Detailed information for compound 322059

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.32 | Formula: C20H22Cl2N4O2
  • H donors: 3 H acceptors: 3 LogP: 5.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1c(CNCCCNc2nc(O)c3c(n2)cccc3)cc(cc1Cl)Cl
  • InChi: 1S/C20H22Cl2N4O2/c1-2-28-18-13(10-14(21)11-16(18)22)12-23-8-5-9-24-20-25-17-7-4-3-6-15(17)19(27)26-20/h3-4,6-7,10-11,23H,2,5,8-9,12H2,1H3,(H2,24,25,26,27)
  • InChiKey: PAEABCHPEVTPCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus subsp. aureus MW2 Methionyl-tRNA synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Onchocerca volvulus Get druggable targets OG5_127468 All targets in OG5_127468
Schistosoma japonicum ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative Get druggable targets OG5_127468 All targets in OG5_127468
Neospora caninum Methionine--tRNA ligase (EC 6.1.1.10), related Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium hominis methionine -- tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Babesia bovis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium ulcerans methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium berghei methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania mexicana methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium yoelii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium leprae Probable methionyl-tRNA synthase MetS Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) Get druggable targets OG5_127468 All targets in OG5_127468
Echinococcus multilocularis methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Toxoplasma gondii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium parvum methionyl-tRNA synthetase of possible bacterial origin Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Schistosoma mansoni methionine-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania braziliensis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trichomonas vaginalis methionine-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) tyrosyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Giardia lamblia Methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania infantum methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma congolense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium falciparum methionine--tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei gambiense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium knowlesi methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania major methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium vivax methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma cruzi methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania donovani methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Methionyl-tRNA synthetase   657 aa 662 aa 23.4 %
Treponema pallidum methionyl-tRNA synthetase Methionyl-tRNA synthetase   657 aa 755 aa 25.4 %
Dictyostelium discoideum methionine-tRNA ligase Methionyl-tRNA synthetase   657 aa 698 aa 25.6 %
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic Methionyl-tRNA synthetase   657 aa 560 aa 25.2 %
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic Methionyl-tRNA synthetase   657 aa 561 aa 25.1 %
Entamoeba histolytica methionyl-tRNA synthetase, putative Methionyl-tRNA synthetase   657 aa 699 aa 26.5 %
Brugia malayi methionyl-tRNA synthetase Methionyl-tRNA synthetase   657 aa 665 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0645 0.103
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0231 0.0363
Schistosoma mansoni protein kinase 0.0036 0.0231 0.0401
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.0645 0.071
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0094 0.0164
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.0645 0.071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0645 0.0922
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0645 0.071
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0645 0.0922
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0645 0.1122
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.0645 0.0645
Schistosoma mansoni opsin-like receptor 0.0065 0.0645 0.1122
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0237 0.7845
Plasmodium falciparum methionine--tRNA ligase 0.0033 0.0193 0.0178
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0231 0.0363
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0075 0.0082
Echinococcus granulosus somatostatin receptor 0.0065 0.0645 0.0645
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0302 0.0343
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Brugia malayi Serotonin receptor 0.0065 0.0645 0.0922
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus nmda type glutamate receptor 0.0057 0.0533 0.0533
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0231 0.0235
Onchocerca volvulus 0.0065 0.0645 0.2151
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0237 0.1423
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.022 0.0384
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0645 0.0922
Loa Loa (eye worm) hypothetical protein 0.0465 0.6258 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0069 0.0076
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0057 0.0533 0.0587
Onchocerca volvulus 0.0065 0.0645 0.2151
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0041 0.0307 1
Loa Loa (eye worm) sugar transporter 0.0117 0.1372 0.2192
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0645 0.0922
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Plasmodium vivax CDK-related protein kinase 6, putative 0.0497 0.6707 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0094 0.3067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0128 0.0204
