Detailed information for compound 401985

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 984.154 | Formula: C49H69N13O9
  • H donors: 10 H acceptors: 10 LogP: 1.73 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccc(cc2)O)NC(=O)[C@@H](NC(=O)[C@@H](CCCN=C(N)N)N(C)C(=O)CNC(=O)[C@H](NC(=O)[C@H]2N(C(=O)[C@H](NC1=O)Cc1c[nH]cn1)CCC2)Cc1ccccc1)C(C)C)C
  • InChi: 1S/C49H69N13O9/c1-6-29(4)41-47(70)58-36(24-32-25-52-27-55-32)48(71)62-21-11-15-38(62)45(68)56-34(22-30-12-8-7-9-13-30)42(65)54-26-39(64)61(5)37(14-10-20-53-49(50)51)44(67)59-40(28(2)3)46(69)57-35(43(66)60-41)23-31-16-18-33(63)19-17-31/h7-9,12-13,16-19,25,27-29,34-38,40-41,63H,6,10-11,14-15,20-24,26H2,1-5H3,(H,52,55)(H,54,65)(H,56,68)(H,57,69)(H,58,70)(H,59,67)(H,60,66)(H4,50,51,53)/t29-,34+,35+,36+,37+,38-,40-,41-/m0/s1
  • InChiKey: QVWPKBPMHZJIBE-PMRGTHHISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0167 0.0187
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1361 0.5419 0.6335
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0038 0.0034 0.0032
Schistosoma mansoni cpg binding protein 0.0031 0.0007 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0027 0.0032
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Loa Loa (eye worm) hypothetical protein 0.0316 0.1165 0.2031
Trypanosoma brucei polo-like protein kinase 0.0102 0.0297 0.0257
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0167 0.0187
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0167 0.0291
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0167 0.0187
Echinococcus granulosus beta LACTamase domain containing family member 0.0194 0.067 0.0776
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0027 0.0022
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0125 0.0138
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0167 0.0291
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0112 0.0121
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0247 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Onchocerca volvulus 0.0194 0.067 0.7223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2131 0.8551 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0095 0.0112
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0043 0.005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.0297 0.0339
Brugia malayi chromobox protein homolog 3 0.0124 0.0385 0.045
Brugia malayi Dopamine receptor protein 1 0.007 0.0167 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0148 0.0173
Onchocerca volvulus 0.007 0.0167 0.1797
Onchocerca volvulus 0.0164 0.0547 0.5893
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0691 0.2693 0.2664
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Trypanosoma brucei beta lactamase 0.0343 0.1277 0.1242
Echinococcus multilocularis muscleblind protein 1 0.0316 0.1165 0.1356
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0027 0.0022
Onchocerca volvulus 0.0103 0.0298 0.321
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Echinococcus multilocularis chromobox protein 1 0.0221 0.078 0.0905
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Trichomonas vaginalis chromobox protein, putative 0.0221 0.078 0.0883
Mycobacterium tuberculosis Probable lipase LipE 0.0194 0.067 0.1092
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Trichomonas vaginalis esterase, putative 0.0194 0.067 0.0754
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0167 0.0187
Brugia malayi putative neuropeptide receptor 0.007 0.0167 0.0195
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0194 0.067 0.0621
Schistosoma mansoni chromobox protein 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0167 0.0291
Onchocerca volvulus 0.007 0.0167 0.1797
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Brugia malayi G-protein coupled receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0098 0.0171
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0167 0.0187
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1361 0.5419 0.6326
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0343 0.1277 0.3138
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0132 0.0154
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.0167 0.0187
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0167 0.0291
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.0297 0.0517
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0167 0.0291
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi Serotonin receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0043 0.0074
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1361 0.5419 0.9445
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0167 0.0195
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0055 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0194 0.067 0.0632
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0167 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Brugia malayi G-protein coupled receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0015
Brugia malayi hypothetical protein 0.0036 0.0027 0.0032
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Mycobacterium ulcerans lipase LipD 0.0194 0.067 0.0621
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0027 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0042 0.0017
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.004 0.0039
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0038 0.0034 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0034 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0167 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0167 0.0187
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0167 0.0187
Echinococcus granulosus Chromo domain 0.0036 0.0027 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0167 0.0195
Brugia malayi sulfakinin receptor protein 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1439 0.5737 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) MBCTL1 0.006 0.0125 0.0218
