Detailed information for compound 40291

Basic information

Technical information
  • TDR Targets ID: 40291
  • Name: (E)-3-[2-amino-3-(2,2-dimethylpropanoyl)imida zo[1,2-a]pyridin-6-yl]-N-methyl-3-phenylprop- 2-enamide
  • MW: 376.452 | Formula: C22H24N4O2
  • H donors: 2 H acceptors: 3 LogP: 4.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)/C=C(/c1ccc2n(c1)c(c(n2)N)C(=O)C(C)(C)C)\c1ccccc1
  • InChi: 1S/C22H24N4O2/c1-22(2,3)20(28)19-21(23)25-17-11-10-15(13-26(17)19)16(12-18(27)24-4)14-8-6-5-7-9-14/h5-13H,23H2,1-4H3,(H,24,27)/b16-12+
  • InChiKey: DRYZDJFGWFBVCN-FOWTUZBSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[2-amino-3-(2,2-dimethylpropanoyl)imidazo[1,2-a]pyridin-6-yl]-N-methyl-3-phenyl-prop-2-enamide
  • (E)-3-[2-amino-3-(2,2-dimethyl-1-oxopropyl)-6-imidazo[1,2-a]pyridinyl]-N-methyl-3-phenyl-2-propenamide
  • (E)-3-[2-azanyl-3-(2,2-dimethylpropanoyl)imidazo[1,2-a]pyridin-6-yl]-N-methyl-3-phenyl-prop-2-enamide
  • (E)-3-(2-amino-3-pivaloyl-imidazo[1,2-a]pyridin-6-yl)-N-methyl-3-phenyl-acrylamide
  • (E)-3-[2-amino-3-(2,2-dimethylpropanoyl)imidazo[2,1-f]pyridin-6-yl]-N-methyl-3-phenylprop-2-enamide
  • (E)-3-[2-amino-3-(2,2-dimethylpropanoyl)imidazo[2,1-f]pyridin-6-yl]-N-methyl-3-phenyl-prop-2-enamide
  • (E)-3-[2-amino-3-(2,2-dimethyl-1-oxopropyl)-6-imidazo[2,1-f]pyridinyl]-N-methyl-3-phenylprop-2-enamide
  • (E)-3-(2-amino-3-pivaloyl-imidazo[2,1-f]pyridin-6-yl)-N-methyl-3-phenyl-acrylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus multilocularis muscleblind protein 1 0.0159 0.6062 0.6031
Brugia malayi Serotonin receptor 0.0049 0.1389 0.1351
Schistosoma mansoni biogenic amine receptor 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Onchocerca volvulus 0.0049 0.1389 0.5776
Schistosoma mansoni bromodomain containing protein 0.0068 0.2169 0.3113
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Onchocerca volvulus 0.0049 0.1389 0.5776
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1916 0.2749
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1916 0.1852
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0157 0.0225
Loa Loa (eye worm) hypothetical protein 0.0043 0.115 0.1079
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.1389 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.1389 0.132
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1406 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0157 0.0113
Schistosoma mansoni opsin-like receptor 0.0049 0.1389 0.1993
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.1389 0.1351
Echinococcus granulosus g-protein coupled receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus survival motor neuron protein 1 0.0252 1 1
Echinococcus granulosus muscleblind protein 0.0159 0.6062 0.6031
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1406 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0157 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus granulosus FTZ F1 alpha 0.002 0.0157 0.0078
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0157 0.0113
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.1389 0.132
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.1389 0.1351
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.1389 0.132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0157 0.0078
Echinococcus granulosus tar DNA binding protein 0.0062 0.1916 0.1852
Loa Loa (eye worm) hypothetical protein 0.0027 0.0448 0.0372
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.1389 0.1993
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.3105 0.305
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.1389 0.132
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Onchocerca volvulus 0.0049 0.1389 0.5776
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.1389 0.132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.1389 0.1993
Brugia malayi PHD-finger family protein 0.0027 0.0435 0.0392
Onchocerca volvulus Ribonuclease H1 homolog 0.0021 0.0217 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0157 0.0078
Brugia malayi Dopamine receptor protein 1 0.0049 0.1389 0.1351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.1389 0.132
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1406 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0157 0.0078
Echinococcus granulosus zinc finger protein 0.0021 0.0193 0.0115
Brugia malayi Serotonin receptor 0.0049 0.1389 0.1351
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1916 0.1852
Onchocerca volvulus 0.0049 0.1389 0.5776
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0448 0.1648
Brugia malayi hypothetical protein 0.0027 0.0448 0.0406
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.4491 0.4447
Schistosoma mansoni opsin-like receptor 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi neuropeptide F receptor 0.0049 0.1389 0.1351
Schistosoma mansoni neuropeptide receptor 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus allatostatin A receptor 0.0049 0.1389 0.132
Echinococcus multilocularis survival motor neuron protein 1 0.0252 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.1389 0.132
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.1389 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus multilocularis orexin receptor type 2 0.0049 0.1389 0.132
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.1389 0.1993
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.1389 0.132
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0448 0.1939
Brugia malayi neuropeptide F receptor 0.0049 0.1389 0.1351
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1406 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.1389 0.1351
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi nuclear hormone receptor 0.002 0.0157 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Brugia malayi RNase H family protein 0.0021 0.0217 0.0174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0328 0.025
Schistosoma mansoni zinc finger protein 0.0021 0.0193 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.1389 0.132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.2008 0.1944
Schistosoma mansoni hypothetical protein 0.0049 0.1389 0.1993
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1406 0.1337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0079 0.0114
