Detailed information for compound 426286

Basic information

Technical information
  • TDR Targets ID: 426286
  • Name: (5R)-3-[3-fluoro-4-(4-thiophen-2-ylsulfonylpi perazin-1-yl)phenyl]-5-(triazol-1-ylmethyl)-1 ,3-oxazolidin-2-one
  • MW: 492.547 | Formula: C20H21FN6O4S2
  • H donors: 0 H acceptors: 5 LogP: 1.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[C@H](CN1c1ccc(c(c1)F)N1CCN(CC1)S(=O)(=O)c1cccs1)Cn1nncc1
  • InChi: 1S/C20H21FN6O4S2/c21-17-12-15(27-14-16(31-20(27)28)13-25-6-5-22-23-25)3-4-18(17)24-7-9-26(10-8-24)33(29,30)19-2-1-11-32-19/h1-6,11-12,16H,7-10,13-14H2/t16-/m0/s1
  • InChiKey: IFQWVBGDXZAILU-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)piperazin-1-yl]phenyl]-5-(triazol-1-ylmethyl)oxazolidin-2-one
  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)-1-piperazinyl]phenyl]-5-(1-triazolylmethyl)-2-oxazolidinone
  • (5R)-3-[3-fluoro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)phenyl]-5-(1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one
  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)piperazino]phenyl]-5-(triazol-1-ylmethyl)oxazolidin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii subtilisin SUB12 0.008 0.067 0.1686
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Brugia malayi celfurPC protein 0.0144 0.1483 0.1483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0535 0.651 0.7458
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0167 0.0191
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Loa Loa (eye worm) hypothetical protein 0.0117 0.1137 0.1137
Brugia malayi Trypsin family protein 0.0117 0.1137 0.1137
Toxoplasma gondii hypothetical protein 0.0049 0.0271 0.0683
Toxoplasma gondii subtilisin SUB8 0.0031 0.0035 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0306 0.3568 0.4087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0035 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0263
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0114 0.1106 0.1267
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Onchocerca volvulus 0.006 0.0412 0.362
Echinococcus granulosus cathepsin L cysteine protease 0.0041 0.0167 0.0191
Trypanosoma cruzi major cysteine proteinase, putative 0.0075 0.0597 0.0684
Trichomonas vaginalis hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Echinococcus granulosus cathepsin l1 0.006 0.0412 0.0471
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0807 1 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0031 0.0035 0.0041
Echinococcus multilocularis neuroendocrine convertase 2 0.0117 0.1145 0.1312
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Brugia malayi cathepsin L-like precursor 0.0047 0.0245 0.0245
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0049 0.0271 0.0683
Entamoeba histolytica cysteine proteinase 2 0.0041 0.0167 0.4054
Echinococcus granulosus tm gpcr rhodopsin 0.0535 0.651 0.7458
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Onchocerca volvulus 0.0047 0.0245 0.2152
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Brugia malayi calpain 7 0.0058 0.0382 0.0382
Toxoplasma gondii cathepsin CPL 0.006 0.0412 0.1036
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0106 0.0121
Plasmodium vivax vivapain-3 0.0041 0.0167 0.2374
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni site-1 peptidase (S08 family) 0.0031 0.0035 0.0035
Toxoplasma gondii kringle domain-containing protein 0.0083 0.0703 0.1769
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Schistosoma mansoni inositol monophosphatase 0.0036 0.0106 0.0106
Echinococcus multilocularis cathepsin b 0.0708 0.8729 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Brugia malayi calpain family protein 1 0.0154 0.1612 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Plasmodium falciparum cysteine proteinase falcipain 1 0.0041 0.0167 0.2374
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0172 0.185 0.185
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0708 0.8729 0.8729
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trypanosoma brucei antigen, putative 0.0058 0.0382 0.1301
Loa Loa (eye worm) hypothetical protein 0.0113 0.1091 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus tissue type plasminogen activator 0.0083 0.0703 0.0805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0083 0.0703 0.0703
Trypanosoma cruzi kinesin, putative 0.0041 0.0158 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni site-1 peptidase (S08 family) 0.0031 0.0035 0.0035
Loa Loa (eye worm) calpain family protein 1 0.0113 0.1091 0.1091
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0703 0.0805
Toxoplasma gondii subtilisin SUB1 0.0031 0.0035 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.0703 0.0703
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0245 0.5946
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0031 0.0035 0.0035
Echinococcus multilocularis hypothetical protein 0.0058 0.0382 0.0438
Echinococcus granulosus calpain 5 0.0058 0.0382 0.0438
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0041 0.0167 0.0191
Brugia malayi Inositol-1 0.0036 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0058 0.038 0.038
