Detailed information for compound 322961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 369.845 | Formula: C20H20ClN3O2
  • H donors: 3 H acceptors: 2 LogP: 3.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(Cl)cc(cc2C2(N1)CCCCC2)c1ccc(cc1)C(=O)N
  • InChi: 1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26)
  • InChiKey: WQHMBRVYRFOUDL-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 1C, calmodulin-dependent 70kDa References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 1B, calmodulin-dependent Starlite/ChEMBL References
Homo sapiens phosphodiesterase 7A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 1A, calmodulin-dependent References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative phosphodiesterase 1B, calmodulin-dependent 536 aa 465 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tailless protein 0.0019 0.0089 0.0112
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0114 0.1115 0.2389
Chlamydia trachomatis malate dehydrogenase 0.0114 0.1115 1
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.2829 0.2829
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0173 0.0245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0089 0.0112
Brugia malayi hypothetical protein 0.0019 0.0089 0.0112
Echinococcus granulosus malate dehydrogenase 0.0114 0.1115 0.1314
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0077 0.0714 0.233
Toxoplasma gondii hypothetical protein 0.0023 0.0132 0.0431
Onchocerca volvulus 0.0041 0.0326 0.0784
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0114 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0114 0.0134
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.01 0.0969 0.1141
Loa Loa (eye worm) hypothetical protein 0.0251 0.2608 0.3294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0638 0.0751
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0144
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0405 0.0476
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.074 0.7916 0.9322
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0175 0.1779 0.2095
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.006 0.0426
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus granulosus C type lectin domian containing protein 0.0031 0.021 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Leishmania major malate dehydrogenase, putative 0.0293 0.3063 0.6514
Plasmodium falciparum malate dehydrogenase 0.0293 0.3063 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0142 0.1416 0.3032
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0285 0.2977 0.6376
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0114 0.1115 0.7878
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0132 0.0431
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0326 0.0383
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus granulosus carbonic anhydrase 0.0251 0.2608 0.3071
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0326 0.0383
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0089 0.0089
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.068 0.068
Echinococcus granulosus single minded 2 0.0048 0.0399 0.047
Echinococcus granulosus transient receptor potential gamma protein 0.0112 0.1089 0.1282
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0124
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0098 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0219
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0144
Echinococcus granulosus L lactate dehydrogenase 0.0179 0.1824 0.2148
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0326 0.0383
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0285 0.2977 0.9721
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0393 0.4152 0.5245
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Echinococcus granulosus microtubule associated protein 2 0.0793 0.8492 1
Leishmania major hypothetical protein, conserved 0.0077 0.0714 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.006 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.01 0.0969 0.1224
Echinococcus multilocularis lactate dehydrogenase protein 0.0293 0.3063 0.3063
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0714 0.1528
Toxoplasma gondii lactate dehydrogenase LDH2 0.0293 0.3063 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0077 0.0714 0.084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0579 0.4091
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0577 0.6146 0.7764
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0285 0.2977 0.9721
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.1552
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0123 0.1211 0.1529
Schistosoma mansoni single-minded 0.0065 0.0582 0.0686
Brugia malayi GCC2 and GCC3 family protein 0.0031 0.021 0.0265
Onchocerca volvulus 0.0031 0.021 0.0505
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0326 0.0383
Echinococcus multilocularis c4b binding protein beta chain 0.0031 0.021 0.021
Echinococcus multilocularis malate dehydrogenase 0.0114 0.1115 0.1115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.1819 0.594
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Echinococcus multilocularis C type lectin domian containing protein 0.0031 0.021 0.021
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0326 0.0383
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.006 0.0426
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0098 0.0881
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0089 0.0112
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.1106 0.1397
Loa Loa (eye worm) hypothetical protein 0.0112 0.1089 0.1375
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0114 0.1115 0.2389
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0089 0.0104
Plasmodium falciparum L-lactate dehydrogenase 0.0293 0.3063 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0142 0.1416 0.3032
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0114 0.1115 0.2389
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0114 0.0134
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0044 0.0052
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0142 0.1416 1
Plasmodium vivax apical sushi protein, putative 0.0031 0.021 0.0685
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.233
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.0942 0.0942
