Detailed information for compound 336696

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.414 | Formula: C23H29Cl2N5O3--
  • H donors: 2 H acceptors: 3 LogP: 3.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)N1CCCc2c(C1)cc(OCC1(CCN(CC1)c1ccncc1)C(=O)O)cc2.[Cl-].[Cl-]
  • InChi: 1S/C23H29N5O3.2ClH/c24-22(25)28-11-1-2-17-3-4-20(14-18(17)15-28)31-16-23(21(29)30)7-12-27(13-8-23)19-5-9-26-10-6-19;;/h3-6,9-10,14H,1-2,7-8,11-13,15-16H2,(H3,24,25)(H,29,30);2*1H/p-2
  • InChiKey: XWPGVOPNFXYHLF-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0427 0.1333
Brugia malayi hypothetical protein 0.0037 0.0086 0.0261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.007 0.0168
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Brugia malayi hypothetical protein 0.0086 0.0293 0.0912
Plasmodium vivax serine-repeat antigen (SERA) 0.0033 0.0068 0.2723
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0368 0.1148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0891 1
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0043 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0068 0.0557
Onchocerca volvulus 0.0036 0.0082 0.0467
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0049 0.0139 0.0427
Giardia lamblia Hypothetical protein 0.0033 0.0068 0.0557
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0004 0.0044
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0033 0.0068 0.1776
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0026
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0449 0.1272
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0195 0.0184
Echinococcus granulosus cathepsin L cysteine protease 0.0049 0.0139 0.0364
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Schistosoma mansoni cathepsin C 0.0033 0.0068 0.0186
Onchocerca volvulus Cathepsin L homolog 0.0074 0.0242 0.1682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0171 0.1571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Schistosoma mansoni hypothetical protein 0.0033 0.007 0.0192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.019 0.0723 0.2051
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Echinococcus granulosus cathepsin L 0.0033 0.0068 0.0162
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0171 0.5014
Giardia lamblia Cathepsin B precursor 0.0033 0.0068 0.0557
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Giardia lamblia Cathepsin B precursor 0.0264 0.1031 1
Onchocerca volvulus 0.0074 0.0242 0.1682
Trypanosoma cruzi oligopeptidase b 0.0027 0.0043 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0033 0.0068 0.2723
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0082 0.3324
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0028 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0711 0.2017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0099 0.4038
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0139 0.0427
Onchocerca volvulus 0.0089 0.0305 0.2159
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0033 0.0068 0.2723
Schistosoma mansoni cpg binding protein 0.0089 0.0305 0.0861
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0043 0.0128
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0082 0.0923
Plasmodium falciparum serine repeat antigen 2 0.0033 0.0068 0.2688
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0113 0.0404 0.3852
Schistosoma mansoni hypothetical protein 0.0071 0.023 0.0648
Loa Loa (eye worm) hypothetical protein 0.0071 0.023 0.0715
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0099 0.0304
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0711 0.07
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0337 0.1336 0.1326
Plasmodium falciparum cysteine proteinase falcipain 1 0.0049 0.0139 0.5652
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Brugia malayi fibroinase precursor 0.0033 0.0068 0.0205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0779 0.3183 0.9064
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.0545
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0021 0.0714
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0082 0.0923
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0057 0.0171 0.053
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0264 0.1031 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0337 0.1336 0.38
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0305 0.095
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0171 0.0481
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0068 0.0186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0028 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0068 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0086 0.0237
Schistosoma mansoni hypothetical protein 0.0033 0.007 0.0192
Schistosoma mansoni cathepsin S (C01 family) 0.0033 0.0068 0.0186
Echinococcus multilocularis cathepsin L 0.0033 0.0068 0.0057
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0033 0.0068 0.2723
Schistosoma mansoni patched 1 0.0041 0.0103 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0068 0.0557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Trypanosoma brucei cysteine peptidase C (CPC) 0.0264 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0211
Echinococcus granulosus GPCR family 2 0.0033 0.007 0.0168
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0449 0.1251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0082 0.1761
Echinococcus granulosus cathepsin b 0.0779 0.3183 0.9062
Schistosoma mansoni cpg binding protein 0.0094 0.0326 0.0921
Echinococcus granulosus cathepsin l cysteine peptidase 0.0074 0.0242 0.066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0068 0.0557
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0043 0.0128
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.007 0.0211
Brugia malayi cathepsin L precursor 0.0033 0.0068 0.0205
Echinococcus multilocularis cysteine protease 0.0074 0.0242 0.0231
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0195 0.0603
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0099 0.0865
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.0242 0.0231
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0043 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0546
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0043 0.0317
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0082 0.0698
Loa Loa (eye worm) RNA binding protein 0.0063 0.0195 0.0603
Plasmodium falciparum serine repeat antigen 9 0.0033 0.0068 0.2688
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0099 0.0865
Loa Loa (eye worm) fibroinase 0.0074 0.0242 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0033 0.0068 0.0557