Schistosoma mansoni jun-related protein 0.0073 0.2394 0.3435
Brugia malayi TAR-binding protein 0.0062 0.1916 0.1881
Brugia malayi RNase H family protein 0.0021 0.0217 0.0174
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.1389 0.132
Schistosoma mansoni phosphoglucomutase 0.0021 0.0217 0.0312
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0157 0.0078
Schistosoma mansoni histamine h1 receptor 0.0049 0.1389 0.1993
Schistosoma mansoni thyroid hormone receptor 0.0142 0.534 0.7661
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0419 0.0342
Echinococcus multilocularis allatostatin A receptor 0.0049 0.1389 0.132
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.1389 0.1993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni survival motor neuron protein 0.0051 0.1489 0.2136
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.1389 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Onchocerca volvulus 0.0049 0.1389 0.5776
Brugia malayi G-protein coupled receptor 0.0049 0.1389 0.1351
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0252 1 1
Onchocerca volvulus 0.0049 0.1389 0.5776
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0021 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.1389 0.132
Echinococcus multilocularis muscleblind protein 0.0159 0.6062 0.6031
Onchocerca volvulus 0.0049 0.1389 0.5776
Brugia malayi Dopamine receptor 0.0049 0.1389 0.1351
Schistosoma mansoni amine GPCR 0.0049 0.1389 0.1993
Echinococcus granulosus ribonuclease H1 0.0021 0.0217 0.0139
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0157 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0157 0.0078
Schistosoma mansoni phosphoglucomutase 0.0021 0.0217 0.0312
Trypanosoma brucei ribonuclease H1 0.0021 0.0217 0.08
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.4491 0.4447
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.4706 0.4664
Schistosoma mansoni hypothetical protein 0.0049 0.1389 0.1993
Brugia malayi Muscleblind-like protein 0.0159 0.6062 0.6045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.3105 0.305
Echinococcus multilocularis ribonuclease H1 0.0021 0.0217 0.0139
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus orexin receptor type 2 0.0049 0.1389 0.132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0157 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1916 0.2749
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.1389 0.132
Echinococcus multilocularis g protein coupled receptor 0.0049 0.1389 0.132
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.1389 0.1993
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0328 0.047
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.1389 0.5776
Brugia malayi G protein-coupled receptor 0.0049 0.1389 0.1351
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.1389 0.132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0159 0.6062 0.6031
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0157 0.0078
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.1389 0.132
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0157 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0448 0.3186
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.1389 0.132
Onchocerca volvulus 0.0049 0.1389 0.5776
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0295 0.1084
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.1389 0.132
Echinococcus granulosus lamin dm0 0.0026 0.0419 0.0342
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.1389 0.132
Brugia malayi RNase H family protein 0.0021 0.0217 0.0174
Echinococcus multilocularis neuropeptide receptor 0.0049 0.1389 0.132
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0419 0.0376
Schistosoma mansoni biogenic amine receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.1389 0.132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.534 0.5302
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1916 0.1852
Leishmania major ribonuclease H1, putative 0.0021 0.0217 0.1546
Onchocerca volvulus 0.0049 0.1389 0.5776
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0157 0.0113
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1489 0.1451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0419 0.0342
Onchocerca volvulus 0.0049 0.1389 0.5776
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis fmrfamide receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1406 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0157 0.0225
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.1389 0.132
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.2008 0.1944
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0241 0.0163
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.1389 0.132
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1916 0.1881
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0157 0.0078
Brugia malayi AKH receptor 0.0049 0.1389 0.1351
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.1389 0.1993
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0157 0.0225
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.1389 0.132
Schistosoma mansoni nuclear hormone receptor 0.002 0.0157 0.0225
Schistosoma mansoni hypothetical protein 0.0022 0.0241 0.0346
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus g protein coupled receptor 0.0049 0.1389 0.132
Schistosoma mansoni hypothetical protein 0.008 0.2718 0.3899
Onchocerca volvulus 0.0049 0.1389 0.5776
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.1389 0.132
Brugia malayi hypothetical protein 0.007 0.229 0.2256
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0157 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0398 0.0321
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus neuropeptide receptor 0.0049 0.1389 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.1389 0.132
Schistosoma mansoni coup transcription factor 0.002 0.0157 0.0225
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.1389 0.1993
Treponema pallidum ribonuclease H (rnhA) 0.0021 0.0217 0.5
Schistosoma mansoni neuropeptide receptor 0.0049 0.1389 0.1993
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1406 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0448 0.3186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0328 0.025
