Detailed information for compound 406252

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1599.64 | Formula: C79H94N10O26
  • H donors: 23 H acceptors: 19 LogP: -0.92 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC1OC(Oc2ccc(cc2)C2c3ccc([nH]3)C(c3ccc([nH]3)C(c3[nH]c(C(c4[nH]c2cc4)c2ccc(cc2)OC2OC(CO)C(C(C2O)O)O)cc3)c2ccc(cc2)OC2OC(CO)C(C(C2O)O)O)c2ccccc2OCCCCC(=O)NC(C(=O)NCC(=O)NC(C(=O)O)CC(=O)O)CCCNC(=N)N)C(C(C1O)O)O
  • InChi: 1S/C79H94N10O26/c80-79(81)82-30-5-7-52(74(106)83-33-59(94)89-53(75(107)108)32-60(95)96)88-58(93)9-3-4-31-109-54-8-2-1-6-43(54)64-50-28-26-48(86-50)62(38-12-18-41(19-13-38)111-77-72(104)69(101)66(98)56(35-91)114-77)46-24-22-44(84-46)61(37-10-16-40(17-11-37)110-76-71(103)68(100)65(97)55(34-90)113-76)45-23-25-47(85-45)63(49-27-29-51(64)87-49)39-14-20-42(21-15-39)112-78-73(105)70(102)67(99)57(36-92)115-78/h1-2,6,8,10-29,52-53,55-57,61-73,76-78,84-87,90-92,97-105H,3-5,7,9,30-36H2,(H,83,106)(H,88,93)(H,89,94)(H,95,96)(H,107,108)(H4,80,81,82)
  • InChiKey: MIENAGWRFMQLKO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Schistosoma mansoni protein tyrosine phosphatase 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0036 0.0926
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0034 0.0036 0.0036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0036 0.0313
Onchocerca volvulus 0.0122 0.0276 0.0629
Leishmania major As/Sb Reductase 0.0034 0.0036 0.0926
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Trypanosoma cruzi mercaptopyruvate sulfurtransferase, putative 0.0034 0.0036 0.0926
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0122 0.0276 0.0276
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.013 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0034 0.0036 0.1289
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0437 0.1134 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0122 0.0276 0.7185
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Onchocerca volvulus 0.0122 0.0276 0.0629
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Giardia lamblia Dual specificity phosphatase Cdc25, putative 0.0034 0.0036 0.1289
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.017 0.0405 0.0405
Schistosoma mansoni Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specificprotein A14 protein) 0.0034 0.0036 0.0036
Trypanosoma cruzi As/Sb Reductase, putative 0.0034 0.0036 0.0926
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0176 0.0423 0.0423
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Giardia lamblia Hypothetical protein 0.0034 0.0036 0.1289
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.013 0.0297 0.0297
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Loa Loa (eye worm) hypothetical protein 0.0437 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0046 0.0068 0.0068
Leishmania major hypothetical protein, unknown function 0.0034 0.0036 0.0926
Onchocerca volvulus 0.1434 0.3858 1
Trypanosoma cruzi As/Sb Reductase, putative 0.0034 0.0036 0.0926
Schistosoma mansoni receptor protein tyrosine phosphatase 0.013 0.0297 0.0297
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Mycobacterium ulcerans thiosulfate sulfurtransferase SseA 0.0034 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0437 0.1134 0.1134
Echinococcus multilocularis hypothetical protein 0.0122 0.0276 0.0276
Echinococcus granulosus protein tyrosine phosphatase n9 0.0122 0.0276 0.0276
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0034 0.0036 0.0036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0176 0.0423 0.0423
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0122 0.0276 0.0276
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Echinococcus multilocularis Rhodanese 0.0034 0.0036 0.0036
Trichomonas vaginalis cdc25b, putative 0.0437 0.1134 1
Brugia malayi hypothetical protein 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Mycobacterium ulcerans thiosulfate sulfurtransferase, CysA2 0.0034 0.0036 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0176 0.0423 0.0423
Trichomonas vaginalis thiosulfate sulfertansferase, putative 0.0034 0.0036 0.0313
Leishmania major 3-mercaptopyruvate sulfurtransferase 0.0034 0.0036 0.0926
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0034 0.0036 0.0313
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein tyrosine phosphatase 0.0122 0.0276 0.0276
Schistosoma mansoni protein tyrosine phosphatase 0.013 0.0297 0.0297
Brugia malayi Rhodanese-like domain containing protein 0.0034 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1434 0.3858 0.3858
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Brugia malayi RIKEN cDNA 4930451A13 0.0034 0.0036 0.0036
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.013 0.0297 0.0297
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.017 0.0405 0.0405
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0437 0.1134 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.017 0.0405 0.0405
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0034 0.0036 0.1289