Echinococcus multilocularis tissue type plasminogen activator 0.0083 0.0703 0.0805
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0245 0.0906
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.1106 0.4098
Loa Loa (eye worm) hypothetical protein 0.0172 0.185 0.185
Loa Loa (eye worm) inositol-1 0.0036 0.0106 0.0106
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Brugia malayi cathepsin B-like cysteine proteinase 0.0708 0.8729 0.8729
Brugia malayi Cathepsin L-like cysteine proteinase 0.0047 0.0245 0.0245
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0106 0.2567
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Giardia lamblia High cysteine membrane protein Group 2 0.0055 0.0341 0.1263
Loa Loa (eye worm) hypothetical protein 0.0117 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Echinococcus multilocularis calpain A 0.0164 0.1747 0.2001
Toxoplasma gondii microneme protein MIC17B 0.0049 0.0271 0.0683
Onchocerca volvulus 0.0049 0.0271 0.2385
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.0047 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus cathepsin L cysteine proteinase 0.006 0.0412 0.0471
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0106 0.0391
Echinococcus granulosus calpain A 0.0058 0.0382 0.0438
Trypanosoma cruzi kinesin, putative 0.0041 0.0158 0.0181
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Entamoeba histolytica protein kinase, putative 0.0041 0.0158 0.3841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0263
Echinococcus granulosus calpain 0.0058 0.0382 0.0438
Onchocerca volvulus 0.0092 0.0818 0.7195
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0154 0.1612 0.1612
Echinococcus granulosus cathepsin b 0.0708 0.8729 1
Toxoplasma gondii microneme protein MIC4 0.0049 0.0271 0.0683
Toxoplasma gondii hypothetical protein 0.0049 0.0271 0.0683
Toxoplasma gondii subtilisin SUB11 0.0031 0.0035 0.0089
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0031 0.0035 0.0041
Echinococcus multilocularis 0.0144 0.1483 0.1699
Echinococcus multilocularis calpain 0.0058 0.0382 0.0438
Echinococcus multilocularis cysteine protease 0.006 0.0412 0.0471
Loa Loa (eye worm) calpain 0.0058 0.0382 0.0382
Loa Loa (eye worm) subtilase 0.0807 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1388 0.1388
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Loa Loa (eye worm) fibroinase 0.006 0.0412 0.0412
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Echinococcus granulosus cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Plasmodium vivax calpain, putative 0.0058 0.0382 0.5437
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Echinococcus granulosus cathepsin l1 0.0047 0.0245 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Toxoplasma gondii PAN/Apple domain-containing protein 0.0049 0.0271 0.0683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0412 1
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni Mername-AA248 (C02 family) 0.0058 0.0382 0.0382
Brugia malayi Protein kinase domain containing protein 0.0083 0.0703 0.0703
Onchocerca volvulus 0.006 0.0412 0.362
Toxoplasma gondii PAN domain-containing protein 0.0338 0.3972 1
Echinococcus multilocularis cathepsin b 0.0708 0.8729 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0094 0.0842 0.0964
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0083 0.0703 1
Entamoeba histolytica cysteine protease, putative 0.006 0.0412 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Trypanosoma cruzi subtilisin peptidase 0.0031 0.0035 0.0041
Loa Loa (eye worm) cathepsin B 0.0238 0.27 0.27
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0164 0.1744 0.1998
Trypanosoma cruzi cysteine protease, putative 0.0041 0.0167 0.0191
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0035
Plasmodium vivax vivapain-2 0.006 0.0412 0.5856
Loa Loa (eye worm) proprotein convertase 2 0.006 0.0402 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Leishmania major cysteine peptidase A (CPA) 0.006 0.0412 0.1412
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Echinococcus granulosus calpain A 0.0164 0.1747 0.2001
Echinococcus multilocularis calpain 7 (C02 family) 0.0058 0.0382 0.0438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0167 0.0618
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0412 0.0471
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.0049 0.0271 0.2385
Onchocerca volvulus Cathepsin F homolog 0.006 0.0412 0.362
Onchocerca volvulus 0.006 0.0412 0.362
Plasmodium falciparum subtilisin-like protease 3 0.0031 0.0035 0.0504
Schistosoma mansoni hypothetical protein 0.0083 0.0703 0.0703
Loa Loa (eye worm) calpain 5 0.0041 0.0158 0.0158
Echinococcus multilocularis Furin 1 0.006 0.0402 0.0461
Onchocerca volvulus 0.0049 0.0271 0.2385
Echinococcus granulosus calpain 7 C02 family 0.0058 0.0382 0.0438
Entamoeba histolytica calpain large subunit domain III containing protein 0.0041 0.0158 0.3841
Onchocerca volvulus 0.0049 0.0271 0.2385
Loa Loa (eye worm) ctsf protein 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Echinococcus multilocularis calpain family protein 1, d 0.0113 0.1091 0.125
