TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 222.154 | Formula: C9H6N2O5
H donors: 3 H acceptors: 6 LogP: 1 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1nc(nc(c1O)O)c1ccco1
InChi: 1S/C9H6N2O5/c12-6-5(9(14)15)10-7(11-8(6)13)4-2-1-3-16-4/h1-3,12H,(H,14,15)(H,10,11,13)
InChiKey: PAQPHTZYNPKGGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin alpha	0.1437	0.5006	0.5006
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.2741	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin subunit TubB	0.1944	0.6948	0.6948
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.1944	0.6948	0.6948
Schistosoma mansoni	alpha tubulin	0.1944	0.6948	0.6948
Loa Loa (eye worm)	BEN-1 protein	0.2741	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.1944	0.6948	0.6948
Trypanosoma brucei	epsilon tubulin	0.1437	0.5006	0.5006
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Onchocerca volvulus		0.0729	0.2296	0.8711
Brugia malayi	hypothetical protein	0.0155	0.0099	0.0099
Leishmania major	delta tubulin, putative	0.0624	0.1894	0.1894
Echinococcus granulosus	tubulin epsilon chain	0.1437	0.5006	0.5006
Loa Loa (eye worm)	tubulin alpha 2	0.0507	0.1447	0.1447
Echinococcus granulosus	Tubulin beta 2C chain	0.2741	1	1
Trypanosoma cruzi	tubulin delta chain	0.0624	0.1894	0.1894
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	Tubulin beta 2C chain	0.2741	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1944	0.6948	0.6235
Echinococcus granulosus	Tubulin beta 2C chain	0.2741	1	1
Leishmania major	beta tubulin	0.2741	1	1
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Brugia malayi	Tubulin alpha-2 chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin alpha 3 chain	0.1944	0.6948	0.6948
Leishmania major	epsilon tubulin, putative	0.1437	0.5006	0.5006
Trypanosoma brucei	beta tubulin	0.1437	0.5006	0.5006
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0219	0.0345	0.0345
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.1437	0.5006	0.5006
Schistosoma mansoni	alpha tubulin	0.1944	0.6948	0.6948
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin alpha 3 chain	0.1944	0.6948	0.6948
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0624	0.1894	0.5
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Loa Loa (eye worm)	tubulin beta chain	0.2741	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.1944	0.6948	0.6948
Echinococcus granulosus	geminin	0.1385	0.4809	0.4809
Echinococcus granulosus	peroxisome assembly protein 26	0.1944	0.6948	0.6948
Loa Loa (eye worm)	hypothetical protein	0.016	0.012	0.012
Plasmodium falciparum	alpha tubulin 1	0.1944	0.6948	0.6948
Echinococcus multilocularis	Tubulin beta 2C chain	0.2741	1	1
Trypanosoma brucei	beta tubulin	0.2741	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0624	0.1894	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0219	0.0345	0.0345
Toxoplasma gondii	alpha-tubulin I, putative	0.1944	0.6948	0.6948
Trypanosoma brucei	epsilon tubulin	0.1437	0.5006	0.5006
Echinococcus granulosus	tubulin alpha 3 chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin alpha chain	0.1944	0.6948	0.6948
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	alpha tubulin	0.1944	0.6948	0.6948
Trypanosoma brucei	beta tubulin	0.2741	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0155	0.0099	0.0099
Brugia malayi	Tubulin alpha-2 chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.2741	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.1437	0.5006	0.3839
Giardia lamblia	Beta tubulin	0.2741	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Giardia lamblia	Gamma tubulin	0.1437	0.5006	0.3839
Schistosoma mansoni	tubulin subunit alpha	0.0624	0.1894	0.1894
Echinococcus multilocularis	hypothetical protein	0.1944	0.6948	0.6948
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Loa Loa (eye worm)	tubulin alpha-3 chain	0.1131	0.3835	0.3835
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Schistosoma mansoni	tubulin subunit alpha	0.1944	0.6948	0.6948