Echinococcus granulosus sex peptide receptor 0.0049 0.1389 0.132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1916 0.2749
Trypanosoma cruzi ribonuclease H1, putative 0.0021 0.0217 0.1546
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.1389 0.5776
Echinococcus granulosus jun protein 0.009 0.3105 0.305
Schistosoma mansoni amine GPCR 0.0049 0.1389 0.1993
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0157 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0448 0.5
Brugia malayi MAP kinase sur-1 0.005 0.1406 0.1368
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0157 0.0225
Brugia malayi MH2 domain containing protein 0.0127 0.4706 0.4683
Echinococcus multilocularis geminin 0.0181 0.697 0.6946
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0157 0.0113
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0295 0.1084
Schistosoma mansoni lamin 0.0026 0.0419 0.0601
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0157 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0157 0.0113
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.1389 0.1993
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0157 0.0078
Echinococcus multilocularis zinc finger protein 0.0021 0.0193 0.0115
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1406 0.1337
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0107 0.0028
Brugia malayi Bromodomain containing protein 0.008 0.2699 0.2667
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.1389 0.132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0157 0.0078
Brugia malayi larval opioid receptor 0.0049 0.1389 0.1351
Schistosoma mansoni neuropeptide receptor 0.0049 0.1389 0.1993
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Schistosoma mansoni biogenic amine receptor 0.0049 0.1389 0.1993
Brugia malayi RE15519p 0.0049 0.1389 0.1351
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0157 0.0078
Schistosoma mansoni amine GPCR 0.0049 0.1389 0.1993
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0079 0.0114
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.1389 0.132
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.1389 0.132
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0295 0.1084
Schistosoma mansoni amine GPCR 0.0049 0.1389 0.1993
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.1389 0.1993
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1406 1
Echinococcus granulosus geminin 0.0181 0.697 0.6946
Schistosoma mansoni thyroid hormone receptor 0.0142 0.534 0.7661
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1916 0.2749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1406 1
Onchocerca volvulus 0.0051 0.1489 0.6246
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.1389 0.1993
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0157 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0157 0.0113
Schistosoma mansoni intermediate filament proteins 0.0026 0.0419 0.0601
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Schistosoma mansoni hypothetical protein 0.0181 0.697 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.1389 0.132
Echinococcus granulosus neuropeptide s receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus intermediate filament protein 0.0026 0.0419 0.0342
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi steroid hormone receptor 0.002 0.0157 0.0113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.1389 0.132
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0079 0.0114
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.1389 0.132
Brugia malayi G-protein coupled receptor 0.0049 0.1389 0.1351
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.4706 0.4664
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.1389 0.132
Echinococcus multilocularis lamin dm0 0.0026 0.0419 0.0342
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.1389 0.132
Echinococcus granulosus serotonin receptor 0.0049 0.1389 0.132
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.1389 0.132
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.1389 0.132
Brugia malayi putative neuropeptide receptor 0.0049 0.1389 0.1351
Schistosoma mansoni hypothetical protein 0.0073 0.2394 0.3435
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.1389 0.132
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.1389 0.132
Echinococcus multilocularis serotonin receptor 0.0049 0.1389 0.132
Brugia malayi ORL1-like opioid receptor 0.0049 0.1389 0.1351
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus multilocularis serotonin receptor 0.0049 0.1389 0.132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0157 0.0078
Onchocerca volvulus 0.0049 0.1389 0.5776
Echinococcus multilocularis g protein coupled receptor 0.0049 0.1389 0.132
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.1389 0.132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0157 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0023 0.0295 0.1084
Echinococcus multilocularis g protein coupled receptor 0.0049 0.1389 0.132
Trypanosoma brucei protein kinase, putative 0.005 0.1406 0.5174
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni myosin xvIII 0.0049 0.1389 0.1993
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0157 0.0225
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Onchocerca volvulus 0.007 0.229 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0157 0.0225
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0157 0.0078
Brugia malayi nuclear receptor NHR-88 0.002 0.0157 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Trypanosoma brucei unspecified product 0.0023 0.0295 0.1084
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis neuropeptide receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0087 0.3001 0.2945
Echinococcus multilocularis somatostatin receptor 0.0049 0.1389 0.132
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1406 0.1337
Echinococcus multilocularis fmrfamide receptor 0.0049 0.1389 0.132
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.1389 0.132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1916 0.2749
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0157 0.0113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.1389 0.132
