TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.435 | Formula: C22H22N4O3
H donors: 2 H acceptors: 2 LogP: 2.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc2c(c1)[nH]nc2c1cc2c([nH]1)ccc(c2)CN1CCOCC1
InChi: 1S/C22H22N4O3/c1-28-22(27)15-3-4-17-19(11-15)24-25-21(17)20-12-16-10-14(2-5-18(16)23-20)13-26-6-8-29-9-7-26/h2-5,10-12,23H,6-9,13H2,1H3,(H,24,25)
InChiKey: WSNMWYMIZKBEKA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 7	Starlite/ChEMBL	References
Homo sapiens	checkpoint kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130454	All targets in OG5_130454
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	Get druggable targets OG5_129224	All targets in OG5_129224
Schistosoma japonicum	Serine/threonine-protein kinase Chk1, putative	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129224	All targets in OG5_129224
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129224	All targets in OG5_129224
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129224	All targets in OG5_129224
Brugia malayi	cyclin-dependent kinase 7 homolog	Get druggable targets OG5_129224	All targets in OG5_129224
Echinococcus multilocularis	cyclin dependent kinase 7	Get druggable targets OG5_129224	All targets in OG5_129224
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Candida albicans	Serine-threonine kinase, subunit of RNA Pol TFIIK.	Get druggable targets OG5_129224	All targets in OG5_129224
Echinococcus granulosus	cyclin dependent kinase 7	Get druggable targets OG5_129224	All targets in OG5_129224
Candida albicans	Serine-threonine kinase, subunit of RNA Pol TFIIK.	Get druggable targets OG5_129224	All targets in OG5_129224

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 7	346 aa	311 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1696	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0048	0.0477	0.0316
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	contactin	0.014	0.2924	0.2805
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Schistosoma mansoni	septate junction protein	0.014	0.2924	0.3112
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0058	0.0745	0.0745
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Leishmania major	protein kinase, putative	0.0059	0.0775	1
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Trichomonas vaginalis	tubulin beta chain, putative	0.0048	0.0477	0.448
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Brugia malayi	protein-tyrosine kinase	0.0058	0.0745	0.0848
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Echinococcus granulosus	raf serine:threonine protein kinase	0.0058	0.0745	0.0589
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0161	0.3504	0.3394
Brugia malayi	Receptor family ligand binding region containing protein	0.0058	0.0745	0.0848
Brugia malayi	Peroxidasin	0.014	0.2924	0.3326
Schistosoma mansoni	nephrin related	0.0103	0.1954	0.2017
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0059	0.0775	0.062
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0166	0.0188
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0058	0.0745	0.0654
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0103	0.1954	0.1818
Brugia malayi	Tyrosine-protein kinase abl-1	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin domain containing protein	0.0036	0.0166	0.0188
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0775	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.014	0.2924	0.2924
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0059	0.0775	0.062
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Trichomonas vaginalis	CAMK family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	transfer RNA-Thr	0.0058	0.0745	0.0589
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0058	0.0745	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0301	0.7242	0.7242
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Onchocerca volvulus		0.0103	0.1954	0.4381
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Leishmania major	hypothetical protein, conserved	0.0058	0.0745	0.9003
Brugia malayi	Heparan sulfate	0.0036	0.0166	0.0188
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Onchocerca volvulus		0.0103	0.1954	0.4381
Echinococcus granulosus	tubulin beta 4A class IVa	0.0048	0.0477	0.0316
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0058	0.0745	0.0589
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Echinococcus granulosus	tyrosine protein kinase shark	0.0058	0.0745	0.0589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Toxoplasma gondii	protein kinase	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Schistosoma mansoni	myosin-binding protein-related	0.0103	0.1954	0.2017
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	cyclin dependent kinase 7	0.0094	0.1696	0.1556
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Fibronectin type III domain containing protein	0.0265	0.6271	0.7133
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0258	0.3334
