TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.627 | Formula: C25H34N4O3S
H donors: 0 H acceptors: 2 LogP: 3.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)C)c1ccc(s1)C(=O)N([C@H]1CCN(C1)C(=O)N([C@@H]1CCN(C1)C)C)C
InChi: 1S/C25H34N4O3S/c1-17-14-20(32-5)6-7-21(17)22-8-9-23(33-22)24(30)27(3)19-11-13-29(16-19)25(31)28(4)18-10-12-26(2)15-18/h6-9,14,18-19H,10-13,15-16H2,1-5H3/t18-,19+/m1/s1
InChiKey: IFEYOUAEYYSZDQ-MOPGFXCFSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Tubulin beta 2C chain	0.0044	0.0045	0.002
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0073	0.0311	0.0267
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0073	0.0311	0.0267
Echinococcus multilocularis	tubulin alpha 1C chain	0.0044	0.0045	0.002
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0898	0.7889	0.788
Echinococcus granulosus	beta tubulin	0.0044	0.0045	0.002
Loa Loa (eye worm)	beta-tubulin	0.0044	0.0045	0.002
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0059	0.0187	0.0143
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0073	0.0311	0.5
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0073	0.0311	0.0364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0897	0.7881	0.7881
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0213	0.1602	0.1564
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0073	0.0311	0.0364
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0213	0.1602	0.1564
Echinococcus multilocularis	Polycystic kidney disease protein	0.0082	0.04	0.0376
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0073	0.0311	0.0287
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0073	0.0311	0.0267
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0112	0.0088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0897	0.7881	0.7881
Loa Loa (eye worm)	phosphatidylinositol 3	0.0073	0.0311	0.0287
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0378	0.3116	0.3085
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0468	0.3945	0.3917
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Schistosoma mansoni	loxhd1	0.0082	0.04	0.0357
Leishmania major	fk506-binding protein 1-like protein	0.0059	0.0187	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0378	0.3116	0.3116
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0059	0.0187	0.5
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	Tubulin beta 2C chain	0.0044	0.0045	0.002
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1128	1	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0059	0.0187	0.0163
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0051	0.0112	0.0088
Echinococcus granulosus	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Schistosoma mansoni	rab6-interacting	0.0082	0.04	0.0357
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0073	0.0311	0.0267
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1128	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0044	0.0045	0.002
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0378	0.3116	0.3116
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0674	0.5832	0.5832
Leishmania major	hypothetical protein, conserved	0.0073	0.0311	0.0267
Echinococcus multilocularis	tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1128	1	1
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0059	0.0187	0.3998
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0378	0.3116	0.3085
Brugia malayi	hypothetical protein	0.0082	0.04	0.0376
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0059	0.0187	0.0143
Loa Loa (eye worm)	tubulin alpha chain	0.0044	0.0045	0.002
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1128	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0073	0.0311	0.0287
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0073	0.0311	0.0311
Echinococcus multilocularis	tubulin alpha 1C chain	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0378	0.3116	0.3085
Echinococcus granulosus	tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.6367	0.6367
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0073	0.0311	0.0287
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0059	0.0187	0.0163
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0073	0.0311	0.0311
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1128	1	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0073	0.0311	0.0287
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0073	0.0311	0.0267
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Brugia malayi	alpha-tubulin	0.0044	0.0045	0.002
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0213	0.1602	0.1564
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0073	0.0311	0.0311
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0609	0.5235	0.5235
Entamoeba histolytica	hypothetical protein	0.0073	0.0311	0.0267
Echinococcus multilocularis	tubulin beta 1 chain	0.0044	0.0045	0.002
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0213	0.1602	0.1602
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0378	0.3116	0.3085
Schistosoma mansoni	immunophilin	0.0051	0.0112	0.0067
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Echinococcus granulosus	tubulin beta 1 chain	0.0044	0.0045	0.002
Loa Loa (eye worm)	doublecortin family protein	0.0082	0.04	0.0376
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0059	0.0187	0.0143
Leishmania major	peptidylprolyl isomerase-like protein	0.0059	0.0187	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0897	0.7881	0.7881
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0533	0.4541	0.4516
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0378	0.3116	0.3085
Echinococcus granulosus	tubulin alpha chain	0.0044	0.0045	0.002
