Detailed information for compound 344577

Basic information

Technical information
  • TDR Targets ID: 344577
  • Name: 2-[4-(11-aminoundecanoylamino)piperidin-1-yl] ethyl 4-amino-5-chloro-2-methoxybenzoate
  • MW: 511.097 | Formula: C26H43ClN4O4
  • H donors: 3 H acceptors: 2 LogP: 4.37 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCCCCCCCCC(=O)NC1CCN(CC1)CCOC(=O)c1cc(Cl)c(cc1OC)N
  • InChi: 1S/C26H43ClN4O4/c1-34-24-19-23(29)22(27)18-21(24)26(33)35-17-16-31-14-11-20(12-15-31)30-25(32)10-8-6-4-2-3-5-7-9-13-28/h18-20H,2-17,28-29H2,1H3,(H,30,32)
  • InChiKey: FNTPFIQEKNCIBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(11-aminoundecanoylamino)-1-piperidyl]ethyl 4-amino-5-chloro-2-methoxy-benzoate
  • 4-amino-5-chloro-2-methoxybenzoic acid 2-[4-[(11-amino-1-oxoundecyl)amino]-1-piperidinyl]ethyl ester
  • 2-[4-(11-azanylundecanoylamino)piperidin-1-yl]ethyl 4-azanyl-5-chloro-2-methoxy-benzoate
  • 4-amino-5-chloro-2-methoxy-benzoic acid 2-[4-(11-aminoundecanoylamino)piperidino]ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 388 aa 314 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.0542
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0069 0.0068
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.021 0.0792
Schistosoma mansoni neprilysin-2 (M13 family) 0.01 0.032 0.1211
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0063 0.1595
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0069 0.1736
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0352 0.1335
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0063 0.0534
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1109 1
Echinococcus granulosus expressed conserved protein 0.0101 0.0322 0.1222
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0348 0.6499
Leishmania major hypothetical protein, conserved 0.0025 0.0023 0.0164
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0063 0.0534
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.009 0.0814
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0541 0.2793
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0439 0.2264
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0048 0.0115 0.0433
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0119 0.0448
Schistosoma mansoni polycystin 1-related 0.0102 0.0329 0.1246
Echinococcus multilocularis expressed conserved protein 0.0101 0.0322 0.0322
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0541 0.2793
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0039 0.0079 0.0078
Schistosoma mansoni lamin 0.0056 0.0146 0.055
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0942 0.3656 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.01 0.032 0.1211
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0004 0.004
Toxoplasma gondii peptidase family M13 protein 0.0198 0.0709 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0063 0.1595
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Loa Loa (eye worm) hypothetical protein 0.0158 0.0549 0.2836
Echinococcus multilocularis geminin 0.0515 0.1964 0.1963
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0039 0.0079 0.0297
Loa Loa (eye worm) sugar transporter 0.0114 0.0374 0.1932
Schistosoma mansoni endothelin-converting enzyme-related 0.0048 0.0115 0.0433
Brugia malayi hypothetical protein 0.0025 0.0023 0.0112
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0108 0.0352 0.0351
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0154
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0069 0.0618
Loa Loa (eye worm) zinc metallopeptidase 4 0.0048 0.0115 0.0589
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.009 0.0814
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0328 0.1692
Echinococcus multilocularis zinc finger transcription factor gli2 0.0353 0.1323 0.1323
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0119 0.061
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0063 0.0534
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.0373
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.0373
Loa Loa (eye worm) inositol-1 0.0037 0.0069 0.035
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0374 0.1419
Onchocerca volvulus 0.0056 0.0146 0.0974
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0063 0.0571
Loa Loa (eye worm) hypothetical protein 0.0146 0.0504 0.2602
Loa Loa (eye worm) hypothetical protein 0.0158 0.0549 0.2836
Loa Loa (eye worm) hypothetical protein 0.0146 0.0504 0.2602
Schistosoma mansoni lipoxygenase 0.0082 0.0247 0.0936
Schistosoma mansoni inositol monophosphatase 0.0037 0.0069 0.0257
Loa Loa (eye worm) hypothetical protein 0.0107 0.0348 0.1797
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0119 0.061
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0127 0.1143
Loa Loa (eye worm) hypothetical protein 0.0055 0.0142 0.0728
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0063 0.0571
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0352 0.1335