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Trichomonas vaginalis	STE family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0203	0.4611	0.4611
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Echinococcus granulosus	kinase suppressor of Ras 1	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine kinase	0.0079	0.132	0.1302
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	disorganized muscle protein 1	0.0103	0.1954	0.1954
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0058	0.0745	0.0745
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	insulin growth factor binding	0.0103	0.1954	0.1818
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0058	0.0745	0.0589
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0105	0.2	0.1865
Schistosoma mansoni	protein kinase	0.0059	0.0775	0.0687
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0103	0.1954	0.1818
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0058	0.0745	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Immunoglobulin I-set domain containing protein	0.026	0.6145	0.699
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0058	0.0745	0.9616
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0058	0.0745	0.0745
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0058	0.0745	0.9616
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0103	0.1954	0.2222
Plasmodium falciparum	tyrosine kinase-like protein	0.0058	0.0745	0.9003
Echinococcus granulosus	tyrosine protein kinase Srms	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.014	0.2924	0.2805
Echinococcus granulosus	ephrin type A receptor 4 A	0.0058	0.0745	0.0589
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0166	0.0188
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0058	0.0745	0.0589
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Onchocerca volvulus		0.0103	0.1954	0.4381
Schistosoma mansoni	ephrin receptor	0.0058	0.0745	0.0654
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus granulosus	defective proboscis extension response	0.0265	0.6271	0.6209
Giardia lamblia	Kinase, NEK	0.0058	0.0745	1
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0258	0.0094
Brugia malayi	Immunoglobulin domain containing protein	0.0036	0.0166	0.0188
Echinococcus multilocularis	titin	0.0103	0.1954	0.1818
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.014	0.2924	0.2805
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	FL cytokine receptor	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0058	0.0745	0.9003
Onchocerca volvulus		0.0104	0.1984	0.4489
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.0745	0.0589
Brugia malayi	beta-tubulin, identical	0.0048	0.0477	0.0542
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.1984	0.2051
Schistosoma mansoni	tyrosine kinase	0.0105	0.2	0.2069
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0058	0.0745	0.0654
Echinococcus granulosus	epidermal growth factor receptor	0.0207	0.4719	0.463
Echinococcus multilocularis	neuroglian	0.014	0.2924	0.2805
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Echinococcus multilocularis	epidermal growth factor receptor	0.0207	0.4719	0.463
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.014	0.2924	0.3112
Echinococcus multilocularis	titin	0.0104	0.1984	0.1849
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0058	0.0745	0.0589
Echinococcus granulosus	beta tubulin	0.0048	0.0477	0.0316
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	c src tyrosine kinase	0.0058	0.0745	0.0589
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0059	0.0775	0.062
Brugia malayi	SH2 domain containing protein	0.0058	0.0745	0.0848
Schistosoma mansoni	slit	0.0103	0.1954	0.2017
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0141	0.2954	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	hypothetical protein	0.0058	0.0745	0.0848
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	TK/ACK protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Brugia malayi	Prion-like-	0.0103	0.1954	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Brugia malayi	Raf kinase	0.0058	0.0745	0.0848
Loa Loa (eye worm)	TK/RYK protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0058	0.0745	0.0745
Brugia malayi	basement membrane proteoglycan precursor	0.0036	0.0166	0.0188
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0058	0.0745	0.0589
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0103	0.1954	0.1818
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0058	0.0745	0.0745
Trypanosoma brucei	beta tubulin	0.0048	0.0477	0.6148
Trypanosoma cruzi	protein kinase, putative	0.0058	0.0745	0.9424
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Brugia malayi	Leucine Rich Repeat family protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0058	0.0745	0.0848
Echinococcus multilocularis	protein tyrosine kinase	0.0058	0.0745	0.0589
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0058	0.0745	0.0848
