TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 269.295 | Formula: C16H15NO3
H donors: 2 H acceptors: 2 LogP: 2.31 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCCC/N=c/1\cc(O)c2c(o1)c1ccccc1cc2
InChi: 1S/C16H15NO3/c18-9-3-8-17-15-10-14(19)13-7-6-11-4-1-2-5-12(11)16(13)20-15/h1-2,4-7,10,18-19H,3,8-9H2/b17-15+
InChiKey: ZMLTVRKAKCBFFR-BMRADRMJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	neuropeptide receptor A26	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.1049	0.1049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	g protein coupled receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.007	0.1668	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	adenoreceptor	0.0052	0.1049	0.6289
Echinococcus granulosus	neuropeptide receptor	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.007	0.1668	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.1049	0.1049
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.007	0.1668	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.007	0.1668	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Giardia lamblia	GTOR	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.007	0.1668	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.007	0.1668	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0052	0.1049	0.1049
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0052	0.1049	0.6289
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.1049	0.1049
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.007	0.1668	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0052	0.1049	0.1049
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.007	0.1668	0.5539
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.1049	0.1049
Toxoplasma gondii	cytochrome p450 superfamily protein	0.007	0.1668	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0052	0.1049	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.007	0.1668	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.007	0.1668	0.5
Schistosoma mansoni	biogenic amine receptor	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.007	0.1668	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.1049	0.1049
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.007	0.1668	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0052	0.1049	0.6289
Echinococcus granulosus	sex peptide receptor	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.007	0.1668	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.007	0.1668	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0052	0.1049	0.6289
Brugia malayi	putative neuropeptide receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	biogenic amine receptor	0.0052	0.1049	0.6289
Brugia malayi	Melatonin receptor type 1A	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.1049	0.1049
Echinococcus granulosus	neuropeptide receptor A26	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.1049	0.1049
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	fmrfamide receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.007	0.1668	0.5539
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	Cytochrome P450 family protein	0.007	0.1668	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.007	0.1668	0.5
Leishmania major	cytochrome p450-like protein	0.007	0.1668	0.5286
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.007	0.1668	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Brugia malayi	Dopamine receptor protein 2	0.0052	0.1049	0.6289
Echinococcus multilocularis	serotonin receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0052	0.1049	0.6289
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0052	0.1049	0.6289
Brugia malayi	Dopamine receptor	0.0052	0.1049	0.6289
Brugia malayi	G protein-coupled receptor F59B2.13	0.0052	0.1049	0.6289
Brugia malayi	G-protein coupled receptor	0.0052	0.1049	0.6289
Brugia malayi	Cytochrome P450 family protein	0.007	0.1668	1
Brugia malayi	neuropeptide F receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Leishmania major	cytochrome p450-like protein	0.007	0.1668	0.5286
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0052	0.1049	0.1049
Loa Loa (eye worm)	TYRA-2 protein	0.0052	0.1049	0.6289
Schistosoma mansoni	opsin-like receptor	0.0052	0.1049	0.6289
Brugia malayi	Cytochrome P450 family protein	0.007	0.1668	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.1049	0.1049
Echinococcus granulosus	neuropeptide s receptor	0.0052	0.1049	0.1049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.007	0.1668	1
Loa Loa (eye worm)	cytochrome P450	0.007	0.1668	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Schistosoma mansoni	amine GPCR	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.007	0.1668	0.5
Schistosoma mansoni	hypothetical protein	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.007	0.1668	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.007	0.1668	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	histamine h1 receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	serotonin receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	cytochrome P450 family protein	0.007	0.1668	1
Schistosoma mansoni	amine GPCR	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0052	0.1049	0.1049
Echinococcus granulosus	dro:myosuppressin receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	cytochrome P450 family protein	0.007	0.1668	1
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	neuropeptide f receptor 76f	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.007	0.1668	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.1049	0.1049
Echinococcus multilocularis	neuropeptide s receptor	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	opsin-like receptor	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Echinococcus granulosus	g protein coupled receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0052	0.1049	0.1049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Echinococcus granulosus	cytochrome P450 2K1	0.007	0.1668	0.1668
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.007	0.1668	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0052	0.1049	0.1049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	GnHR receptor homolog	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Leishmania major	hypothetical protein, conserved	0.0114	0.3155	1
Echinococcus granulosus	allatostatin A receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.1049	0.1049
Brugia malayi	Serotonin receptor	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.007	0.1668	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0052	0.1049	0.1049
