Detailed information for compound 32659

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.582 | Formula: C26H30FNO7S
  • H donors: 4 H acceptors: 4 LogP: 2.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1cc(Sc2ccc3c(c2)CC/C/3=N\OC[C@H]2OC(O)[C@@H]([C@H]([C@H]2O)O)O)cc(c1)C1CCOCC1
  • InChi: 1S/C26H30FNO7S/c27-17-9-16(14-5-7-33-8-6-14)11-19(12-17)36-18-2-3-20-15(10-18)1-4-21(20)28-34-13-22-23(29)24(30)25(31)26(32)35-22/h2-3,9-12,14,22-26,29-32H,1,4-8,13H2/b28-21+/t22-,23+,24+,25-,26?/m1/s1
  • InChiKey: SWYQBNLBYJDQNO-GUAXATAJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0136 0.1025 0.0971
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Entamoeba histolytica PH domain containing protein kinase, putative 0.015 0.1139 0.1139
Plasmodium vivax prenyltransferase alpha subunit, putative 0.1004 0.8371 0.8371
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Echinococcus granulosus serine/threonine protein kinase 0.015 0.1139 0.1086
Plasmodium vivax aspartyl protease, putative 0.0068 0.0447 0.0447
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Trichomonas vaginalis AGC family protein kinase 0.007 0.0467 0.0467
Brugia malayi aspartic protease BmAsp-2, identical 0.0068 0.0447 0.0389
Brugia malayi Ras protein let-60 0.0337 0.2722 0.2678
Loa Loa (eye worm) aspartyl protease 6 0.0068 0.0447 0.0389
Echinococcus granulosus nervana 2 0.0135 0.1012 0.0958
Trypanosoma cruzi hypothetical protein, conserved 0.0336 0.2717 0.2717
Trypanosoma cruzi Protein kinase B 0.015 0.1139 0.1139
Trichomonas vaginalis rap1 and, putative 0.0337 0.2722 0.2722
Plasmodium falciparum protein farnesyltransferase subunit beta 0.1196 1 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0135 0.1012 0.0958
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.006 0.006
Onchocerca volvulus 0.0068 0.0447 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Giardia lamblia Rab geranylgeranyltransferase 0.1004 0.8371 0.8185
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.006 0.006
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.1004 0.8371 0.8371
Trichomonas vaginalis ral, putative 0.0337 0.2722 0.2722
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0136 0.1025 0.1025
Entamoeba histolytica protein kinase, putative 0.0205 0.1606 0.1606
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.046 0.3769 0.3769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0336 0.2717 0.2717
Echinococcus granulosus protein farnesyltransferase subunit beta 0.1196 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.046 0.3769 0.3732
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.006 0.006
Schistosoma mansoni serine/threonine kinase 0.007 0.0467 0.041
Entamoeba histolytica PH domain containing protein kinase, putative 0.015 0.1139 0.1139
Loa Loa (eye worm) hypothetical protein 0.1004 0.8371 0.8362
Echinococcus granulosus Protein kinase C brain isozyme 0.007 0.0467 0.041
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0336 0.2717 0.2673
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.2299 0.2253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.1004 0.8371 0.8371
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.007 0.0467 0.041
Echinococcus granulosus ras gtpase 0.0337 0.2722 0.2678
Leishmania major cysteine peptidase A (CPA) 0.0022 0.006 0.006
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0135 0.1012 0.0958
Trichomonas vaginalis AGC family protein kinase 0.007 0.0467 0.0467
Schistosoma mansoni cathepsin D (A01 family) 0.0845 0.7026 0.7009
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.1196 1 1
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Entamoeba histolytica protein kinase, putative 0.0218 0.172 0.172
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Leishmania major farnesyltransferase beta subunit 0.1196 1 1
Plasmodium vivax aspartyl protease, putative 0.0068 0.0447 0.0447
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.1196 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trypanosoma brucei lanosterol synthase 0.0984 0.82 0.82
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0136 0.1025 0.1025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Plasmodium vivax aspartyl proteinase, putative 0.0287 0.2299 0.2299
Trypanosoma brucei hypothetical protein, conserved 0.046 0.3769 0.3769
Echinococcus multilocularis serine:threonine protein kinase 38 0.007 0.0467 0.041
Leishmania major protein farnesyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Leishmania major geranylgeranyltransferase, putative 0.0336 0.2717 0.2717