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Plasmodium falciparum	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0058	0.0745	0.0589
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0775	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0058	0.0745	0.0745
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Trypanosoma brucei	beta tubulin	0.0048	0.0477	0.6148
Trichomonas vaginalis	tubulin gamma chain, putative	0.0048	0.0477	0.448
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0058	0.0745	0.0589
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Brugia malayi	Immunoglobulin domain containing protein	0.0036	0.0166	0.0188
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.014	0.2924	0.2805
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0103	0.1954	0.2222
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0058	0.0745	0.0589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Brugia malayi	basement membrane proteoglycan	0.0036	0.0166	0.0188
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Onchocerca volvulus		0.0103	0.1954	0.4381
Echinococcus granulosus	lachesin	0.014	0.2924	0.2805
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Plasmodium falciparum	tyrosine kinase-like protein	0.0058	0.0745	0.9003
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Brugia malayi	SH2 domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0103	0.1954	0.1818
Echinococcus multilocularis	beta tubulin	0.0048	0.0477	0.0316
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Trypanosoma brucei	beta tubulin	0.0048	0.0477	0.6148
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0058	0.0745	0.9003
Schistosoma mansoni	vesicular amine transporter	0.0265	0.6271	0.6888
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0036	0.0166	0.0166
Loa Loa (eye worm)	TK/ALK protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0058	0.0745	0.0589
Echinococcus multilocularis	down syndrome cell adhesion	0.0103	0.1954	0.1818
Echinococcus multilocularis	titin	0.0103	0.1954	0.1818
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Prion-like-	0.0103	0.1954	0.2222
Onchocerca volvulus		0.0103	0.1954	0.4381
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0745	0.0654
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0157	0.3387	0.3275
Loa Loa (eye worm)	animal heme peroxidase	0.0103	0.1954	0.1954
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.1984	0.2051
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0104	0.1984	0.1984
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Onchocerca volvulus		0.0103	0.1954	0.4381
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.1696	0.1726
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0103	0.1954	0.1818
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0048	0.0477	0.448
Echinococcus granulosus	tyrosine protein kinase Blk	0.0058	0.0745	0.0589
Loa Loa (eye worm)	CAMK protein kinase	0.0104	0.1984	0.1984
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0059	0.0775	1
Echinococcus multilocularis	hemicentin 1	0.014	0.2924	0.2805
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0103	0.1954	0.1818
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.014	0.2924	0.2805
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0058	0.0745	0.0745
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Echinococcus granulosus	receptor type guanylyl cyclase	0.0058	0.0745	0.0589
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0058	0.0745	0.0589
Trichomonas vaginalis	AGC family protein kinase	0.0058	0.0745	1
Onchocerca volvulus		0.0103	0.1954	0.4381
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0058	0.0745	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	roundabout 2	0.014	0.2924	0.2805
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine kinase	0.0197	0.4474	0.486
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0166	0.0188
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Plasmodium falciparum	protein kinase, putative	0.0059	0.0775	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.014	0.2924	0.2805
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	tubulin beta-1 chain	0.0048	0.0477	0.0477
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	dna polymerase kappa	0.004	0.0258	0.0094
Echinococcus granulosus	tyrosine protein kinase HCK	0.0058	0.0745	0.0589
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Echinococcus multilocularis	tyrosine protein kinase otk	0.014	0.2924	0.2805
Trypanosoma cruzi	protein kinase, putative	0.0058	0.0745	0.9424
Trypanosoma brucei	DNA polymerase IV, putative	0.0033	0.0088	0.113
Schistosoma mansoni	cell adhesion molecule	0.014	0.2924	0.3112
Brugia malayi	follicle stimulating hormone receptor	0.0224	0.519	0.5904
Echinococcus granulosus	down syndrome cell adhesion	0.0103	0.1954	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0404	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0058	0.0745	0.0589
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0157	0.3387	0.3275
