Detailed information for compound 336374

Basic information

Technical information
  • TDR Targets ID: 336374
  • Name: (1E)-1-[amino-(4-chloroanilino)methylidene]-2 -propan-2-ylguanidine
  • MW: 253.731 | Formula: C11H16ClN5
  • H donors: 3 H acceptors: 0 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=N)NC(=N)Nc1ccc(cc1)Cl)C
  • InChi: 1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
  • InChiKey: SSOLNOMRVKKSON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1E)-1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine
  • (1E)-1-[amino-(4-chloroanilino)methylene]-2-isopropylguanidine
  • (1E)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine
  • (1E)-1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropyl-guanidine
  • (1E)-1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropylguanidine
  • (1E)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • (1E)-1-[azanyl-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • (1Z)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
  • (1Z)-1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine
  • (1Z)-1-[amino-(4-chloroanilino)methylene]-2-isopropylguanidine
  • (1Z)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine
  • (1Z)-1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropyl-guanidine
  • (1Z)-1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropylguanidine
  • (1Z)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • (1Z)-1-[azanyl-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • (hydrochloride)
  • 1-(p-Chlorophenyl)-5-isopropylbiguanide
  • 1-Isopropyl-5-(4-chlorophenyl)biguanide
  • 1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
  • 1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine
  • 1-[amino-(4-chloroanilino)methylene]-2-isopropylguanidine
  • 1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine
  • 1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropyl-guanidine
  • 1-[amino-[(4-chlorophenyl)amino]methylene]-2-isopropylguanidine
  • 1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • 1-[azanyl-[(4-chlorophenyl)amino]methylidene]-2-propan-2-yl-guanidine
  • 4-12-00-01198 (Beilstein Handbook Reference)
  • 46920-30-3
  • 500-92-5
  • 637-32-1 (HYDROCHLORIDE)
  • AIDS-008307
  • AIDS008307
  • BIGUANIDE, 1-(p-CHLOROPHENYL)-5-ISOPROPYL-
  • Bigumal
  • BPBio1_001207
  • BRN 2811599
  • BSPBio_001097
  • BSPBio_003417
  • C07631
  • CAS-637-32-1
  • Chlorguanid
  • Chlorguanide
  • Chloroguanide
  • Diguanyl (hydrochloride)
  • DivK1c_006763
  • Drinupal (hydrochloride)
  • EINECS 207-915-6
  • Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
  • KBio1_001707
  • KBio2_002068
  • KBio2_004636
  • KBio2_007204
  • KBio3_002637
  • KBioGR_001204
  • KBioSS_002068
  • M-4888 (hydrochloride)
  • malarone
  • N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide
  • N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
  • N1-p-Chlorophenyl-N5-isopropylbiguanide
  • NCGC00016528-01
  • NSC12977 (HYDROCHLORIDE)
  • Paludrin
  • Paludrine (hydrochloride)
  • Palusil (hydrochloride)
  • Prestwick0_000999
  • Prestwick1_000999
  • Prestwick2_000999
  • Prestwick3_000999
  • Proguanil
  • Proguanile [DCIT]
  • Proguanilum [INN-Latin]
  • RP-3359
  • SN-12837 (hydrochloride)
  • SPBio_001029
  • SPBio_002988
  • SpecPlus_000667
  • Spectrum2_001135
  • Spectrum3_001659
  • Spectrum4_000622
  • Spectrum5_001384
  • Spectrum_001588
  • Tirian (hydrochloride)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Plasmodium falciparum dihydroorotase, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum dihydroorotase protein, putative Get druggable targets OG5_130129 All targets in OG5_130129
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii hypothetical protein Get druggable targets OG5_130129 All targets in OG5_130129
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Dihydrooratase: used in pyrimidine biosynthesis. Get druggable targets OG5_130129 All targets in OG5_130129
Toxoplasma gondii dihydroorotase Get druggable targets OG5_130129 All targets in OG5_130129
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Plasmodium knowlesi dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Candida albicans Dihydrooratase: used in pyrimidine biosynthesis. Get druggable targets OG5_130129 All targets in OG5_130129
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydroorotase, putative Get druggable targets OG5_130129 All targets in OG5_130129
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Wolbachia endosymbiont of Brugia malayi dihydroorotase, PyrC dihydroorotase, putative 358 aa 301 aa 23.9 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0061 0.0505
Schistosoma mansoni hypothetical protein 0.0101 0.0219 0.1656
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0061 0.0505
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0052 0.0147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Trichomonas vaginalis CK1 family protein kinase 0.051 0.1205 1
Schistosoma mansoni amine GPCR 0.0035 0.0061 0.0316
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Onchocerca volvulus 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Echinococcus multilocularis nibrin 0.0031 0.0052 0.0052
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0024
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0061 0.0452
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Onchocerca volvulus 0.0033 0.0055 0.0269
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0076 0.0441
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0045 0.037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0207 0.1403
Onchocerca volvulus Protein patched homolog 0.0024 0.0035 0.0097
