TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.454 | Formula: C25H22N2O3
H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCCn1nc(c2ccccc2)c(c(c1=O)c1cccc(c1)OC)c1ccccc1
InChi: 1S/C25H22N2O3/c1-30-21-14-8-13-20(17-21)23-22(18-9-4-2-5-10-18)24(19-11-6-3-7-12-19)26-27(15-16-28)25(23)29/h2-14,17,28H,15-16H2,1H3
InChiKey: OMCPCDQVFTVLKL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	allatostatin A receptor	0.0054	0.1596	0.1529
Onchocerca volvulus		0.0054	0.1596	0.6749
Leishmania major	ribonuclease H1, putative	0.0022	0.0217	0.1547
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.2008	0.1944
Onchocerca volvulus		0.0054	0.1596	0.6749
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1596	0.229
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0328	0.025
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0217	0.0312
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0157	0.0225
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1596	0.229
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0157	0.0113
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.534	0.5303
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0419	0.0342
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.1596	0.229
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.1406	0.1338
Brugia malayi	RNase H family protein	0.0022	0.0217	0.0174
Onchocerca volvulus	Ribonuclease H1 homolog	0.0022	0.0217	0.0285
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0157	0.0078
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1406	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.1596	0.1529
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1916	0.275
Schistosoma mansoni	hypothetical protein	0.0073	0.2394	0.3435
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0079	0.0114
Brugia malayi	Dopamine receptor	0.0054	0.1596	0.1559
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.4492	0.4448
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.1596	0.1529
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.1406	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1916	0.1881
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0448	0.1939
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1596	0.1529
Brugia malayi	Melatonin receptor type 1A	0.0054	0.1596	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.1596	0.1529
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0448	0.3186
Echinococcus granulosus	orexin receptor type 2	0.0054	0.1596	0.1529
Schistosoma mansoni	hypothetical protein	0.0054	0.1596	0.229
Onchocerca volvulus		0.0054	0.1596	0.6749
Onchocerca volvulus		0.0054	0.1596	0.6749
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.1596	0.229
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0157	0.0113
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.1596	0.1529
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.1596	0.6749
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Echinococcus granulosus	survival motor neuron protein 1	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.1596	0.229
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0448	0.3186
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1916	0.1852
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0157	0.0078
Brugia malayi	bZIP transcription factor family protein	0.009	0.3105	0.3075
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.1406	1
Brugia malayi	Dopamine receptor protein 2	0.0054	0.1596	0.1559
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.1596	0.229
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1489	0.2136
Schistosoma mansoni	coup transcription factor	0.002	0.0157	0.0225
Brugia malayi	nuclear receptor NHR-88	0.002	0.0157	0.0113
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1596	0.229
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0022	0.0217	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0157	0.0078
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.1596	0.1559
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.1596	0.229
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0157	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	RNase H family protein	0.0022	0.0217	0.0174
Echinococcus granulosus	somatostatin receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.1406	0.1338
Leishmania major	hypothetical protein, conserved	0.0027	0.0448	0.3186
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0044	0.115	0.1079
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1916	0.1852
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.1596	0.1529
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.1596	0.1529
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.1406	1
Schistosoma mansoni	opsin-like receptor	0.0054	0.1596	0.229
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1596	0.1529
Schistosoma mansoni	bromodomain containing protein	0.0068	0.2169	0.3113
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1916	0.275
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0157	0.0113
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1596	0.229
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0157	0.0113
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.1596	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus multilocularis	muscleblind protein	0.0161	0.6062	0.6031
Echinococcus multilocularis	serotonin receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.1596	0.1529
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0157	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0161	0.6062	0.6031
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.1596	0.229
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0157	0.0113
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	hypothetical protein	0.0022	0.0241	0.0346
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.1596	0.6749
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Schistosoma mansoni	histamine h1 receptor	0.0054	0.1596	0.229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0157	0.0078
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0157	0.0078
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.1596	0.229
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1916	0.275
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0157	0.0078
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0157	0.0225
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0419	0.0342
Schistosoma mansoni	opsin-like receptor	0.0054	0.1596	0.229
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1596	0.229
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.1596	0.1529
Schistosoma mansoni	hypothetical protein	0.0054	0.1596	0.229
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0157	0.0078
Onchocerca volvulus		0.0071	0.229	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.1596	0.1529
Trypanosoma brucei	RNA helicase, putative	0.0081	0.2718	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1406	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.1596	0.1529
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0157	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	lamin	0.0026	0.0419	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	zinc finger protein	0.0021	0.0193	0.0277
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1916	0.1852
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.534	0.7662
Onchocerca volvulus		0.0054	0.1596	0.6749
Echinococcus multilocularis	ribonuclease H1	0.0022	0.0217	0.0139
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.1596	0.1559