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0213	0.1602	0.1564
Echinococcus granulosus	Tubulin beta 2C chain	0.0044	0.0045	0.002
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.7492
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0897	0.7881	0.7881
Echinococcus multilocularis	tubulin alpha 3 chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0609	0.5235	0.5235
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0267
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.7492
Echinococcus multilocularis	tubulin gamma 1 chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0608	0.5227	0.5227
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0059	0.0187	0.0143
Plasmodium vivax	multidomain scavenger receptor, putative	0.0082	0.04	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0073	0.0311	0.0267
Brugia malayi	hypothetical protein	0.0082	0.04	0.0376
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0213	0.1602	0.1581
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0311
Onchocerca volvulus		0.0082	0.04	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0044	0.0045	0.0045
Trichomonas vaginalis	tubulin gamma chain, putative	0.0044	0.0045	0.0045
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0213	0.1602	0.1564
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0311
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0059	0.0187	0.0187
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0073	0.0311	0.0287
Echinococcus multilocularis	Tubulin beta 2C chain	0.0044	0.0045	0.002
Echinococcus multilocularis	beta tubulin	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0044	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0165	0.1158	0.1117
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0238	0.1826	0.2439
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0082	0.04	0.0376
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0073	0.0311	0.0287
Echinococcus granulosus	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0059	0.0187	0.5
Echinococcus multilocularis	tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0073	0.0311	0.0311
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0059	0.0187	0.0143
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	lipoxygenase domain containing protein	0.0082	0.04	0.0376
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0059	0.0187	0.0143
Plasmodium vivax	hypothetical protein	0.0073	0.0311	0.7492
Echinococcus granulosus	lipoxygenase domain containing protein	0.0082	0.04	0.0376
Schistosoma mansoni	immunophilin	0.0059	0.0187	0.0143
Echinococcus granulosus	Tubulin beta 2C chain	0.0044	0.0045	0.002
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0378	0.3116	0.3099
Loa Loa (eye worm)	tubulin gamma chain	0.0044	0.0045	0.002
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1128	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0839	0.7346	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0073	0.0311	0.0364
Leishmania major	hypothetical protein, unknown function	0.0073	0.0311	0.0267
Trichomonas vaginalis	immunophilin, putative	0.0059	0.0187	0.0187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0073	0.0311	0.0287
Echinococcus multilocularis	tubulin alpha 3 chain	0.0044	0.0045	0.002
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0073	0.0311	0.0267
Loa Loa (eye worm)	phosphatidylinositol 3	0.0073	0.0311	0.0287
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0073	0.0311	0.0267
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267
Brugia malayi	tubulin alpha-2 chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0757	0.659	0.659
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0073	0.0311	0.0267
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0213	0.1602	0.1581
Trichomonas vaginalis	conserved hypothetical protein	0.0238	0.1826	0.1826
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0073	0.0311	0.0267
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0073	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0082	0.04	0.0376
Echinococcus multilocularis	serine protein kinase ATM	0.0213	0.1602	0.1581
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0073	0.0311	0.0267
Loa Loa (eye worm)	BEN-1 protein	0.0044	0.0045	0.002
Echinococcus multilocularis	tubulin alpha chain	0.0044	0.0045	0.002
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0378	0.3116	0.3085
Trichomonas vaginalis	tubulin alpha chain, putative	0.0044	0.0045	0.0045
Giardia lamblia	GTOR	0.1128	1	1
Brugia malayi	Tubulin gamma chain	0.0044	0.0045	0.002
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0073	0.0311	0.0287
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0044	0.0045	0.002
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0073	0.0311	0.0287
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0082	0.04	0.0376
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.0934	0.0934
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0608	0.5227	0.5227
Loa Loa (eye worm)	phosphatidylinositol 3	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0667	0.577	0.577
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0073	0.0311	0.0287
Echinococcus multilocularis		0.0073	0.0311	0.0287
Schistosoma mansoni	hypothetical protein	0.0082	0.04	0.0357
Echinococcus multilocularis	peroxisome assembly protein 26	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin gamma chain, putative	0.0044	0.0045	0.0045
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0165	0.1158	0.1135
Loa Loa (eye worm)	phosphatidylinositol 3	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0674	0.5832	0.5832
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0213	0.1602	0.1581
