Detailed information for compound 42327

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 469.57 | Formula: C27H35NO6
  • H donors: 1 H acceptors: 3 LogP: 6.18 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)OCCCCCCCCCCC(=O)Nc1ccc(cc1)C(=O)OC
  • InChi: 1S/C27H35NO6/c1-32-26(30)21-12-16-23(17-13-21)28-25(29)11-9-7-5-3-4-6-8-10-20-34-24-18-14-22(15-19-24)27(31)33-2/h12-19H,3-11,20H2,1-2H3,(H,28,29)
  • InChiKey: NKKTXKHWLPKMCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0223
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0189 0.0641
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1562 0.4405
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0503 0.1417
Echinococcus granulosus transcription factor eb 0.0123 0.1307 0.1558
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0105 0.0357
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0074 0.0088
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0105 0.0851
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0346 0.0413
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0347 0.1001
Brugia malayi PHD-finger family protein 0.003 0.0219 0.0617
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0189 0.3738
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0105 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0105 0.0851
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0123 0.13 0.4402
Schistosoma mansoni ap endonuclease 0.0041 0.0347 0.0413
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0289 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1562 0.1862
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1562 0.1862
Echinococcus multilocularis transcription factor eb 0.0123 0.1307 0.1307
Brugia malayi hypothetical protein 0.0035 0.0278 0.0785
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0078
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0363 0.0363
Echinococcus granulosus Smad4 0.0018 0.0074 0.0088
Schistosoma mansoni smad1 5 8 and 0.0018 0.0074 0.0088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0289 0.0345
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0223 0.3355
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0196 0.2918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi Bromodomain containing protein 0.0087 0.0888 0.2505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0074 0.0251
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0044 0.0377 0.1275
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.1623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.01 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi Flap endonuclease-1 0.0028 0.0189 0.0533
Entamoeba histolytica hypothetical protein 0.0314 0.3546 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0092 0.0109
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0152 0.0152
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0105 0.0851
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0289 0.0289
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0066 0.0066
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0081 0.0809 0.274
Schistosoma mansoni hypothetical protein 0.0727 0.8388 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0344 0.0344
Echinococcus granulosus flap endonuclease 1 0.0028 0.0189 0.0226
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0105 0.2083
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0189 0.2812
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0347 0.0978
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1562 0.1562
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0139 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0072 0.071 0.0847
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0092 0.0109
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0189 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) bromodomain containing protein 0.002 0.01 0.0338
Schistosoma mansoni cpg binding protein 0.0037 0.0301 0.0359
Schistosoma mansoni bromodomain containing protein 0.0074 0.0732 0.0872
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1622 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0301 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0196 0.3672
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0078
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.3463 1
Echinococcus granulosus zinc finger protein 0.0024 0.0148 0.0176
Schistosoma mansoni zinc finger protein 0.0017 0.0068 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.01 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0347 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0289 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0346 0.1172
Schistosoma mansoni hypothetical protein 0.0024 0.0139 0.0166
Schistosoma mansoni flap endonuclease-1 0.0025 0.0158 0.0188
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.03 0.0847
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0105 0.2083
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0289 0.5711
Brugia malayi Smad1 0.0018 0.0074 0.0209
Entamoeba histolytica hypothetical protein 0.0314 0.3546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.071 0.2003
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0506 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0066 0.0186
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0189 0.2763
Brugia malayi PHD-finger family protein 0.0014 0.0029 0.0081
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0289 0.0979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi jmjC domain containing protein 0.01 0.104 0.2932
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0105 0.2083
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0223 0.4348
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0105 0.0126
Brugia malayi MH1 domain containing protein 0.0018 0.0074 0.0209
Schistosoma mansoni transcription factor LCR-F1 0.0314 0.3546 0.4228
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0078 0.0093
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0092 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0105 0.1831
Loa Loa (eye worm) hypothetical protein 0.0055 0.0506 0.1714
