TDR Targets

Basic information

Technical information

TDR Targets ID: 370921
Name: N-(cyanomethyl)-4-methyl-2-[3-[3-(2-piperazin -1-yl-1,3-thiazol-4-yl)phenyl]phenyl]pentanam ide
MW: 473.633 | Formula: C27H31N5OS
H donors: 2 H acceptors: 3 LogP: 4.76 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)C(c1cccc(c1)c1cccc(c1)c1csc(n1)N1CCNCC1)CC(C)C
InChi: 1S/C27H31N5OS/c1-19(2)15-24(26(33)30-10-9-28)22-7-3-5-20(16-22)21-6-4-8-23(17-21)25-18-34-27(31-25)32-13-11-29-12-14-32/h3-8,16-19,24,29H,10-15H2,1-2H3,(H,30,33)
InChiKey: OXTNJKCSQHCZQO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(cyanomethyl)-4-methyl-2-[3-[3-(2-piperazin-1-ylthiazol-4-yl)phenyl]phenyl]pentanamide
N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(1-piperazinyl)-4-thiazolyl]phenyl]phenyl]pentanamide
N-(cyanomethyl)-4-methyl-2-[3-[3-(2-piperazinothiazol-4-yl)phenyl]phenyl]valeramide
N-(cyanomethyl)-4-methyl-2-[3-[3-(2-piperazin-1-ylthiazol-4-yl)phenyl]phenyl]valeramide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Brugia malayi	cathepsin L-like precursor	0.0059	0.0379	0.057
Giardia lamblia	Cathepsin B precursor	0.007	0.0539	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0377	0.027
Echinococcus granulosus	glutamate receptor 2	0.0122	0.1339	0.1243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Echinococcus granulosus	cathepsin L	0.0047	0.0189	0.0079
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0081	0.0709	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0025
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0122	0.1339	0.1243
Brugia malayi	hypothetical protein	0.0072	0.057	0.0858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Entamoeba histolytica	cysteine protease, putative	0.0086	0.0785	1
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0081	0.0718	0.0615
Echinococcus granulosus	lamin	0.0054	0.0297	0.0189
Echinococcus granulosus	cathepsin b	0.0181	0.2226	0.214
Echinococcus granulosus	cathepsin l1	0.0086	0.0785	0.0682
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.057	0.057
Echinococcus granulosus	geminin	0.0338	0.4611	0.4551
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0198	0.0299
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0375	0.5175	0.5121
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.0785	0.1182
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0375	0.5175	0.5121
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.024	0.0362
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0207	0.2631	1
Chlamydia trachomatis	glutamine binding protein	0.0207	0.2631	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0198	0.0694
Schistosoma mansoni	hypothetical protein	0.0072	0.057	0.057
Onchocerca volvulus		0.0086	0.0785	0.4029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.2226	0.2226
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0379	0.057
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0785	0.1331
Brugia malayi	Guanylyl cyclase protein 23	0.0041	0.0111	0.0166
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.0785	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0297	0.0447
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0139	0.1598	0.2937
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0198	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0297	0.0447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Entamoeba histolytica	hypothetical protein	0.0072	0.057	0.6812
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.0785	0.1331
Leishmania major		0.0375	0.5175	1
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0139	0.1598	0.2826
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.0785	0.1182
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0189	0.1164
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0198	0.0173
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0189	0.1164
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0198	0.0694
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.0785	0.0785
Echinococcus granulosus	survival motor neuron protein 1	0.0471	0.664	0.6602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.0539	0.0701
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0375	0.5175	1
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0081	0.0718	0.0615
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0081	0.0709	0.0606
Brugia malayi	jmjC domain containing protein	0.0059	0.0377	0.0568
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.0785	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Schistosoma mansoni	tyrosine kinase	0.0041	0.0111	0.0111
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0377	0.0377
Toxoplasma gondii	fructose-bisphospatase I	0.0139	0.1598	0.2285
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1348	0.7395
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0377	0.0377
Schistosoma mansoni	hypothetical protein	0.0338	0.4611	0.4611
Brugia malayi	jmjC domain containing protein	0.0059	0.0377	0.0568
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0189	0.0285
Echinococcus multilocularis	cathepsin L	0.0047	0.0189	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0471	0.664	0.6602
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.0785	0.1331
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0377	0.027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0139	0.1598	0.2285
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.057	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Onchocerca volvulus		0.0086	0.0785	0.4029
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.4108	0.6186
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Brugia malayi	hypothetical protein	0.0471	0.664	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0198	0.0694