Brugia malayi	Furin-like cysteine rich region family protein	0.0207	0.4719	0.5367
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Schistosoma mansoni	protein kinase	0.0059	0.0775	0.0687
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	tyrosine kinase	0.0058	0.0745	0.0589
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0301	0.7242	0.7195
Schistosoma mansoni	titin	0.014	0.2924	0.3112
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Toxoplasma gondii	STE kinase	0.0058	0.0745	0.9003
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0058	0.0745	0.0848
Onchocerca volvulus	Netrin receptor homolog	0.0103	0.1954	0.4381
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0058	0.0745	0.0589
Brugia malayi	hypothetical protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Brugia malayi	integrin-linked kinase	0.0058	0.0745	0.0848
Echinococcus granulosus	tubulin beta 1 chain	0.0048	0.0477	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Echinococcus multilocularis	lachesin	0.014	0.2924	0.2805
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Loa Loa (eye worm)	projectin	0.0103	0.1954	0.1954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Brugia malayi	Guanylyl cyclase protein 23	0.0058	0.0745	0.0848
Echinococcus multilocularis	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0058	0.0745	0.0654
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.0745	0.0589
Loa Loa (eye worm)	TK/FAK protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	titin	0.0103	0.1954	0.1818
Echinococcus granulosus	activated cdc42 kinase 1	0.0058	0.0745	0.0589
Loa Loa (eye worm)	tubulin beta chain	0.0048	0.0477	0.0477
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.0745	0.0589
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	cell adhesion molecule	0.0103	0.1954	0.2017
Entamoeba histolytica	ankyrin repeat protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	neuroglian	0.0368	0.903	0.9013
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.014	0.2924	0.3112
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	tubulin, putative	0.0048	0.0477	0.448
Echinococcus granulosus	protein kinase	0.0058	0.0745	0.0589
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	tyrosine kinase	0.0105	0.2	0.2069
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	cell adhesion molecule	0.014	0.2924	0.3112
Brugia malayi	hypothetical protein	0.0036	0.0166	0.0188
Onchocerca volvulus	Putative titin	0.0103	0.1954	0.4381
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0058	0.0745	0.9003
Leishmania major	protein kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	protein unc-22	0.0104	0.1984	0.2256
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Giardia lamblia	Kinase, NEK	0.0058	0.0745	1
Brugia malayi	hypothetical protein	0.0265	0.6271	0.7133
Entamoeba histolytica	receptor protein kinase, putative	0.0058	0.0745	0.9003
Entamoeba histolytica	cysteine surface protein, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	BEN-1 protein	0.0048	0.0477	0.0477
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Echinococcus granulosus	tyrosine protein kinase	0.0058	0.0745	0.0589
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.0745	0.0589
Onchocerca volvulus	Peroxidasin homolog	0.0103	0.1954	0.4381
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0058	0.0745	0.0589
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0265	0.6271	0.6888
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Trypanosoma brucei	unspecified product	0.0033	0.0088	0.113
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	tubulin beta 1 chain	0.0048	0.0477	0.0316
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0058	0.0745	0.0654
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TK protein kinase	0.026	0.6145	0.6145
Echinococcus multilocularis	activin receptor type	0.0059	0.0775	0.062
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	tyrosine kinase	0.0157	0.3387	0.3634
Trichomonas vaginalis	tubulin alpha chain, putative	0.0048	0.0477	0.448
Loa Loa (eye worm)	tubulin beta-4 chain	0.0048	0.0477	0.0477
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Onchocerca volvulus	Peroxidasin homolog	0.0103	0.1954	0.4381
Trichomonas vaginalis	protein kinase atn1, putative	0.0058	0.0745	1
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0103	0.1954	0.1818
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0258	0.3334
Echinococcus granulosus	protein tyrosine kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	titin	0.0103	0.1954	0.1818
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Echinococcus multilocularis	neuroglian	0.0368	0.903	0.9013
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Echinococcus multilocularis	protein kinase	0.0058	0.0745	0.0589
Echinococcus granulosus	twitchin	0.0369	0.906	0.9044
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	titin	0.0104	0.1984	0.1849
Trichomonas vaginalis	TK family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	insulin receptor	0.0105	0.2	0.1865
