Detailed information for compound 340961

Basic information

Technical information
  • TDR Targets ID: 340961
  • Name: 4-[[4-(2-morpholin-4-ylethyl)-3-oxoquinoxalin -2-yl]amino]-N-(thiophen-2-ylmethyl)benzamide
  • MW: 489.589 | Formula: C26H27N5O3S
  • H donors: 2 H acceptors: 2 LogP: 2.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Nc1nc2ccccc2n(c1=O)CCN1CCOCC1)NCc1cccs1
  • InChi: 1S/C26H27N5O3S/c32-25(27-18-21-4-3-17-35-21)19-7-9-20(10-8-19)28-24-26(33)31(12-11-30-13-15-34-16-14-30)23-6-2-1-5-22(23)29-24/h1-10,17H,11-16,18H2,(H,27,32)(H,28,29)
  • InChiKey: HGCYNEZZLJDDFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[4-(2-morpholinoethyl)-3-oxo-quinoxalin-2-yl]amino]-N-(2-thienylmethyl)benzamide
  • 4-[[4-(2-morpholinoethyl)-3-oxo-2-quinoxalinyl]amino]-N-(2-thienylmethyl)benzamide
  • 4-[[4-(2-morpholin-4-ylethyl)-3-oxo-quinoxalin-2-yl]amino]-N-(thiophen-2-ylmethyl)benzamide
  • 4-[[3-keto-4-(2-morpholinoethyl)quinoxalin-2-yl]amino]-N-(2-thenyl)benzamide
  • 4-[[3-keto-4-(2-morpholinoethyl)quinoxalin-2-yl]amino]-N-(2-thienylmethyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Glycogen phosphorylase 0.013 0.0194 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0037 0.0051
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0218
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0005 0.0076
Plasmodium vivax importin-beta 2, putative 0.003 0.0036 0.0122
Plasmodium falciparum DNA repair protein RAD2, putative 0.0011 0.0005 0.0006
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.0054
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0014 0.0218
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.0194 0.2949
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0086 0.1739
Loa Loa (eye worm) glutaminase 2 0.0284 0.0437 0.8854
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0017 0.005
Entamoeba histolytica hypothetical protein 0.0009 0.0003 0.0005
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0017 0.0261
Echinococcus multilocularis smad 0.0016 0.0014 0.0217
Giardia lamblia Telomerase catalytic subunit 0.1732 0.2723 1
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0021 0.0316
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0021 0.0316
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0103 0.1558
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0017 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.009 0.1366
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.0194 0.0194
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0009 0.0114
Schistosoma mansoni hypothetical protein 0.0066 0.0093 0.1415
Echinococcus multilocularis GPCR, family 2 0.0031 0.0037 0.0561
Toxoplasma gondii RNA-directed DNA polymerase 0.1732 0.2723 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.1732 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Echinococcus multilocularis exonuclease 1 0.0011 0.0005 0.008
Brugia malayi SET domain containing protein 0.0008 0.0001 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0024
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.0077 0.2687
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0561
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.002
Giardia lamblia Flap structure-specific endonuclease 0.0052 0.0071 0.0248
Schistosoma mansoni DNA helicase recq1 0.0018 0.0017 0.0261
Schistosoma mansoni flap endonuclease-1 0.0047 0.0063 0.0959
Plasmodium falciparum flap endonuclease 1 0.0052 0.0071 0.0248
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0561
Entamoeba histolytica hypothetical protein 0.0072 0.0103 0.0919
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0087
Schistosoma mansoni DNA polymerase IV / kappa 0.0022 0.0024 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0086 0.1301
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0076
Entamoeba histolytica hypothetical protein 0.0199 0.0303 0.2753
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0026 0.0212
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0037 0.0749
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0005 0.0076
Brugia malayi hypothetical protein 0.0025 0.0027 0.0037
Loa Loa (eye worm) flap endonuclease-1 0.0052 0.0071 0.1443
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0073 0.0258
Echinococcus multilocularis nibrin 0.001 0.0004 0.0054
Plasmodium vivax DNA repair protein REV1, putative 0.0022 0.0024 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Schistosoma mansoni hypothetical protein 0.032 0.0493 0.7482
Echinococcus multilocularis flap endonuclease 1 0.0052 0.0071 0.108
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0014 0.0217
Giardia lamblia DINP protein human, muc B family 0.0078 0.0112 0.0398
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0561
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0024 0.0075
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0112 0.0399
Echinococcus multilocularis disco interacting protein 2 0.004 0.0052 0.0783
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0008
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0021 0.0065
Schistosoma mansoni topbp1 0.001 0.0004 0.0054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0014 0.0217
Echinococcus granulosus global transcription activator snf2l2 0.007 0.0099 0.1496
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0096
Echinococcus multilocularis hepatoma derived growth factor protein 0.0009 0.0003 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0086 0.1301
Echinococcus multilocularis snurportin 1 0.032 0.0493 0.7482
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.004 0.0604
Loa Loa (eye worm) glutaminase 0.0284 0.0437 0.8854
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Echinococcus granulosus importin subunit beta 1 0.003 0.0036 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0007
Trichomonas vaginalis flap endonuclease-1, putative 0.0052 0.0071 0.156
Plasmodium vivax exonuclease I, putative 0.0011 0.0005 0.001
Brugia malayi Telomerase reverse transcriptase 0.4608 0.7265 1
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.004 0.0604
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0014 0.029
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1732 0.2723 1
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0021 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0102
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0089
Schistosoma mansoni cpg binding protein 0.0065 0.009 0.1373