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0041	0.0111	0.0166
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0189	0.0189
Onchocerca volvulus		0.0086	0.0785	0.4029
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0122	0.1339	0.1243
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0147	0.1714	0.1621
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0189	0.0079
Schistosoma mansoni	ATP-binding cassette transporter	0.0081	0.0709	0.0709
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0375	0.5175	1
Echinococcus multilocularis	NMDA receptor	0.0081	0.0709	0.0606
Echinococcus granulosus	cathepsin l1	0.0059	0.0379	0.0271
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0297	0.0447
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0377	0.0568
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0025
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0189	0.1164
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1348	0.7395
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.2226	0.2226
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.0785	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0941	0.1417
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0122	0.1339	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0379	0.057
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0122	0.1339	0.1243
Echinococcus granulosus	cathepsin b	0.0181	0.2226	0.214
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.0785	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1348	0.203
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Entamoeba histolytica	hypothetical protein	0.0072	0.057	0.6812
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0122	0.1339	0.1243
Onchocerca volvulus		0.0086	0.0785	0.4029
Loa Loa (eye worm)	cysteine protease	0.0086	0.0785	0.1182
Schistosoma mansoni	glutamate receptor AMPA	0.0081	0.0709	0.0709
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0207	0.2631	1
Brugia malayi	hypothetical protein	0.0152	0.1784	0.2687
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0207	0.2631	1
Echinococcus multilocularis	lamin dm0	0.0054	0.0297	0.0189
Brugia malayi	Glutamate receptor 2 precursor	0.0081	0.0709	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.0379	0.057
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0122	0.1339	0.1243
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0198	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0282	0.0425
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.057	0.0464
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0198	0.0694
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0224	0.0224
Brugia malayi	Glutamate receptor 1 precursor	0.0081	0.0709	0.1068
Echinococcus multilocularis	nmda type glutamate receptor	0.0292	0.3912	0.3844
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.0785	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.0785	0.0682
Brugia malayi	Receptor family ligand binding region containing protein	0.0041	0.0111	0.0166
Giardia lamblia	Cathepsin B precursor	0.007	0.0539	0.5
Onchocerca volvulus		0.0086	0.0785	0.4029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0379	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Schistosoma mansoni	hypothetical protein	0.0096	0.0941	0.0941
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0377	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1348	0.203
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.0785	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1784	0.2687
Echinococcus multilocularis	glutamate receptor NMDA	0.025	0.3282	0.3207
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0375	0.5175	0.7793
Echinococcus multilocularis	glutamate receptor 2	0.0081	0.0709	0.0606
Loa Loa (eye worm)	cathepsin B	0.007	0.0539	0.0811
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0198	0.0694
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.0785	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Echinococcus granulosus	lamin dm0	0.0054	0.0297	0.0189
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0081	0.0718	0.0718
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0025
Echinococcus multilocularis	cathepsin b	0.0181	0.2226	0.214
Loa Loa (eye worm)	hypothetical protein	0.005	0.024	0.0362
Giardia lamblia	Cathepsin B precursor	0.007	0.0539	0.5
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.0539	0.0845
Echinococcus multilocularis	cysteine protease	0.0086	0.0785	0.0682
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0198	0.0299
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.0785	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Brugia malayi	hypothetical protein	0.0041	0.0111	0.0166
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Brugia malayi	intermediate filament protein	0.0054	0.0297	0.0447
Schistosoma mansoni	tyrosine kinase	0.0041	0.0111	0.0111
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0377	0.027
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0189	0.1164
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Plasmodium vivax	vivapain-2	0.0086	0.0785	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.0785	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0189	0.0155
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0718	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0379	0.057
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Plasmodium vivax	vivapain-1	0.0047	0.0189	0.2242
Echinococcus multilocularis	microtubule associated protein 2	0.0692	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.0539	0.0845
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0122	0.1339	0.1243
Schistosoma mansoni	microtubule-associated protein tau	0.0692	1	1