Schistosoma mansoni coup transcription factor 0.0041 0.0076 0.0441
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0052 0.5
Echinococcus multilocularis casein kinase I alpha 0.051 0.1205 0.1205
Schistosoma mansoni hypothetical protein 0.0052 0.0102 0.0667
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Loa Loa (eye worm) TAR-binding protein 0.0138 0.0308 0.2559
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0052 0.0147
Echinococcus granulosus orexin receptor type 2 0.0035 0.0061 0.0452
Brugia malayi hypothetical protein 0.0031 0.0052 0.028
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0207 0.1589
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0102 0.0703
Schistosoma mansoni biogenic amine receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0061 0.0505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0076 0.0441
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0122 0.3404
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0096 0.0207 0.1722
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0045 0.037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Trypanosoma cruzi casein kinase, putative 0.051 0.1205 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0055 0.0411
Onchocerca volvulus 0.0035 0.0061 0.0316
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0052 0.0242
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0045 0.037
Echinococcus multilocularis sterol regulatory element binding protein 0.0171 0.0388 0.0388
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0207 0.6657
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0076 0.0563
Brugia malayi ecdysteroid receptor 0.0041 0.0076 0.0478
Loa Loa (eye worm) patched family protein 0.0024 0.0035 0.029
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Schistosoma mansoni protein kinase 0.051 0.1205 1
Schistosoma mansoni hypothetical protein 0.0205 0.0469 0.3774
Brugia malayi G-protein coupled receptor 0.0035 0.0061 0.0353
Schistosoma mansoni intermediate filament proteins 0.0033 0.0055 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0061 0.0316
Onchocerca volvulus 0.0096 0.0207 0.1557
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0207 0.1589
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0061 0.0452
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0061 0.0316
Echinococcus multilocularis survival motor neuron protein 1 0.0493 0.1164 0.1164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus granulosus expressed conserved protein 0.0374 0.0876 0.6514
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0207 0.6657
Brugia malayi hypothetical protein 0.0019 0.0024 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0076 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0061 0.0316
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0045 0.037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0076 0.0478
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0045 0.037
Onchocerca volvulus 0.0028 0.0045 0.0179
Loa Loa (eye worm) hypothetical protein 0.0191 0.0437 0.3627
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0061 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0076 0.0441
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0052 0.0065
Mycobacterium ulcerans hypothetical protein 0.0096 0.0207 0.6657
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0171 0.0388 0.3218
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.0289 0.2249
Echinococcus multilocularis serotonin receptor 0.0035 0.0061 0.0061
Brugia malayi Niemann-Pick C1 protein precursor 0.0398 0.0934 0.7716
Echinococcus granulosus casein kinase I delta 0.051 0.1205 0.896
Brugia malayi larval opioid receptor 0.0035 0.0061 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0028 0.0045 0.037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0264 0.2193
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0024 0.0039
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Entamoeba histolytica hypothetical protein 0.0146 0.0328 0.2445
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0065
Leishmania major casein kinase, putative 0.051 0.1205 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0076 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Onchocerca volvulus 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi Dopamine receptor 0.0035 0.0061 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0388 0.2957
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0055 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0076 0.0478
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0398 0.0934 0.7666
Onchocerca volvulus 0.0035 0.0061 0.0316
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0061 0.0353
Brugia malayi tailless protein 0.0019 0.0024 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Onchocerca volvulus 0.0024 0.0035 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0061 0.0316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0076 0.0563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0061 0.0452
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0122 0.0905
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.1238
Schistosoma mansoni biogenic amine receptor 0.0035 0.0061 0.0316
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0076 0.0076
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0024 0.0195
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0104 0.0684
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi neuropeptide F receptor 0.0035 0.0061 0.0353
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0061 0.0316
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0052 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0076 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Toxoplasma gondii casein kinase I 0.051 0.1205 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.1238
