Detailed information for compound 34798

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.422 | Formula: C19H27NO4
  • H donors: 3 H acceptors: 3 LogP: 2.06 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN(CC(O)C)CC(O)C)COc1cccc2c1cccc2
  • InChi: 1S/C19H27NO4/c1-14(21)10-20(11-15(2)22)12-17(23)13-24-19-9-5-7-16-6-3-4-8-18(16)19/h3-9,14-15,17,21-23H,10-13H2,1-2H3
  • InChiKey: MTYUQXAZBSKVAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0156 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0273 0.0183
Brugia malayi Cache domain containing protein 0.0058 0.1166 0.1166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0956 0.0872
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Protein kinase domain containing protein 0.0022 0.0178 0.0178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0273 0.0183
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0273 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0525 0.0437
Loa Loa (eye worm) hypothetical protein 0.0027 0.0301 0.0211
Echinococcus multilocularis serotonin receptor 0.0168 0.4209 0.486
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3625 0.3566
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0315 0.0315
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0049 0.0927 1
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0273 0.0273
Onchocerca volvulus 0.0048 0.0884 0.9472
Schistosoma mansoni slit 0.005 0.0956 0.0872
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0273 0.0183
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0238 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0156 0.0156
Loa Loa (eye worm) ACC-1 protein 0.002 0.0109 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0273 0.0273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.2868 1
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0267 0.6924 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0178 0.1028
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0156 0.0065
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0109 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0156 0.0065
Brugia malayi Serotonin receptor 0.0021 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0273 0.0273
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0109 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.2868 0.3277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0273 0.0183
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0156 0.0076
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Echinococcus multilocularis pikachurin 0.005 0.0956 0.102
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0044 0.0792 0.0827
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0109 0.002
Leishmania major hypothetical protein, conserved 0.0022 0.0178 0.0309
Echinococcus granulosus hypothetical protein 0.0021 0.0156 0.0076
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0156 0.0156
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0379 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0049 0.0927 1
Brugia malayi G protein-coupled receptor 0.0021 0.0156 0.0156
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0156 0.0076
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0956 0.0872
Onchocerca volvulus 0.0027 0.0315 0.2517
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0273 0.0213
Schistosoma mansoni lamin 0.0027 0.0315 0.0225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0273 0.0183
Brugia malayi RE15519p 0.0021 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Brugia malayi Serotonin receptor 0.0021 0.0156 0.0156
Brugia malayi AKH receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) ACC-1 protein 0.002 0.0109 0.0017
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus nAChR subunit 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Brugia malayi G-protein coupled receptor 0.0021 0.0156 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0273 0.0213
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0273 0.0183
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.3625 0.417
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0109 0.002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0956 0.102
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0273 0.0213
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0131 0.318 0.3645
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0156 0.0076
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0109 0.0017
Echinococcus granulosus neuropeptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0238 0.0148
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.4209 0.4156
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0884 0.0799
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Brugia malayi laminin alpha chain 0.005 0.0956 0.0956
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi neuropeptide F receptor 0.0021 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0273 0.0273
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0109 0.0109
Echinococcus granulosus allatostatin A receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0315 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0273 0.0273
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus sex peptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni laminin gamma-3 chain 0.005 0.0956 0.0872
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0156 0.0156
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2868 0.2802
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0109 0.002
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0156 0.0076
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0049 0.0927 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2868 0.2802
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3625 0.3566
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0092 0.0092
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0156 0.0065
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0238 0.175
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0049 0.0927 0.0843
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0156 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0273 0.0183
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2919 0.3337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni intermediate filament proteins 0.0027 0.0315 0.0225
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0049 0.0927 0.0843
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0927 0.0843
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0273 0.0183
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0156 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0068 0.1433 0.1354
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0156 0.0065
Echinococcus multilocularis tumor protein p63 0.0326 0.8564 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0109 0.002
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0109 0.0109
Echinococcus granulosus voltage dependent calcium channel subunit 0.0288 0.7512 0.8758
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Brugia malayi neuropeptide F receptor 0.0021 0.0156 0.0156