Brugia malayi	cytochrome P450	0.007	0.1668	1
Brugia malayi	larval opioid receptor	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3011	1
Brugia malayi	Dopamine receptor protein 1	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.007	0.1668	0.5
Brugia malayi	G-protein coupled receptor	0.0052	0.1049	0.6289
Brugia malayi	Cytochrome P450 family protein	0.007	0.1668	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	G protein-coupled receptor	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.007	0.1668	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.007	0.1668	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.1049	0.1049
Onchocerca volvulus		0.0052	0.1049	0.5
Brugia malayi	sulfakinin receptor protein	0.0052	0.1049	0.6289
Schistosoma mansoni	amine GPCR	0.0052	0.1049	0.6289
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.007	0.1668	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.007	0.1668	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium leprae	Conserved hypothetical protein	0.007	0.1668	0.5
Echinococcus multilocularis	sex peptide receptor	0.0052	0.1049	0.1049
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.1049	0.6289
Brugia malayi	neuropeptide F receptor	0.0052	0.1049	0.6289
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.007	0.1668	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Trypanosoma brucei	cytochrome P450, putative	0.007	0.1668	1
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.007	0.1668	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Echinococcus granulosus	g protein coupled receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0052	0.1049	0.1049
Schistosoma mansoni	neuropeptide receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	hypothetical protein	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.1049	0.6289
Brugia malayi	AKH receptor	0.0052	0.1049	0.6289
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	cytochrome P450 family protein	0.007	0.1668	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.1049	0.6289
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.007	0.1668	0.5286
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Leishmania major	cytochrome p450-like protein	0.007	0.1668	0.5286
Brugia malayi	putative neuropeptide receptor NPR1	0.0052	0.1049	0.6289
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.007	0.1668	0.5
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.007	0.1668	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.007	0.1668	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0052	0.1049	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0052	0.1049	0.6289
Trypanosoma cruzi	cytochrome P450, putative	0.007	0.1668	0.5539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.007	0.1668	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	neuropeptide receptor	0.0052	0.1049	0.6289
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.1049	0.1049
Brugia malayi	follicle stimulating hormone receptor	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	orexin receptor type 2	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.007	0.1668	0.5
Mycobacterium leprae	putative cytochrome p450	0.007	0.1668	0.5
Schistosoma mansoni	amine GPCR	0.0052	0.1049	0.6289
Brugia malayi	RE15519p	0.0052	0.1049	0.6289
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Brugia malayi	Serotonin receptor	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	biogenic amine receptor	0.0052	0.1049	0.6289
Echinococcus granulosus	7TM GPCR rhodopsin	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.007	0.1668	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Echinococcus granulosus	G protein coupled receptor 139	0.0052	0.1049	0.1049
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0052	0.1049	0.1049
Onchocerca volvulus		0.0052	0.1049	0.5
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.007	0.1668	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0052	0.1049	0.1049
Schistosoma mansoni	opsin-like receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.007	0.1668	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0052	0.1049	0.6289
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.007	0.1668	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	hypothetical protein	0.007	0.1668	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	myosin xvIII	0.0052	0.1049	0.6289
Loa Loa (eye worm)	CYP4Cod1	0.007	0.1668	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.007	0.1668	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0052	0.1049	0.1049
Echinococcus multilocularis	serotonin receptor	0.0052	0.1049	0.1049
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0052	0.1049	0.1049
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.007	0.1668	0.5
Echinococcus granulosus	somatostatin receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.1049	0.1049
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.007	0.1668	0.5
Echinococcus multilocularis		0.007	0.1668	0.1668
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.1049	0.6289
Echinococcus multilocularis	G protein coupled receptor 139	0.0052	0.1049	0.1049
Trypanosoma cruzi	cytochrome P450, putative	0.007	0.1668	0.5539
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.1049	0.1049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.1049	0.6289
Schistosoma mansoni	amine GPCR	0.0052	0.1049	0.6289
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.007	0.1668	0.5539
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.1049	0.1049
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0052	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	neuropeptide receptor	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	cytochrome P450	0.007	0.1668	1
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.1049	0.1049
Echinococcus multilocularis	somatostatin receptor	0.0052	0.1049	0.1049
Brugia malayi	ORL1-like opioid receptor	0.0052	0.1049	0.6289
Brugia malayi	hypothetical protein	0.0052	0.1049	0.6289
Echinococcus granulosus	7tm_1 domain containing protein	0.0052	0.1049	0.1049
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.1049	0.1049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.007	0.1668	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1049	0.6289
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0052	0.1049	0.6289

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822
IC50 (binding)	> 10 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 348851