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0506 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1562 0.1862
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0074 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0456 0.1544
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0363 0.0433
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0289 0.5711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0074 0.0088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0347 0.0413
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0253 0.0857
Schistosoma mansoni smad1 5 8 and 0.0018 0.0074 0.0088
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0066 0.0066
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0189 0.0546
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0689 0.0822
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0066 0.0078
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0187 0.0223
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0105 0.1831
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0123 0.1307 0.3684
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.3463 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1562 0.5291
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0066 0.0186
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0187 0.0187
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0344 0.041
Echinococcus granulosus geminin 0.0727 0.8388 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0347 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0016 0.0045
Brugia malayi isocitrate dehydrogenase 0.0036 0.0289 0.0815
Schistosoma mansoni zinc finger protein 0.0024 0.0148 0.0176
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0347 0.0347
Loa Loa (eye worm) TAR-binding protein 0.0072 0.071 0.2406
Trypanosoma brucei ISWI complex protein 0.0017 0.0068 0.1072
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0223 0.0266
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0347 0.682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) hypothetical protein 0.0037 0.03 0.1017
Echinococcus multilocularis tar DNA binding protein 0.0072 0.071 0.071
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0347 0.0978
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0027 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0289 0.0289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0105 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0072 0.071 0.0847
Echinococcus multilocularis GPCR, family 2 0.0017 0.0066 0.0066
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0506 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3463 0.9766
Brugia malayi MH2 domain containing protein 0.0018 0.0074 0.0209
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0187 0.0223
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0289 0.5575
Brugia malayi Bromodomain containing protein 0.0033 0.0254 0.0717
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0314 0.3546 0.3546
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0189 0.0249
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.104 0.124
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0105 0.1831
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0189 0.3539
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0105 0.0126
Loa Loa (eye worm) hypothetical protein 0.0046 0.0408 0.1383
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0078
Echinococcus granulosus peregrin 0.0033 0.0254 0.0303
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0347 0.1174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0105 0.0297
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0105 0.1455
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0105 0.0357
Schistosoma mansoni hypothetical protein 0.0727 0.8388 1
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0196 0.0196
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0074 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0347 0.685
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0347 0.682
Brugia malayi Bromodomain containing protein 0.0044 0.0376 0.1059
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0027 0.0033
Trypanosoma cruzi ISWI complex protein 0.0017 0.0068 0.1347
Leishmania major hypothetical protein, conserved 0.0055 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0339
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0223 0.0266
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1622 1
Brugia malayi PHD-finger family protein 0.0031 0.0223 0.0628
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0223 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Schistosoma mansoni hypothetical protein 0.0031 0.0223 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0105 0.0126
Schistosoma mansoni Smad4 0.0018 0.0074 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0149 0.0505
Schistosoma mansoni cpg binding protein 0.0037 0.0301 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi MH2 domain containing protein 0.0018 0.0074 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.01 0.0119
Plasmodium falciparum phd finger protein, putative 0.0031 0.0223 0.4348
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0106 0.0861
Echinococcus granulosus GPCR family 2 0.0017 0.0066 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0196 0.0565
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0105 0.0851
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0314 0.3546 0.4228
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0289 0.0289
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0289 0.5575
Plasmodium falciparum flap endonuclease 1 0.0028 0.0189 0.3679
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0506 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0105 0.2083
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0105 0.2083
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.071 0.2406
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0605 0.2049
Brugia malayi RNA binding protein 0.0072 0.071 0.2003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0503 0.1702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1562 0.1862