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0241
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.1238
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Brugia malayi G protein-coupled receptor 0.0035 0.0061 0.0353
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0104 0.2719
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Echinococcus granulosus lamin 0.0033 0.0055 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0126 0.0697
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0076 0.0441
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Onchocerca volvulus 0.013 0.0289 0.2249
Schistosoma mansoni topbp1 0.0031 0.0052 0.0242
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0052 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni hypothetical protein 0.0052 0.0102 0.0667
Schistosoma mansoni amine GPCR 0.0035 0.0061 0.0316
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0061 0.0316
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0076 0.0563
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0061 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0065
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0045 0.037
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0045 0.0082
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Onchocerca volvulus Protein patched homolog 0.0024 0.0035 0.0097
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0045 0.037
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0061 0.0061
Onchocerca volvulus 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi hypothetical protein 0.0022 0.0029 0.0086
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0045 0.0217
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0328 0.2441
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0328 0.258
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0104 0.072
Schistosoma mansoni neuropeptide receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0241
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0061 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Brugia malayi MH2 domain containing protein 0.0119 0.0264 0.2068
Onchocerca volvulus 0.0024 0.0035 0.0097
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0149 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0096 0.0207 0.1722
Schistosoma mansoni histamine h1 receptor 0.0035 0.0061 0.0316
Schistosoma mansoni lamin 0.0033 0.0055 0.0269
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0076 0.0441
Onchocerca volvulus 0.0031 0.0051 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Trypanosoma cruzi casein kinase, putative 0.051 0.1205 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0111
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0051 0.0427
Onchocerca volvulus 0.0048 0.0093 0.0585
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0207 0.6781
Schistosoma mansoni hypothetical protein 0.0441 0.1038 0.8586
Echinococcus granulosus neuropeptide receptor 0.0035 0.0061 0.0452
Onchocerca volvulus 0.0101 0.0219 0.1656
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0104 0.2439
Echinococcus multilocularis thymidylate synthase 0.013 0.0289 0.0289
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0061 0.0061
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0045 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0241
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0052 0.0065
Echinococcus multilocularis cpg binding protein 0.0033 0.0056 0.0056
Echinococcus granulosus GPCR family 2 0.0052 0.0102 0.0761
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0076 0.0441
Schistosoma mansoni survival motor neuron protein 0.0101 0.0219 0.1656
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0061 0.0452
Echinococcus multilocularis tar DNA binding protein 0.0138 0.0308 0.0308
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0076 0.0076
Loa Loa (eye worm) patched family protein 0.0024 0.0035 0.029
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0045 0.037
Brugia malayi neuropeptide F receptor 0.0035 0.0061 0.0353
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0207 0.6657
Brugia malayi nuclear receptor NHR-88 0.0041 0.0076 0.0478
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0102 0.0849
Schistosoma mansoni DNA ligase IV 0.0031 0.0052 0.0242
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0045 0.0179
Onchocerca volvulus 0.0035 0.0061 0.0316
Brugia malayi Dihydrofolate reductase 0.0053 0.0104 0.072
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0045 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0308 0.2411
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0076 0.0441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0045 0.037
Schistosoma mansoni hypothetical protein 0.0165 0.0373 0.2957
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi hypothetical protein 0.0024 0.0035 0.0135
Echinococcus granulosus survival motor neuron protein 1 0.0493 0.1164 0.8657
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0076 0.0478
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0061 0.0452
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0207 0.1403
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0061 0.0452
Schistosoma mansoni neuropeptide receptor 0.0035 0.0061 0.0316
Echinococcus granulosus neuropeptide receptor 0.0035 0.0061 0.0452
Schistosoma mansoni hypothetical protein 0.0062 0.0127 0.0878
Echinococcus granulosus somatostatin receptor 0.0035 0.0061 0.0452
Brugia malayi hypothetical protein 0.0024 0.0035 0.0135
Schistosoma mansoni amine GPCR 0.0035 0.0061 0.0316
