TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 593.56 | Formula: C30H39Cl2FN4O3
H donors: 2 H acceptors: 3 LogP: 4.66 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: OCCN[C@H](c1cccc(c1N1CCN(CC1)C(=O)[C@H](N1CCCC1=O)Cc1ccc(cc1Cl)Cl)F)CC(C)C
InChi: 1S/C30H39Cl2FN4O3/c1-20(2)17-26(34-10-16-38)23-5-3-6-25(33)29(23)35-12-14-36(15-13-35)30(40)27(37-11-4-7-28(37)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,34,38H,4,7,10-18H2,1-2H3/t26-,27+/m0/s1
InChiKey: HAYIRZKTTMIXAL-RRPNLBNLSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanocortin 4 receptor	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0028	0.0634	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3172	0.3172
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0634	0.0634
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0634	0.0634
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0028	0.0634	0.5
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0634	0.0083
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0229	1	1
Onchocerca volvulus		0.0083	0.3172	0.277
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0028	0.0634	0.0083
Mycobacterium ulcerans	dipeptidase PepE	0.0028	0.0634	1
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0028	0.0634	0.0634
Treponema pallidum	aminopeptidase P	0.0028	0.0634	0.5
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Schistosoma mansoni	peptidase	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0028	0.0634	0.0083
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0634	0.0634
Echinococcus multilocularis	FACT complex subunit SPT16	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3172	0.3172
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0028	0.0634	0.0083
Schistosoma mansoni	peroxidasin	0.0083	0.3172	0.277
Echinococcus granulosus	Proliferation associated protein 2G4	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Echinococcus granulosus	FACT complex subunit SPT16	0.0028	0.0634	0.0083
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0027	0.0555	0.0555
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0229	1	1
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0028	0.0634	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3172	0.3172
Mycobacterium ulcerans	methionine aminopeptidase	0.0028	0.0634	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0028	0.0634	0.5
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0634	0.0634
Trypanosoma cruzi	aminopeptidase P1, putative	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0028	0.0634	0.0083
Leishmania major	transcription factor-like protein	0.0028	0.0634	0.0634
Onchocerca volvulus	Dipeptidase C homolog	0.0028	0.0634	0.0083
Toxoplasma gondii	methionine aminopeptidase	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0028	0.0634	0.0083
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0229	1	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0634	0.0634
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Onchocerca volvulus		0.0028	0.0634	0.0083
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0028	0.0634	0.0634
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0634	0.0634
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0028	0.0634	0.0634
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0028	0.0634	0.0083
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0028	0.0634	0.0083
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3172	0.3172
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0229	1	1
Entamoeba histolytica	methionine aminopeptidase, putative	0.0229	1	1
Brugia malayi	Methionine aminopeptidase protein type I	0.0028	0.0634	0.0634
Mycobacterium tuberculosis	Dipeptidase PepE	0.0028	0.0634	0.5
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0555	0.0555
Echinococcus multilocularis	peroxidasin	0.0083	0.3172	0.277
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0634	0.0083
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0028	0.0634	1
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Onchocerca volvulus	Chorion peroxidase homolog	0.0083	0.3172	0.277
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0028	0.0634	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3172	0.3172
Mycobacterium leprae	Probable cytoplasmic peptidase PepQ	0.0028	0.0634	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.3172	0.277
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0634	0.0083
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0229	1	1
Brugia malayi	Cadherin domain containing protein	0.0027	0.0555	0.0555
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.3172	0.277
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0634	0.0634
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0229	1	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Brugia malayi	notch-like transmembrane receptor	0.0027	0.0555	0.0555
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0028	0.0634	0.0083