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0058	0.0745	0.0848
Schistosoma mansoni	neuroglian	0.014	0.2924	0.3112
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	BEN-1 protein	0.0048	0.0477	0.0477
Echinococcus multilocularis	integrin linked protein kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Brugia malayi	C-terminal src kinase protein 1	0.0058	0.0745	0.0848
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0207	0.4719	0.4719
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0058	0.0745	0.0589
Echinococcus multilocularis	epidermal growth factor receptor	0.0137	0.287	0.275
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	nephrin	0.014	0.2924	0.3112
Echinococcus granulosus	nephrin	0.0103	0.1954	0.1818
Echinococcus granulosus	Immunoglobulin	0.0265	0.6271	0.6209
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0058	0.0745	0.0654
Schistosoma mansoni	septate junction protein	0.014	0.2924	0.3112
Brugia malayi	hypothetical protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	heat shock protein 70	0.0058	0.0745	0.0589
Echinococcus multilocularis	roundabout 2	0.014	0.2924	0.2805
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Toxoplasma gondii	protein kinase domain-containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0058	0.0745	0.0589
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Schistosoma mansoni	serine/threonine RGC	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	protein tyrosine kinase	0.0058	0.0745	0.0654
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0058	0.0745	0.0745
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0058	0.0745	0.0589
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0775	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.014	0.2924	0.2924
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Schistosoma mansoni	nephrin	0.0368	0.903	1
Plasmodium falciparum	protein kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Entamoeba histolytica	hypothetical protein, conserved	0.0058	0.0745	0.9003
Brugia malayi	Disorganized muscle protein 1	0.0103	0.1954	0.2222
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0058	0.0745	0.0589
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0265	0.6271	0.7133
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0258	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Tubulin beta-1 chain	0.0048	0.0477	0.0542
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0103	0.1954	0.1818
Echinococcus granulosus	tyrosine protein kinase otk	0.014	0.2924	0.2805
Schistosoma mansoni	roundabout	0.014	0.2924	0.3112
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.0745	0.0589
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Onchocerca volvulus		0.0103	0.1954	0.4381
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.0745	0.0589
Echinococcus granulosus	activated cdc42 kinase 1	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Echinococcus granulosus	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Echinococcus multilocularis	protein kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	LAD-2 short isoform	0.0036	0.0166	0.0166
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0058	0.0745	0.0589
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.014	0.2924	0.2805
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0265	0.6271	0.6209
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0166	0.0188
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Echinococcus granulosus	peroxidasin	0.014	0.2924	0.2805
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Echinococcus granulosus	hemicentin 1	0.014	0.2924	0.2805
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	cell adhesion molecule	0.0301	0.7242	0.7983
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0775	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Protein kinase domain containing protein	0.0105	0.2	0.2274
Echinococcus multilocularis	tubulin subunit beta	0.0048	0.0477	0.0316
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0094	0.1696	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0058	0.0745	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0105	0.2	0.1865
Entamoeba histolytica	ankyrin repeat protein	0.0058	0.0745	0.9003
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	TK/ROR protein kinase	0.0161	0.3504	0.3504
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0058	0.0745	0.0848
Echinococcus multilocularis	transfer RNA-Phe	0.0103	0.1954	0.1818
Echinococcus granulosus	titin	0.0103	0.1954	0.1818
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0058	0.0745	0.0589
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.014	0.2924	0.7899
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Echinococcus granulosus	activin receptor type	0.0059	0.0775	0.062
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Brugia malayi	Prion-like-	0.014	0.2924	0.3326
Loa Loa (eye worm)	one IG domain family member	0.0103	0.1954	0.1954