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0082 0.0698
Brugia malayi RNA binding protein 0.0063 0.0195 0.0603
Loa Loa (eye worm) hypothetical protein 0.0104 0.0368 0.1148
Toxoplasma gondii cathepsin CPC1 0.0033 0.0068 0.0465
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0033 0.0068 0.0186
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0502 0.0491
Mycobacterium tuberculosis Conserved protein 0.0036 0.0082 0.0923
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Plasmodium vivax vivapain-2 0.0074 0.0242 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0779 0.3183 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0082 0.1761
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0043 0.101
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.007 0.0211
Mycobacterium tuberculosis Conserved protein 0.0036 0.0082 0.0923
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0043 0.0317
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0128
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0139 0.0427
Loa Loa (eye worm) cysteine protease 0.0074 0.0242 0.0752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0711 0.2017
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0068 0.0205
Brugia malayi Cathepsin L-like precursor 0.0057 0.0171 0.053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0099 0.0304
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0043 0.0116
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.0242 0.0231
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0043 0.0171
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0449 0.5039
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0021 0.0057
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0043 0.0116
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0113 0.0404 0.3852
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0242 0.0752
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0043 0.17
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0017 0.0053
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0449 0.1272
Schistosoma mansoni DNA polymerase eta 0.0019 0.0011 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.0711 0.2226
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0028 0.0545
Entamoeba histolytica cysteine protease, putative 0.0074 0.0242 0.7222
Brugia malayi Cathepsin L-like precursor 0.0057 0.0171 0.053
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0331 0.1032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0099 0.0252
Loa Loa (eye worm) hypothetical protein 0.0057 0.0171 0.053
Echinococcus granulosus cysteine protease 0.0049 0.0139 0.0364
Schistosoma mansoni cpg binding protein 0.0094 0.0326 0.0921
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0033 0.0068 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0139 0.1248
Schistosoma mansoni ap endonuclease 0.004 0.0099 0.0275
Onchocerca volvulus 0.0074 0.0242 0.1682
Schistosoma mansoni hypothetical protein 0.0021 0.0021 0.0052
Brugia malayi Latrophilin receptor protein 2 0.0033 0.007 0.0211
Mycobacterium tuberculosis Conserved protein 0.0036 0.0082 0.0923
Loa Loa (eye worm) cathepsin B 0.0264 0.1031 0.3234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Giardia lamblia Cathepsin B precursor 0.0033 0.0068 0.0557
Plasmodium vivax vivapain-1 0.0049 0.0139 0.5673
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0043 0.0128
Trichomonas vaginalis esterase, putative 0.0036 0.0082 0.0698
Brugia malayi cathepsin L-like precursor 0.0057 0.0171 0.053
Mycobacterium ulcerans hypothetical protein 0.0023 0.0028 0.0545
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0128
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0033 0.0068 0.2723
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0427 0.1333
Echinococcus granulosus cpg binding protein 0.0094 0.0326 0.09
Entamoeba histolytica hypothetical protein 0.0033 0.0068 0.1776
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0195 0.0603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0011 0.0125
Plasmodium falciparum serine repeat antigen 5 0.0033 0.0068 0.2688
Toxoplasma gondii cathepsin CPC2 0.0033 0.0068 0.0465
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0021 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0068 0.0186
Schistosoma mansoni hypothetical protein 0.004 0.0097 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0242 0.7222
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Giardia lamblia Cathepsin B precursor 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0099 0.1115
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0043 0.0888
Giardia lamblia Cysteine protease 0.0033 0.0068 0.0557
Trichomonas vaginalis helicase, putative 0.002 0.0017 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0331 0.0914
Brugia malayi CXXC zinc finger family protein 0.0089 0.0305 0.095
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0068 0.0186
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0004 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Giardia lamblia Cathepsin L-like protease 0.0033 0.0068 0.0557
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0033 0.0068 0.2723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0449 0.4293
Plasmodium falciparum cysteine proteinase falcipain 3 0.0074 0.0242 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0113 0.0404 0.3852
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0103 0.0263
Echinococcus granulosus expressed conserved protein 0.009 0.0307 0.0844
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0074 0.0242 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0171 0.1571
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0043 0.0128
Schistosoma mansoni hypothetical protein 0.004 0.0097 0.0269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0711 0.1998
Plasmodium vivax unspecified product 0.0033 0.0068 0.2723
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0043 0.0317
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0033 0.0068 0.2723
Echinococcus granulosus cathepsin b 0.0779 0.3183 0.9062
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0113 0.0404 0.1262
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0068 0.0357
Brugia malayi prolyl oligopeptidase family protein 0.0337 0.1336 0.4192
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0043 0.0317
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0171 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.0242 0.2263
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0043 0.0092
Plasmodium falciparum peptidase, putative 0.0027 0.0043 0.166