Onchocerca volvulus		0.0026	0.0419	0.1228
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	hypothetical protein	0.0054	0.1596	0.1529
Treponema pallidum	ribonuclease H (rnhA)	0.0022	0.0217	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.2008	0.1944
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0157	0.0113
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	G-protein coupled receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.1596	0.229
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.1596	0.1529
Brugia malayi	ORL1-like opioid receptor	0.0054	0.1596	0.1559
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0328	0.025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.1596	0.1529
Onchocerca volvulus		0.0054	0.1596	0.6749
Onchocerca volvulus		0.0054	0.1596	0.6749
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0157	0.0225
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.1596	0.1529
Brugia malayi	TAR-binding protein	0.0062	0.1916	0.1881
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1596	0.1529
Trypanosoma cruzi	ribonuclease H1, putative	0.0022	0.0217	0.1547
Echinococcus multilocularis	jun protein	0.009	0.3105	0.305
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.1406	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0161	0.6062	0.6031
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0448	0.0372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0419	0.0342
Onchocerca volvulus		0.0054	0.1596	0.6749
Echinococcus granulosus	neuropeptide receptor	0.0054	0.1596	0.1529
Trypanosoma brucei	ingi protein (ORF1)	0.0023	0.0295	0.1084
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.1596	0.1529
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0157	0.0078
Echinococcus granulosus	serotonin receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0157	0.0113
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Echinococcus multilocularis	muscleblind protein 1	0.0161	0.6062	0.6031
Echinococcus granulosus	muscleblind protein	0.0161	0.6062	0.6031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.1406	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	zinc finger protein	0.0021	0.0193	0.0115
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.1596	0.1529
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.1596	0.1529
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Echinococcus multilocularis	survival motor neuron protein 1	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1489	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Onchocerca volvulus		0.0054	0.1596	0.6749
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.4706	0.4664
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.4492	0.4448
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0157	0.0078
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0241	0.0163
Brugia malayi	RNase H family protein	0.0022	0.0217	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.1596	0.1559
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0157	0.0078
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0217	0.0312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Brugia malayi	Serotonin receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0157	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.1596	0.229
Trypanosoma brucei	ingi protein (ORF1)	0.0023	0.0295	0.1084
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0157	0.0113
Schistosoma mansoni	amine GPCR	0.0054	0.1596	0.229
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0157	0.0113
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.1596	0.1529
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0088	0.3001	0.2945
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0295	0.1084
Schistosoma mansoni	myosin xvIII	0.0054	0.1596	0.229
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0157	0.0078
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0157	0.0078
Brugia malayi	hypothetical protein	0.0071	0.229	0.2256
Echinococcus granulosus	sex peptide receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0157	0.0225
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1596	0.1529
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0157	0.0078
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0079	0.0114
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0419	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Trypanosoma brucei	protein kinase, putative	0.005	0.1406	0.5174
Schistosoma mansoni	hypothetical protein	0.0054	0.1596	0.229
Schistosoma mansoni	hypothetical protein	0.0182	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Echinococcus multilocularis	musashi	0.0026	0.0419	0.0342
Brugia malayi	steroid hormone receptor	0.002	0.0157	0.0113
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.1596	0.229
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	jun-related protein	0.0073	0.2394	0.3435
Onchocerca volvulus		0.0054	0.1596	0.6749
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.1596	0.1529
Brugia malayi	GnHR receptor homolog	0.0054	0.1596	0.1559
Echinococcus multilocularis	somatostatin receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Schistosoma mansoni	adenoreceptor	0.0054	0.1596	0.229
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1596	0.229
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	MH2 domain containing protein	0.0128	0.4706	0.4683
Schistosoma mansoni	lamin	0.0026	0.0419	0.0601
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Echinococcus granulosus	neuropeptide receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Brugia malayi	Dopamine receptor protein 1	0.0054	0.1596	0.1559
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0157	0.0078
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0157	0.0113
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.1406	1
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1596	0.1529
Brugia malayi	putative neuropeptide receptor	0.0054	0.1596	0.1559
Brugia malayi	G-protein coupled receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	hypothetical protein	0.0081	0.2718	0.3899
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.1596	0.1529
Trypanosoma brucei	ribonuclease H1	0.0022	0.0217	0.08
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0107	0.0028
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.1596	0.229
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.534	0.7662
Echinococcus granulosus	geminin	0.0182	0.697	0.6946
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	hypothetical protein	0.0054	0.1596	0.229
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1916	0.1852
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1596	0.229
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.1406	0.1338
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0023	0.0295	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	amine GPCR	0.0054	0.1596	0.229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0079	0.0114
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1596	0.1529
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Brugia malayi	PHD-finger family protein	0.0027	0.0435	0.0392
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.1596	0.229
Echinococcus granulosus	jun protein	0.009	0.3105	0.305
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0157	0.0113
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.1596	0.1559
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0328	0.047
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.1406	0.1338