Onchocerca volvulus		0.0086	0.0785	0.4029
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0539	0.0539
Onchocerca volvulus		0.0096	0.0941	0.4961
Schistosoma mansoni	glutamate receptor NMDA	0.0147	0.1714	0.1714
Schistosoma mansoni	hypothetical protein	0.0081	0.0718	0.0718
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0111	0.0111
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0198	0.0694
Schistosoma mansoni	hypothetical protein	0.0305	0.4108	0.4108
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.0785	0.0682
Schistosoma mansoni	glutamate receptor NMDA	0.0373	0.5141	0.5141
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0785	0.1331
Schistosoma mansoni	hypothetical protein	0.0081	0.0718	0.0718
Loa Loa (eye worm)	glutamate receptor 1	0.0081	0.0709	0.1068
Echinococcus granulosus	cysteine protease	0.0047	0.0189	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0941	0.0941
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.0379	0.3975
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Brugia malayi	fructose-1,6-bisphosphatase	0.0375	0.5175	0.7793
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0041	0.0111	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Plasmodium vivax	vivapain-2	0.0086	0.0785	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0785	0.1331
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0189	0.1164
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0189	0.2242
Echinococcus granulosus	intermediate filament protein	0.0054	0.0297	0.0189
Schistosoma mansoni	apoptosis regulator bax	0.0081	0.0718	0.0718
Schistosoma mansoni	hypothetical protein	0.0081	0.0709	0.0709
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0081	0.0718	0.1082
Leishmania major	cathepsin L-like protease	0.0086	0.0785	0.1331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Brugia malayi	hypothetical protein	0.0123	0.1348	0.203
Schistosoma mansoni	glutamate receptor AMPA	0.0081	0.0709	0.0709
Schistosoma mansoni	protein kinase	0.0041	0.0111	0.0111
Echinococcus multilocularis	cysteine protease	0.0086	0.0785	0.0682
Plasmodium vivax	vivapain-3	0.0047	0.0189	0.2242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.2226	0.4178
Echinococcus multilocularis	cathepsin b	0.0181	0.2226	0.214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Loa Loa (eye worm)	fibroinase	0.0086	0.0785	0.1182
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0375	0.5175	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.0785	0.0682
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.024	0.0362
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0377	0.027
Echinococcus granulosus	tumor protein p63	0.0334	0.456	0.4499
Brugia malayi	metabotropic glutamate receptor type 2	0.0041	0.0111	0.0166
Schistosoma mansoni	lamin	0.0054	0.0297	0.0297
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Entamoeba histolytica	hypothetical protein	0.0072	0.057	0.6812
Schistosoma mansoni	hypothetical protein	0.0338	0.4611	0.4611
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0198	0.1302
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0111	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0198	0.0299
Echinococcus multilocularis	nmda type glutamate receptor	0.0538	0.7661	0.7634
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0041	0.0111	0.0166
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0111	0.0111
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.0785	0.4029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0198	0.1302
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0297	0.0447
Echinococcus granulosus	glutamate receptor NMDA	0.025	0.3282	0.3207
Plasmodium vivax	unspecified product	0.0047	0.0189	0.2242
Echinococcus multilocularis	lamin	0.0054	0.0297	0.0189
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0198	0.0694
Onchocerca volvulus		0.0054	0.0297	0.1114
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0081	0.0709	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0025
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.0379	0.0379
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0081	0.0709	0.0606
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0189	0.0189
Toxoplasma gondii	cathepsin CPL	0.0086	0.0785	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0181	0.2226	0.3353
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0081	0.0718	0.0615
Echinococcus multilocularis	glutamate receptor 2	0.0122	0.1339	0.1243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0198	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0189	0.0155
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0081	0.0718	0.0615
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0297	0.0297
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0189	0.0155
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.2226	0.3353
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Brugia malayi	Receptor family ligand binding region containing protein	0.0041	0.0111	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Schistosoma mansoni	glutamate receptor kainate	0.0081	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0041	0.0111	0.0166
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Echinococcus granulosus	snurportin 1	0.0305	0.4108	0.4042
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0198	0.0694
Schistosoma mansoni	hypothetical protein	0.0081	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0189	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0111	0.0166
Onchocerca volvulus		0.0059	0.0379	0.1602
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0288	0.3859	0.3791
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0379	0.0529
Echinococcus granulosus	nmda type glutamate receptor	0.0292	0.3912	0.3844