Toxoplasma gondii subtilisin SUB5 0.0031 0.0035 0.0089
Onchocerca volvulus 0.006 0.0412 0.362
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0238 0.27 1
Brugia malayi calpain family protein 1 0.0154 0.1612 0.1612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Onchocerca volvulus 0.0049 0.0271 0.2385
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0031 0.0035 0.0035
Onchocerca volvulus 0.0049 0.0271 0.2385
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0167 0.0167
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.006 0.0412 0.0412
Loa Loa (eye worm) cysteine protease 0.006 0.0412 0.0412
Plasmodium falciparum cysteine proteinase falcipain 2b 0.006 0.0412 0.5856
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0412 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0167 0.0191
Onchocerca volvulus 0.006 0.0412 0.362
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Toxoplasma gondii subtilisin SUB7 0.0031 0.0035 0.0089
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0121
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0029 0.0003 0.0013
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Plasmodium vivax vivapain-2 0.006 0.0412 0.5856
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0412 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0238 0.27 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0167 0.0493
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0382 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Brugia malayi Kringle domain containing protein 0.0083 0.0703 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1744
Loa Loa (eye worm) hypothetical protein 0.0708 0.8729 0.8729
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0106 0.0266
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.1137 0.1137
Plasmodium vivax subtilisin-like serine protease, putative 0.0031 0.0035 0.0504
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Toxoplasma gondii microneme protein MIC17C 0.0049 0.0271 0.0683
Onchocerca volvulus Cathepsin L homolog 0.006 0.0412 0.362
Onchocerca volvulus 0.0049 0.0271 0.2385
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Onchocerca volvulus 0.0096 0.0867 0.7628
Echinococcus multilocularis cathepsin L 0.0041 0.0167 0.0191
Brugia malayi proprotein convertase 2 0.0117 0.1145 0.1145
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0412 0.0471
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine proteinase 1, putative 0.0041 0.0167 0.4054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Onchocerca volvulus 0.0031 0.0035 0.0312
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0167 0.0191
Toxoplasma gondii subtilisin SUB4 0.0031 0.0035 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.006 0.0402 0.0402
Brugia malayi calpain 5 0.0041 0.0158 0.0158
Plasmodium vivax unspecified product 0.0041 0.0167 0.2374
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0096 0.0867 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0167 0.0493
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.1009 0.1156
Loa Loa (eye worm) calpain family protein 1 0.0154 0.1612 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus neuroendocrine convertase 2 0.0117 0.1145 0.1312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.1106 0.4098
Onchocerca volvulus 0.0083 0.0703 0.6181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.006 0.0412 0.362
Plasmodium falciparum subtilisin-like protease 2 0.0031 0.0035 0.0504
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Onchocerca volvulus Cathepsin L homolog 0.006 0.0412 0.362
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0238 0.27 0.3093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0031 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Plasmodium falciparum cysteine repeat modular protein 1 0.0083 0.0703 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0412 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Echinococcus granulosus membrane bound transcription factor site 1 0.0031 0.0035 0.0041
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Toxoplasma gondii microneme protein MIC17A 0.0049 0.0271 0.0683
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Toxoplasma gondii subtilisin SUB10 0.0031 0.0035 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0106 0.0391
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Brugia malayi endoprotease bli-4 precursor 0.0172 0.185 0.185
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.006 0.0412 0.362
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0412 0.0471
Plasmodium vivax subtilisin-like protease 1 0.0031 0.0035 0.0504
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Echinococcus granulosus cathepsin L 0.0041 0.0167 0.0191
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0412 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Leishmania major kinesin, putative 0.0041 0.0158 0.046
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0238 0.27 0.27