Trypanosoma cruzi rac serine-threonine kinase, putative 0.015 0.1139 0.1139
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0135 0.1012 0.0958
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0336 0.2717 0.2717
Echinococcus granulosus serine:threonine protein kinase N2 0.007 0.0467 0.041
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1004 0.8371 0.8371
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0136 0.1025 0.1025
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Loa Loa (eye worm) AGC/NDR protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0581 0.0581
Echinococcus multilocularis nervana 2 0.0135 0.1012 0.0958
Toxoplasma gondii aspartyl protease 0.0068 0.0447 0.0447
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.1004 0.8371 0.8371
Plasmodium falciparum plasmepsin VI 0.0287 0.2299 0.2299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Echinococcus multilocularis serine:threonine protein kinase N2 0.007 0.0467 0.041
Entamoeba histolytica Ras family GTPase 0.0337 0.2722 0.2722
Giardia lamblia Prenyltransferase 0.1196 1 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.007 0.0467 0.041
Plasmodium falciparum plasmepsin VII 0.0068 0.0447 0.0447
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0069 0.0454 0.0454
Trypanosoma cruzi protein farnesyltransferase, putative 0.1196 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.015 0.1139 0.1086
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.006 0.006
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.007 0.0467 0.041
Echinococcus multilocularis Protein kinase C, brain isozyme 0.007 0.0467 0.041
Echinococcus multilocularis nervana 2 0.0135 0.1012 0.0958
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.006 0.006
Plasmodium vivax aspartyl proteinase, putative 0.0068 0.0447 0.0447
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0068 0.0447 0.0447
Trypanosoma brucei rac serine-threonine kinase, putative 0.0218 0.172 0.172
Plasmodium falciparum plasmepsin I 0.0287 0.2299 0.2299
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Entamoeba histolytica ras-1, putative 0.0337 0.2722 0.2722
Echinococcus granulosus protein kinase C gamma type 0.007 0.0467 0.041
Entamoeba histolytica protein kinase, putative 0.007 0.0467 0.0467
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0336 0.2717 0.2673
Toxoplasma gondii aspartyl protease ASP3 0.0068 0.0447 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Echinococcus granulosus Glutaredoxin protein 5 0.0135 0.1012 0.0958
Loa Loa (eye worm) AGC/PKN protein kinase 0.007 0.0467 0.041
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.046 0.3769 0.3732
Trypanosoma cruzi lanosterol synthase, putative 0.0984 0.82 0.82
Trypanosoma brucei protein farnesyltransferase beta subunit 0.1196 1 1
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis rheb, putative 0.0337 0.2722 0.2722
Echinococcus multilocularis ras gtpase 0.0337 0.2722 0.2678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0287 0.2299 0.2299
Plasmodium vivax plasmepsin V, putative 0.0068 0.0447 0.0447
Plasmodium vivax conserved Plasmodium protein, unknown function 0.086 0.7156 0.7156
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0336 0.2717 0.2717
Trichomonas vaginalis GTP-binding protein rit, putative 0.0337 0.2722 0.2722
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0336 0.2717 0.2673
Loa Loa (eye worm) AGC/AKT protein kinase 0.0218 0.172 0.167
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.1004 0.8371 0.8362
Plasmodium vivax vivapain-2 0.0022 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Plasmodium falciparum plasmepsin X 0.0068 0.0447 0.0447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0336 0.2717 0.2717
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.046 0.3769 0.3732
Loa Loa (eye worm) hypothetical protein 0.0336 0.2717 0.2673
Brugia malayi Protein kinase domain containing protein 0.007 0.0467 0.041
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0287 0.2299 0.2253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.046 0.3769 0.3732
Plasmodium falciparum plasmepsin II 0.0287 0.2299 0.2299
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.006 0.006
Schistosoma mansoni atypical protein kinase C 0.007 0.0467 0.041
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Echinococcus granulosus serine threonine protein kinase nrc 0.0136 0.1025 0.0971
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0336 0.2717 0.2717