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Leishmania major	beta tubulin	0.2741	1	1
Leishmania major	beta tubulin	0.2741	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.1437	0.5006	0.5006
Trypanosoma cruzi	zeta tubulin, putative	0.0624	0.1894	0.1894
Trypanosoma brucei	alpha tubulin	0.1944	0.6948	0.6948
Brugia malayi	tubulin alpha chain - mouse	0.1944	0.6948	0.6948
Trypanosoma brucei	beta tubulin	0.2741	1	1
Brugia malayi	hypothetical protein	0.0219	0.0345	0.0345
Echinococcus multilocularis	beta tubulin	0.2741	1	1
Schistosoma mansoni	tubulin subunit delta	0.0624	0.1894	0.1894
Echinococcus multilocularis	tubulin subunit TubB	0.1944	0.6948	0.6948
Echinococcus granulosus	Tubulin beta 2C chain	0.2741	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.2741	1	1
Trypanosoma brucei	tubulin delta chain	0.0624	0.1894	0.1894
Trichomonas vaginalis	tubulin beta chain, putative	0.2741	1	1
Schistosoma mansoni	hypothetical protein	0.1385	0.4809	0.4809
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.1131	0.3835	0.2395
Echinococcus granulosus	tubulin alpha 1C chain	0.1944	0.6948	0.6948
Schistosoma mansoni	tubulin subunit alpha	0.1944	0.6948	0.6948
Toxoplasma gondii	alpha tubulin TUBA1	0.1944	0.6948	0.6948
Echinococcus multilocularis	peroxisome assembly protein 26	0.1944	0.6948	0.6948
Echinococcus multilocularis	Tubulin beta 2C chain	0.2741	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.1944	0.6948	0.6948
Echinococcus granulosus	beta tubulin	0.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.1131	0.3835	0.3835
Loa Loa (eye worm)	tubulin beta chain	0.0624	0.1894	0.1894
Giardia lamblia	Beta tubulin	0.2741	1	1
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.1944	0.6948	0.6235
Plasmodium vivax	tubulin beta chain, putative	0.2741	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0155	0.0099	0.0099
Echinococcus granulosus	tubulin alpha chain	0.1944	0.6948	0.6948
Echinococcus granulosus	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin alpha chain	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin beta 4A class IVa	0.2741	1	1
Loa Loa (eye worm)	alpha-tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin alpha chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin delta chain	0.0624	0.1894	0.1894
Trichomonas vaginalis	tubulin, putative	0.0813	0.2618	0.0893
Plasmodium vivax	delta tubulin, putative	0.0624	0.1894	0.1894
Leishmania major	beta tubulin	0.2741	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0155	0.0099	0.0099
Leishmania major	beta tubulin	0.2741	1	1
Onchocerca volvulus		0.0813	0.2618	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0624	0.1894	0.1894
Loa Loa (eye worm)	beta-tubulin	0.2741	1	1
Leishmania major	zeta tubulin, putative	0.0624	0.1894	0.1894
Entamoeba histolytica	tubulin gamma chain	0.1437	0.5006	0.4828
Plasmodium falciparum	tubulin delta chain, putative	0.0624	0.1894	0.1894
Giardia lamblia	Alpha-tubulin	0.1944	0.6948	0.6235
Leishmania major	beta tubulin	0.2741	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0624	0.1894	0.5
Echinococcus multilocularis	tubulin alpha chain	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0813	0.2618	0.0893
Loa Loa (eye worm)	MH2 domain-containing protein	0.0733	0.2312	0.2312
Trypanosoma cruzi	beta tubulin, putative	0.2741	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.2741	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0155	0.0099	0.0099
Brugia malayi	alpha-tubulin	0.1944	0.6948	0.6948
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Schistosoma mansoni	tubulin subunit gamma	0.1437	0.5006	0.5006
Echinococcus multilocularis	tubulin beta 1 chain	0.2741	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Trypanosoma brucei	alpha tubulin, putative	0.0813	0.2618	0.2618
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Loa Loa (eye worm)	tubulin beta-4 chain	0.2741	1	1