Onchocerca volvulus 0.0074 0.0242 0.1682
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0068 0.0205
Giardia lamblia Encystation-specific protease 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0096 0.0331 0.1032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0011 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0082 0.0071
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0368 0.1148
Entamoeba histolytica cysteine proteinase 1, putative 0.0049 0.0139 0.3983
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0086 0.0213
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0779 0.3183 0.9064
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Echinococcus multilocularis expressed conserved protein 0.009 0.0307 0.0296
Onchocerca volvulus 0.0057 0.0171 0.1145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0449 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0043 0.0317
Brugia malayi MH2 domain containing protein 0.0119 0.0427 0.1333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Leishmania major hypothetical protein, conserved 0.0021 0.0021 0.0096
Giardia lamblia Hypothetical protein 0.0033 0.0068 0.0557
Plasmodium falciparum serine repeat antigen 1 0.0033 0.0068 0.2688
Loa Loa (eye worm) hypothetical protein 0.0074 0.0242 0.0752
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0242 0.7222
Loa Loa (eye worm) hypothetical protein 0.005 0.0142 0.0437
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0028 0.0545
Brugia malayi Protein kinase domain containing protein 0.0021 0.0021 0.0057
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0331 1
Echinococcus multilocularis cpg binding protein 0.0094 0.0326 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.0545
Onchocerca volvulus 0.0023 0.0028 0.0055
Onchocerca volvulus Cathepsin F homolog 0.0074 0.0242 0.1682
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0082 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0068 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0546
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0171 0.053
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0337 0.1336 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0113 0.0404 0.3793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0028 0.0545
Entamoeba histolytica cysteine proteinase 2 0.0049 0.0139 0.3983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0317
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0043 0.2818
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0043 0.101
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0779 0.3183 0.9064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0082 0.0203
Schistosoma mansoni hypothetical protein 0.004 0.0097 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0404 0.1262
Trypanosoma cruzi oligopeptidase b 0.0027 0.0043 0.0128
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0043 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0139 0.1248
Toxoplasma gondii cathepsin B 0.0264 0.1031 1
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0043 0.0092
Trypanosoma cruzi cysteine protease, putative 0.0049 0.0139 0.0427
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0011 0.0125
Plasmodium vivax unspecified product 0.0049 0.0139 0.5673
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0033 0.0068 0.0557
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0028 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0103 0.0263
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0082 0.0923
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0043 0.0116
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0242 0.0752
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0162
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.008
Brugia malayi TAR-binding protein 0.0063 0.0195 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0195 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0167
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0337 0.1336 0.3785
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0082 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0082 0.0698
Giardia lamblia Cathepsin B precursor 0.0033 0.0068 0.0557
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0033 0.0068 0.0205
Plasmodium falciparum serine repeat antigen 7 0.0033 0.0068 0.2688
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0046 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0082 0.0698
Giardia lamblia Cysteine protease 0.0033 0.0068 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0068 0.0557
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0025 0.0063
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0139 0.0387
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0017 0.0053
Toxoplasma gondii ABC1 family protein 0.0036 0.0082 0.0608
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0068 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0099 0.0088
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0021 0.0057
Plasmodium falciparum serine repeat antigen 8 0.0033 0.0068 0.2688
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0082 0.025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Plasmodium falciparum serine repeat antigen 6 0.0033 0.0068 0.2688
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0043 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Onchocerca volvulus 0.0033 0.0068 0.0357
Echinococcus granulosus cathepsin L cysteine proteinase 0.0074 0.0242 0.066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0047 0.0104
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0043 0.0128
Entamoeba histolytica hypothetical protein 0.0037 0.0086 0.2335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0449 0.0439
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0043 0.0223
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0043 0.0223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0082 0.1761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0099 0.5
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0033 0.0068 0.2688
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.023 0.0715
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0082 0.0227
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0021 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0264 0.1031 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0449 1
Echinococcus granulosus cathepsin l1 0.0074 0.0242 0.066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0068 0.0186
Echinococcus granulosus dnaJ subfamily B 0.0858 0.3512 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0033 0.0068 0.2723