Loa Loa (eye worm) transcription factor SMAD2 0.0264 0.2952 1
Echinococcus granulosus cpg binding protein 0.0037 0.0301 0.0359
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0346 0.0413
Schistosoma mansoni hypothetical protein 0.0025 0.0152 0.0181
Trypanosoma cruzi ISWI complex protein 0.0017 0.0068 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1622 0.5
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0196 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0347 0.685
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0125 0.0354
Schistosoma mansoni ap endonuclease 0.0041 0.0347 0.0413
Schistosoma mansoni cpg binding protein 0.0033 0.0253 0.0302
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.104 0.104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0092 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1562 0.1562
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0055 0.0503 0.1702
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0223 0.0754
Onchocerca volvulus 0.0033 0.0253 1
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0289 0.443
Echinococcus granulosus tar DNA binding protein 0.0072 0.071 0.0847
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0066 0.0078
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0223 0.3355
Brugia malayi CXXC zinc finger family protein 0.0033 0.0253 0.0713
Brugia malayi hypothetical protein 0.0314 0.3546 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1562 0.1862
Echinococcus multilocularis zinc finger protein 0.0024 0.0148 0.0148
Schistosoma mansoni jumonji domain containing protein 0.008 0.0798 0.0951
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.01 0.01
Schistosoma mansoni tar DNA-binding protein 0.0072 0.071 0.0847
Toxoplasma gondii exonuclease III APE 0.0041 0.0347 0.5364
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0105 0.1831
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0196 0.0233
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0196 0.0552
Brugia malayi jmjC domain containing protein 0.0041 0.0346 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0264 0.2952 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0105 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0045
Echinococcus multilocularis geminin 0.0727 0.8388 0.8388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0066 0.0223
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0105 0.0851
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Schistosoma mansoni smad 0.0018 0.0074 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0506 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3463 0.9766
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0149 0.2948
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0347 0.636
Loa Loa (eye worm) hypothetical protein 0.0123 0.13 0.4402
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0506 0.7946
Loa Loa (eye worm) Smad1 0.0018 0.0074 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0072 0.071 0.0847
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0074 0.0251
Giardia lamblia PHD finger protein 15 0.0031 0.0223 0.0349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0105 0.0297
Entamoeba histolytica hypothetical protein 0.0314 0.3546 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.071 0.0847
Echinococcus granulosus smad 0.0018 0.0074 0.0088
Brugia malayi hypothetical protein 0.0055 0.0506 0.1427
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0074 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0506 1
Brugia malayi MH1 domain containing protein 0.0018 0.0074 0.0209
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0196 0.3867
Echinococcus multilocularis Smad4 0.0018 0.0074 0.0074
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0289 0.567
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Echinococcus multilocularis peregrin 0.0033 0.0254 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0289 0.5043
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0105 0.1831
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0347 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Brugia malayi MH2 domain containing protein 0.0264 0.2952 0.8326
Loa Loa (eye worm) hypothetical protein 0.0031 0.0223 0.0754
Schistosoma mansoni smad1 5 8 and 0.0018 0.0074 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0105 0.0304
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0289 0.443
Brugia malayi TAR-binding protein 0.0072 0.071 0.2003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0346 0.0413
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0189 0.3679
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0289 0.0345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0503 0.1417
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0152 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0633 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0347 0.675
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0289 0.567
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3463 1
Schistosoma mansoni hypothetical protein 0.0037 0.03 0.0358
Echinococcus multilocularis smad 0.0018 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0314 0.3546 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0684 0.0815
Loa Loa (eye worm) RNA binding protein 0.0072 0.071 0.2406
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.0081
Entamoeba histolytica hypothetical protein 0.0028 0.0196 0.0552
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0106 0.2092
Schistosoma mansoni hypothetical protein 0.0314 0.3546 0.4228
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0289 0.0815

Activities

Activity type Activity value Assay description Source Reference
Diet (functional) = 94 % In vivo sterol lowering activity at dose of 0.10 % of the diet ChEMBL. 6604818
Diet (functional) = 118 % In vivo Triglyceride lowering activity at a dose of 0.10 % of the diet ChEMBL. 6604818
Inhibition (binding) < 63 % In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604818
Inhibition (binding) < 63 % In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.