Trypanosoma cruzi	ribonuclease H1, putative	0.0022	0.0217	0.1547
Brugia malayi	RNA binding protein	0.0062	0.1916	0.1881
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.1596	0.1529
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0448	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.1596	0.229
Echinococcus multilocularis	zinc finger protein	0.0021	0.0193	0.0115
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.1596	0.229
Brugia malayi	neuropeptide F receptor	0.0054	0.1596	0.1559
Onchocerca volvulus		0.0052	0.1489	0.6246
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0157	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0157	0.0113
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0157	0.0225
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0157	0.0113
Trypanosoma brucei	unspecified product	0.0023	0.0295	0.1084
Echinococcus multilocularis	lamin dm0	0.0026	0.0419	0.0342
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0157	0.0225
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.4706	0.4664
Echinococcus multilocularis	geminin	0.0182	0.697	0.6946
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2506	0.2446
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.1596	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0157	0.0113
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.1406	1
Schistosoma mansoni	amine GPCR	0.0054	0.1596	0.229
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1916	0.1852
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1916	0.275
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Brugia malayi	hypothetical protein	0.0054	0.1596	0.1559
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0079	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0157	0.0078
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.1596	0.1529
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0448	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0157	0.0078
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1596	0.229
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.1596	0.1529
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	hypothetical protein	0.0052	0.1489	0.2136
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1406	1
Brugia malayi	AKH receptor	0.0054	0.1596	0.1559
Brugia malayi	nuclear hormone receptor	0.002	0.0157	0.0113
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0448	0.1648
Onchocerca volvulus		0.0026	0.0419	0.1228
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1596	0.229
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0157	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0157	0.0078
Echinococcus granulosus	ribonuclease H1	0.0022	0.0217	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1043	0.0972
Brugia malayi	Bromodomain containing protein	0.0041	0.104	0.1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.009	0.3105	0.305
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.1596	0.1529
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0157	0.0225
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.1596	0.1529
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0157	0.0225
Brugia malayi	RE15519p	0.0054	0.1596	0.1559
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	lamin dm0	0.0026	0.0419	0.0342
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.1596	0.229
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0933	0.086
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.009	0.3105	0.305
Echinococcus granulosus	intermediate filament protein	0.0026	0.0419	0.0342
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.1596	0.229
Schistosoma mansoni	lamin	0.0026	0.0419	0.0601
Schistosoma mansoni	hypothetical protein	0.0123	0.4492	0.6444
Echinococcus multilocularis	sex peptide receptor	0.0054	0.1596	0.1529
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.1596	0.1559
Schistosoma mansoni	amine GPCR	0.0054	0.1596	0.229
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.1406	0.5174
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1406	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.1596	0.1529
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1406	0.2018
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0157	0.0078
Brugia malayi	hypothetical protein	0.0027	0.0448	0.0406
Schistosoma mansoni	hypothetical protein	0.0182	0.697	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.1596	0.1529
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0157	0.0078
Brugia malayi	sulfakinin receptor protein	0.0054	0.1596	0.1559
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0157	0.0078
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	Muscleblind-like protein	0.0161	0.6062	0.6045
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.1596	0.1529
Brugia malayi	G protein-coupled receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0398	0.0322
Brugia malayi	neuropeptide F receptor	0.0054	0.1596	0.1559
Brugia malayi	ecdysteroid receptor	0.002	0.0157	0.0113
Onchocerca volvulus		0.0054	0.1596	0.6749
Brugia malayi	MAP kinase sur-1	0.005	0.1406	0.1368
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0157	0.0078
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1596	0.229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0157	0.0078
Brugia malayi	Serotonin receptor	0.0054	0.1596	0.1559
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.1596	0.229
Brugia malayi	intermediate filament protein	0.0026	0.0419	0.0376
Onchocerca volvulus		0.0054	0.1596	0.6749
Schistosoma mansoni	opsin-like receptor	0.0054	0.1596	0.229
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.1596	0.1529
Echinococcus multilocularis	serotonin receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.1596	0.1529
Schistosoma mansoni	amine GPCR	0.0054	0.1596	0.229
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.1406	1
Brugia malayi	Bromodomain containing protein	0.0081	0.2699	0.2667
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.1596	0.1529
Brugia malayi	larval opioid receptor	0.0054	0.1596	0.1559
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1237	0.1166
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.1596	0.1529
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.1596	0.1529
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.1406	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1596	0.229
Echinococcus granulosus	fmrfamide receptor	0.0054	0.1596	0.1529
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0157	0.0225
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1916	0.275
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1596	0.1529
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.1596	0.1559
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.1596	0.1529
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0217	0.0312
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0419	0.0601
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.1596	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1596	0.1529
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0078
Echinococcus multilocularis	lamin	0.0026	0.0419	0.0342
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0933	0.086

Activities

Activity type	Activity value	Assay description	Source	Reference
BP (functional)	NA 0 mmHg	Antihypertensive activity in spontaneously hypertensive rats, measured as average blood pressure at 100 mg/kg,po before predose; No significant lowering of blood pressure	ChEMBL.	7452694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 40373