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Echinococcus granulosus	titin	0.0104	0.1984	0.1849
Schistosoma mansoni	protein kinase	0.0058	0.0745	0.0654
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Trypanosoma cruzi	beta tubulin, putative	0.0048	0.0477	0.4222
Echinococcus multilocularis	insulin receptor	0.0105	0.2	0.1865
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0058	0.0745	1
Giardia lamblia	Protein 21.1	0.0058	0.0745	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0058	0.0745	0.0589
Echinococcus multilocularis	insulin growth factor binding	0.0103	0.1954	0.1818
Echinococcus granulosus	tyrosine kinase	0.0058	0.0745	0.0589
Echinococcus granulosus	epidermal growth factor receptor	0.0137	0.287	0.275
Brugia malayi	kettin	0.0103	0.1954	0.2222
Schistosoma mansoni	cell adhesion molecule	0.0103	0.1954	0.2017
Loa Loa (eye worm)	TK/EPH protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Echinococcus granulosus	titin	0.0103	0.1954	0.1818
Loa Loa (eye worm)	beta-tubulin	0.0048	0.0477	0.0477
Echinococcus granulosus	cyclin dependent kinase 7	0.0094	0.1696	0.1556
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Brugia malayi	Protein kinase domain containing protein	0.0203	0.4611	0.5245
Echinococcus granulosus	roundabout 2	0.014	0.2924	0.2805
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0258	0.5
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Brugia malayi	Tyrosine-protein kinase PR2	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0359	0.8791	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Schistosoma mansoni	cell adhesion molecule	0.014	0.2924	0.3112
Echinococcus multilocularis	roundabout 2	0.014	0.2924	0.2805
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0103	0.1954	0.2017
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Schistosoma mansoni	tyrosine kinase	0.0207	0.4719	0.5137
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0104	0.1984	0.2256
Echinococcus multilocularis		0.0103	0.1954	0.1818
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0058	0.0745	0.0848
Loa Loa (eye worm)	tubulin beta-2A chain	0.0048	0.0477	0.0477
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.4611	0.5015
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Brugia malayi	Prion-like-	0.0103	0.1954	0.2222
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0157	0.3387	0.3275
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus granulosus	c src tyrosine kinase	0.0058	0.0745	0.0589
Echinococcus granulosus	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Echinococcus multilocularis	roundabout 2	0.0404	1	1
Trypanosoma brucei	beta tubulin	0.0048	0.0477	0.6148
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Onchocerca volvulus		0.0103	0.1954	0.4381
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0058	0.0745	0.0589
Echinococcus multilocularis	beta tubulin	0.0048	0.0477	0.0316
Echinococcus multilocularis	tyrosine protein kinase csk	0.0058	0.0745	0.0589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.014	0.2924	0.2924
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Schistosoma mansoni	cell adhesion molecule	0.0103	0.1954	0.2017
Brugia malayi	SRC-1	0.0058	0.0745	0.0848
Onchocerca volvulus		0.0103	0.1954	0.4381
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0137	0.287	0.275
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0094	0.1696	0.1696
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Schistosoma mansoni	hemicentin	0.0103	0.1954	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	twitchin	0.0104	0.1984	0.1849
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Schistosoma mansoni	hypothetical protein	0.0103	0.1954	0.2017
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	tubulin subunit beta	0.0048	0.0477	0.0316
Echinococcus multilocularis	Immunoglobulin	0.0265	0.6271	0.6209
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0058	0.0745	1
Entamoeba histolytica	receptor protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	integrin linked protein kinase	0.0058	0.0745	0.0589
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Schistosoma mansoni	tubulin subunit beta	0.0048	0.0477	0.0351
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0359	0.8791	0.8791
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Trypanosoma brucei	protein kinase, putative	0.0059	0.0775	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0166	0.0188
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.0745	0.0589
Plasmodium vivax	protein kinase, putative	0.0058	0.0745	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0103	0.1954	0.1954
Schistosoma mansoni	tyrosine protein kinase	0.0058	0.0745	0.0654
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	natriuretic peptide receptor 1	0.0058	0.0745	0.0589
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.0745	0.9003
Echinococcus granulosus	tyrosine kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Echinococcus granulosus	tyrosine kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0058	0.0745	0.0589