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0125 0.0146
Mycobacterium tuberculosis Probable esterase LipL 0.0194 0.067 0.1092
Brugia malayi Heterochromatin protein 1 0.0221 0.078 0.0913
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0194 0.067 0.1092
Loa Loa (eye worm) heterochromatin protein 1 0.0221 0.078 0.136
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0691 0.2693 0.315
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0167 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Echinococcus granulosus neuropeptide receptor A26 0.007 0.0167 0.0187
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2131 0.8551 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Schistosoma mansoni histamine h1 receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0132 0.023
Mycobacterium tuberculosis Probable hydrolase 0.0194 0.067 0.1092
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0715 0.2791 0.5532
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0167 0.0195
Plasmodium vivax SET domain protein, putative 0.0033 0.0014 0.0007
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0175
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0167 0.0195
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.067 0.2606 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Toxoplasma gondii ABC1 family protein 0.0194 0.067 0.0774
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Brugia malayi Protein cec-1. 0.0036 0.0027 0.0032
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.0297 0.0347
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus granulosus neuropeptide s receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.0053 0.0095 0.0166
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0715 0.2791 0.3146
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Leishmania major hypothetical protein, conserved 0.0194 0.067 0.0632
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0043 0.005
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Onchocerca volvulus 0.007 0.0167 0.1797
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0167 0.0187
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0009 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0167 0.0187
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0095 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0086 0.0069
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0167 0.0291
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.004 0.0015
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Brugia malayi Bromodomain containing protein 0.0032 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0171 0.0574 0.0671
Brugia malayi jmjC domain containing protein 0.004 0.0043 0.005
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0167 0.0187
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0095 0.0166
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0343 0.1277 0.2364
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0167 0.0187
Echinococcus multilocularis serotonin receptor 0.007 0.0167 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.0036 0.0027 0.0296
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2131 0.8551 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1361 0.5419 0.6335
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.0069 0.0162 0.1744
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0167 0.0195
Echinococcus multilocularis chromobox protein 1 0.0221 0.078 0.0905
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0167 0.0187
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0407 0.0709
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0247 0.0289
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0125 0.0138
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0014 0.0009
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.0257 0.0927 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Schistosoma mansoni hypothetical protein 0.0321 0.1188 0.139
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.0167 0.1797
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0316 0.1165 0.2031
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0167 0.0187
Trichomonas vaginalis chromobox protein, putative 0.0221 0.078 0.0883
Echinococcus granulosus geminin 0.0171 0.0574 0.0664
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.0297 0.0257
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0194 0.067 0.1168
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.007 0.0167 0.1797
Mycobacterium ulcerans esterase/lipase LipP 0.0194 0.067 0.0621
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0167 0.0187
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0247 0.0281
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0801 0.1395
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1439 0.5737 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi CHD4 protein 0.0038 0.0034 0.004
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.0297 0.32
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0423 0.0464
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0297 0.0347
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0927 0.1056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0301 0.0345
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Brugia malayi beta-lactamase family protein 0.0194 0.067 0.0783
Mycobacterium tuberculosis Probable lipase LipD 0.0194 0.067 0.1092
Onchocerca volvulus 0.007 0.0167 0.1797
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0139 0.0163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Brugia malayi Muscleblind-like protein 0.0316 0.1165 0.1363
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0167 0.0195
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0027 0.0032
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0167 0.0195