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0061 0.0353
Brugia malayi RE15519p 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0052 0.0065
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0024 0.0175
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0024 0.0175
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0207 0.6657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0191 0.0437 0.3525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0076 0.0628
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0029 0.0086
Entamoeba histolytica hypothetical protein 0.0146 0.0328 0.2445
Schistosoma mansoni hypothetical protein 0.0052 0.0102 0.0667
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0052 0.0052
Brugia malayi protein C24B5.3 0.0024 0.0035 0.0135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0076 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni opsin-like receptor 0.0035 0.0061 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0122 0.315
Brugia malayi casein kinase I 0.051 0.1205 1
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.014 0.4116
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0061 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Schistosoma mansoni hypothetical protein 0.0146 0.0328 0.258
Brugia malayi hypothetical protein 0.0062 0.0126 0.0898
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0061 0.0353
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0316
Brugia malayi nuclear hormone receptor 0.0019 0.0024 0.0039
Onchocerca volvulus 0.0028 0.0045 0.0179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0061 0.0061
Brugia malayi protein C24B5.3 0.0024 0.0035 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0045 0.037
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0061 0.0505
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0122 0.315
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0122 0.0664
Onchocerca volvulus 0.0024 0.0035 0.0097
Onchocerca volvulus 0.0035 0.0061 0.0316
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0052 0.0307
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Echinococcus multilocularis casein kinase I alpha 0.051 0.1205 0.1205
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0424 0.3273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0076 0.0628
Brugia malayi Patched protein homolog 1 0.0024 0.0035 0.0135
Brugia malayi Patched related family protein 10 0.0024 0.0035 0.0135
Treponema pallidum DNA ligase (lig) 0.0031 0.0052 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0122 0.0741
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0104 0.0775
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi conserved hypotetical protein 0.0019 0.0024 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.0373 0.2988
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0076 0.0478
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0061 0.0452
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0061 0.0061
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus granulosus casein kinase I delta 0.051 0.1205 0.896
Onchocerca volvulus 0.0031 0.0052 0.0242
Echinococcus granulosus nibrin 0.0031 0.0052 0.0388
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.014 0.4116
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0076 0.0478
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0061 0.0452
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus multilocularis tumor protein p63 0.0328 0.0767 0.0767
Echinococcus multilocularis Niemann Pick C1 protein 0.0398 0.0934 0.0934
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0118 0.071
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0024 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0308 0.2411
Loa Loa (eye worm) patched family protein 0.0024 0.0035 0.029
Entamoeba histolytica hypothetical protein 0.0146 0.0328 0.2445
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0207 0.6781
Onchocerca volvulus 0.0035 0.0061 0.0316
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0316
Echinococcus granulosus serotonin receptor 0.0035 0.0061 0.0452
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0316
Loa Loa (eye worm) patched family protein 0.0024 0.0035 0.029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0219 0.1688
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0061 0.0316
Onchocerca volvulus 0.0024 0.0035 0.0097
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0052 0.0065
Plasmodium falciparum dihydroorotase, putative 0.0271 0.0628 0.5068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0149 0.4275
Echinococcus multilocularis lamin 0.0033 0.0055 0.0055
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Echinococcus multilocularis musashi 0.0033 0.0055 0.0055
Brugia malayi Serotonin receptor 0.0035 0.0061 0.0353
Echinococcus granulosus g protein coupled receptor 0.0035 0.0061 0.0452
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0061 0.0353
Entamoeba histolytica hypothetical protein 0.0146 0.0328 0.2445
Schistosoma mansoni hypothetical protein 0.0165 0.0373 0.2957
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0052 0.0388
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0061 0.0061
Brugia malayi nuclear receptor NHR-67 0.0019 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0076 0.0478
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0076 0.0441
Trypanosoma brucei casein kinase I, isoform 2 0.051 0.1205 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0076 0.0076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0404 0.0949 0.7833
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Toxoplasma gondii dihydroorotase 0.0271 0.0628 0.5068
Schistosoma mansoni hypothetical protein 0.0052 0.0102 0.0667