Brugia malayi Zinc finger, C2H2 type family protein 0.0353 0.1323 0.6843
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0548 0.772
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.01 0.032 0.1211
Echinococcus granulosus dna polymerase eta 0.002 0.0004 0.0013
Echinococcus multilocularis muscleblind protein 0.0158 0.0549 0.0548
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.009 0.0814
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0069 0.0618
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0004 0.0018
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0448
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0328 0.1242
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0119 0.061
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0052 0.0129 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0439 0.2264
Schistosoma mansoni glucose transport protein 0.0114 0.0374 0.1419
Loa Loa (eye worm) hypothetical protein 0.0507 0.1934 1
Brugia malayi hypothetical protein 0.0395 0.1488 0.7692
Plasmodium falciparum hexose transporter 0.0114 0.0374 1
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0106 0.0398
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0448
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0374 0.0373
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.004
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Schistosoma mansoni DNA polymerase eta 0.002 0.0004 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0079 0.0297
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0448
Loa Loa (eye worm) hypothetical protein 0.0395 0.1488 0.7692
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0069 0.0581
Echinococcus granulosus geminin 0.0515 0.1964 0.7457
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.0374 0.5127
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0069 0.0912
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0485 0.437
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0106 0.0542
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0119 0.0118
Brugia malayi hypothetical protein 0.0154 0.0533 0.2755
Echinococcus granulosus microtubule associated protein 2 0.0684 0.2633 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0063 0.1595
Echinococcus multilocularis dna polymerase kappa 0.002 0.0004 0.0003
Loa Loa (eye worm) peptidase family M13 containing protein 0.0146 0.0504 0.2602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0133
Echinococcus multilocularis lamin dm0 0.0056 0.0146 0.0145
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.01 0.032 0.1211
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0328 0.1692
Toxoplasma gondii melibiase subfamily protein 0.0108 0.0352 0.4807
Onchocerca volvulus Huntingtin homolog 0.0395 0.1488 1
Onchocerca volvulus 0.0098 0.0313 0.2096
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0108 0.0352 0.1335
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0063 0.1595
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0541 0.2793
Schistosoma mansoni hypothetical protein 0.0106 0.0345 0.1309
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0348 0.1797
Loa Loa (eye worm) zinc finger protein 0.0353 0.1323 0.6843
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0115 0.0433
Entamoeba histolytica hypothetical protein 0.0154 0.0533 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.0533 0.0533
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0023 0.0577
Brugia malayi Peptidase family M13 containing protein 0.0198 0.0709 0.3662
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0106 0.0105
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.2633 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0133
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0023 0.0203
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.053 0.053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0043 0.0215
Loa Loa (eye worm) hypothetical protein 0.0156 0.0541 0.2793
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.0577
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0198 0.0709 1
Brugia malayi Inositol-1 0.0037 0.0069 0.035
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.004
Entamoeba histolytica protein kinase, putative 0.0039 0.0079 0.1412
Schistosoma mansoni patched 1 0.0046 0.0106 0.0398
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0039 0.0079 0.0297
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0004 0.0013
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.0374 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Brugia malayi CHE-14 protein 0.0046 0.0106 0.0542
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0374 0.1419
Entamoeba histolytica protein kinase, putative 0.0039 0.0079 0.1412
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Loa Loa (eye worm) hypothetical protein 0.0198 0.0709 0.3662
Brugia malayi hypothetical protein 0.0507 0.1934 1
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0549 0.0548