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.0745	0.9003
Loa Loa (eye worm)	TK/CSK protein kinase	0.0058	0.0745	0.0745
Loa Loa (eye worm)	TK protein kinase	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0048	0.0477	0.448
Brugia malayi	ephrin receptor 1 precursor	0.0058	0.0745	0.0848
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine kinase	0.0058	0.0745	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0745	0.0654
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0745	0.0589
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0161	0.3504	0.3394
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	0.519	0.519
Echinococcus multilocularis	tyrosine protein kinase	0.0058	0.0745	0.0589
Loa Loa (eye worm)	TK/ABL protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	ephrin receptor	0.0058	0.0745	0.0654
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Loa Loa (eye worm)	serine/threonine protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	titin	0.0104	0.1984	0.2051
Echinococcus multilocularis	peroxidasin	0.014	0.2924	0.2805
Schistosoma mansoni	tyrosine kinase	0.0137	0.287	0.3051
Echinococcus multilocularis	hemicentin 1	0.014	0.2924	0.2805
Echinococcus granulosus	beta tubulin	0.0048	0.0477	0.0316
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0058	0.0745	0.0589
Brugia malayi	Immunoglobulin I-set domain containing protein	0.014	0.2924	0.3326
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0745	0.0654
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Echinococcus multilocularis		0.0046	0.0432	0.0271
Giardia lamblia	Kinase	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0058	0.0745	0.0589
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0404	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0157	0.3387	0.3275
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0745	0.9003
Trypanosoma brucei	Pseudokinase, putative	0.0058	0.0745	0.9616
Echinococcus granulosus	neuroglian	0.014	0.2924	0.2805
Schistosoma mansoni	hypothetical protein	0.0058	0.0745	0.0654
Loa Loa (eye worm)	TK/DDR protein kinase	0.0058	0.0745	0.0745
Schistosoma mansoni	tyrosine kinase	0.0079	0.132	0.1302
Echinococcus multilocularis	Immunoglobulin	0.0265	0.6271	0.6209
Schistosoma mansoni	titin	0.0103	0.1954	0.2017
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1954	0.1954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0103	0.1954	0.2222
Echinococcus granulosus	tyrosine protein kinase pr2	0.0058	0.0745	0.0589
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.0745	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0058	0.0745	0.0589
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Entamoeba histolytica	protein kinase, putative	0.0058	0.0745	0.9003
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0058	0.0745	0.0589
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0036	0.0166	0.0166
Onchocerca volvulus	Tyrosine kinase homolog	0.0161	0.3504	1
Schistosoma mansoni	tyrosine kinase	0.0079	0.132	0.1302
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.0745	0.9003
Loa Loa (eye worm)	SRC-1	0.0058	0.0745	0.0745
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0745	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0265	0.6271	0.6271
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.0477	0.0316
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0058	0.0745	0.0589
Schistosoma mansoni	protein kinase	0.0059	0.0775	0.0687
Schistosoma mansoni	tyrosine kinase	0.0137	0.287	0.3051
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0265	0.6271	0.6888
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0258	0.3334
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0058	0.0745	1
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Entamoeba histolytica	hypothetical protein	0.0058	0.0745	0.9003
Trichomonas vaginalis	TKL family protein kinase	0.0058	0.0745	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.0745	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.014	0.2924	0.2924
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0058	0.0745	0.0589
Loa Loa (eye worm)	TK/INSR protein kinase	0.0105	0.2	0.2

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1930 nM	Release of NCI-H1299 cells from DNA damage-induced cell cycle arrest by CEA	ChEMBL.	16978863
EC50 (functional)	= 1930 nM	Release of NCI-H1299 cells from DNA damage-induced cell cycle arrest by CEA	ChEMBL.	16978863
IC50 (binding)	= 62 nM	Inhibition of Chek1	ChEMBL.	16978863
IC50 (binding)	= 62 nM	Inhibition of Chek1	ChEMBL.	16978863
IC50 (binding)	= 6500 nM	Inhibition of Cdk7	ChEMBL.	16978863
IC50 (binding)	= 6500 nM	Inhibition of Cdk7	ChEMBL.	16978863
Ratio IC50 (binding)	= 100	Selectivity for Chek1 over Cdk7	ChEMBL.	16978863

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16978863

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL221633

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 413908