Schistosoma mansoni	immunophilin	0.0059	0.0187	0.0143
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0059	0.0187	0.0143
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0059	0.0187	0.0143
Echinococcus granulosus	RUN	0.0082	0.04	0.0376
Brugia malayi	Doublecortin family protein	0.0082	0.04	0.0376
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0073	0.0311	0.0364
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1128	1	1
Echinococcus granulosus	tubulin alpha chain	0.0044	0.0045	0.002
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0073	0.0311	0.0267
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0059	0.0187	0.0187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trichomonas vaginalis	tubulin alpha chain, putative	0.0044	0.0045	0.0045
Echinococcus granulosus	Polycystic kidney disease protein	0.0082	0.04	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0609	0.5235	0.5235
Toxoplasma gondii	FATC domain-containing protein	0.0213	0.1602	0.2132
Entamoeba histolytica	hypothetical protein	0.0213	0.1602	0.1564
Brugia malayi	Tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0378	0.3116	0.3116
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0213	0.1602	0.1602
Trichomonas vaginalis	fk506-binding protein, putative	0.0059	0.0187	0.0187
Loa Loa (eye worm)	phosphatidylinositol 3	0.1128	1	1
Echinococcus granulosus	tubulin alpha	0.0044	0.0045	0.002
Echinococcus granulosus	tubulin gamma 1 chain	0.0044	0.0045	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.1158	0.1158
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0311	0.7492
Echinococcus multilocularis	tubulin subunit beta	0.0044	0.0045	0.002
Schistosoma mansoni	lipoxygenase	0.0345	0.281	0.2777
Echinococcus granulosus	tubulin alpha 3 chain	0.0044	0.0045	0.002
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0051	0.0112	0.0088
Brugia malayi	beta-tubulin, identical	0.0044	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0311	0.0287
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Schistosoma mansoni	rab6-interacting	0.0082	0.04	0.0357
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.006	0.0015
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0059	0.0187	0.0163
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0059	0.0187	0.0163
Echinococcus granulosus	serine protein kinase ATM	0.0213	0.1602	0.1581
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0059	0.0187	0.3998
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0378	0.3116	0.3085
Schistosoma mansoni	lipoxygenase	0.0493	0.4173	0.4146
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	tubulin epsilon chain	0.0044	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.023	0.1754	0.1733
Echinococcus multilocularis	tubulin subunit TubB	0.0044	0.0045	0.002
Echinococcus granulosus	tubulin subunit beta	0.0044	0.0045	0.002
Echinococcus multilocularis	tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0311
Loa Loa (eye worm)	tubulin alpha chain	0.0044	0.0045	0.002
Brugia malayi	Tubulin alpha-2 chain	0.0044	0.0045	0.002
Echinococcus granulosus	tubulin subunit TubB	0.0044	0.0045	0.002
Echinococcus multilocularis	beta tubulin	0.0044	0.0045	0.002
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0667	0.577	0.577
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Loa Loa (eye worm)	phosphatidylinositol 3	0.0378	0.3116	0.3099
Plasmodium falciparum	LCCL domain-containing protein	0.0082	0.04	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0044	0.0045	0.002
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0073	0.0311	0.7492
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0165	0.1158	0.1135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.0934	0.0934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0303	0.2422	0.2422
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0059	0.0187	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0141	0.0934	0.0892
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0609	0.5235	0.5235
Echinococcus multilocularis	hypothetical protein	0.0044	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1826	0.1805
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0267
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0897	0.7881	0.7881
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0213	0.1602	0.1581
Loa Loa (eye worm)	tubulin beta-4 chain	0.0044	0.0045	0.002
Loa Loa (eye worm)	tubulin beta chain	0.0044	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0311	0.0287
Entamoeba histolytica	hypothetical protein	0.0073	0.0311	0.0267
Loa Loa (eye worm)	alpha-tubulin	0.0044	0.0045	0.002
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.7492
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0073	0.0311	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0963	0.8486	0.8486
Entamoeba histolytica	hypothetical protein	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0378	0.3116	0.3116
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1128	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0311	0.0311
Echinococcus granulosus	tubulin alpha 3 chain	0.0044	0.0045	0.002
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0073	0.0311	0.0287
Echinococcus multilocularis	RUN	0.0082	0.04	0.0376
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0073	0.0311	0.0311
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0073	0.0311	0.0267
Schistosoma mansoni	hypothetical protein	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0213	0.1602	0.1602
Echinococcus granulosus	Tubulin beta 2C chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0378	0.3116	0.3116
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0073	0.0311	0.0287