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0005 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0086 0.1301
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0725
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0561
Schistosoma mansoni SET domain protein 0.0033 0.004 0.0604
Leishmania major importin beta-1 subunit, putative 0.0024 0.0027 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0056
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0077 0.0688
Leishmania major DNA polymerase eta, putative 0.0096 0.0141 0.0506
Echinococcus granulosus dnaJ subfamily B 0.0425 0.0659 1
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.0368 0.7453
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0076
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0112 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0007
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0014 0.004
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0027 0.0536
Entamoeba histolytica deoxycytidyl transferase, putative 0.0072 0.0102 0.0909
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0093 0.0128
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.005 0.0169
Trypanosoma brucei DNA repair protein RAD2, putative 0.0011 0.0005 0.0008
Plasmodium falciparum DNA repair protein REV1, putative 0.0022 0.0024 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0007
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0007
Onchocerca volvulus 0.004 0.0052 0.0052
Schistosoma mansoni Smad4 0.0016 0.0014 0.0217
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0027 0.0536
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0021 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0014 0.0291
Echinococcus granulosus FTZ F1 alpha 0.001 0.0005 0.0076
Brugia malayi PWWP domain containing protein 0.0009 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0072 0.0103 0.0919
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088 0.0127 0.0454
Brugia malayi carbohydrate phosphorylase 0.013 0.0194 0.0267
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0233 0.3541
Trypanosoma brucei DNA polymerase eta, putative 0.0096 0.0141 0.0506
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0063 0.0219
Entamoeba histolytica hypothetical protein 0.0024 0.0027 0.0222
Mycobacterium ulcerans hypothetical protein 0.0165 0.0249 0.5673
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0102 0.014
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0024 0.0075
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0223 0.0808
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0021 0.0063
Plasmodium falciparum exonuclease I, putative 0.0011 0.0005 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0027 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0019 0.0293
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0026 0.0083
Echinococcus granulosus bloom syndrome protein 0.0044 0.0058 0.0882
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0011 0.0006 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0007
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0014 0.0217
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0035 0.0117
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0006
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.0368 0.7453
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0039
Brugia malayi steroid hormone receptor 0.001 0.0005 0.0007
Brugia malayi isocitrate dehydrogenase 0.0016 0.0014 0.002
Echinococcus granulosus flap endonuclease GEN 1 0.0011 0.0005 0.008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0052
Schistosoma mansoni phd finger protein 0.0011 0.0006 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0086 0.0118
Onchocerca volvulus 0.0009 0.0003 0.0003
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0014 0.002
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0036 0.0121
Brugia malayi hypothetical protein 0.0072 0.0103 0.0141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0027 0.0536
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0006 0.0088
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0699 0.1092 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0142 0.2874
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0102 0.3714
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0047
Echinococcus multilocularis muscleblind protein 0.0155 0.0233 0.3541
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0014 0.029
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0017 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0484 0.1767
Loa Loa (eye worm) hypothetical protein 0.004 0.0052 0.1047
Echinococcus multilocularis BRK domain 0.0012 0.0008 0.0114
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.009 0.1835
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.002
Echinococcus granulosus Smad4 0.0016 0.0014 0.0217
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0028
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0041
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0194 0.4406
Loa Loa (eye worm) PWWP domain-containing protein 0.0009 0.0003 0.0062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.006
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0052 0.0071 0.025
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0086 0.1301
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.0077 0.1707
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0005 0.0102
Trypanosoma brucei unspecified product 0.0049 0.0066 0.0233
Echinococcus granulosus nibrin 0.001 0.0004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0107
Echinococcus multilocularis Smad4 0.0016 0.0014 0.0217
Loa Loa (eye worm) BRM protein 0.0045 0.0059 0.1192
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0027 0.0087
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0039
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0019 0.0154
Treponema pallidum DNA ligase (lig) 0.001 0.0004 0.0289
Brugia malayi CXXC zinc finger family protein 0.0065 0.009 0.0125
Echinococcus granulosus cpg binding protein 0.0066 0.0093 0.1413
Echinococcus granulosus GPCR family 2 0.0031 0.0037 0.0561
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0004 0.0002
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0005 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0102
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0223 0.0808
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0024 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0141 0.0194