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0068 0.0205
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0099 0.0865
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0139 0.3983
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0028 0.0316
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0033 0.0068 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Mycobacterium ulcerans lipase LipD 0.0036 0.0082 0.1761
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0028 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0068 0.0557
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0033 0.0068 0.0186
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0113 0.0404 0.1144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0068 0.0557
Leishmania major oligopeptidase b 0.0027 0.0043 0.0317
Echinococcus multilocularis GPCR, family 2 0.0033 0.007 0.0059
Onchocerca volvulus 0.0074 0.0242 0.1682
Leishmania major hypothetical protein, conserved 0.0036 0.0082 0.0698
Giardia lamblia Cathepsin B precursor 0.0264 0.1031 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0082 0.0923
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0099 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0139 0.0427
Echinococcus multilocularis cathepsin b 0.0779 0.3183 0.3176
Loa Loa (eye worm) hypothetical protein 0.0086 0.0293 0.0912
Plasmodium falciparum serine repeat antigen 4 0.0033 0.0068 0.2688
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.0242 0.0752
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0021 0.0758
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0638 0.6108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Plasmodium falciparum serine repeat antigen 3 0.0033 0.0068 0.2688
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.0242 0.0231
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Giardia lamblia Cysteine protease 0.0033 0.0068 0.0557
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0082 0.0698
Onchocerca volvulus Cathepsin L homolog 0.0074 0.0242 0.1682
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0043 0.0032
Toxoplasma gondii preprocathepsin c precursor, putative 0.0033 0.0068 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0033 0.0068 0.0557
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0043 0.0032
Echinococcus multilocularis protein patched 0.0041 0.0103 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0546
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0033 0.0068 0.2723
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0082 0.0923
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0242 0.0752
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0043 0.0116
Onchocerca volvulus 0.0074 0.0242 0.1682
Echinococcus granulosus cathepsin l1 0.0057 0.0171 0.0458
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0033 0.0068 0.0186
Trypanosoma cruzi cysteine proteinase, putative 0.0049 0.0139 0.0427
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.007 0.0059
Giardia lamblia Cathepsin L precursor 0.0033 0.0068 0.0557
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0103 0.0092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0082 0.025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0099 0.276
Entamoeba histolytica hypothetical protein 0.0037 0.0086 0.2335
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0033 0.0068 0.1776
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0099 0.4009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0449 1
Echinococcus multilocularis cathepsin L 0.0049 0.0139 0.0128
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0033 0.0068 0.2688
Brugia malayi Papain family cysteine protease containing protein 0.0074 0.0242 0.0752
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.0545
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0082 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0033 0.0068 0.2723
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0025 0.0039
Brugia malayi beta-lactamase family protein 0.0036 0.0082 0.025
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0043 0.0128
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0082 0.0923
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0068 0.0205
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0043 0.101
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0043 0.0487
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.0711 0.2226
Brugia malayi cathepsin L-like cysteine proteinase 0.0033 0.0068 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.007 0.0059
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0103 0.0316
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0074 0.0242 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0068 0.0205
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0139 0.0387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0711 0.1998
Echinococcus multilocularis cathepsin b 0.0779 0.3183 0.3176
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0033 0.0068 0.2688
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0011 0.0024
Trypanosoma brucei oligopeptidase b 0.0027 0.0043 0.0317
Toxoplasma gondii cathepsin CPL 0.0074 0.0242 0.2189
Giardia lamblia Cathepsin B precursor 0.0033 0.0068 0.0557
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.0242 0.0682
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0139 0.3983
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Brugia malayi Kringle domain containing protein 0.0021 0.0021 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0099 0.0304
Echinococcus granulosus tar DNA binding protein 0.0063 0.0195 0.0524
Loa Loa (eye worm) hypothetical protein 0.0041 0.0103 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0711 0.2017
Plasmodium vivax vivapain-2 0.0074 0.0242 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0113 0.0404 0.0393
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.0242 0.0682
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0337 0.0953
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0502 0.1402
Giardia lamblia Cathepsin L-like protease 0.0033 0.0068 0.0557
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0025 0.0014
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0033 0.0068 0.0186
Toxoplasma gondii exonuclease III APE 0.004 0.0099 0.0777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0139 0.1248
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0099 0.0304
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0068 0.0557
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0368 0.1148
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0043 0.101