Trypanosoma cruzi malate dehydrogenase, putative 0.0114 0.1115 0.2389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0089 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.1552
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0142 0.1416 0.3032
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1634 0.1634
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0114 0.1115 0.1409
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0679 0.0679
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.006 0.0426
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.006 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.1528
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0219
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0089 0.0112
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0405 0.0511
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0142 0.1416 0.1416
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0173 0.0565
Schistosoma mansoni hypothetical protein 0.0055 0.0479 0.0564
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0114 0.0114
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.2608 0.3294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0057
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0293 0.3063 0.3063
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.00000034704 0.0000011331
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.0961
Brugia malayi Sushi domain 0.0031 0.021 0.0265
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.01 0.0969 0.6842
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0326 0.0784
Onchocerca volvulus 0.0027 0.0173 0.0417
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0114 0.1115 1
Brugia malayi nuclear receptor RXR 0.0022 0.0114 0.0144
Echinococcus multilocularis L lactate dehydrogenase 0.0179 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0059 0.0523 0.0661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.0754 0.2462
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.0942 0.119
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.1106 0.3612
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0326 0.0784
Trypanosoma brucei glycosomal malate dehydrogenase 0.0114 0.1115 0.2389
Onchocerca volvulus 0.0031 0.021 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0326 0.0411
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0441 0.467 0.5899
Echinococcus granulosus cytosolic malate dehydrogenase 0.0114 0.1115 0.1314
Onchocerca volvulus 0.0031 0.021 0.0505
Brugia malayi hypothetical protein 0.0272 0.2829 0.3574
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus multilocularis jun protein 0.009 0.0851 0.0851
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0326 0.0411
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0044 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0144
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.0961
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0173 0.0245
Plasmodium falciparum lactate dehydrogenase, putative 0.0114 0.1115 0.3642
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0175 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0055
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0328 0.0414
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0173 0.1552
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0441 0.467 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0236 0.0298
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0326 0.0326
Trypanosoma brucei malate dehydrogenase-related 0.0114 0.1115 0.2389
Leishmania major glycosomal malate dehydrogenase 0.0114 0.1115 0.2289
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.00000034704 0.00000034704
Loa Loa (eye worm) hypothetical protein 0.007 0.0638 0.0806
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0089 0.0104
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0142 0.1416 0.3032
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.01 0.0969 0.6842
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Echinococcus granulosus L lactate dehydrogenase B chain 0.0293 0.3063 0.3607
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0175 0.1779 0.2095
Loa Loa (eye worm) hypothetical protein 0.0251 0.2608 0.3294
Treponema pallidum DNA ligase (lig) 0.0011 0 0.5
Echinococcus multilocularis lactate dehydrogenase a 0.0293 0.3063 0.3063
Echinococcus multilocularis lactate dehydrogenase a 0.0293 0.3063 0.3063
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0142 0.1416 0.3032
Brugia malayi steroid hormone receptor 0.0041 0.0326 0.0411
Brugia malayi Uncoordinated protein 44 0.0015 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Leishmania major cAMP-specific phosphodiesterase, putative 0.0077 0.0714 0.1417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0731 0.0731
Schistosoma mansoni malate dehydrogenase 0.0293 0.3063 0.3607
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Schistosoma mansoni jun-related protein 0.0073 0.0668 0.0787
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0077 0.0714 0.1528
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.0942 0.111
Onchocerca volvulus 0.0031 0.021 0.0505
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Schistosoma mansoni hypothetical protein 0.0251 0.2608 0.3071
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0089 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0326 0.0411
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.1552
Echinococcus granulosus malate dehydrogenase 0.0114 0.1115 0.1314
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0031 0.021 0.0265
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.0851 0.0851
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Onchocerca volvulus 0.007 0.0642 0.1546
Schistosoma mansoni coup transcription factor 0.0041 0.0326 0.0383
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0326 0.0411
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0294 0.0294
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0731 0.0861
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0405 0.0405
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0089 0.0104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0326 0.0383
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0326 0.0326
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.233
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0326 0.0326
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Onchocerca volvulus 0.0055 0.0479 0.1154