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0058 0.0382 0.1301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Plasmodium falciparum cysteine proteinase falcipain 3 0.006 0.0412 0.5856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0057 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0114 0.1106 0.1267
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.0049 0.0271 0.2385
Plasmodium vivax vivapain-1 0.0041 0.0167 0.2374
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0306 0.3568 0.4087
Leishmania major hypothetical protein, conserved 0.0083 0.0703 0.2505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0167 0.0618
Schistosoma mansoni inositol monophosphatase 0.0036 0.0106 0.0106
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1744
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0057 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0106 0.0121
Echinococcus multilocularis cysteine protease 0.006 0.0412 0.0471
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0106 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0106 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Echinococcus multilocularis calpain 5 0.0058 0.0382 0.0438
Echinococcus granulosus cysteine protease 0.0041 0.0167 0.0191
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0708 0.8729 1
Echinococcus granulosus cathepsin b 0.0708 0.8729 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0058 0.0382 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Toxoplasma gondii subtilisin SUB6 0.0031 0.0035 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0106 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Trypanosoma brucei kinesin, putative 0.0041 0.0158 0.046
Echinococcus granulosus Furin 1 0.006 0.0402 0.0461
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0167 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.1137 0.1137
Brugia malayi Cathepsin L-like precursor 0.0047 0.0245 0.0245
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Loa Loa (eye worm) endoprotease bli-4 0.0172 0.185 0.185
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Giardia lamblia Furin precursor putative serine protease 0.0029 0.0003 0.0013
Plasmodium vivax subtilisin-like protease 2, putative 0.0031 0.0035 0.0504
Echinococcus granulosus furin 0.0172 0.185 0.2119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) hypothetical protein 0.0154 0.1612 0.1612
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0035 0.0041
Onchocerca volvulus 0.0117 0.1137 1
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Brugia malayi neuroendocrine convertase 1 precursor 0.0117 0.1145 0.1145
Schistosoma mansoni furin-1 (S08 family) 0.0089 0.0779 0.0779
Plasmodium falciparum cysteine proteinase falcipain 2a 0.006 0.0412 0.5856
Toxoplasma gondii subtilisin SUB9 0.0031 0.0035 0.0089
Schistosoma mansoni calpain (C02 family) 0.0058 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Toxoplasma gondii microneme protein, putative 0.0049 0.0271 0.0683
Schistosoma mansoni calpain C (C02 family) 0.0058 0.0382 0.0382
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Plasmodium falciparum subtilisin-like protease 1 0.0031 0.0035 0.0504
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0412 0.0412
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Onchocerca volvulus 0.0049 0.0271 0.2385
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Toxoplasma gondii PAN domain-containing protein 0.0338 0.3972 1
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Toxoplasma gondii subtilisin SUB2 0.0031 0.0035 0.0089
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Toxoplasma gondii cathepsin B 0.0238 0.27 0.6796
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0245 0.0906
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0245 0.0245
Trypanosoma brucei cysteine peptidase C (CPC) 0.0238 0.27 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-resistant Staphylococcus aureus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-susceptible coagulase-negative staphylococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against vancomycin-sensitive Enterococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against vancomycin-resistant Enterococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Staphylococcus aureus ATCC 25922 by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Streptococcus pneumoniae by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-susceptible Staphylococcus aureus by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-resistant Staphylococcus aureus by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against Enterococcus faecalis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by microdilution broth method ChEMBL. 17363116
MIC (functional) > 8 ug ml-1 Antimicrobial activity against Staphylococcus aureus ATCC 25922 in presence of 50% human plasma by agar dilution method ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial avtivity against Haemophilus influenzae ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Moraxella catarrhalis ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 ChEMBL. 17140706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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