Echinococcus multilocularis casein kinase I alpha 0.051 0.1205 0.1205
Onchocerca volvulus 0.051 0.1205 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0076 0.0628
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0029 0.0047
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0039
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0052 0.028
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0061 0.0452
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0029 0.0241
Schistosoma mansoni myosin xvIII 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0096 0.0207 0.1722
Schistosoma mansoni biogenic amine receptor 0.0035 0.0061 0.0316
Onchocerca volvulus 0.0035 0.0061 0.0316
Echinococcus granulosus casein kinase I alpha 0.051 0.1205 0.896
Echinococcus granulosus geminin 0.0205 0.0469 0.349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Brugia malayi hypothetical protein 0.0146 0.0328 0.2608
Loa Loa (eye worm) hypothetical protein 0.0052 0.0102 0.0849
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Brugia malayi Serotonin receptor 0.0035 0.0061 0.0353
Brugia malayi ORL1-like opioid receptor 0.0035 0.0061 0.0353
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0061 0.0061
Brugia malayi Melatonin receptor type 1A 0.0035 0.0061 0.0353
Onchocerca volvulus 0.0035 0.0061 0.0316
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0039
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Schistosoma mansoni hypothetical protein 0.0113 0.0248 0.1899
Echinococcus granulosus casein kinase i 0.051 0.1205 0.896
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0447
Brugia malayi GnHR receptor homolog 0.0035 0.0061 0.0353
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0061 0.0452
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0076 0.0563
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.051 0.1205 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0061 0.0316
Loa Loa (eye worm) patched family protein 0.0024 0.0035 0.029
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0061 0.0316
Entamoeba histolytica casein kinase 1, putative 0.051 0.1205 1
Onchocerca volvulus 0.0024 0.0035 0.0097
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0061 0.0316
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0061 0.0061
Loa Loa (eye worm) thymidylate synthase 0.013 0.0289 0.24
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus granulosus tumor protein p63 0.0328 0.0767 0.5704
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0045 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0061 0.0316
Brugia malayi DKFZp564C0469 protein 0.0031 0.0052 0.028
Brugia malayi sulfakinin receptor protein 0.0035 0.0061 0.0353
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0061 0.0061
Plasmodium vivax dihydroorotase, putative 0.0271 0.0628 0.5068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Onchocerca volvulus 0.0035 0.0061 0.0316
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0328 0.0328
Echinococcus granulosus tar DNA binding protein 0.0138 0.0308 0.2293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0076 0.0628
Brugia malayi casein kinase 1, delta 0.051 0.1205 1
Echinococcus multilocularis protein dispatched 1 0.0195 0.0446 0.0446
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0061 0.0353
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.051 0.1205 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.014 0.4116
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0052 0.0065
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Brugia malayi CXXC zinc finger family protein 0.0031 0.0051 0.0274
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0061 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni neuropeptide receptor 0.0035 0.0061 0.0316
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0061 0.0452
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0052 0.0307
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0045 0.037
Brugia malayi ecdysone receptor 0.0019 0.0024 0.0039
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0061 0.0452
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0102 0.0761
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0061 0.0353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0024 0.0175
Echinococcus granulosus casein kinase I alpha 0.051 0.1205 0.896
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus multilocularis casein kinase i 0.051 0.1205 0.1205
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.0417 0.3205
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0045 0.0217
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0061 0.0353
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0061 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0061 0.0452
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0045 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0207 0.1589
Trichomonas vaginalis CK1 family protein kinase 0.051 0.1205 1
Brugia malayi topoisomerase 0.0031 0.0052 0.028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0076 0.0478
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0398 0.0934 0.7752
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Brugia malayi nuclear receptor RXR 0.0022 0.0029 0.0086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0175
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0045 0.0082
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0061 0.0316
Schistosoma mansoni cpg binding protein 0.0033 0.0056 0.0272
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Onchocerca volvulus 0.0035 0.0061 0.0316
Brugia malayi putative neuropeptide receptor 0.0035 0.0061 0.0353
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0104 0.5373