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.0645 0.0645
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0645 0.0922
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0645 0.103
Onchocerca volvulus 0.0065 0.0645 0.2151
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0075 0.013
Loa Loa (eye worm) hypothetical protein 0.0183 0.2296 0.3668
Schistosoma mansoni methionine-tRNA synthetase 0.0033 0.0193 0.0336
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0094 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Brugia malayi methionyl-tRNA synthetase 0.0026 0.009 0.0024
Echinococcus multilocularis serotonin receptor 0.0183 0.2296 0.2528
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.1372 0.3017
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0237 0.7803
Leishmania major glucose transporter, lmgt3 0.0036 0.0237 0.7845
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0237 0.1423
Brugia malayi neuropeptide F receptor 0.0065 0.0645 0.0922
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Onchocerca volvulus 0.0065 0.0645 0.2151
Echinococcus granulosus neuropeptide s receptor 0.0065 0.0645 0.0645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0645 0.071
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.2384 0.5373
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0645 0.0645
Entamoeba histolytica hypothetical protein 0.0039 0.0279 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0094 0.014
Brugia malayi Dopamine receptor 0.0065 0.0645 0.0922
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0075 0.0075
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0302 0.0529
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.0645 0.0645
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.0645 0.0645
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0075 0.0082
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.0645 0.1122
Echinococcus granulosus g protein coupled receptor 0.0065 0.0645 0.0645
Brugia malayi Melatonin receptor type 1A 0.0065 0.0645 0.0922
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0645 0.071
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0231 0.0363
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0645 0.071
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1372 0.1372
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0645 0.0645
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.022 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Loa Loa (eye worm) solute carrier family 6 member 4 0.0146 0.1776 0.2838
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0645 0.0645
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0075 0.013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.0645 0.071
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0237 0.1423
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Echinococcus granulosus neuropeptide receptor 0.0065 0.0645 0.0645
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.0645 0.071
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0075 0.013
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0302 1
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0645 0.071
Echinococcus granulosus serotonin receptor 0.0065 0.0645 0.0645
Schistosoma mansoni opsin-like receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.0645 0.071
Plasmodium vivax hexose transporter 0.0117 0.1372 0.2045
Schistosoma mansoni hypothetical protein 0.0065 0.0645 0.1122
Trypanosoma brucei glucose transporter 2A 0.0036 0.0237 0.6871
Loa Loa (eye worm) hypothetical protein 0.0146 0.1776 0.2838
Brugia malayi Dopamine receptor protein 1 0.0465 0.6258 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Leishmania major glucose transporter, lmgt1 0.0036 0.0237 0.7845
Echinococcus granulosus neuropeptide receptor A26 0.0065 0.0645 0.0645
Onchocerca volvulus 0.0065 0.0645 0.2151
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0075 0.013
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0075 0.0075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0645 0.103
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.1372 1
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0254
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0033 0.0193 0.1089
Echinococcus granulosus fmrfamide receptor 0.0065 0.0645 0.0645
Plasmodium vivax methionine--tRNA ligase, putative 0.0033 0.0193 0.0288
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0146 0.1776 0.2751
Onchocerca volvulus 0.0146 0.1776 0.642
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Giardia lamblia Methionyl-tRNA synthetase 0.0033 0.0193 0.7822
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0041 0.0307 0.1728
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0237 0.1423
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0199 0.0199
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0645 0.071
Schistosoma mansoni biogenic amine receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0237 0.6871
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0645 0.071
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0645 0.0922
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0069 0.012
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0214 0.2724 0.4353
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0231 0.0344
Onchocerca volvulus 0.0065 0.0645 0.2151
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0075 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0231 0.0235
Onchocerca volvulus 0.0065 0.0645 0.2151
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.022 0.0235
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0069 0.0069
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0645 0.071
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0237 0.7803