Onchocerca volvulus 0.0056 0.0146 0.0974
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0374 0.1419
Plasmodium vivax hexose transporter 0.0114 0.0374 1
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0348 0.1319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0328 0.0327
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0023 0.0164
Loa Loa (eye worm) hypothetical protein 0.0056 0.0147 0.0755
Entamoeba histolytica hypothetical protein 0.0154 0.0533 1
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0345 0.1782
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0198 0.0709 0.3662
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.2633 0.2632
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0039 0.0079 0.0078
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0069 0.0671
Giardia lamblia DINP protein human, muc B family 0.002 0.0004 0.5
Schistosoma mansoni hypothetical protein 0.0515 0.1964 0.7457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0328 0.1242
Echinococcus granulosus survival motor neuron protein 1 0.0507 0.1934 0.7343
Schistosoma mansoni Nep2 peptidase (M13 family) 0.01 0.032 0.1211
Brugia malayi Muscleblind-like protein 0.0158 0.0549 0.2836
Schistosoma mansoni lamin 0.0056 0.0146 0.055
Echinococcus multilocularis GPCR, family 2 0.0049 0.0119 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0063 0.1595
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0106 0.0398
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Loa Loa (eye worm) hypothetical protein 0.0098 0.0313 0.1612
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1109 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0504 0.2602
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1109 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0108 0.0352 0.0351
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0023 0.0203
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0348 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0106 0.2742
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0355 0.1344
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0004 0.0013
Echinococcus granulosus zinc finger transcription factor gli2 0.0353 0.1323 0.5025
Leishmania major glucose transporter, lmgt2 0.0035 0.0063 0.0534
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.053 0.2012
Echinococcus multilocularis lamin 0.0056 0.0146 0.0145
Echinococcus multilocularis General substrate transporter 0.0098 0.0311 0.031
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Loa Loa (eye worm) hypothetical protein 0.0198 0.0709 0.3662
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.0577
Loa Loa (eye worm) peptidase family M13 containing protein 0.0146 0.0504 0.2602
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0031 0.003
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0063 0.0571
Mycobacterium leprae probable zinc metalloprotease 0.0198 0.0709 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0146 0.055
Loa Loa (eye worm) hypothetical protein 0.0395 0.1488 0.7692
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.0373
Leishmania major glucose transporter, lmgt1 0.0035 0.0063 0.0534
Schistosoma mansoni lipoxygenase 0.0117 0.0387 0.1465
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.0373
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0146 0.0749
Loa Loa (eye worm) hypothetical protein 0.0072 0.021 0.1079
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0374 0.1419
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Brugia malayi Melibiase family protein 0.0072 0.021 0.1079
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0069 0.1214
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0115 0.0433
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.009 0.0778
Loa Loa (eye worm) hypothetical protein 0.0146 0.0504 0.2602
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0053 0.0696
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Echinococcus multilocularis musashi 0.0056 0.0146 0.0145
Entamoeba histolytica hypothetical protein 0.0154 0.0533 1
Entamoeba histolytica hypothetical protein 0.0154 0.0533 1
Mycobacterium ulcerans hypothetical protein 0.0158 0.0548 0.772
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0063 0.1595
Mycobacterium ulcerans zinc metalloprotease 0.0198 0.0709 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.021 0.0792
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0334 0.1721
Trypanosoma brucei glucose transporter 2A 0.0035 0.0063 0.0534
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0004 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.0533 0.2023
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Echinococcus granulosus lamin 0.0056 0.0146 0.055
Schistosoma mansoni hypothetical protein 0.0114 0.0374 0.1419
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0374 0.0373
Schistosoma mansoni glucose transport protein 0.0114 0.0374 0.1419