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0076 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0207 0.1403
Schistosoma mansoni hypothetical protein 0.0165 0.0373 0.2957
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0061 0.0316
Brugia malayi Dopamine receptor protein 2 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.1238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0102 0.0703
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.0417 0.3261
Brugia malayi hypothetical protein 0.0019 0.0024 0.0039
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Trypanosoma cruzi casein kinase, putative 0.051 0.1205 1
Echinococcus multilocularis casein kinase I delta 0.051 0.1205 0.1205
Echinococcus granulosus Protein patched homolog 1 0.0171 0.0388 0.2883
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.0417 0.3205
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0061 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0104 0.0865
Echinococcus granulosus thymidylate synthase 0.013 0.0289 0.215
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0029 0.0047
Brugia malayi hypothetical protein 0.0493 0.1164 0.9656
Echinococcus multilocularis protein patched 0.0171 0.0388 0.0388
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0029 0.0216
Schistosoma mansoni neuropeptide receptor 0.0035 0.0061 0.0316
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0135 0.0943
Brugia malayi CHE-14 protein 0.0171 0.0388 0.3109
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0207 0.6657
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0024 0.0024
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0076 0.0441
Mycobacterium ulcerans thymidylate synthase 0.013 0.0289 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0122 0.0831
Onchocerca volvulus 0.0035 0.0061 0.0316
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0207 0.6657
Brugia malayi intermediate filament protein 0.0033 0.0055 0.0307
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0122 0.315
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0045 0.037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0076 0.0441
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0076 0.0076
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0045 0.0045
Onchocerca volvulus 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0113 0.0248 0.2057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.0308 0.2559
Echinococcus granulosus allatostatin A receptor 0.0035 0.0061 0.0452
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0045 0.0217
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0076 0.0441
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0308 0.2411
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus sterol regulatory element binding protein 0.0171 0.0388 0.2883
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.014 0.4116
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0175
Brugia malayi G-protein coupled receptor 0.0035 0.0061 0.0353
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi hypothetical protein 0.0022 0.0029 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0061 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0076 0.0441
Onchocerca volvulus 0.0028 0.0045 0.0179
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0061 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0076 0.0563
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.051 0.1205 1
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0316
Schistosoma mansoni patched 1 0.0171 0.0388 0.3083
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0061 0.0452
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0061 0.0452
Brugia malayi Myosin head containing protein 0.0024 0.0035 0.0135
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0024 0.0039
Trypanosoma cruzi casein kinase, delta isoform, putative 0.051 0.1205 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0207 0.6657
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0045 0.037
Echinococcus granulosus calcium activated potassium channel 0.0011 0.0004 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0061 0.0452
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0055 0.0459
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0149 0.0976
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0061 0.0452
Schistosoma mansoni opsin-like receptor 0.0035 0.0061 0.0316
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0207 0.1403
Echinococcus multilocularis expressed conserved protein 0.0374 0.0876 0.0876
Loa Loa (eye worm) hypothetical protein 0.0209 0.048 0.3985
Echinococcus granulosus g protein coupled receptor 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0207 0.6657
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0149 0.4487
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0061 0.0061
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0061 0.0452
Echinococcus granulosus hypothetical protein 0.0035 0.0061 0.0452
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus multilocularis sex peptide receptor 0.0035 0.0061 0.0061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0061 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.0568 0.1345 0.1345
Schistosoma mansoni lamin 0.0033 0.0055 0.0269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0061 0.0061
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Brugia malayi Patched related family protein 12 0.0024 0.0035 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0061 0.0061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0122 0.0122
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.0417 0.3205
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0061 0.0061