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0114 0.1115 0.3642
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0089 0.0104
Schistosoma mansoni zinc finger protein 0.0019 0.0089 0.0104
Trichomonas vaginalis malate dehydrogenase, putative 0.0056 0.048 0.3393
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0089 0.0089
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0393 0.4152 0.5245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0326 0.0383
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0114 0.1115 0.2389
Giardia lamblia Malate dehydrogenase 0.0114 0.1115 0.627
Plasmodium falciparum apical sushi protein 0.0031 0.021 0.0685
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Brugia malayi ecdysone receptor 0.0019 0.0089 0.0112
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0044 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0326 0.0383
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Toxoplasma gondii hypothetical protein 0.0065 0.0579 0.1891
Echinococcus granulosus jun protein 0.009 0.0851 0.1002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0326 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.006 0.0426
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0175 0.1779 0.1779
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.006 0.0129
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0326 0.0411
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.0454
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.00000034704 0.00000040868
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.006 0.0426
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.068 0.0801
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0326 0.0411
Plasmodium vivax phosphodiesterase gamma, putative 0.0077 0.0714 0.233
Leishmania major malate dehydrogenase 0.0114 0.1115 0.2289
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0098 0.0321
Schistosoma mansoni hypothetical protein 0.0038 0.0294 0.0347
Leishmania major malate dehydrogenase, putative 0.0114 0.1115 0.2289
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0089 0.0213
Loa Loa (eye worm) DR-78 0.0019 0.0089 0.0112
Echinococcus multilocularis carbonic anhydrase II 0.0441 0.467 0.467
Trypanosoma cruzi malate dehydrogenase, putative 0.0114 0.1115 0.2389
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0175 0.1779 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0056 0.048 0.3393
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0326 0.0326
Echinococcus multilocularis Ankyrin 0.0015 0.0045 0.0045
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0142 0.1416 0.1667
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0326 0.0784
Echinococcus multilocularis expressed conserved protein 0.0106 0.1032 0.1032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0405 0.0511
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0219
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0326 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0326 0.0383
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0144
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0089 0.0089
Brugia malayi small heat shock protein 0.0616 0.6574 0.8305
Schistosoma mansoni survival motor neuron protein 0.0055 0.0479 0.0564
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0405 0.0476
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0142 0.1416 0.1667
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0294 0.0347
Schistosoma mansoni cpg binding protein 0.0035 0.0256 0.0302
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1125 0.1325
Mycobacterium leprae Possible regulatory protein 0.0017 0.006 0.0541
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0089 0.0104
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0089 0.0112
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0173 0.0844
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0089 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0114 0.1115 0.2389
Echinococcus granulosus replication factor c subunit 1 0.0011 0.00000034704 0.00000040868
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Schistosoma mansoni nuclear receptor 0.0019 0.0089 0.0104
Echinococcus granulosus carbonic anhydrase II 0.0441 0.467 0.5499
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0293 0.3063 1
Echinococcus multilocularis protein patched 0.0049 0.0405 0.0405
Brugia malayi nuclear receptor NHR-88 0.0019 0.0089 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0114 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0714 0.504
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0405 0.2857
Entamoeba histolytica malate dehydrogenase, putative 0.0114 0.1115 0.3642
Loa Loa (eye worm) malate dehydrogenase 0.0114 0.1115 0.1409
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0077 0.0714 0.084
Brugia malayi ecdysteroid receptor 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0076
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.504
Leishmania major mitochondrial malate dehydrogenase 0.0114 0.1115 0.2289
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0173 0.0565
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.006 0.0426
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.2608 0.3071
Echinococcus multilocularis cpg binding protein 0.0035 0.0256 0.0256
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0285 0.2977 0.6376
Loa Loa (eye worm) hypothetical protein 0.0038 0.0287 0.0363
Brugia malayi conserved hypotetical protein 0.0019 0.0089 0.0112
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.233
Loa Loa (eye worm) hypothetical protein 0.0087 0.0824 0.1041
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0441 0.467 0.5899
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0326 0.0411
Brugia malayi CXXC zinc finger family protein 0.0033 0.0236 0.0298
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0052
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0132 0.0431
Loa Loa (eye worm) hypothetical protein 0.014 0.1394 0.1761
Schistosoma mansoni cpg binding protein 0.0033 0.0236 0.0277
Plasmodium falciparum phosphodiesterase gamma, putative 0.0077 0.0714 0.233
Plasmodium vivax lactate dehydrogenase 0.0293 0.3063 1
Echinococcus granulosus lactate dehydrogenase protein 0.0293 0.3063 0.3607
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0077 0.0714 0.0714
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.1161 0.8199