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0122	0.1339	0.1243
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0198	0.0694
Schistosoma mansoni	lamin	0.0054	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0785	0.1182
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0041	0.0111	0.0166
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0379	0.057
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0189	0.1164
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0785	0.1331
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0147	0.1714	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0198	0.0299
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.0539	0.5868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0785	1
Onchocerca volvulus		0.0152	0.1784	1
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0081	0.0709	0.0606
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0375	0.5175	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0025
Schistosoma mansoni	glutamate receptor kainate	0.0081	0.0709	0.0709
Loa Loa (eye worm)	apoptosis regulator protein	0.0081	0.0718	0.1082
Loa Loa (eye worm)	glutamate receptor	0.0041	0.0111	0.0166
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0379	0.057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0198	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0471	0.664	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.0785	0.0785
Echinococcus multilocularis	musashi	0.0054	0.0297	0.0189
Echinococcus granulosus	nmda type glutamate receptor	0.0538	0.7661	0.7634
Echinococcus multilocularis	geminin	0.0338	0.4611	0.4551
Onchocerca volvulus		0.0086	0.0785	0.4029
Onchocerca volvulus		0.0047	0.0198	0.0525
Onchocerca volvulus		0.0049	0.0224	0.0678
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.2226	0.2226
Echinococcus multilocularis	snurportin 1	0.0305	0.4108	0.4042
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.0785	0.4029
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0207	0.2631	0.5
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0081	0.0709	0.0606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0189	0.1164
Entamoeba histolytica	hypothetical protein	0.0072	0.057	0.6812
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.0785	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0111	0.0166
Toxoplasma gondii	fructose-bisphospatase II	0.0375	0.5175	1
Echinococcus multilocularis	tumor protein p63	0.0334	0.456	0.4499
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0081	0.0709	0.0606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0379	0.3182
Schistosoma mansoni	glutamate receptor kainate	0.0081	0.0709	0.0709
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0198	0.0299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0198	0.0173
Onchocerca volvulus		0.0054	0.0297	0.1114
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.0785	0.0682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0111	0.0166
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0207	0.2631	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.024	0.0362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0198	0.0299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0785	0.1182
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0139	0.1598	0.2937
Brugia malayi	RNA, U transporter 1	0.0081	0.0713	0.1074
Loa Loa (eye worm)	glutamate receptor 2	0.0081	0.0709	0.1068
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0189	0.0155
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.0785	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0224	0.0337
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.2226	0.2226
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0198	0.0694
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0785	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0189	0.0285
Loa Loa (eye worm)	ctsf protein	0.0086	0.0785	0.1182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0785	0.1195

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 560 uM.min	AUC in rat at 10 mg/kg, po	ChEMBL.	16750630
CL (ADMET)	= 25 ml/min.kg	Clearance in rat at 0.5 mg/kg, iv	ChEMBL.	16750630
Cmax (ADMET)	= 1.1 mM	Cmax in rat at 10 mg/kg, po	ChEMBL.	16750630
F (ADMET)	= 85 %	Oral bioavailability in rat at 10 mg/kg, po	ChEMBL.	16750630
IC50 (functional)	= 349 nM	Effect on degradation of bovine bone by rabbit osteoclast	ChEMBL.	16750630
Ki (binding)	= 0.8 nM	Inhibition of human cathepsin K	ChEMBL.	16750630
Ki (binding)	= 0.8 nM	Inhibition of human cathepsin K	ChEMBL.	16750630
Ki (binding)	= 190 nM	Inhibition of human cathepsin L	ChEMBL.	16750630
Ki (binding)	= 190 nM	Inhibition of human cathepsin L	ChEMBL.	16750630
Ki (binding)	= 5600 nM	Inhibition of human cathepsin S	ChEMBL.	16750630
Ki (binding)	= 5600 nM	Inhibition of human cathepsin S	ChEMBL.	16750630
Ki (binding)	= 18000 nM	Inhibition of human cathepsin B	ChEMBL.	16750630
Ki (binding)	= 18000 nM	Inhibition of human cathepsin B	ChEMBL.	16750630
MRT (ADMET)	= 176 min	Mean residence time in rat at 0.5 mg/kg, iv	ChEMBL.	16750630
Selectivity ratio (binding)	= 237	Selectivity for cathepsin L over cathepsin K	ChEMBL.	16750630
Selectivity ratio (binding)	= 7000	Selectivity for cathepsin S over cathepsin K	ChEMBL.	16750630
Selectivity ratio (binding)	= 22500	Selectivity for cathepsin B over cathepsin K	ChEMBL.	16750630
T1/2 (ADMET)	= 3.9 hr	Half life in rat at 10 mg/kg, po	ChEMBL.	16750630
Tmax (ADMET)	= 200 min	Tmax in rat at 10 mg/kg, po	ChEMBL.	16750630
Vss (ADMET)	= 4.3 L/Kg	Volume of distribution in rat at 0.5 mg/kg, iv	ChEMBL.	16750630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL212907
PubChem: 9891030

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 370921