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0076
Brugia malayi polk-prov protein 0.0048 0.0064 0.0089
Loa Loa (eye worm) RNA binding protein 0.0062 0.0086 0.1739
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0072 0.0102 0.1542
Schistosoma mansoni hypothetical protein 0.0072 0.0103 0.1558
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0005 0.0005
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0004 0.0002
Brugia malayi ecdysteroid receptor 0.001 0.0005 0.0007
Leishmania major modification methylase-like protein 0.0021 0.0021 0.0065
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.0077 0.0688
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0014 0.0043
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0013 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0086 0.1739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0059 0.0893
Leishmania major DNA polymerase kappa, putative 0.0022 0.0024 0.0075
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1732 0.2723 1
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0011 0.0005 0.008
Echinococcus granulosus peregrin 0.0011 0.0006 0.0091
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0003 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0019 0.0363
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.0484 0.1767
Trypanosoma cruzi DNA polymerase eta, putative 0.0096 0.0141 0.0506
Loa Loa (eye worm) hypothetical protein 0.0155 0.0233 0.4732
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0112 0.4145
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Schistosoma mansoni hypothetical protein 0.0341 0.0527 0.7996
Brugia malayi topoisomerase 0.001 0.0004 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0019 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0077 0.027
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0063 0.0219
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0059 0.0893
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0026 0.0083
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0003 0.0047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0024
Entamoeba histolytica hypothetical protein 0.001 0.0004 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0076
Echinococcus granulosus flap endonuclease 1 0.0052 0.0071 0.108
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0749
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.002
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0076
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0014 0.0217
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0019 0.006
Schistosoma mansoni DNA ligase IV 0.001 0.0004 0.0054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0076
Brugia malayi Importin beta-1 subunit 0.003 0.0036 0.0049
Schistosoma mansoni DNA helicase recq5 0.0018 0.0017 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0028
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0006 0.0007
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0003 0.0047
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0003 0.0047
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.002
Leishmania major DNA damage repair protein, putative 0.0022 0.0024 0.0075
Brugia malayi hypothetical protein 0.001 0.0004 0.0005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0041
Schistosoma mansoni DNA polymerase eta 0.0096 0.0141 0.2135
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0003 0.0047
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0076
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0011 0.0006 0.0088
Loa Loa (eye worm) Smad1 0.0016 0.0014 0.029
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0019 0.0363
Onchocerca volvulus 0.0065 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0561
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0064 0.1306
Schistosoma mansoni hypothetical protein 0.0341 0.0527 0.7996
Loa Loa (eye worm) RecQ helicase 0.0044 0.0058 0.1178
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0142 0.3207
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0077 0.0688
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0003 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0102
Echinococcus granulosus dna polymerase eta 0.0096 0.0141 0.2135
Brugia malayi Smad1 0.0016 0.0014 0.002
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0004
Echinococcus granulosus hepatoma derived growth factor protein 0.0009 0.0003 0.0047
Echinococcus granulosus disco interacting protein 2 0.004 0.0052 0.0783
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0017 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0063
Echinococcus granulosus glycogen phosphorylase 0.013 0.0194 0.2949
Brugia malayi RNA, U transporter 1 0.0085 0.0123 0.0169
Plasmodium vivax DNA repair protein RAD2, putative 0.0011 0.0005 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0561
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0493 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0036 0.012
Brugia malayi TAR-binding protein 0.0062 0.0086 0.0118
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.0194 0.2949
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0005 0.0102
Brugia malayi Flap endonuclease-1 0.0052 0.0071 0.0098
Schistosoma mansoni cpg binding protein 0.0066 0.0093 0.1413
Loa Loa (eye worm) hypothetical protein 0.0096 0.0141 0.2854
Toxoplasma gondii exonuclease III APE 0.002 0.0019 0.006
Mycobacterium ulcerans hypothetical protein 0.0022 0.0024 0.0462
Schistosoma mansoni glycogen phosphorylase 0.013 0.0194 0.2949
Loa Loa (eye worm) nuclear factor I 0.0009 0.0003 0.0056
Brugia malayi DKFZp564C0469 protein 0.001 0.0004 0.0005
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0014 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0036 0.012
Giardia lamblia DNA repair protein RAD52 0.0699 0.1092 0.4003
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0076
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0082 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0007
Schistosoma mansoni SET domain protein 0.0013 0.0008 0.0129
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0194 0.2949
Brugia malayi BRM protein 0.007 0.0099 0.0136
Echinococcus multilocularis geminin 0.0341 0.0527 0.7996
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0058 0.0202
Giardia lamblia DNA damage repair protein 0.0022 0.0024 0.0074
Brugia malayi MH2 domain containing protein 0.024 0.0368 0.0506