Loa Loa (eye worm) hypothetical protein 0.0123 0.1211 0.1529
Brugia malayi nuclear receptor NHR-67 0.0019 0.0089 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0294 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.006 0.0426
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Loa Loa (eye worm) hypothetical protein 0.0113 0.1106 0.1397
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0272 0.2829 0.3574
Brugia malayi Cytochrome P450 family protein 0.0044 0.0358 0.0452
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.0902
Schistosoma mansoni microtubule-associated protein tau 0.0793 0.8492 1
Brugia malayi nuclear hormone receptor 0.0041 0.0326 0.0411
Schistosoma mansoni L-lactate dehydrogenase 0.0293 0.3063 0.3607
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0045 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0326 0.0383
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0251 0.2608 0.3294
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0066 0.0078
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0077 0.0714 0.504
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0532 0.5652 0.5652
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.01 0.0969 0.0969
Trypanosoma brucei cytosolic malate dehydrogenase 0.0114 0.1115 0.2389
Brugia malayi bHLH-PAS transcription factor 0.0048 0.0399 0.0504
Schistosoma mansoni transient receptor potential channel 4 0.0112 0.1089 0.1282
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0132 0.1185
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0326 0.0383
Brugia malayi Death domain containing protein 0.0015 0.0044 0.0055
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0044 0.0055
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0326 0.0383
Plasmodium vivax malate dehydrogenase, putative 0.0293 0.3063 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0077 0.0714 0.233
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0173 0.0245
Echinococcus granulosus cpg binding protein 0.0035 0.0256 0.0302
Loa Loa (eye worm) hypothetical protein 0.05 0.531 0.6708
Onchocerca volvulus 0.0031 0.021 0.0505
Giardia lamblia hypothetical protein 0.0077 0.0714 0.4012
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus multilocularis dnaJ subfamily B 0.047 0.4983 0.4983
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0479 0.0605
Brugia malayi hypothetical protein 0.007 0.0642 0.0811
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Loa Loa (eye worm) hypothetical protein 0.0175 0.1779 0.2247
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0124
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Toxoplasma gondii hypothetical protein 0.0023 0.0132 0.0431
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0132 0.1185
Echinococcus granulosus transient receptor potential ion channel A 0.0108 0.1048 0.1235
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0114 0.1115 0.7878
Onchocerca volvulus 0.0019 0.0089 0.0213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0098 0.0881
Brugia malayi hypothetical protein 0.0022 0.0114 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0132 0.0431
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034704 0.0000024512
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0173 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0326 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Leishmania major hypothetical protein, conserved 0.0077 0.0714 0.1417
Echinococcus multilocularis protein dispatched 1 0.0055 0.0479 0.0479
Echinococcus multilocularis transfer RNA-Lys 0.0048 0.0399 0.0399
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.00000034704 0.0000024512
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0326 0.0411
Schistosoma mansoni nuclear receptor 0.0019 0.0089 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0326 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0579 0.4091
Brugia malayi lactate dehydrogenase. 0.0293 0.3063 0.3869
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0124
Onchocerca volvulus 0.0393 0.4152 1
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0326 0.0383
Toxoplasma gondii rhoptry neck protein RON9 0.0031 0.021 0.0685
Echinococcus multilocularis transient receptor potential gamma protein 0.0112 0.1089 0.1089
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.006 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0251 0.2608 0.3294
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.2608 0.3294
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0326 0.0326
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0285 0.2977 0.6328
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0089 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0219
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0089 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0326 0.0411
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.006 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0326 0.0411
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0358 0.0452
Echinococcus granulosus lactate dehydrogenase a 0.0293 0.3063 0.3607
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.006 0.0426
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Echinococcus multilocularis microtubule associated protein 2 0.0793 0.8492 0.8492
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0326 0.0411
Leishmania major cytosolic malate dehydrogenase 0.0114 0.1115 0.2289
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0326 0.0383
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0031 0.021 0.0505
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0251 0.2608 0.3294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0326 0.0411
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.01 0.0969 0.1224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0326 0.0411
Onchocerca volvulus 0.014 0.1394 0.3358
Plasmodium falciparum phosphodiesterase delta, putative 0.0077 0.0714 0.233
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0714 0.504
Brugia malayi hypothetical protein 0.0031 0.021 0.0265
Leishmania major carbonic anhydrase-like protein 0.0441 0.467 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Brugia malayi bZIP transcription factor family protein 0.009 0.0851 0.1075
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.233
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Toxoplasma gondii rhoptry neck protein RON1 0.0031 0.021 0.0685