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0122 0.0276 0.7185
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0162 0.0384 0.0384
Trichomonas vaginalis cdc25a, putative 0.0034 0.0036 0.0313
Mycobacterium tuberculosis Possible transcriptional regulatory protein (possibly ArsR-family) 0.0034 0.0036 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0122 0.0276 0.0276
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0437 0.1134 1
Echinococcus granulosus Rhodanese 0.0034 0.0036 0.0036
Entamoeba histolytica rodhanase-like domain containing protein 0.0437 0.1134 1
Brugia malayi hypothetical protein 0.0122 0.0276 0.0276
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Echinococcus granulosus heat shock protein 67b2 0.0034 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Giardia lamblia Thiosulfate sulfurtransferase 0.0034 0.0036 0.1289
Plasmodium falciparum mitogen-activated protein kinase phosphatase 1, putative 0.0034 0.0036 1
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0034 0.0036 0.0036
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0034 0.0036 0.5
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0034 0.0036 0.0036
Echinococcus granulosus centrosomal protein of 41 kDa 0.0034 0.0036 0.0036
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0034 0.0036 0.0036
Trypanosoma brucei protein tyrosine phosphatase 1 0.0122 0.0276 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Mycobacterium tuberculosis Conserved protein 0.0034 0.0036 0.5
Plasmodium vivax mitogen-activated protein kinase phosphatase 1, putative 0.0034 0.0036 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0122 0.0276 0.0276
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseB 0.0034 0.0036 0.5
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0437 0.1134 0.1134
Onchocerca volvulus 0.0122 0.0276 0.0629
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0034 0.0036 0.0313
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0437 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1434 0.3858 0.3858
Loa Loa (eye worm) protein-tyrosine phosphatase 0.3684 1 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.3684 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0036 0.0313
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0036
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0402 0.1041 0.1041
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.3684 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0176 0.0423 0.0423
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0437 0.1134 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0162 0.0384 1
Onchocerca volvulus 0.1434 0.3858 1
Leishmania major tyrosine specific protein phosphatase, putative 0.0162 0.0384 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0176 0.0423 0.0423
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0122 0.0276 0.2187
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) 0.0034 0.0036 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0036 0.0313
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0122 0.0276 0.0276
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Brugia malayi MoeZ/MoeB domain containing protein 0.0034 0.0036 0.0036
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.013 0.0297 0.0297
Mycobacterium leprae Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) 0.0034 0.0036 0.5
Onchocerca volvulus 0.0122 0.0276 0.0629
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0034 0.0036 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0122 0.0276 0.0276
Trichomonas vaginalis cdc25b, putative 0.0437 0.1134 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0034 0.0036 0.0313
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) hypothetical protein 0.0402 0.1041 0.1041
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0036 0.5
Brugia malayi Rhodanese-like domain containing protein 0.0437 0.1134 0.1134
Echinococcus multilocularis 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0437 0.1134 0.2874
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0437 0.1134 0.1134
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.017 0.0405 0.0405
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0176 0.0423 0.0423
Onchocerca volvulus 0.0122 0.0276 0.0629
Plasmodium vivax rhodanese like protein, putative 0.0034 0.0036 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Schistosoma mansoni pcd6 interacting protein-related 0.0122 0.0276 0.0276
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0437 0.1134 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Giardia lamblia Hypothetical protein 0.0034 0.0036 0.1289
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Schistosoma mansoni protein tyrosine phosphatase 0.0122 0.0276 0.0276
Trichomonas vaginalis pten, drome, putative 0.0122 0.0276 0.2432
Brugia malayi hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0034 0.0036 0.5
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0034 0.0036 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0162 0.0384 0.0384