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0645 0.071
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0352
Schistosoma mansoni neuropeptide receptor 0.0065 0.0645 0.1122
Chlamydia trachomatis glutamine binding protein 0.0041 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.2296 0.3668
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus vesicular acetylcholine transporter 0.0214 0.2724 0.2724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1372 0.151
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.022 0.1297
Schistosoma mansoni hypothetical protein 0.0065 0.0645 0.1122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0094 0.3046
Entamoeba histolytica protein kinase, putative 0.0036 0.0231 0.7456
Echinococcus multilocularis General substrate transporter 0.0101 0.114 0.1256
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.0645 0.1122
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.1372 0.151
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.022 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1372 0.1372
Onchocerca volvulus 0.0065 0.0645 0.2151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis neuropeptide receptor A26 0.0065 0.0645 0.071
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.2384 0.3555
Brugia malayi Dopamine receptor protein 2 0.0065 0.0645 0.0922
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.2384 0.3483
Onchocerca volvulus 0.0065 0.0645 0.2151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.022 0.0384
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0094 0.3115
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Trypanosoma cruzi hexose transporter 0.0036 0.0237 0.7803
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0237 0.1423
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.0645 0.1122
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0231 0.0235
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0645 0.0645
Echinococcus multilocularis orexin receptor type 2 0.0065 0.0645 0.071
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0041 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Schistosoma mansoni myosin xvIII 0.0065 0.0645 0.1122
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.022 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0075 0.0075
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1372 0.1372
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0645 0.071
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.0645 0.071
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0231 0.6561
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0254
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1372 0.151
Brugia malayi ORL1-like opioid receptor 0.0065 0.0645 0.0922
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0069 0.0076
Echinococcus granulosus allatostatin A receptor 0.0065 0.0645 0.0645
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0237 0.6871
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0645 0.103
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0094 0.0104
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.0645 0.071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0033 0.0193 0.6287
Plasmodium vivax amine transporter, putative 0.0025 0.0075 0.0112
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.0645 0.0645
Echinococcus granulosus neuropeptide receptor 0.0065 0.0645 0.0645
Schistosoma mansoni biogenic amine (5HT) receptor 0.0183 0.2296 0.3994
Echinococcus multilocularis neuropeptide s receptor 0.0065 0.0645 0.071
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0075 0.0075
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0231 0.0344
Treponema pallidum methionyl-tRNA synthetase 0.0026 0.009 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0231 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Brugia malayi RE15519p 0.0065 0.0645 0.0922
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0254
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0645 0.103
Brugia malayi larval opioid receptor 0.0065 0.0645 0.0922
Echinococcus granulosus g-protein coupled receptor 0.0065 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0146 0.1776 0.2838
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.0645 0.1122
Brugia malayi vesicular acetylcholine transporter unc-17 0.0214 0.2724 0.4285
Echinococcus granulosus biogenic amine 5HT receptor 0.0429 0.5748 0.5748
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0645 0.0645
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.0645 0.0645
Onchocerca volvulus 0.0065 0.0645 0.2151
Schistosoma mansoni histamine h1 receptor 0.0065 0.0645 0.1122
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.0645 0.071
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1372 0.151
Echinococcus granulosus g protein coupled receptor 0.0065 0.0645 0.0645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0645 0.071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0214 0.2724 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0094 0.0045
Plasmodium falciparum protein kinase 6 0.0497 0.6707 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0302 1
Echinococcus multilocularis somatostatin receptor 0.0065 0.0645 0.071
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0094 0.0031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0645 0.0922
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0075 0.013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0645 0.103
Onchocerca volvulus 0.0027 0.011 0.0133
Echinococcus granulosus methionine tRNA synthetase 0.0033 0.0193 0.0193
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.0645 0.0645
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.022 0.6918