Echinococcus multilocularis flap endonuclease GEN 1 0.0011 0.0005 0.008
Plasmodium falciparum telomerase reverse transcriptase 0.1732 0.2723 1
Giardia lamblia hypothetical protein 0.0011 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0007
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0194 0.2949
Plasmodium vivax flap endonuclease 1, putative 0.0052 0.0071 0.0252
Echinococcus multilocularis dna polymerase eta 0.0096 0.0141 0.2135
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0026 0.0083
Trichomonas vaginalis exonuclease%2C+putative 0.0011 0.0005 0.0039
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0223 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Toxoplasma gondii hypothetical protein 0.0088 0.0127 0.0456
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0058 0.0202
Loa Loa (eye worm) hypothetical protein 0.0134 0.02 0.4059
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0425 0.0659 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0142 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0052 0.0071
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0017 0.0349
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0142 0.3207
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0561
Echinococcus multilocularis importin subunit beta 1 0.003 0.0036 0.0542
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0021 0.0065
Echinococcus multilocularis cpg binding protein 0.0066 0.0093 0.1413
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0005 0.0076
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Echinococcus granulosus dna polymerase kappa 0.0098 0.0142 0.2161
Brugia malayi XPG I-region family protein 0.0011 0.0005 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0059 0.1193
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0086 0.1301
Schistosoma mansoni exonuclease 0.0011 0.0005 0.008
Chlamydia trachomatis glycogen phosphorylase 0.013 0.0194 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus multilocularis Chromo domain 0.0012 0.0008 0.0114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0019 0.0293
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0058 0.0202
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0052 0.0071 0.025
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0028
Echinococcus granulosus Chromo domain 0.0012 0.0008 0.0114
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0004 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0076
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0024 0.0075
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0004
Trypanosoma brucei exonuclease, putative 0.0011 0.0005 0.0008
Echinococcus multilocularis global transcription activator snf2l2 0.007 0.0099 0.1496
Echinococcus granulosus tar DNA binding protein 0.0062 0.0086 0.1301
Onchocerca volvulus 0.001 0.0004 0.0004
Echinococcus granulosus BRK domain containing protein 0.0012 0.0008 0.0114
Schistosoma mansoni glycogen phosphorylase 0.0056 0.0077 0.1176
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0024 0.0075
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0076
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0014 0.0041
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0052 0.0071 0.025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0102
Schistosoma mansoni glycogen phosphorylase 0.013 0.0194 0.2949
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0004 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0072 0.0102 0.1542
Echinococcus granulosus muscleblind protein 0.0155 0.0233 0.3541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0059 0.0893
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0008
Brugia malayi hypothetical protein 0.001 0.0004 0.0005
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0024 0.0075
Trypanosoma brucei unspecified product 0.0049 0.0066 0.0233
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0004 0.0005
Toxoplasma gondii hypothetical protein 0.0051 0.0068 0.024
Schistosoma mansoni glutaminase 0.0284 0.0437 0.6625
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0019 0.0058
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.0054
Plasmodium falciparum importin beta, putative 0.003 0.0036 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Schistosoma mansoni importin beta-1 0.003 0.0036 0.0542
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0014 0.0218
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0132 0.0475
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0014 0.0041
Loa Loa (eye worm) BRM protein 0.0036 0.0045 0.092
Giardia lamblia Exonuclease 1 0.0011 0.0005 0.0006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0072 0.0102 0.1542
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0021 0.0316
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0003 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0098 0.0142 0.3207
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0058 0.1259
Trypanosoma brucei chrX additional, unordered contigs 0.0022 0.0024 0.0075
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0194 0.176
Brugia malayi Muscleblind-like protein 0.0155 0.0233 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0005 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0059 0.0893
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0142 0.0195
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0019 0.021
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0009 0.002
Leishmania major DNA polymerase kappa, putative 0.0078 0.0112 0.0399
Echinococcus granulosus exonuclease 1 0.0011 0.0005 0.008
Trichomonas vaginalis DNA polymerase eta, putative 0.0098 0.0142 0.3207
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0155 0.0233 0.4732
Loa Loa (eye worm) hypothetical protein 0.0066 0.0093 0.189
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0017 0.0261
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0293
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0005 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0059 0.0893
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0024 0.0075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0059 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0007
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0076
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0004 0.0002
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0293
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0004 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0027 0.009