Echinococcus granulosus dnaJ subfamily B 0.0441 0.1038 0.7717
Schistosoma mansoni cpg binding protein 0.0031 0.0051 0.0236
Schistosoma mansoni cpg binding protein 0.0033 0.0056 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0076 0.0628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0111
Brugia malayi TAR-binding protein 0.0138 0.0308 0.244
Schistosoma mansoni serine/threonine protein kinase 0.051 0.1205 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0061 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0241
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0628
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0061 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0207 0.1403
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Onchocerca volvulus 0.0035 0.0061 0.0316
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0019 0.0157
Brugia malayi hypothetical protein 0.0024 0.0035 0.0135
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0248 0.193
Schistosoma mansoni adenoreceptor 0.0035 0.0061 0.0316
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0093 0.0585
Echinococcus granulosus cpg binding protein 0.0033 0.0056 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0076 0.0628
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0076 0.0628
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0104 0.2439
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0061 0.0316
Loa Loa (eye worm) DR-78 0.0019 0.0024 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0076 0.0478
Trichomonas vaginalis CK1 family protein kinase 0.051 0.1205 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus sex peptide receptor 0.0035 0.0061 0.0452
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0076 0.0441
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0123
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0061 0.0505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0045 0.037
Onchocerca volvulus 0.0028 0.0045 0.0179
Plasmodium falciparum casein kinase 1 0.051 0.1205 1
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0061 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.1238
Brugia malayi AKH receptor 0.0035 0.0061 0.0353
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0061 0.0061
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0126 0.0697
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Loa Loa (eye worm) RNA binding protein 0.0138 0.0308 0.2559
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0504 0.119 0.9872
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.0417 0.3261
Echinococcus multilocularis calcium activated potassium channel 0.0011 0.0004 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0207 0.1403
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0061 0.0505
Echinococcus multilocularis GPCR, family 2 0.0052 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0076 0.0076
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0024 0.0195
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Echinococcus multilocularis geminin 0.0205 0.0469 0.0469
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0061 0.0316
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.0373 0.2988
Trypanosoma cruzi casein kinase, putative 0.051 0.1205 1
Plasmodium vivax casein kinase 1, putative 0.051 0.1205 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.0373 0.3098
Loa Loa (eye worm) oxidoreductase 0.0028 0.0045 0.037
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0052 0.0065
Loa Loa (eye worm) hypothetical protein 0.0171 0.0388 0.3218
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0149 0.0976
Echinococcus multilocularis lamin dm0 0.0033 0.0055 0.0055
Onchocerca volvulus 0.0024 0.0035 0.0097
Brugia malayi thymidylate synthase 0.013 0.0289 0.2279
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0024 0.0195
Brugia malayi steroid hormone receptor 0.0041 0.0076 0.0478
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0122 0.0831
Onchocerca volvulus 0.0035 0.0061 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0076 0.0478
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0102 0.0102
Onchocerca volvulus 0.0504 0.119 0.9874
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0207 0.6657
Entamoeba histolytica casein kinase, putative 0.051 0.1205 1
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0308 0.2411
Echinococcus multilocularis serotonin receptor 0.0035 0.0061 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0076 0.0441
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0076 0.0628
Echinococcus granulosus Niemann Pick C1 protein 0.0568 0.1345 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0061 0.0061
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0045 0.0332
Echinococcus granulosus Niemann Pick C1 protein 0.0398 0.0934 0.6946
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Schistosoma mansoni opsin-like receptor 0.0035 0.0061 0.0316
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0052 0.028
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.0417 0.3261
Onchocerca volvulus 0.0024 0.0035 0.0097
Brugia malayi Patched related family protein 4 0.0024 0.0035 0.0135
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0076 0.0441
Trypanosoma cruzi casein kinase, putative 0.051 0.1205 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0076 0.0478
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0061 0.0061
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0126 0.3554
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0061 0.0316
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Brugia malayi hypothetical protein 0.0035 0.0061 0.0353
Brugia malayi Dopamine receptor protein 1 0.0035 0.0061 0.0353