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0156 0.0076
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0109 0.002
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0109 0.0017
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0273 0.2002
Brugia malayi nuclear hormone receptor 0.0026 0.0273 0.0273
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0273 0.0273
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0956 0.0956
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0273 0.0183
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0168 0.4209 0.4156
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0109 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0525 0.0437
Echinococcus granulosus tumor protein p63 0.0326 0.8564 1
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) LGC-31 protein 0.002 0.0109 0.0017
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0156 0.0076
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0273 0.0183
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0156 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Schistosoma mansoni myosin xvIII 0.0021 0.0156 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0273 0.0213
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0178 0.0087
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0273 0.0273
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0156 0.0065
Brugia malayi Cytochrome P450 family protein 0.0023 0.0194 0.0194
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0273 0.0183
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis sex peptide receptor 0.0021 0.0156 0.0076
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0273 0.2002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0156 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0238 0.175
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0525 0.0511
Schistosoma mansoni cell polarity protein 0.005 0.0956 0.0872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0273 0.0183
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0178 0.5874
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0884 0.0799
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0156 0.0076
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1
Schistosoma mansoni hypothetical protein 0.0122 0.2919 0.2853
Loa Loa (eye worm) hypothetical protein 0.0168 0.4209 0.4156
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0044 0.0792 0.0827
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0126 0.3033 0.2968
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi larval opioid receptor 0.0021 0.0156 0.0156
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0156 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0194 0.0103
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0178 0.0101
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0315 0.0225
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0238 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0238 0.175
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Brugia malayi putative neuropeptide receptor 0.0021 0.0156 0.0156
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2919 0.3337
Schistosoma mansoni hypothetical protein 0.0022 0.0178 0.0087
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Schistosoma mansoni adenoreceptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus lamin 0.0027 0.0315 0.0263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0156 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0273 0.0273
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0109 0.0109
Brugia malayi hypothetical protein 0.0024 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0273 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0156 0.0076
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0956 0.102
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis lamin dm0 0.0027 0.0315 0.0263
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0273 0.0183
Onchocerca volvulus 0.0022 0.0178 0.0841
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0156 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0273 0.0213
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus serotonin receptor 0.0021 0.0156 0.0076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0273 0.0213
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0178 0.0309
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0156 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0092 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0273 0.0183
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0956 0.0956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0109 0.0109
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0156 0.0065
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0109 0.0109
Echinococcus granulosus fmrfamide receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0109 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni lamin 0.0027 0.0315 0.0225
Echinococcus multilocularis lysosomal protective protein 0.0049 0.0927 0.0986
Echinococcus multilocularis serotonin receptor 0.0168 0.4209 0.486
Schistosoma mansoni neuropeptide receptor 0.0021 0.0156 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0109 0.0017
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0273 0.0273
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0109 0.002
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0156 0.0065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.2868 0.3277
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Onchocerca volvulus 0.0021 0.0156 0.0577
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0049 0.0927 1
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0156 0.0076
Echinococcus multilocularis slit 2 protein 0.005 0.0956 0.102
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0063 0.1314 0.1233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0156 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0156 0.0076
Echinococcus multilocularis lamin 0.0027 0.0315 0.0263
Echinococcus granulosus lamin dm0 0.0027 0.0315 0.0263
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0156 0.0076
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0092 0.5
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0273 0.0213
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0049 0.0927 1
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0156 0.0076
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0109 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0315 0.0225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Brugia malayi G-protein coupled receptor 0.0021 0.0156 0.0156
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0178 0.5874
Echinococcus granulosus lysosomal protective protein 0.0049 0.0927 0.0986
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0288 0.7512 0.8758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis musashi 0.0027 0.0315 0.0263
Echinococcus granulosus somatostatin receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0178 0.0101
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0109 0.002
Onchocerca volvulus 0.0021 0.0156 0.0577