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0167 0.0187
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2131 0.8551 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0095 0.0104
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.004 0.007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0055 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.0602 0.1049
Echinococcus granulosus microtubule associated protein 2 0.0748 0.2924 0.3414
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0691 0.2693 0.2664
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0167 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0385 0.0419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.004 0.0015
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0027 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0042 0.0017
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0059 0.0061
Echinococcus granulosus neuropeptide receptor 0.007 0.0167 0.0187
Brugia malayi jmjC domain containing protein 0.0103 0.0301 0.0352
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0167 0.0187
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0167 0.0187
Echinococcus multilocularis allatostatin A receptor 0.007 0.0167 0.0187
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0059 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0423 0.0464
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Loa Loa (eye worm) helicase 0.0036 0.0027 0.0048
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1361 0.5419 0.6326
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0167 0.0291
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0133 0.0423 0.4562
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0027 0.0024
Mycobacterium ulcerans beta-lactamase 0.0194 0.067 0.0621
Onchocerca volvulus 0.0097 0.0276 0.2973
Echinococcus granulosus allatostatin A receptor 0.007 0.0167 0.0187
Mycobacterium tuberculosis Conserved protein 0.0194 0.067 0.1092
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0167 0.0195
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0194 0.067 0.0783
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0125 0.0138
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0215 0.0251
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.067 0.0783
Brugia malayi mbt repeat family protein 0.0053 0.0095 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.067 0.0632
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.009 0.0247 0.2661
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0167 0.0187
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0167 0.0187
Plasmodium vivax hypothetical protein, conserved 0.0194 0.067 0.0774
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0014 0.0007
Schistosoma mansoni kinase 0.0052 0.0092 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0132 0.023
Onchocerca volvulus 0.007 0.0167 0.1797
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0095 0.0112
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1461 0.5825 0.6809
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0015
Schistosoma mansoni chromobox protein 0.0221 0.078 0.0913
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0027 0.0022
Echinococcus granulosus orexin receptor type 2 0.007 0.0167 0.0187
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0132 0.0147
Loa Loa (eye worm) hypothetical protein 0.006 0.0125 0.0218
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0148 0.0173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.004 0.0015
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0297 0.0257
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi PHD-finger family protein 0.0032 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Echinococcus granulosus chromobox protein 1 0.0221 0.078 0.0905
Echinococcus granulosus fmrfamide receptor 0.007 0.0167 0.0187
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0301 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0146 0.0254
Echinococcus multilocularis tumor protein p63 0.0366 0.137 0.1596
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0167 0.0291
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0167 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0237 0.0246
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.0053 0.0095 0.1028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.067 0.0783
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0297 0.0257
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.004 0.0047
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0095 0.0104
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2131 0.8551 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0167 0.0195
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0167 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Brugia malayi AKH receptor 0.007 0.0167 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.0297 0.0339
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0027 0.0032
Echinococcus multilocularis neuropeptide receptor 0.007 0.0167 0.0187
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0009 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0237 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Mycobacterium ulcerans lipoprotein LpqF 0.0343 0.1277 0.1344
Brugia malayi mbt repeat family protein 0.0053 0.0095 0.0112
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0167 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0167 0.0195
Echinococcus granulosus peregrin 0.0032 0.0009 0.0002
Onchocerca volvulus Alhambra homolog 0.0032 0.0009 0.0094
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.004 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus chromobox protein 1 0.0221 0.078 0.0905
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Echinococcus multilocularis somatostatin receptor 0.007 0.0167 0.0187