Treponema pallidum sodium- and chloride- dependent transporter 0.0146 0.1776 1
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0645 0.0645
Plasmodium falciparum hexose transporter 0.0117 0.1372 0.1955
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0075 0.013
Brugia malayi GnHR receptor homolog 0.0065 0.0645 0.0922
Schistosoma mansoni glucose transport protein 0.0117 0.1372 0.2386
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.0645 0.0645
Schistosoma mansoni amine GPCR 0.0065 0.0645 0.1122
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0199 0.022
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.022 0.022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0069 0.0069
Echinococcus granulosus glutamate receptor 2 0.0024 0.0069 0.0069
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0094 0.0164
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0033 0.0193 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.0645 0.071
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0094 0.3067
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0645 0.103
Echinococcus multilocularis nmda type glutamate receptor 0.0057 0.0533 0.0587
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0041 0.0307 1
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0645 0.071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0645 0.0645
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0041 0.0307 0.1728
Schistosoma mansoni amine GPCR 0.0065 0.0645 0.1122
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0075 0.0082
Brugia malayi AKH receptor 0.0065 0.0645 0.0922
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0033 0.0193 0.8485
Echinococcus granulosus sex peptide receptor 0.0065 0.0645 0.0645
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0231 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0075 0.0082
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0645 0.071
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0237 0.1423
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0024 0.0069 0.0076
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Brugia malayi sulfakinin receptor protein 0.0065 0.0645 0.0922
Plasmodium falciparum protein kinase 7 0.0331 0.4373 0.6482
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0231 0.0252
Leishmania major glucose transporter, lmgt2 0.0036 0.0237 0.7845
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0645 0.103
Schistosoma mansoni opsin-like receptor 0.0065 0.0645 0.1122
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0231 0.0344
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0075 0.0075
Schistosoma mansoni glucose transport protein 0.0117 0.1372 0.2386
Echinococcus multilocularis serotonin transporter 0.0146 0.1776 0.1955
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni protein kinase 0.0036 0.0231 0.0401
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Trypanosoma brucei glucose transporter, putative 0.0036 0.0237 0.6871
Brugia malayi G-protein coupled receptor 0.0065 0.0645 0.0922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0645 0.071
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.0645 0.1122
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0094 0.0342
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1372 0.1372
Onchocerca volvulus 0.0065 0.0645 0.2151
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0075 0.012
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0106 0.0185
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0645 0.0645
Brugia malayi G protein-coupled receptor 0.0065 0.0645 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0645 0.0645
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.022 0.0235
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0352
Schistosoma mansoni sodium/chloride dependent transporter 0.0146 0.1776 0.309
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0254
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0302 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0024 0.0069 0.0069
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0075 0.0075
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0094 0.3067
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0033 0.0193 0.4748
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.0645 0.1122
Brugia malayi putative neuropeptide receptor 0.0065 0.0645 0.0922
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0645 0.071
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni neuropeptide receptor 0.0065 0.0645 0.1122
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0075 0.0112
Schistosoma mansoni hypothetical protein 0.0065 0.0645 0.1122
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0645 0.0645
Echinococcus multilocularis conserved hypothetical protein 0.0667 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.0645 0.071
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0033 0.0193 0.0308
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0302 1
Leishmania major protein kinase, putative 0.0036 0.0231 0.7632
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Entamoeba histolytica protein kinase, putative 0.0036 0.0231 0.7456
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0094 0.2979
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.0645 0.2151
Brugia malayi G-protein coupled receptor 0.0065 0.0645 0.0922
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0231 0.1374
Brugia malayi neuropeptide F receptor 0.0065 0.0645 0.0922
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.0645 0.071
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0075 0.2439
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0369
Schistosoma mansoni neuropeptide receptor 0.0065 0.0645 0.1122
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0033 0.0193 0.5749