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0049 0.0927 0.3008
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0156 0.0076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0273 0.2002
Echinococcus multilocularis somatostatin receptor 0.0021 0.0156 0.0076
Onchocerca volvulus 0.0021 0.0156 0.0577
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0049 0.0927 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0109 0.0109
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0156 0.0076
Brugia malayi steroid hormone receptor 0.0026 0.0273 0.0273
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Echinococcus granulosus pikachurin 0.005 0.0956 0.102
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0109 0.0109
Echinococcus granulosus slit 2 protein 0.005 0.0956 0.102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0273 0.0273
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0109 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0273 0.0183
Echinococcus multilocularis nAChR subunit 0.002 0.0109 0.002
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0109 0.002
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0049 0.0927 0.0927
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0156 0.0076
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0156 0.0076
Schistosoma mansoni nAChR subunit 0.002 0.0109 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0273 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0525 0.0511
Onchocerca volvulus 0.0021 0.0156 0.0577
Schistosoma mansoni amine GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Brugia malayi Melatonin receptor type 1A 0.0021 0.0156 0.0156
Schistosoma mansoni biogenic amine receptor 0.0021 0.0156 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0273 0.0273
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0238 0.0527
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0156 0.0076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0109 0.0017
Onchocerca volvulus 0.0021 0.0156 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0273 0.0273
Brugia malayi Cation transporter family protein 0.002 0.0109 0.0109
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0273 0.0213
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0156 0.0065
Echinococcus granulosus voltage dependent calcium channel subunit 0.0131 0.318 0.3645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Onchocerca volvulus 0.0026 0.0273 0.2002
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0109 0.002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0109 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi Dopamine receptor protein 2 0.0021 0.0156 0.0156
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0156 0.0577
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Echinococcus granulosus neuropeptide receptor 0.0021 0.0156 0.0076
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.4209 0.486
Schistosoma mansoni opsin-like receptor 0.0021 0.0156 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0273 0.0213
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0156 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.2868 1
Brugia malayi nuclear receptor NHR-88 0.0026 0.0273 0.0273
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0156 0.0065
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0156 0.0076
Brugia malayi ecdysteroid receptor 0.0026 0.0273 0.0273
Schistosoma mansoni coup transcription factor 0.0026 0.0273 0.0183
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0156 0.0076
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0156 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0156 0.0065
Brugia malayi intermediate filament protein 0.0027 0.0315 0.0315
Onchocerca volvulus 0.0027 0.0315 0.2517
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0156 0.0156
Brugia malayi GnHR receptor homolog 0.0021 0.0156 0.0156
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0156 0.0065
Brugia malayi sulfakinin receptor protein 0.0021 0.0156 0.0156
Brugia malayi Dopamine receptor protein 1 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0156 0.0076
Schistosoma mansoni hypothetical protein 0.0021 0.0156 0.0065
Echinococcus granulosus orexin receptor type 2 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0156 0.0076
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0156 0.0076
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0273 0.0183
Leishmania major hypothetical protein, conserved 0.0024 0.0238 0.0527
Schistosoma mansoni histamine h1 receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0022 0.0178 0.0087
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0109 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0273 0.0273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0273 0.0213
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2868 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0156 0.0076
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0156 0.0076
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0156 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0109 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Echinococcus granulosus g protein coupled receptor 0.0021 0.0156 0.0076
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0156 0.0076
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0273 0.0213
Brugia malayi Kringle domain containing protein 0.0022 0.0178 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0109 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0156 0.0076
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi ORL1-like opioid receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0017
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0109 0.0109
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0156 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0956 0.0872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Brugia malayi hypothetical protein 0.0035 0.0525 0.0525
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0156 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0156 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0156 0.0076
Brugia malayi Dopamine receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0058 0.1166 0.1085
Echinococcus granulosus intermediate filament protein 0.0027 0.0315 0.0263
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0273 0.0213
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0156 0.0577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0183
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0065
Schistosoma mansoni serine-rich repeat protein 0.0068 0.1433 0.1354
Brugia malayi EGF-like domain containing protein 0.005 0.0956 0.0956
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0156 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0273 0.0183
Entamoeba histolytica hypothetical protein 0.0035 0.0525 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -5.88 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Log Ki (binding) = 5.88 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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