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Echinococcus multilocularis fmrfamide receptor 0.007 0.0167 0.0187
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0194 0.067 0.1092
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0125 0.0138
Onchocerca volvulus 0.007 0.0167 0.1797
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.067 0.0754
Echinococcus granulosus serotonin receptor 0.007 0.0167 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0769 0.3012 0.3501
Echinococcus multilocularis microtubule associated protein 2 0.0748 0.2924 0.3414
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.067 0.0632
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0009 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0125 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0124 0.0385 0.0671
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0691 0.2693 0.2664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0167 0.0195
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni hypothetical protein 0.0032 0.0009 0.001
Schistosoma mansoni chromobox protein 0.0221 0.078 0.0913
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0167 0.0291
Echinococcus multilocularis serotonin receptor 0.007 0.0167 0.0187
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0036 0.0034
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0095 0.0104
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0148 0.0165
Brugia malayi RNA binding protein 0.0062 0.0132 0.0154
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0027 0.0032
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.0728 0.0844
Schistosoma mansoni myosin xvIII 0.007 0.0167 0.0195
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0015
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0691 0.2693 0.2664
Echinococcus multilocularis neuropeptide receptor 0.007 0.0167 0.0187
Schistosoma mansoni cpg binding protein 0.0031 0.0007 0.0008
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2487 1 1
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.1361 0.5419 0.9445
Echinococcus multilocularis sex peptide receptor 0.007 0.0167 0.0187
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2131 0.8551 0.8545
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2131 0.8551 1
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Brugia malayi follicle stimulating hormone receptor 0.007 0.0167 0.0195
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0691 0.2693 0.2664
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0095 0.1028
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0014 0.0009
Echinococcus multilocularis geminin 0.0171 0.0574 0.0664
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0098 0.0115
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0148 0.0108
Brugia malayi RE15519p 0.007 0.0167 0.0195
Schistosoma mansoni opsin-like receptor 0.007 0.0167 0.0195
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0148 0.0163
Brugia malayi larval opioid receptor 0.007 0.0167 0.0195
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.0728 0.0844
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0148 0.0165
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0167 0.0187
Echinococcus multilocularis Chromo domain 0.0036 0.0027 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0167 0.0187
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.0167 0.1797
Schistosoma mansoni biogenic amine receptor 0.007 0.0167 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0086 0.0069
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0167 0.0195
Schistosoma mansoni alpha glucosidase 0.0039 0.004 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2131 0.8551 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0014 0.0017
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0167 0.0187
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.0167 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.067 0.0754
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Brugia malayi ORL1-like opioid receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0164 0.0547 0.0953
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0055 0.0032
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0027 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0194 0.067 0.1092
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0009 0.0015
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) beta-lactamase 0.0194 0.067 0.1168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2131 0.8551 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2131 0.8551 0.8545
Echinococcus multilocularis g protein coupled receptor 0.007 0.0167 0.0187
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0014 0.0009
Loa Loa (eye worm) CHromoDomain protein family member 0.0038 0.0034 0.006
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni alpha-glucosidase 0.0153 0.0502 0.0587
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.0297 0.0316
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0167 0.0187
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0167 0.0187
Brugia malayi neuropeptide F receptor 0.007 0.0167 0.0195
Schistosoma mansoni alpha-glucosidase 0.0153 0.0502 0.0587
Onchocerca volvulus 0.0054 0.0098 0.106
Echinococcus multilocularis muscleblind protein 0.0316 0.1165 0.1356
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.067 0.2606 0.5145
Echinococcus multilocularis beta LACTamase domain containing family member 0.0194 0.067 0.0776
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0048
Brugia malayi Dopamine receptor 0.007 0.0167 0.0195
Echinococcus multilocularis orexin receptor type 2 0.007 0.0167 0.0187
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2131 0.8551 1
Schistosoma mansoni hypothetical protein 0.007 0.0167 0.0195
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0167 0.0187
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1361 0.5419 0.9445