Schistosoma mansoni amine GPCR 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0075 0.013
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Echinococcus granulosus serotonin transporter 0.0146 0.1776 0.1776
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0231 0.0369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.015
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0645 0.071
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0075 0.013
Onchocerca volvulus 0.0065 0.0645 0.2151
Onchocerca volvulus 0.0065 0.0645 0.2151
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0237 0.1423
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0231
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0231 0.0231
Brugia malayi hypothetical protein 0.0065 0.0645 0.0922
Onchocerca volvulus 0.0065 0.0645 0.2151
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0645 0.0922
Schistosoma mansoni neuropeptide receptor 0.0065 0.0645 0.1122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0231 0.0235
Echinococcus granulosus g protein coupled receptor 0.0065 0.0645 0.0645
Echinococcus multilocularis allatostatin A receptor 0.0065 0.0645 0.071
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0237 0.6871
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0645 0.0645
Echinococcus multilocularis sex peptide receptor 0.0065 0.0645 0.071
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni vesicular acetylcholine transporter 0.0214 0.2724 0.474
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0094 0.0029
Brugia malayi Cam kinase protein 1 0.0036 0.0231 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0183 0.2296 0.2296
Loa Loa (eye worm) hypothetical protein 0.0146 0.1776 0.2838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0645 0.1122
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.0645 0.071
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0021 0.0015 0.0024
Onchocerca volvulus 0.0065 0.0645 0.2151
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0231
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0075 0.013
Leishmania major methionyl-tRNA synthetase, putative 0.0033 0.0193 0.6384
Schistosoma mansoni hypothetical protein 0.0065 0.0645 0.1122
Trypanosoma brucei glucose transporter 1E 0.0036 0.0237 0.6871
Brugia malayi Sugar transporter family protein 0.0117 0.1372 0.2097
Schistosoma mansoni biogenic amine receptor 0.0065 0.0645 0.1122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0429 0.5748 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0075 0.012
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0645 0.071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.012
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0302 0.0451
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0645 0.1122
Echinococcus granulosus orexin receptor type 2 0.0065 0.0645 0.0645
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0146 0.1776 0.309
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.0645 0.1122
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.103
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0645 0.1122
Echinococcus multilocularis serotonin receptor 0.0183 0.2296 0.2528
Onchocerca volvulus 0.0065 0.0645 0.2151
Schistosoma mansoni protein kinase 0.0036 0.0231 0.0401
Toxoplasma gondii methionyl-tRNA synthetase 0.0046 0.0378 0.0704
Schistosoma mansoni biogenic amine receptor 0.0065 0.0645 0.1122
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0645 0.0922
Loa Loa (eye worm) serotonin transporter b 0.0146 0.1776 0.2838
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0237 0.7803
Toxoplasma gondii protein kinase, putative 0.0331 0.4373 1
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0033 0.0193 0.6313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0645 0.1122
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0075 0.013
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0429 0.5748 0.6328
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0231 0.0344
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.0645 0.2151
Onchocerca volvulus 0.0065 0.0645 0.2151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0645 0.1122
Schistosoma mansoni hypothetical protein 0.0117 0.1372 0.2386
Schistosoma mansoni adenoreceptor 0.0065 0.0645 0.1122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0231 0.0231
Loa Loa (eye worm) norepinephrine transporter 0.0146 0.1776 0.2838
Brugia malayi Serotonin receptor 0.0065 0.0645 0.0922
Echinococcus granulosus General substrate transporter 0.0101 0.114 0.114
Echinococcus multilocularis vesicular acetylcholine transporter 0.0214 0.2724 0.3
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0231 0.0235
Schistosoma mansoni amine GPCR 0.0065 0.0645 0.1122
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0645 0.071
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.0645 0.0645
Schistosoma mansoni glucose transport protein 0.0117 0.1372 0.2386
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.0645 0.1122
Schistosoma mansoni amine GPCR 0.0065 0.0645 0.1122
Brugia malayi methionyl-tRNA synthetase 0.0033 0.0193 0.0191
Echinococcus multilocularis methionine tRNA synthetase 0.0033 0.0193 0.0212

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 3 nM Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase ChEMBL. 15225702
IC50 (binding) < 3 nM Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase ChEMBL. 15225702
MIC (functional) <= 0.06 ug ml-1 Antibacterial activity against Enterococcus faecalis 1 ChEMBL. 15225702
MIC (functional) = 0.13 ug ml-1 Antibacterial activity against Staphylococcus aureus Oxford ChEMBL. 15225702

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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