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0028	0.0634	0.0083
Schistosoma mansoni	peroxidasin	0.0083	0.3172	0.277
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Echinococcus granulosus	methionyl aminopeptidase 2	0.0229	1	1
Trypanosoma cruzi	aminopeptidase P, putative	0.0028	0.0634	0.0634
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Loa Loa (eye worm)	Notch2	0.0027	0.0555	0.0555
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0028	0.0634	0.0634
Loa Loa (eye worm)	blistered cuticle protein 3	0.0083	0.3172	0.3172
Leishmania major	methionine aminopeptidase 2, putative	0.0229	1	1
Echinococcus granulosus	peroxidasin	0.0083	0.3172	0.277
Mycobacterium ulcerans	aminopeptidase	0.0028	0.0634	1
Onchocerca volvulus		0.0083	0.3172	0.277
Onchocerca volvulus		0.0083	0.3172	0.277
Leishmania major	hypothetical protein, conserved	0.0028	0.0634	0.0634
Echinococcus granulosus	methionine aminopeptidase type I	0.0028	0.0634	0.0083
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Brugia malayi	Peroxidasin	0.0083	0.3172	0.3172
Giardia lamblia	Methionine aminopeptidase	0.0229	1	1
Brugia malayi	Muscle positioning protein 4	0.0027	0.0555	0.0555
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3172	0.3172
Plasmodium falciparum	methionine aminopeptidase 2	0.0229	1	1
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0229	1	1
Trypanosoma brucei	methionine aminopeptidase, putative	0.0028	0.0634	0.0634
Loa Loa (eye worm)	notch protein	0.0027	0.0555	0.0555
Brugia malayi	Delta serrate ligand family protein	0.0027	0.0555	0.0555
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0229	1	1
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0028	0.0634	0.0083
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0229	1	1
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0028	0.0634	0.0083
Chlamydia trachomatis	aminopeptidase P	0.0028	0.0634	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0634	0.0083
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0028	0.0634	0.0634
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0028	0.0634	0.0083
Onchocerca volvulus	Peroxidase homolog	0.0083	0.3172	0.277
Toxoplasma gondii	peptidase D, putative	0.0028	0.0634	0.0083
Mycobacterium ulcerans	dipeptidase	0.0028	0.0634	1
Toxoplasma gondii	creatinase domain-containing protein	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0634	0.0634
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0028	0.0634	0.5
Brugia malayi	hypothetical protein	0.0083	0.3172	0.3172
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0229	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Brugia malayi	GCC2 and GCC3 family protein	0.0027	0.0555	0.0555
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0229	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3172	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Echinococcus multilocularis	xaa pro aminopeptidase	0.0028	0.0634	0.0083
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0028	0.0634	0.5
Chlamydia trachomatis	methionine aminopeptidase	0.0028	0.0634	0.5
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0028	0.0634	0.5
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Toxoplasma gondii	methionine aminopeptidase	0.0028	0.0634	0.0083
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Brugia malayi	Blistered cuticle protein 3	0.0083	0.3172	0.3172
Treponema pallidum	methionine aminopeptidase (map)	0.0028	0.0634	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3172	0.3172
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0028	0.0634	0.0083
Onchocerca volvulus	FACT complex subunit SPT16 homolog	0.0028	0.0634	0.0083
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0229	1	1
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0028	0.0634	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Echinococcus granulosus	xaa pro aminopeptidase	0.0028	0.0634	0.0083
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0028	0.0634	0.0634
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0229	1	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Loa Loa (eye worm)	DNA-binding protein	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3172	0.3172
Brugia malayi	EGF-like domain containing protein	0.0027	0.0555	0.0555
Onchocerca volvulus	Peroxidase homolog	0.0083	0.3172	0.277
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0555	0.0555
Brugia malayi	Cadherin domain containing protein	0.0027	0.0555	0.0555
Onchocerca volvulus	Dual oxidase homolog	0.0083	0.3172	0.277
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0229	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 480 nM	Inhibition of microsomal CYP3A4	ChEMBL.	17822895
IC50 (ADMET)	= 480 nM	Inhibition of microsomal CYP3A4	ChEMBL.	17822895
Ki (binding)	= 6.4 nM	Binding affinity at human MC4R	ChEMBL.	17822895
Ki (binding)	= 6.4 nM	Binding affinity at human MC4R	ChEMBL.	17822895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL237147

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 443573