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.1389 0.132
Schistosoma mansoni amine GPCR 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1406 1
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Trypanosoma brucei RNA helicase, putative 0.008 0.2718 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0046 0.1237 0.1166
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.1389 0.1351
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0933 0.086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0157 0.0225
Echinococcus granulosus somatostatin receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0419 0.0342
Echinococcus multilocularis lamin 0.0026 0.0419 0.0342
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.1389 0.1351
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Schistosoma mansoni phosphoglucomutase 0.0021 0.0217 0.0312
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi ecdysteroid receptor 0.002 0.0157 0.0113
Schistosoma mansoni neuropeptide receptor 0.0049 0.1389 0.1993
Brugia malayi sulfakinin receptor protein 0.0049 0.1389 0.1351
Echinococcus multilocularis musashi 0.0026 0.0419 0.0342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1406 0.1337
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1406 0.1337
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.1389 0.1351
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1406 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0159 0.6062 0.6031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0157 0.0078
Schistosoma mansoni hypothetical protein 0.0181 0.697 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0448 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.1389 0.132
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.1389 0.132
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.1389 0.1993
Brugia malayi hypothetical protein 0.0049 0.1389 0.1351
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.1389 0.1993
Brugia malayi Melatonin receptor type 1A 0.0049 0.1389 0.1351
Onchocerca volvulus 0.0026 0.0419 0.1228
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.1389 0.132
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.1389 0.132
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0157 0.0078
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.1389 0.1993
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.1389 0.132
Brugia malayi Dopamine receptor protein 2 0.0049 0.1389 0.1351
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1406 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.1389 0.1351
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0933 0.086
Schistosoma mansoni lamin 0.0026 0.0419 0.0601
Echinococcus granulosus lamin 0.0026 0.0419 0.0342
Brugia malayi bZIP transcription factor family protein 0.009 0.3105 0.3075
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.1389 0.132
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.1389 0.1993
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0041 0.1043 0.0972
Echinococcus multilocularis jun protein 0.009 0.3105 0.305
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0157 0.0078
Trypanosoma cruzi ribonuclease H1, putative 0.0021 0.0217 0.1546
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0157 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0157 0.0113
Brugia malayi Bromodomain containing protein 0.0041 0.104 0.1
Echinococcus granulosus neuropeptide receptor 0.0049 0.1389 0.132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0157 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Echinococcus granulosus g protein coupled receptor 0.0049 0.1389 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.1389 0.132
Schistosoma mansoni hypothetical protein 0.0122 0.4491 0.6444
Schistosoma mansoni hypothetical protein 0.0049 0.1389 0.1993
Brugia malayi intermediate filament protein 0.0026 0.0419 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.1389 0.1351
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0079 0.0114
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0157 0.0225
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1406 0.5174
Schistosoma mansoni opsin-like receptor 0.0049 0.1389 0.1993
Loa Loa (eye worm) RNA binding protein 0.0062 0.1916 0.1852
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni adenoreceptor 0.0049 0.1389 0.1993
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.1389 0.132
Brugia malayi RNA binding protein 0.0062 0.1916 0.1881
Echinococcus multilocularis sex peptide receptor 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Loa Loa (eye worm) hypothetical protein 0.0075 0.2506 0.2446
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0157 0.0078
Schistosoma mansoni hypothetical protein 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Brugia malayi GnHR receptor homolog 0.0049 0.1389 0.1351
Schistosoma mansoni hypothetical protein 0.0051 0.1489 0.2136
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1406 0.2017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0157 0.0113
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0448 0.5
Onchocerca volvulus 0.0026 0.0419 0.1228
Brugia malayi follicle stimulating hormone receptor 0.0049 0.1389 0.1351
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Loa Loa (eye worm) hypothetical protein 0.0049 0.1389 0.132
Echinococcus granulosus fmrfamide receptor 0.0049 0.1389 0.132
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.1389 0.132
Leishmania major hypothetical protein, conserved 0.0027 0.0448 0.3186
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0157 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.1389 0.1993
Echinococcus granulosus g protein coupled receptor 0.0049 0.1389 0.132

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.17 ug ml-1 Inhibitory concentration required against Human rhinovirus-14(HRV-14) using plaque reduction assay ChEMBL. 10360742
TC50 (ADMET) > 10 ug ml-1 Cellular toxic concentration against Human rhinovirus-14(HRV-14) using cytopathic effect assay(CPE/XTT) ChEMBL. 10360742

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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