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Echinococcus granulosus	tubulin beta 4A class IVa	0.0044	0.0045	0.002
Echinococcus multilocularis	tubulin alpha	0.0044	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0934	0.0911
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0311
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1128	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0044	0.0045	0.002
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0073	0.0311	0.7492
Onchocerca volvulus		0.0082	0.04	1
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0073	0.0311	0.7492
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	peroxisome assembly protein 26	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin, putative	0.0044	0.0045	0.0045
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	tubulin alpha 1C chain	0.0044	0.0045	0.002
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0073	0.0311	0.0287
Echinococcus granulosus	tubulin alpha chain	0.0044	0.0045	0.002
Entamoeba histolytica	hypothetical protein	0.0073	0.0311	0.0267
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1128	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0378	0.3116	0.3099
Echinococcus multilocularis	tubulin alpha chain	0.0044	0.0045	0.002
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0059	0.0187	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1158	0.1135
Echinococcus granulosus	Tubulin alpha 1 chain	0.0044	0.0045	0.002
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0073	0.0311	0.0311
Brugia malayi	Tubulin alpha-2 chain	0.0044	0.0045	0.002
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0073	0.0311	0.0287
Echinococcus multilocularis	Tubulin beta 2C chain	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0044	0.0045	0.0045
Echinococcus multilocularis	Tubulin beta 2C chain	0.0044	0.0045	0.002
Echinococcus multilocularis	fk506 binding protein	0.0059	0.0187	0.0163
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0073	0.0311	0.0267
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0378	0.3116	0.3099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0311	0.0311
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0493	0.4173	0.4158
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.006	0.0015
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0073	0.0311	0.0287
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1128	1	1
Brugia malayi	tubulin alpha chain - mouse	0.0044	0.0045	0.002
Giardia lamblia	Hypothetical protein	0.0073	0.0311	0.0267
Loa Loa (eye worm)	tubulin beta-1 chain	0.0044	0.0045	0.002
Entamoeba histolytica	protein kinase rad3, putative	0.0213	0.1602	0.1564
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0073	0.0311	0.0364
Loa Loa (eye worm)	BEN-1 protein	0.0044	0.0045	0.002
Brugia malayi	FAT domain containing protein	0.0165	0.1158	0.1135
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0898	0.7889	0.788
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0073	0.0311	0.0267
Loa Loa (eye worm)	FKBP5 protein	0.0059	0.0187	0.0163
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0044	0.0045	0.0045
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0044	0.0045	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0608	0.5227	0.5227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0674	0.5832	0.5832
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0073	0.0311	0.0287
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0073	0.0311	0.0311
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0493	0.4173	0.4158
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1602	0.1581
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0044	0.0045	0.0045
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0311	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1128	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0073	0.0311	0.0287
Echinococcus granulosus	alpha tubulin	0.0044	0.0045	0.002
Loa Loa (eye worm)	tubulin beta-2A chain	0.0044	0.0045	0.002
Leishmania major	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0839	0.7346	0.7346
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0213	0.1602	0.1564
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0059	0.0187	0.0163
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0059	0.0187	0.0143
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0073	0.0311	0.0267
Trypanosoma cruzi	target of rapamycin kinase 3	0.0898	0.7889	0.788
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0073	0.0311	0.7492
Echinococcus granulosus	tubulin alpha chain	0.0044	0.0045	0.002
Trichomonas vaginalis	tubulin beta chain, putative	0.0044	0.0045	0.0045
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1128	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0044	0.0045	0.002
Brugia malayi	Tubulin beta-1 chain	0.0044	0.0045	0.002
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0267
Echinococcus multilocularis	tubulin epsilon chain	0.0044	0.0045	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1128	1	1
Schistosoma mansoni	polycystin 1-related	0.0082	0.04	0.0357
Echinococcus granulosus	beta tubulin	0.0044	0.0045	0.002
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0073	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0082	0.04	0.0376
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0059	0.0187	0.0143
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0073	0.0311	0.0267

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3 nM	Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements	ChEMBL.	15950467
Ki (binding)	= 3 nM	Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements	ChEMBL.	15950467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 328975