcus multilocularis	neuropeptide Y receptor	0.0103	0.073	0.07
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0121	0.0121
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0082	0.052	0.052
Schistosoma mansoni	hypothetical protein	0.0103	0.073	0.07
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0082	0.0523	0.2118
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0407	0.3707	0.3688
Schistosoma mansoni	neuropeptide F-like receptor	0.0103	0.073	0.07
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0407	0.3707	1
Schistosoma mansoni	amine GPCR	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0873	0.1561
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0103	0.073	0.07
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0103	0.073	0.07
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0065	0.0351	0.0321
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.1773	0.3213
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0118	0.0873	0.1561
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0065	0.0351	0.0351
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Toxoplasma gondii	histone deacetylase SIR2-like	0.0082	0.0523	0.2431
Schistosoma mansoni	chromatin regulatory protein sir2	0.0082	0.0523	0.0493
Echinococcus granulosus	7TM GPCR rhodopsin	0.0103	0.073	0.073
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0103	0.073	0.3453
Echinococcus multilocularis	c4b binding protein beta chain	0.0048	0.0185	0.0154
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0103	0.073	0.07
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.019	0.0307
Echinococcus granulosus	tm gpcr rhodopsin	0.0103	0.073	0.073
Schistosoma mansoni	neuropeptide receptor	0.0309	0.2742	0.2719
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0103	0.073	0.07
Plasmodium falciparum	plasmepsin VII	0.0056	0.0271	0.0461
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus granulosus	c4b binding protein beta chain	0.0048	0.0185	0.0185
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0407	0.3707	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0103	0.073	0.073
Loa Loa (eye worm)	neuropeptide F receptor	0.0103	0.073	0.1297
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.0523	0.1121
Plasmodium falciparum	plasmepsin III	0.0056	0.0271	0.0461
Echinococcus granulosus	g-protein coupled receptor	0.0103	0.073	0.073
Onchocerca volvulus		0.0048	0.0185	0.0758
Onchocerca volvulus		0.0103	0.073	0.3453
Brugia malayi	AKH receptor	0.0103	0.073	0.1297
Onchocerca volvulus		0.0048	0.0185	0.0758
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0272	0.2382	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0238	0.2053	0.3727
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0407	0.3707	0.6766
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0587	0.5469	0.5454
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0103	0.073	0.073
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus multilocularis	serotonin receptor	0.0103	0.073	0.07
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Schistosoma mansoni	integrin alpha-ps	0.007	0.0403	0.0373
Brugia malayi	ORL1-like opioid receptor	0.0103	0.073	0.1297
Echinococcus granulosus	rhodopsin orphan GPCR	0.0103	0.073	0.073
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0407	0.3707	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0238	0.2053	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.0523	0.1121
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0082	0.0523	0.0493
Schistosoma mansoni	hypothetical protein	0.0103	0.073	0.07
Echinococcus granulosus	integrin alpha 3	0.0119	0.0889	0.0889
Plasmodium vivax	aspartyl proteinase, putative	0.0238	0.2053	1
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0082	0.0523	0.2431
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0082	0.0523	1
Echinococcus granulosus	hypothetical protein	0.0103	0.073	0.073
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0407	0.3707	0.6766
Loa Loa (eye worm)	transcriptional regulator	0.0082	0.0523	0.0917
Echinococcus multilocularis	integrin alpha ps	0.007	0.0403	0.0373
Schistosoma mansoni	hypothetical protein	0.0126	0.0951	0.0922
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus granulosus	neuropeptide Y receptor	0.0103	0.073	0.073
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	aspartic protease BmAsp-1, identical	0.0056	0.0271	0.0455
Schistosoma mansoni	histamine h1 receptor	0.0103	0.073	0.07
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0056	0.0271	0.1184
Schistosoma mansoni	chromatin regulatory protein sir2	0.0082	0.0523	0.0493
Onchocerca volvulus		0.0056	0.0271	0.1183
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0065	0.0351	0.1581
Trypanosoma brucei	SIR2-like protein 4, putative	0.0082	0.0523	0.2118
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0121	0.0414
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0272	0.2382	0.6304
Schistosoma mansoni	growth hormone secretagogue receptor	0.0103	0.073	0.07
Echinococcus granulosus	integrin alpha ps	0.007	0.0403	0.0403
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0139	0.1077	0.2666
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0103	0.073	0.07
Schistosoma mansoni	integrin alpha-ps	0.0036	0.0075	0.0044
Loa Loa (eye worm)	melatonin receptor type 1A	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0351	0.0602
Onchocerca volvulus		0.0056	0.0271	0.1183
Onchocerca volvulus		0.0103	0.073	0.3453
Brugia malayi	hypothetical protein	0.0103	0.073	0.1297
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0831	0.198
Onchocerca volvulus		0.0103	0.073	0.3453
Onchocerca volvulus		0.0238	0.2054	1
Loa Loa (eye worm)	sirtuin 4	0.0082	0.0523	0.0917
Toxoplasma gondii	aspartyl protease ASP3	0.0056	0.0271	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0103	0.073	0.07
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Onchocerca volvulus		0.0103	0.073	0.3453
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0103	0.073	0.1297
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0103	0.073	0.07
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0612	0.0582
Brugia malayi	neuropeptide F receptor	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0296
Echinococcus granulosus	somatostatin receptor	0.0103	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Brugia malayi	neuropeptide F receptor	0.0103	0.073	0.1297
Schistosoma mansoni	amine GPCR	0.0103	0.073	0.07
Brugia malayi	hypothetical protein	0.0048	0.0185	0.0296
Brugia malayi	Protein set-1	0.0065	0.0351	0.0602
Schistosoma mansoni	hypothetical protein	0.0033	0.0047	0.0015
Brugia malayi	Dopamine receptor protein 2	0.0103	0.073	0.1297
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0114	0.0831	0.198
Schistosoma mansoni	furin-1 (S08 family)	0.0255	0.222	0.2195
Onchocerca volvulus		0.0103	0.073	0.3453
Echinococcus granulosus	chromatin regulatory protein sir2	0.0272	0.2382	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297
Echinococcus granulosus	tm gpcr rhodopsin	0.0103	0.073	0.073
Brugia malayi	GCC2 and GCC3 family protein	0.0048	0.0185	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0103	0.073	0.1297

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 30 uM	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	15686910
IC50 (functional)	= 30 uM	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	15686910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 321022