Echinococcus granulosus muscleblind protein 0.0158 0.0549 0.2082
Echinococcus granulosus dna polymerase kappa 0.002 0.0004 0.0013
Schistosoma mansoni inositol monophosphatase 0.0037 0.0069 0.0257
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0004 0.0018
Schistosoma mansoni survival motor neuron protein 0.0103 0.0334 0.1264
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0115 0.0433
Echinococcus multilocularis endothelin converting enzyme 1 0.0198 0.0709 0.0708
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0485 0.4347
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0352 0.1335
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0018
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0069 0.0257
Onchocerca volvulus 0.0103 0.0334 0.2237
Schistosoma mansoni glucose transport protein 0.0114 0.0374 0.1419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0328 0.1242
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1109 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0031 0.0113
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0198 0.0709 0.2689
Echinococcus multilocularis survival motor neuron protein 1 0.0507 0.1934 0.1933
Schistosoma mansoni hypothetical protein 0.0154 0.0533 0.2023
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0043 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0328 0.1242
Brugia malayi MH2 domain containing protein 0.013 0.0439 0.2264
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0485 0.4347
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0063 0.0534
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0387 0.0386
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0352 0.1335
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Brugia malayi peptidase family M13 containing protein 0.0048 0.0115 0.0589
Trypanosoma cruzi hexose transporter 0.0035 0.0063 0.0571
Echinococcus granulosus intermediate filament protein 0.0056 0.0146 0.055
Echinococcus granulosus GPCR family 2 0.0049 0.0119 0.0448
Trypanosoma brucei glucose transporter 1E 0.0035 0.0063 0.0534
Loa Loa (eye worm) hypothetical protein 0.0106 0.0345 0.1782
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0328 0.1242
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0069 0.1736
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0069 0.1736
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0119 0.0448
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0448
Echinococcus granulosus General substrate transporter 0.0098 0.0311 0.1178
Onchocerca volvulus Huntingtin homolog 0.0395 0.1488 1
Leishmania major glucose transporter, lmgt3 0.0035 0.0063 0.0534
Echinococcus multilocularis protein patched 0.0046 0.0106 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0387 0.1465
Schistosoma mansoni hypothetical protein 0.0515 0.1964 0.7457
Schistosoma mansoni hypothetical protein 0.0103 0.0334 0.1264
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0063 0.1595
Trypanosoma brucei glucose transporter, putative 0.0035 0.0063 0.0534
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0119 0.0118
Toxoplasma gondii hypothetical protein 0.0048 0.0115 0.1345
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0069 0.0581
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0146 0.0749
Echinococcus granulosus lamin dm0 0.0056 0.0146 0.055
Echinococcus granulosus endothelin converting enzyme 1 0.0198 0.0709 0.2689
Loa Loa (eye worm) hypothetical protein 0.0198 0.0709 0.3662
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0146 0.0749
Echinococcus multilocularis dna polymerase eta 0.002 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0052 0.0129 0.0484
Schistosoma mansoni neprilysin 0.0052 0.0129 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0328 0.0327
Brugia malayi intermediate filament protein 0.0056 0.0146 0.0749
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0048 0.0115 0.0433
Brugia malayi Sugar transporter family protein 0.0114 0.0374 0.1932
Loa Loa (eye worm) hypothetical protein 0.015 0.0518 0.2673
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0374 0.0373
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.0533 0.2023
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.021 0.5546
Echinococcus multilocularis protein dispatched 1 0.0052 0.0132 0.0131

Activities

Activity type Activity value Assay description Source Reference
cAMP (functional) = 50 % Percent cAMP production in C6 glial cells expressing human 5-hydroxytryptamine 4 receptor ChEMBL. 16190749
cAMP (functional) = 50 % Percent cAMP production in C6 glial cells expressing human 5-hydroxytryptamine 4 receptor ChEMBL. 16190749
Ki (binding) = 13 nM Binding affinity for 5-HT4 receptor using [3H]-GR-113,808 ChEMBL. 16190749
Ki (binding) = 13 nM Binding affinity for 5-HT4 receptor using [3H]-GR-113,808 ChEMBL. 16190749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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