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Echinococcus granulosus smad 0.0016 0.0014 0.0217
Leishmania major telomerase reverse transcriptase, putative 0.1732 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0349
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0008
Trypanosoma brucei unspecified product 0.0091 0.0132 0.0475
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0484 0.1767
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0011 0.0005 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0014 0.0218
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.0194 0.3941
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0003 0.0047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0006 0.0088
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0019 0.0391
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.001
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0217
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0006 0.0011
Brugia malayi RNA binding protein 0.0062 0.0086 0.0118
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0217
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0086 0.1301
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus multilocularis peregrin 0.0011 0.0006 0.0091
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0058 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0024 0.0075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0103 0.1558
Onchocerca volvulus 0.001 0.0005 0.0005
Leishmania major DNA polymerase eta, putative 0.0047 0.0063 0.0219
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.0008 0.0152
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0007
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0005 0.0076
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0039
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0052 0.0071 0.025
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.0659 1
Schistosoma mansoni smad 0.0016 0.0014 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0103 0.1558
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0064 0.0226
Echinococcus granulosus glycogen phosphorylase 0.013 0.0194 0.2949
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0004 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0142 0.0512
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0019 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0076
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0019 1
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0142 0.0512
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0551
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0011 0.0005 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0102
Entamoeba histolytica Flap nuclease, putative 0.0052 0.0071 0.0629
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0077 0.027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0058
Schistosoma mansoni topbp1 0.001 0.0004 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0026 0.051
Onchocerca volvulus 0.0009 0.0003 0.0003
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0199 0.0303 0.2753
Echinococcus granulosus geminin 0.0341 0.0527 0.7996
Entamoeba histolytica hypothetical protein 0.0072 0.0103 0.0919
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.0052 0.0783
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0058 0.1259
Entamoeba histolytica DNA-repair protein, putative 0.0011 0.0005 0.0025
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.0484 0.1767
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0027 0.0089
Schistosoma mansoni cpg binding protein 0.0066 0.0093 0.1413
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0047
Trypanosoma brucei telomerase reverse transcriptase 0.1732 0.2723 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0019 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0064 0.0226
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0072 0.0102 0.206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0249 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0024 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0005 0.0076
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0019 0.0027
Echinococcus granulosus snurportin 1 0.032 0.0493 0.7482
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0059 0.0893
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0194 0.4406
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0043 0.0659
Schistosoma mansoni terminal deoxycytidyl transferase 0.0072 0.0102 0.1542
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0005 0.0005
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0034 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0014 0.0041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.0218
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0076
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0014 0.0217
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0011 0.0005 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0142 0.2874
Echinococcus multilocularis dna polymerase kappa 0.0098 0.0142 0.2161
Brugia malayi glutaminase DH11.1 0.0284 0.0437 0.0601
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0194 0.176
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0021 0.0067
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0076
Loa Loa (eye worm) XPG I-region family protein 0.0011 0.0005 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0076
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0058 0.008
Trichomonas vaginalis glutaminase, putative 0.0284 0.0437 1
Entamoeba histolytica hypothetical protein 0.0072 0.0103 0.0919
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0114
Mycobacterium ulcerans glutaminase 0.0284 0.0437 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0036 0.012
Leishmania major hypothetical protein, conserved 0.0011 0.0005 0.0008
Schistosoma mansoni helicase 0.007 0.0099 0.1496
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0058 0.0882
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0077 0.027
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0008 0.0114

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.35 uM Inhibitory concentration against glycogen phosphorylase of rabbit muscle ChEMBL. 16143521
IC50 (binding) = 0.35 uM Inhibitory concentration against glycogen phosphorylase of rabbit muscle ChEMBL. 16143521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.