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0076 0.0076
Echinococcus multilocularis casein kinase I delta 0.051 0.1205 0.1205
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0308 0.2411
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.1038 0.1038
Brugia malayi nuclear hormone receptor 0.0041 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0175
Schistosoma mansoni amine GPCR 0.0035 0.0061 0.0316
Echinococcus granulosus casein kinase I alpha 0.051 0.1205 0.896
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0061 0.0061
Brugia malayi RNA binding protein 0.0138 0.0308 0.244
Echinococcus granulosus lamin dm0 0.0033 0.0055 0.0411
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.0289 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0061 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0061 0.0505
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Brugia malayi hypothetical protein 0.0031 0.0052 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Echinococcus granulosus g protein coupled receptor 0.0035 0.0061 0.0452
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0459
Brugia malayi Patched family protein 0.0024 0.0035 0.0135
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0061 0.0452
Onchocerca volvulus 0.0033 0.0055 0.0269
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0061 0.0452
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0076 0.0478
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0076 0.0478
Echinococcus granulosus fmrfamide receptor 0.0035 0.0061 0.0452
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0061 0.0452
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0052 0.0147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0102 0.0761
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0433
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0061 0.0505
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Onchocerca volvulus 0.0041 0.0076 0.0441
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0076 0.0076
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0061 0.0061
Brugia malayi hypothetical protein 0.0024 0.0035 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0061 0.0061
Brugia malayi nuclear receptor NHR-88 0.0019 0.0024 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0264 0.2193
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.0308 0.244
Loa Loa (eye worm) hypothetical protein 0.0165 0.0373 0.3098
Brugia malayi nuclear receptor RXR 0.0019 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0165 0.0373 0.2957
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0055 0.0307
Loa Loa (eye worm) hypothetical protein 0.0493 0.1164 0.9662
Onchocerca volvulus 0.0035 0.0061 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0061 0.0316
Giardia lamblia Kinase, CK1 Casein kinase 0.051 0.1205 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0061 0.0316
Schistosoma mansoni amine GPCR 0.0035 0.0061 0.0316
Loa Loa (eye worm) hypothetical protein 0.0048 0.0093 0.0769
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0045 0.0217
Echinococcus multilocularis somatostatin receptor 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.029
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0045 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0505
Schistosoma mansoni hypothetical protein 0.0205 0.0469 0.3774
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0061 0.0452
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0052 0.0065
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0015
Schistosoma mansoni topbp1 0.0031 0.0052 0.0242

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) > 5000 ng ml-1 In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) ChEMBL. 15828818
IC50 (functional) > 5000 ng ml-1 In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) ChEMBL. 15828818
IC50 (functional) > 5000 ng ml-1 In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) ChEMBL. 15828818
IC50 (functional) > 5000 ng ml-1 In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) ChEMBL. 15828818
IC50 (functional) = 36 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
Inhibition (functional) Antimalarial activity against mature gametocytic stage of Plasmodium falciparum assessed as inhibition of mature gamete exflagellation at 10 uM incubated for 24 hrs prior to exflagellation induction at 21 degC measured after 20 mins by microscopic analysis relative to control ChEMBL. 23927658
Km (ADMET) = 111 uM Michaelis menton constant value of the compound against human liver microsomes; (n=6) ChEMBL. 15828818
Km (ADMET) = 111 uM Michaelis menton constant value of the compound against human liver microsomes; (n=6) ChEMBL. 15828818
Potency (functional) 0.3613 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1855 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8695 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.5112 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element beta-lactamase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Vmax (ADMET) = 19.6 nmol/min/mg Maximum velocity of the compound against human liver microsomes; (n=6) ChEMBL. 15828818

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 15828818

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 3027  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 7909690 9425362 9598156
single cell organism (CARO:0000064) decreased time (PATO:0000716) bloodstream stage (PLO:0040) Plasmodium falciparum 3944  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 3909555 6375404

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

633 literature references were collected for this gene.

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