Brugia malayi	Cell division protein ftsZ	0.0624	0.1894	0.1894
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0624	0.1894	0.1894
Trypanosoma brucei	epsilon tubulin	0.1437	0.5006	0.5006
Trichomonas vaginalis	tubulin alpha chain, putative	0.0813	0.2618	0.0893
Echinococcus multilocularis	tubulin alpha chain	0.1944	0.6948	0.6948
Trypanosoma brucei	zeta tubulin, putative	0.0624	0.1894	0.1894
Loa Loa (eye worm)	tubulin gamma chain	0.1437	0.5006	0.5006
Trichomonas vaginalis	tubulin beta chain, putative	0.0813	0.2618	0.0893
Trypanosoma cruzi	zeta tubulin, putative	0.0624	0.1894	0.1894
Loa Loa (eye worm)	BEN-1 protein	0.2741	1	1
Schistosoma mansoni	tubulin subunit alpha	0.1944	0.6948	0.6948
Schistosoma mansoni	hypothetical protein	0.0219	0.0345	0.0345
Toxoplasma gondii	LsmAD domain-containing protein	0.0155	0.0099	0.0099
Echinococcus multilocularis	tubulin alpha 1C chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin alpha	0.1437	0.5006	0.5006
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin alpha chain	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin, putative	0.0813	0.2618	0.0893
Brugia malayi	Tubulin gamma chain	0.1437	0.5006	0.5006
Echinococcus multilocularis	tubulin epsilon chain	0.1437	0.5006	0.5006
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0733	0.2312	0.2312
Toxoplasma gondii	beta-tubulin, putative	0.2741	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1944	0.6948	0.6235
Loa Loa (eye worm)	tubulin alpha chain	0.1944	0.6948	0.6948
Brugia malayi	beta-tubulin, identical	0.2741	1	1
Entamoeba histolytica	tubulin family protein	0.2741	1	1
Loa Loa (eye worm)	pax transcription factor protein 2	0.0729	0.2296	0.2296
Loa Loa (eye worm)	alpha-tubulin	0.1944	0.6948	0.6948
Loa Loa (eye worm)	hypothetical protein	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin subunit beta	0.2741	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.2741	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.1437	0.5006	0.3839
Leishmania major	hypothetical protein, conserved	0.0155	0.0099	0.0099
Loa Loa (eye worm)	tubulin beta-2A chain	0.2741	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.2741	1	1
Brugia malayi	MH2 domain containing protein	0.0733	0.2312	0.2312
Plasmodium falciparum	alpha tubulin 2	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin, putative	0.2741	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.2741	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.2741	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.1944	0.6948	0.6948
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0624	0.1894	1
Trypanosoma cruzi	epsilon tubulin, putative	0.1437	0.5006	0.5006
Echinococcus granulosus	tubulin subunit beta	0.2741	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.1944	0.6948	0.6839
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Echinococcus multilocularis	tubulin alpha 1C chain	0.1944	0.6948	0.6948
Brugia malayi	tubulin alpha-2 chain	0.1944	0.6948	0.6948
Schistosoma mansoni	tubulin subunit beta	0.0624	0.1894	0.1894
Plasmodium vivax	tubulin epsilon chain, putative	0.1437	0.5006	0.5006
Giardia lamblia	Beta tubulin	0.2741	1	1
Leishmania major	beta tubulin	0.2741	1	1
Leishmania major	alpha tubulin	0.1944	0.6948	0.6948
Leishmania major	beta tubulin	0.2741	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.132	0.4559	0.4559
Plasmodium falciparum	tubulin gamma chain	0.1437	0.5006	0.5006
Plasmodium falciparum	tubulin epsilon chain, putative	0.1437	0.5006	0.5006
Trichomonas vaginalis	tubulin epsilon chain, putative	0.2741	1	1
Trypanosoma brucei	alpha tubulin	0.1944	0.6948	0.6948
Leishmania major	beta tubulin	0.2741	1	1
Schistosoma mansoni	hypothetical protein	0.1385	0.4809	0.4809
Leishmania major	beta tubulin	0.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0099	0.0099
Brugia malayi	Tubulin alpha chain	0.1944	0.6948	0.6948
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.132	0.4559	0.4559
Trypanosoma brucei	tubulin gamma chain	0.1437	0.5006	0.5006