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Onchocerca volvulus 0.0033 0.0236 0.0568
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0089 0.0104
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.1106 0.1303
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0679 0.0799
Trypanosoma brucei carbonic anhydrase-like protein 0.0441 0.467 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.006 0.0129
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0017 0.006 0.0541
Mycobacterium ulcerans hypothetical protein 0.0027 0.0173 0.1552
Schistosoma mansoni transient receptor potential channel 0.0112 0.1089 0.1282
Loa Loa (eye worm) PDE1B protein 0.074 0.7916 1
Brugia malayi hypothetical protein 0.0022 0.0114 0.0144
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0077 0.0714 0.0902
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0132 0.0447
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0114 0.1115 0.2389
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.0851 0.1002
Echinococcus multilocularis malate dehydrogenase 0.0114 0.1115 0.1115
Onchocerca volvulus 0.0031 0.021 0.0505
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.0454
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.1161 0.2486
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0285 0.2977 0.9721
Loa Loa (eye worm) hypothetical protein 0.0293 0.3063 0.3869
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0251 0.2608 0.3294
Onchocerca volvulus 0.0019 0.0089 0.0213
Plasmodium falciparum carbonic anhydrase 0.0251 0.2608 0.8515
Loa Loa (eye worm) malate dehydrogenase 0.0114 0.1115 0.1409
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0312
Loa Loa (eye worm) hypothetical protein 0.0616 0.6574 0.8305
Schistosoma mansoni hypothetical protein 0.047 0.4983 0.5868
Echinococcus multilocularis carbonic anhydrase 0.0251 0.2608 0.2608
Schistosoma mansoni aryl hydrocarbon receptor 0.0188 0.1922 0.2263
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0044 0.0052
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0326 0.0411
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Toxoplasma gondii malate dehydrogenase MDH 0.0293 0.3063 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0556 0.1816
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0089 0.0089
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Schistosoma mansoni c4b-binding protein beta chain 0.0031 0.021 0.0247
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0114 0.1115 0.1115
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0077 0.0714 0.0902
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.1106 0.1106
Echinococcus multilocularis lactate dehydrogenase a 0.0293 0.3063 0.3063
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.0942 0.119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.2608 0.3071
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0441 0.467 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0077 0.0714 0.1528
Loa Loa (eye worm) hypothetical protein 0.0251 0.2608 0.3294
Echinococcus granulosus carbonic anhydrase 0.0251 0.2608 0.3071
Onchocerca volvulus 0.0049 0.0405 0.0976
Loa Loa (eye worm) hypothetical protein 0.0577 0.6146 0.7764
Brugia malayi CHE-14 protein 0.0049 0.0405 0.0511
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0326 0.0383
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0114 0.1115 1
Echinococcus granulosus carbonic anhydrase 0.0251 0.2608 0.3071
Loa Loa (eye worm) hypothetical protein 0.0123 0.1217 0.1537
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0326 0.0411
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0114 0.1115 0.1409
Schistosoma mansoni hypothetical protein 0.0073 0.0668 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.1416 1
Echinococcus multilocularis carbonic anhydrase 0.0251 0.2608 0.2608
Toxoplasma gondii lactate dehydrogenase LDH1 0.0293 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0969 0.1224
Echinococcus granulosus Ankyrin 0.0015 0.0045 0.0053
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.01 0.0969 0.6842
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Schistosoma mansoni malate dehydrogenase 0.0114 0.1115 0.1314
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0114 0.1115 0.1115
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0098 0.0321
Schistosoma mansoni L-lactate dehydrogenase 0.0114 0.1115 0.1314
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1634 0.1924
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0089 0.0213
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.504
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.0066 0.0084
Toxoplasma gondii hypothetical protein 0.0251 0.2608 0.8515
Schistosoma mansoni malate dehydrogenase 0.0114 0.1115 0.1314
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0077 0.0714 0.233
Brugia malayi hypothetical protein 0.0017 0.006 0.0076
Schistosoma mansoni transient receptor potential channel 0.0074 0.068 0.0801
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0142 0.1416 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0144
Brugia malayi pregnancy-associated plasma protein-A 0.0031 0.021 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0173 0.0844
Giardia lamblia Hypothetical protein 0.0077 0.0714 0.4012
Schistosoma mansoni carbonic anhydrase-related 0.0251 0.2608 0.3071
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0326 0.0383
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.074 0.7916 1
Brugia malayi hypothetical protein 0.0038 0.0294 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0112
Loa Loa (eye worm) hypothetical protein 0.0041 0.0328 0.0414
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.01 0.0969 0.1141
Schistosoma mansoni netrin receptor unc5 0.0015 0.0044 0.0052
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0532 0.5652 0.6656
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Echinococcus granulosus death domain containing protein 0.0015 0.0044 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0173 0.1552
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0114 0.0134
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0132 0.0447
Echinococcus granulosus lactate dehydrogenase a 0.0293 0.3063 0.3607
Echinococcus granulosus aryl hydrocarbon receptor 0.014 0.14 0.1649
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0285 0.2977 0.2977