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.0602 0.0697
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0037
Schistosoma mansoni hypothetical protein 0.0171 0.0574 0.0671
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni microtubule-associated protein tau 0.0748 0.2924 0.3419
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.0602 0.0704
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.0022
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus tumor protein p63 0.0366 0.137 0.1596
Echinococcus granulosus g protein coupled receptor 0.007 0.0167 0.0187
Brugia malayi G protein-coupled receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi beta-lactamase 0.0194 0.067 0.0783
Echinococcus granulosus chromobox protein 2 0.0036 0.0027 0.0024
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2131 0.8551 0.8545
Onchocerca volvulus 0.0194 0.067 0.7223
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus granulosus muscleblind protein 0.0316 0.1165 0.1356
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0167 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0132 0.0154
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0769 0.3012 0.3522
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 0.8545
Echinococcus granulosus sex peptide receptor 0.007 0.0167 0.0187
Mycobacterium ulcerans hypothetical protein 0.0194 0.067 0.0621
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Onchocerca volvulus 0.0036 0.0027 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0162 0.0189
Echinococcus multilocularis fmrfamide receptor 0.007 0.0167 0.0187
Mycobacterium tuberculosis Possible penicillin-binding protein 0.124 0.4926 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0167 0.0195
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0167 0.0187
Onchocerca volvulus 0.007 0.0167 0.1797
Brugia malayi Pre-SET motif family protein 0.0226 0.0801 0.0936
Brugia malayi TAR-binding protein 0.0062 0.0132 0.0154
Onchocerca volvulus 0.007 0.0167 0.1797
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0167 0.0187
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0027 0.0032
Onchocerca volvulus 0.007 0.0167 0.1797
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0095 0.0112
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0247 0.0289
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Brugia malayi MH2 domain containing protein 0.0129 0.0407 0.0476
Brugia malayi Melatonin receptor type 1A 0.007 0.0167 0.0195
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0167 0.0291
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0297 0.0316
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni chromobox protein 0.0036 0.0027 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Echinococcus granulosus tar DNA binding protein 0.0062 0.0132 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0167 0.0187
Brugia malayi Dopamine receptor protein 2 0.007 0.0167 0.0195
Brugia malayi Serotonin receptor 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0097 0.0276 0.0481
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0027 0.0022
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0167 0.0187
Echinococcus multilocularis chromobox protein 2 0.0036 0.0027 0.0024
Echinococcus granulosus hypothetical protein 0.007 0.0167 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Loa Loa (eye worm) hypothetical protein 0.0194 0.067 0.1168
Echinococcus granulosus Chromobox protein 3 0.0036 0.0027 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.007 0.0167 0.0187
Giardia lamblia Kinase, PLK 0.0102 0.0297 0.0337
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Schistosoma mansoni amine GPCR 0.007 0.0167 0.0195
Loa Loa (eye worm) RNA binding protein 0.0062 0.0132 0.023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0124 0.0385 0.4149
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0407 0.0709
Onchocerca volvulus 0.007 0.0167 0.1797
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0027 0.0024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0167 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0167 0.0195
Brugia malayi GnHR receptor homolog 0.007 0.0167 0.0195
Schistosoma mansoni neuropeptide receptor 0.007 0.0167 0.0195
Onchocerca volvulus 0.0194 0.067 0.7223
Echinococcus granulosus somatostatin receptor 0.007 0.0167 0.0187
Brugia malayi neuropeptide F receptor 0.007 0.0167 0.0195
Echinococcus granulosus neuropeptide receptor 0.007 0.0167 0.0187
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0167 0.0187
Brugia malayi hypothetical protein 0.007 0.0167 0.0195
Echinococcus multilocularis peregrin 0.0032 0.0009 0.0002
Brugia malayi SET domain containing protein 0.0038 0.0035 0.0041
Brugia malayi hypothetical protein 0.0164 0.0547 0.0639
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0167 0.0187
Schistosoma mansoni adenoreceptor 0.007 0.0167 0.0195
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0385 0.0419
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2131 0.8551 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.067 0.0754
Loa Loa (eye worm) hypothetical protein 0.009 0.0247 0.043
Brugia malayi beta-lactamase family protein 0.0194 0.067 0.0783
Echinococcus granulosus g-protein coupled receptor 0.007 0.0167 0.0187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0167 0.0187
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0167 0.0195

Activities

Activity type Activity value Assay description Source Reference
Agonist activity (functional) < 0.1 % Tested for agonist activity of the compound in rat uterus with respect to human angiotensin II ChEMBL. 8071943
pA2 (functional) < 5 Tested for antagonist activity of the compound in rat uterus with respect to human angiotensin II as reference ChEMBL. 8071943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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