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0034 0.0036 0.1289
Echinococcus multilocularis heat shock protein 67b2 0.0034 0.0036 0.0036
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0036 0.0313
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0162 0.0384 0.0384
Onchocerca volvulus 0.0122 0.0276 0.0629
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Entamoeba histolytica rodhanase-like domain containing protein 0.0437 0.1134 1
Brugia malayi Protein-tyrosine phosphatase 0.013 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0036
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Onchocerca volvulus 4.1 G protein, putative homolog 0.0122 0.0276 0.0629
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0034 0.0036 0.5
Chlamydia trachomatis hypothetical protein 0.0034 0.0036 0.5
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0122 0.0276 0.2187
Onchocerca volvulus 0.0122 0.0276 0.0629
Brugia malayi hypothetical protein 0.0122 0.0276 0.0276
Trichomonas vaginalis cdc25c, putative 0.0034 0.0036 0.0313
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0122 0.0276 0.0276
Toxoplasma gondii rhodanese family domain-containing protein 0.0034 0.0036 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.017 0.0405 0.0405
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0122 0.0276 0.2187
Mycobacterium leprae PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN 0.0034 0.0036 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0122 0.0276 0.0276
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0034 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Giardia lamblia Protein tyrosine phosphatase 0.0122 0.0276 1
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0036 0.0926
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Wolbachia endosymbiont of Brugia malayi sulfurtransferase 0.0034 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0036 0.0313
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0122 0.0276 0.0276
Mycobacterium ulcerans hypothetical protein 0.0034 0.0036 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0034 0.0036 0.0036
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0034 0.0036 0.0036
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.3684 1 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0034 0.0036 0.1289
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0034 0.0036 0.0313
Onchocerca volvulus 0.0437 0.1134 0.2874
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Entamoeba histolytica rodhanase-like domain containing protein 0.0437 0.1134 1
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0122 0.0276 0.0276
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0162 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Echinococcus multilocularis sortilin receptor 0.004 0.0051 0.0051
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0034 0.0036 0.0926
Onchocerca volvulus 0.0437 0.1134 0.2874
Brugia malayi Rhodanese-like domain containing protein 0.0437 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Onchocerca volvulus 0.0437 0.1134 0.2874
Onchocerca volvulus 0.0162 0.0384 0.0911
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0276 0.0276
Trypanosoma brucei mercaptopyruvate sulfurtransferase, putative 0.0034 0.0036 0.1289
Brugia malayi hypothetical protein 0.0122 0.0276 0.0276
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Plasmodium falciparum rhodanese like protein, putative 0.0034 0.0036 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0162 0.0384 1
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0122 0.0276 0.0276
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0122 0.0276 0.0276
Trichomonas vaginalis cdc25c, putative 0.0437 0.1134 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0034 0.0036 0.0036
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Brugia malayi Rhodanese-like domain containing protein 0.0034 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0036
Schistosoma mansoni dual specificity protein phosphatase 0.0034 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0034 0.0036 0.0926
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase 1 0.0122 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0122 0.0276 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0276 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0036
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0122 0.0276 0.0276
Onchocerca volvulus 0.0122 0.0276 0.0629
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0276 0.0276

Activities

Activity type Activity value Assay description Source Reference
MBC (functional) = 1.5 ug ml-1 Minimal bacterial concentration against Staphylococcus aureus was evaluated; Range = 1-1.5 ug/mL ChEMBL. 15261271
MIC (functional) = 1 ug ml-1 Minimal inhibitory concentration against Staphylococcus aureus was evaluated; Range = 0.5-1.0 ug/mL ChEMBL. 15261271

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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