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1196 1 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.1196 1 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0336 0.2717 0.2673
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0336 0.2717 0.2717
Brugia malayi Hr1 repeat family protein 0.007 0.0467 0.041
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0336 0.2717 0.2717
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Echinococcus multilocularis serine threonine protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis dexras1, putative 0.0337 0.2722 0.2722
Echinococcus multilocularis protein kinase c iota type 0.007 0.0467 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Leishmania major lanosterol synthase, putative 0.0648 0.5356 0.5356
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Plasmodium vivax vivapain-2 0.0022 0.006 0.006
Onchocerca volvulus 0.0068 0.0447 0.1043
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis AGC family protein kinase 0.007 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0287 0.2299 0.2253
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Giardia lamblia Rab geranylgeranyltransferase 0.0336 0.2717 0.1885
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.1004 0.8371 0.8362
Schistosoma mansoni cathepsin D (A01 family) 0.0845 0.7026 0.7009
Echinococcus granulosus protein kinase c iota type 0.007 0.0467 0.041
Plasmodium falciparum plasmepsin VIII, putative 0.0068 0.0447 0.0447
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.007 0.0467 0.041
Plasmodium vivax aspartyl protease, putative 0.0068 0.0447 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0287 0.2299 0.2253
Plasmodium falciparum plasmepsin IX 0.0068 0.0447 0.0447
Loa Loa (eye worm) Ras protein let-60 0.0337 0.2722 0.2678
Schistosoma mansoni serine/threonine-protein kinase 0.015 0.1139 0.1086
Toxoplasma gondii hypothetical protein 0.0544 0.4475 0.4475
Trichomonas vaginalis ras-dva small GTPase, putative 0.0337 0.2722 0.2722
Brugia malayi Protein kinase domain containing protein 0.007 0.0467 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.006 0.006
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0068 0.0447 0.0389
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.046 0.3769 0.3769
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.007 0.0467 0.041
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.1004 0.8371 0.8362
Loa Loa (eye worm) hypothetical protein 0.0336 0.2717 0.2673
Entamoeba histolytica protein kinase 2, putative 0.0136 0.1025 0.1025
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.006 0.006
Plasmodium falciparum plasmepsin V 0.0068 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0068 0.0447 0.0389
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Entamoeba histolytica protein kinase, putative 0.0218 0.172 0.172
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.007 0.0467 0.041
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0336 0.2717 0.2717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Plasmodium falciparum plasmepsin III 0.0068 0.0447 0.0447
Echinococcus granulosus NDR protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Plasmodium falciparum geranylgeranyltransferase, putative 0.0336 0.2717 0.2717
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0544 0.4475 0.4475
Plasmodium vivax farnesyltransferase beta subunit, putative 0.1196 1 1
Entamoeba histolytica cysteine protease, putative 0.0022 0.006 0.006
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.1004 0.8371 0.8362
Toxoplasma gondii AGC kinase 0.0205 0.1606 0.1606
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.007 0.0467 0.041
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0287 0.2299 0.2299
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Entamoeba histolytica Ras family GTPase 0.0337 0.2722 0.2722
Echinococcus granulosus nervana 2 0.0135 0.1012 0.0958
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.1196 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.046 0.3769 0.3769
Loa Loa (eye worm) hypothetical protein 0.0068 0.0447 0.0389
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.1004 0.8371 0.8362
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0336 0.2717 0.2717
Plasmodium vivax plasmepsin IV, putative 0.0287 0.2299 0.2299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.006 0.006
Echinococcus multilocularis protein kinase c epsilon type 0.007 0.0467 0.041
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0205 0.1606 0.1555
Brugia malayi hypothetical protein 0.0068 0.0447 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Brugia malayi Eukaryotic aspartyl protease family protein 0.0068 0.0447 0.0389