Plasmodium vivax	tubulin alpha chain, putative	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin epsilon chain, putative	0.2741	1	1
Brugia malayi	Tubulin beta chain	0.0624	0.1894	0.1894
Toxoplasma gondii	beta tubulin	0.2741	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Schistosoma mansoni	tubulin subunit beta	0.2741	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0155	0.0099	0.0099
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus multilocularis	geminin	0.1385	0.4809	0.4809
Entamoeba histolytica	tubulin family protein	0.2741	1	1
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.2741	1	1
Brugia malayi	Pax transcription factor protein 2	0.0729	0.2296	0.2296
Trichomonas vaginalis	tubulin alpha chain, putative	0.1437	0.5006	0.3839
Trichomonas vaginalis	tubulin alpha chain, putative	0.0813	0.2618	0.0893
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus multilocularis	tubulin alpha chain	0.1944	0.6948	0.6948
Brugia malayi	Tubulin beta chain	0.0813	0.2618	0.2618
Trypanosoma cruzi	tubulin delta chain	0.0624	0.1894	0.1894
Plasmodium falciparum	tubulin beta chain	0.2741	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.132	0.4559	0.4559
Leishmania major	beta tubulin	0.2741	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.1437	0.5006	0.5006
Trichomonas vaginalis	tubulin alpha chain, putative	0.0813	0.2618	0.0893
Trichomonas vaginalis	tubulin beta chain, putative	0.1944	0.6948	0.6235
Giardia lamblia	Alpha-tubulin	0.1944	0.6948	0.6235
Leishmania major	beta tubulin	0.2741	1	1
Echinococcus granulosus	tubulin alpha chain	0.1944	0.6948	0.6948
Schistosoma mansoni	alpha tubulin	0.1944	0.6948	0.6948
Echinococcus granulosus	Tubulin alpha 1 chain	0.1944	0.6948	0.6948
Trypanosoma brucei	zeta tubulin	0.0624	0.1894	0.1894
Leishmania major	gamma-tubulin	0.1437	0.5006	0.5006
Treponema pallidum	cell division protein FtsZ	0.0624	0.1894	0.5
Trypanosoma brucei	beta tubulin	0.2741	1	1
Brugia malayi	hypothetical protein	0.016	0.012	0.012
Trypanosoma brucei	alpha tubulin	0.1944	0.6948	0.6948
Plasmodium falciparum	ataxin-2 like protein, putative	0.0155	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.132	0.4559	0.4559
Leishmania major	beta tubulin	0.2741	1	1
Brugia malayi	Tubulin alpha chain	0.0624	0.1894	0.1894
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.1437	0.5006	0.5006
Trypanosoma cruzi	tubulin gamma chain	0.1437	0.5006	0.5006
Entamoeba histolytica	tubulin alpha-1 chain	0.1944	0.6948	0.6839
Echinococcus granulosus	beta tubulin	0.2741	1	1
Trypanosoma brucei	alpha tubulin	0.1944	0.6948	0.6948
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.132	0.4559	0.3288
Echinococcus multilocularis	tubulin alpha chain	0.1944	0.6948	0.6948
Echinococcus granulosus	tubulin delta chain	0.0624	0.1894	0.1894
Echinococcus multilocularis	beta tubulin	0.2741	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0219	0.0345	0.0345
Echinococcus multilocularis	tubulin gamma 1 chain	0.1437	0.5006	0.5006
Schistosoma mansoni	tubulin subunit epsilon	0.1437	0.5006	0.5006
Echinococcus multilocularis	Tubulin beta 2C chain	0.2741	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.24 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelation	ChEMBL.	16509585
IC50 (binding)	= 0.24 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelation	ChEMBL.	16509585
IC50 (binding)	= 2.9 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase	ChEMBL.	16509585
IC50 (binding)	= 2.9 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelation	ChEMBL.	16509585
IC50 (binding)	= 2.9 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase	ChEMBL.	16509585
IC50 (binding)	= 2.9 uM	Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelation	ChEMBL.	16509585
pKa	= 7.4	Dissociation constant, pKa of the compound	ChEMBL.	16509585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL205026

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 352821