Schistosoma mansoni hypothetical protein 0.0037 0.0086 0.0237
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0264 0.1031 0.3234
Onchocerca volvulus 0.0036 0.0082 0.0467
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0047 0.0141
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Loa Loa (eye worm) prolyl oligopeptidase 0.0337 0.1336 0.4192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0026
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0043 0.0317
Leishmania major cysteine peptidase A (CPA) 0.0074 0.0242 0.2263
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0043 0.0317
Schistosoma mansoni hypothetical protein 0.0033 0.007 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0139 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0103 0.0903
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Schistosoma mansoni hypothetical protein 0.0858 0.3512 1
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0053
Entamoeba histolytica hypothetical protein 0.0037 0.0086 0.2335
Mycobacterium ulcerans beta-lactamase 0.0036 0.0082 0.1761
Echinococcus multilocularis dnaJ subfamily B 0.0858 0.3512 0.3504
Toxoplasma gondii hypothetical protein 0.0027 0.0043 0.0223
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.008
Echinococcus granulosus cathepsin L 0.0049 0.0139 0.0364
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0068 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0242 0.2263
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0025 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0139 0.3983
Mycobacterium leprae Probable lipase LipE 0.0036 0.0082 1
Giardia lamblia Cysteine protease 0.0033 0.0068 0.0557
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0711 0.07
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0099 0.2145
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0043 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0242 0.2263
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.008
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0043 0.0128
Loa Loa (eye worm) ctsf protein 0.0074 0.0242 0.0752
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0047 0.0036
Trypanosoma cruzi cysteine proteinase, putative 0.0049 0.0139 0.0427
Schistosoma mansoni ap endonuclease 0.004 0.0099 0.0275
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0099 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0043 0.0317
Entamoeba histolytica hypothetical protein 0.0037 0.0086 0.2335
Loa Loa (eye worm) hypothetical protein 0.0057 0.0171 0.053
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0033 0.0068 0.2723
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0068 0.0205
Brugia malayi Cathepsin L-like precursor 0.0074 0.0242 0.0752
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0068 0.0205
Echinococcus multilocularis cysteine protease 0.0074 0.0242 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0139 0.1248
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0242 0.0752
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0099 0.0865
Entamoeba histolytica cysteine protease, putative 0.0033 0.0068 0.1776
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0028 0.0316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0264 0.1031 0.2932
Brugia malayi CHE-14 protein 0.0041 0.0103 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0242 0.0752
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0011 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0082 0.0698
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0331 0.032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0068 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0068 0.0557
Brugia malayi cathepsin B-like cysteine proteinase 0.0779 0.3183 1
Schistosoma mansoni hypothetical protein 0.004 0.0097 0.0269
Schistosoma mansoni cathepsin B (C01 family) 0.0033 0.0068 0.0186
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.008
Giardia lamblia Cathepsin B precursor 0.0264 0.1031 1
Onchocerca volvulus 0.0074 0.0242 0.1682
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0033 0.0068 0.2723
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0025 0.0039
Brugia malayi beta-lactamase 0.0036 0.0082 0.025
Plasmodium vivax vivapain-3 0.0049 0.0139 0.5673
Schistosoma mansoni hypothetical protein 0.0033 0.007 0.0192
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0449 0.4238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0205
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0033 0.0068 0.0557
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0113 0.0404 0.1262
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0043 0.0317
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0068 0.0557
Echinococcus multilocularis protein dispatched 1 0.0047 0.0127 0.0116
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0004 0.5
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0082 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0546
Loa Loa (eye worm) beta-lactamase 0.0036 0.0082 0.025
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0074 0.0242 1
Entamoeba histolytica cysteine protease, putative 0.0049 0.0139 0.3983
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.0242 0.0231
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0043 0.101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.007 0.0168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0779 0.3183 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0017 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0082 0.025
Brugia malayi beta-lactamase family protein 0.0036 0.0082 0.025
Onchocerca volvulus 0.0074 0.0242 0.1682
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.0026
Leishmania major cathepsin L-like protease 0.0074 0.0242 0.2263
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0139 0.3983
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0779 0.3183 0.9064
Onchocerca volvulus 0.0036 0.0082 0.0467
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0086 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0011 0.0026
Echinococcus granulosus Dipeptidyl peptidase 9 0.0113 0.0404 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0033 0.0068 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0242 0.2263

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibitory concentration against human Coagulation factor X ChEMBL. 15887966
IC50 (binding) > 10 uM Inhibitory concentration against human Coagulation factor II (thrombin) ChEMBL. 15887966

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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