Echinococcus multilocularis rac serine:threonine kinase 0.015 0.1139 0.1086
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0336 0.2717 0.2717
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0287 0.2299 0.2253
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0136 0.1025 0.0971
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0336 0.2717 0.2717
Brugia malayi Protein kinase domain containing protein 0.0218 0.172 0.167
Schistosoma mansoni memapsin-2 (A01 family) 0.0068 0.0447 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.046 0.3769 0.3769
Echinococcus granulosus protein prenyltransferase alpha subunit 0.046 0.3769 0.3732
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1004 0.8371 0.8371
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1196 1 1
Echinococcus granulosus protein kinase c epsilon type 0.007 0.0467 0.041
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0336 0.2717 0.2673
Onchocerca volvulus 0.046 0.3769 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0336 0.2717 0.2673
Echinococcus multilocularis serine:threonine protein kinase N2 0.007 0.0467 0.041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0336 0.2717 0.2717
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.046 0.3769 0.3769
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0984 0.82 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Brugia malayi aspartic protease BmAsp-1, identical 0.0068 0.0447 0.0389
Trypanosoma cruzi lanosterol synthase, putative 0.0984 0.82 0.82
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1196 1 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.007 0.0467 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Giardia lamblia Rab geranylgeranyltransferase 0.046 0.3769 0.3058
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0336 0.2717 0.2673
Schistosoma mansoni protein farnesyltransferase subunit beta 0.1196 1 1
Toxoplasma gondii aspartyl protease ASP1 0.0287 0.2299 0.2299
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.041
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.046 0.3769 0.3732
Toxoplasma gondii hypothetical protein 0.046 0.3769 0.3769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Brugia malayi p70 ribosomal S6 kinase beta 0.0205 0.1606 0.1555
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.1196 1 1
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0336 0.2717 0.2673
Leishmania major cathepsin L-like protease 0.0022 0.006 0.006
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.046 0.3769 0.3769
Plasmodium falciparum plasmepsin IV 0.0287 0.2299 0.2299
Trichomonas vaginalis AGC family protein kinase 0.0218 0.172 0.172
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0336 0.2717 0.2673
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.046 0.3769 0.3732
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.006 0.006
Toxoplasma gondii cathepsin CPL 0.0022 0.006 0.006
Brugia malayi Ras-related protein R-Ras2 0.0337 0.2722 0.2678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.006 0.006
Brugia malayi protein kinase C II. 0.007 0.0467 0.041
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.007 0.0467 0.041
Loa Loa (eye worm) hypothetical protein 0.0337 0.2722 0.2678
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.1196 1 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.046 0.3769 0.3769
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.1196 1 1
Plasmodium vivax geranylgeranyltransferase, putative 0.0336 0.2717 0.2717
Brugia malayi hypothetical protein 0.0068 0.0447 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Trypanosoma cruzi protein farnesyltransferase, putative 0.1196 1 1
Brugia malayi Pepsin A precursor 0.0068 0.0447 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.006 0.006
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0467 0.041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0447 0.0389
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.007 0.0467 0.041

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 2.5 uM In vitro inhibitory activity against LTB4 synthesis in A-23,187 stimulated human whole blood (HB1). ChEMBL. No reference
IC50 (functional) > 2.5 uM In vitro inhibitory activity against LTB4 synthesis in A-23,187 stimulated human whole blood (HB1). ChEMBL. No reference
Solubility = 81 uM Solubility of the compound was evaluated ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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