Brugia malayi nuclear hormone receptor 0.0019 0.0089 0.0112
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.0961
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0132 0.1185
Mycobacterium ulcerans malate dehydrogenase 0.0114 0.1115 1
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0326 0.0411
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0219
Schistosoma mansoni malate dehydrogenase 0.0114 0.1115 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0132 0.0933
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0328 0.0386
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.00000034704 0.0000011331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0326 0.0411
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0173 0.1552
Schistosoma mansoni transient receptor potential channel 0.0074 0.0679 0.0799
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0114 0.1115 0.7878
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.074 0.7916 0.9322
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0089 0.0112
Onchocerca volvulus 0.0031 0.021 0.0505
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.074 0.7916 0.7916
Echinococcus multilocularis transient receptor potential ion channel A 0.0108 0.1048 0.1048
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.0961
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0579 0.4091
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0142 0.1416 1
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.0454
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0285 0.2977 0.6376
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.006 0.0426
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0089 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0326 0.0383
Echinococcus granulosus c4b binding protein beta chain 0.0031 0.021 0.0247
Brugia malayi Protein kinase domain containing protein 0.0015 0.0044 0.0055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0326 0.0383
Onchocerca volvulus 0.0393 0.4152 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034704 0.0000024512
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0326 0.0383
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0441 0.467 0.5499
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0077 0.0714 0.1528
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0142 0.1416 1
Schistosoma mansoni cpg binding protein 0.0035 0.0256 0.0302
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.2829 0.3332
Echinococcus granulosus cytosolic malate dehydrogenase 0.0114 0.1115 0.1314
Loa Loa (eye worm) carbonic anhydrase 3 0.0441 0.467 0.5899
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0089 0.0104
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0285 0.2977 0.3506
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0173 0.1552
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.1528
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0175 0.1779 0.2095
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0077 0.0714 0.0902
Loa Loa (eye worm) hypothetical protein 0.0023 0.0132 0.0167
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0326 0.0326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0089 0.0104
Mycobacterium ulcerans putative regulatory protein 0.0048 0.0399 0.3577
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0089 0.0089
Schistosoma mansoni patched 1 0.0049 0.0405 0.0476
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0219
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0173 0.1552
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0114 0.1115 0.7878
Echinococcus granulosus dnaJ subfamily B 0.047 0.4983 0.5868
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0044 0.0105
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0173 0.1552
Brugia malayi nuclear receptor NHR-88 0.0041 0.0326 0.0411
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0089 0.0112
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.006 0.0129
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0118 0.1161 0.8199
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0132 0.1185
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0441 0.467 0.5499
Schistosoma mansoni carbonic anhydrase 0.0251 0.2608 0.3071
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.1528
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.006 0.0426
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0077 0.0714 0.084
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0089 0.0112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0326 0.0383
Onchocerca volvulus 0.0031 0.021 0.0505
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0441 0.467 0.5899
Brugia malayi nuclear receptor RXR 0.0019 0.0089 0.0112
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0077 0.0714 0.504
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0326 0.0411
Entamoeba histolytica malate dehydrogenase, putative 0.0293 0.3063 1
Echinococcus multilocularis carbonic anhydrase 0.0251 0.2608 0.2608
Onchocerca volvulus 0.0031 0.021 0.0505
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0326 0.0326
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0114 0.1115 0.3642
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0031 0.021 0.0265
Trichomonas vaginalis malate dehydrogenase, putative 0.0114 0.1115 0.7878
Brugia malayi PAS domain containing protein 0.0065 0.0582 0.0735
Echinococcus multilocularis aryl hydrocarbon receptor 0.014 0.14 0.14
Echinococcus granulosus expressed conserved protein 0.0106 0.1032 0.1215
Brugia malayi hypothetical protein 0.0019 0.0089 0.0112

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 0.02 uM In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 0.28 uM In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 0.28 uM In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 0.69 uM Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 0.69 uM Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324876
IC50 (binding) = 1.28 uM In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells ChEMBL. 15324876
IC50 (binding) = 1.28 uM In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells ChEMBL. 15324876
IC50 (binding) = 11.6 uM Inhibition of human Phosphodiesterase 5 ChEMBL. 15324876
IC50 (binding) = 11.6 uM Inhibition of human Phosphodiesterase 5 ChEMBL. 15324876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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